• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.6
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• pp.583-588
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• 2015

Asymptotic method has been often used to theoretically analyze the complete contact problem. The error of the asymptotic results increases as the distance from the contact edge increases. The singularity cannot be properly obtained from a finite element (FE) analysis owing to the finiteness of the element size. In the present work, the complete contact problem in bonded condition is analyzed using a combined experimental-numerical approach to assist and/or compare with the asymptotic results. Al and Cu alloys are used for the material combination of the punch and substrate. 120 and 135 degrees are used for the punch angle. The FE models are validated by comparison of displacement distributions obtained by the FE analysis and $moir{\acute{e}}$ experiment. Generalized stress intensity factors are evaluated using the validated FE models. Stress field in the vicinity of the sharp contact edges obtained from the FE and asymptotic analyses are compared. The discrepancies are also discussed.

• Steel and Composite Structures
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• v.28 no.3
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• pp.363-380
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• 2018

This paper presented an integral design procedure for demountable bolted composite frames with semi-rigid joints. Moment-rotation relationships of beam-to-column joints were predicted with analytical models aiming to provide accurate and reliable analytical solutions. Among this, initial stiffness of beam-to-column joints was derived on the basis of Timoshenko's plate theory, and moment capacity was derived in accordance with Eurocodes. The predictions were validated with relevant test results prior to further applications. Frame analysis was conducted by using Abaqus software with material and geometrical nonlinearity considered. Variable lateral loads incorporating wind actions and earthquake actions in accordance with Australian Standards were adopted to evaluate the flexural behaviour of the composite frames. Strength and serviceability limit state criteria were utilized to verify configurations of designed models. A wide range of frames with the varied number of storeys and bays were thereafter programmed to ascertain bending moment envelopes under various load combinations. The analytical results suggest that the proposed approach is capable of predicting the moment-rotation performance of the semi-rigid joints reasonably well. Outcomes of the frame analysis indicate that the load combination with dead loads and live loads only leads to maximum sagging and hogging moment magnitudes in beams. As for lateral loads, wind actions are more crucial to dominate the design of the demountable composite frames than earthquake actions. No hogging moment reversal is expected in the composite beams given that the frames are designed properly. The proposed analysis procedure is demonstrated to be a simple and efficient method, which can be applied into engineering practice.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.899-904
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• 2014

Concurrent chemo-radiation (CRT) has been established as the standard of care for non-metastatic loco-regionally advanced nasopharyngeal carcinoma (NPC) but recently the addition of induction chemotherapy in the already established regimen has presented an attractive multidisciplinary approach. This retrospective study was carried out to evaluate the efficacy of induction chemotherapy (IC) followed by CRT for the management of loco-regionally advanced NPC. Between July 2005 and September 2010, 99 patients were treated with cisplatin based IC followed by CRT. Induction chemotherapy included a 2 drug combination; intravenous gemcitabine $1000mg/m^2$ on day 1 and 8 and cisplatin $75mg/m^2$ on day 1 only. Radiotherapy (RT) was given as a phase treatment to a total dose of 70 Gy in 35 fractions. Concurrent cisplatin ($75mg/m^2$) was administered to all patients on days 1, 22 and 43. All patients were evaluated for tumor response and adverse effects after IC and 6 weeks after the completion of the treatment protocol. Statistical analysis was performed using SPSS version 17 and Kaplan Meier estimates were applied to project survival. Median follow-up duration was 20 months. The 5-year overall survival (OS), loco regional control (LRC) and relapse free survival (RFS) rates were 71%, 73% and 50%respectively. Acute grade 4 toxicity related to induction chemotherapy and concurrent chemo-radiation was 4% and 2% respectively, with only 3 toxicity-related hospital admissions. We conclude that induction gemcitabine and cisplatin followed by chemo-radiation is a safe and effective regimen in management of nasopharyngeal carcinoma, meriting further investigation in randomized clinical trials.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.629-635
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• 2014

Background: Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Myeloid cell leukemia-1 (Mcl-1), a death-inhibiting protein that regulates apoptosis, has been shown to be overexpressed in numerous malignancies. In addition, it has been demonstrated that the expression level of the Mcl-1 gene increases at the time of leukemic relapse following chemotherapy. The aim of this study was to target Mcl-1 by small interference RNA (siRNA) and analyze its effects on survival and chemosensitivity of acute myeloid leukemia cell line HL-60. Materials and Methods: siRNA transfection was performed with a liposome approach. The expression levels of mRNA and protein were measured by real-time quantitative PCR and Western blot analysis, respectively. Trypan blue assays were performed to evaluate tumor cell growth after siRNA transfection. The cytotoxic effects of Mcl-1 siRNA (siMcl-1) and etoposide were determined using MTT assay on their own and in combination. Apoptosis was quantified using a DNA-histone ELISA assay. Results: Transfection with siMcl-1 significantly suppressed the expression of Mcl-1 mRNA and protein in a time-dependent manner, resulting in strong growth inhibition and spontaneous apoptosis. Surprisingly, pretreatment with siMcl-1 synergistically enhanced the cytotoxic effect of etoposide. Furthermore, Mcl-1 down-regulation significantly increased apoptosis sensitivity to etoposide. No significant biological effects were observed with negative control siRNA treatment. Conclusions: Our results suggest that specific suppression of Mcl-1 by siRNA can effectively induce apoptosis and overcome chemoresistance of leukemic cells. Therefore, siMcl-1 may be a potent adjuvant in leukemia chemotherapy.

• Journal of the Korea Computer Industry Society
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• v.2 no.9
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• pp.1191-1198
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• 2001

An increasingly important facet of software development is the ability to estimate the associate cost and effort of development early in the development life cycle. Most of the proposed models are based upon a combination of intuition, expert judgement, and regression analysis of empirical data. Overall, the work has failed to produce any single model that can be applied with a reasonable degree of success to a variety of environments. This paper presents a neural network (NN) model that related software development effort to software size measured in function element types. The heuristic approach is applied to decide the number of hidden neurons in NN from the relationship between input-output pairs. The research describes appropriate NN modeling in the context of a case study for 24 software development projects. Also, this paper compared the NN model with a regression analysis model and found the NN model has better accuracy.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.903-907
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• 2013

Primary screening by HPV DNA testing is an effective method for reducing cervical cancer and has proven more sensitive than cytology. To advance this approach, many molecular methods have been developed. Hybrid capture 2 provides semi-quantitative results in ratios of relative light units and positive cutoff values (RLU/PC). Twenty-five thousand and five patients were included in this study to analyze the correlation between the ratio of RLU/PC and stage of cervical dysplasia. The results show that the RLU/PC ratios ranged from 0-3500 while almost normal cases, ASC-US and ASC-H, had values below 200. Of those samples negative for cytology markers, 94.6% were normal and their RLU/PC ratios were less than 4. With an RLU/PC ratio greater than 4 and less than or equal to 300, the percentages in all age groups were normal 53.6%, LSIL 20.2%, ASC-US 17.2%, HSIL 6.13%, ASC-H 2.72%, and AGC 0.11%, respectively. In contrast, 64.0% of samples with a RLU/PC ratio greater than 300 and less than or equal to 3500 were LSIL. These results should contribute to cost effective cervical cancer management strategies. Further studies of associations with particular HPV genotypes would be useful to predict the risk of progression to cancer.

• Journal of Korea Multimedia Society
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• v.16 no.7
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• pp.870-878
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• 2013

In this paper, we propose a novel fingerprint classification method to enhance the accuracy and efficiency of the fingerprint identification system, one of biometrics systems. According to the previous researches, fingerprints can be categorized into the several patterns based on their pattern of ridges and valleys. After construction of fingerprint database based on their patters, fingerprint classification approach can help to accelerate the fingerprint recognition. The reason is that classification methods reduce the size of the search space to the fingerprints of the same category before matching. First, we suggest a method to extract region of interest (ROI) which have real information about fingerprint from the image. And then we propose a feature extraction method which combines gray level co-occurrence matrix (GLCM) and wavelet features. Finally, we compare the performance of our proposed method with the existing method which use only GLCM as the feature of fingerprint by using the multi-layer perceptron and support vector machine.

• Korean Institute of Interior Design Journal
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• v.22 no.5
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• pp.22-32
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• 2013

Today, the museum historical material and mental, physical culture and heritage to preserve the collection and exhibition organization rather than to recognize that culture acts as a community to respond to the subject of the attitude and the ability jeokgeukhwa also due to the trend of the times due to changes in lifestyle education and research, and public participation in culture by expanding the role of dissemination activities are becoming. Museum exhibit these changes as part of a combination of various technologies in the coexistence of digital and analog display direction proactive and aggressive behavior, such as visitors expect to have an evaluation of the public and communicate the expectations of the plan in the exhibition space, the larger the effect can feel. This effective display for visitors to watch the way for a systematic approach to provide direction to the urgent reality. Museum visitors experienced officials to improve the quality of research in a variety of ways spectators began to try and move the action was to put the attention on the characteristics. Visitors to visit the Museum of History and ages, categorized by the type of display any difference in the behavior of the visitor experience and attributes based on what is being investigated for the History Museum's exhibition of any exhibit to visitors that experience and is to an analysis.

• Korean Journal of Cognitive Science
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• v.21 no.4
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• pp.459-480
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• 2010

A dialogue system includes various morphological analyses for recognizing a user's intention from the user's utterances. However, a user can represent various intentions via emotional states in addition to morphological expressions. Thus, a user's emotion recognition can analyze a user's intention in various manners. This paper presents a new method to automatically recognize a user's emotion for a dialogue system. For general emotions, we define nine categories using a psychological approach. For an optimal feature set, we organize a combination of sentential, a priori, and context features. Then, we employ a support vector machine (SVM) that has been widely used in various learning tasks to automatically classify a user's emotions. The experiment results show that our method has a 62.8% F-measure, 15% higher than the reference system.

• Composites Research
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• v.28 no.2
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• pp.58-64
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• 2015

The purpose of this paper is to suggest the effective equivalent finite element model for the impact limiter of a nuclear spent fuel shipping cask made of sandwich composite panels. The sandwich composite panels were composed of a metallic facesheet and a core material made of urethane foam, balsa wood and red wood, respectively. The effective equivalent finite element model for the impact limiter was proposed by comparing the results of low-velocity impact test of sandwich panels. An explicit finite element analysis based on LS-DYNA 3D was done in this study. The results showed that the solid elements were recommended to model the facesheet and core of sandwich panels for impact limiter compared to combination modeling method, in which the layered shell element for facesheet and solid element for core material are used. In particular, the solid element for balsa and red wood core materials should be modeled by the element elimination approach.