• Title/Summary/Keyword: Colon Cancer

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MOLECULAR TARGETS IN SIGNALING PATHWAYS MEDIATING ANTI-TUMOR EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

  • Hwang, Daniel
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.14-21
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    • 2001
  • Many epidemiological studies have revealed that the use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the risk of colon cancer. Since the well-documented pharmacological action of aspirin and other NSAIDs is the inhibition of cyclooxygenase [COX, the rate-limiting enzyme in prostaglandin (PG) biosynthesis], it has been inferred that the beneficial effect of NSAIDs may be mediated through the inhibition of PG biosynthesis.(omitted)

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The Frequency of MSI in Un selected Korean Colorectal Adenocarcinomas

  • Ryu, Hye-Myung;Lee, Myung-Hoon;Bae, Han-Ik
    • Biomedical Science Letters
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    • v.9 no.3
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    • pp.171-175
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    • 2003
  • Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers (HNPCC) and a portion of sporadic colorectal cancers. Forty unselected colorectal cancer patients were analyzed for MSI using silver stain plus kit. The overall incidence of MSI in studied cases was 17% (7/40). The incidence is similar result with previous study. MSI in colorectal carcers was more prevalent in moderative differentiated adenocarcinoma than well differentiated adenocarcinoma

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Unsual Cytotoxic Phenethylamides form Xenerhabdus nemetophilus

  • Baek, Seon Guk;Park, Yeong Hwan;Seo, Seung Il;Kim, Hyeon Su;Lee, In Seon;Park, Myeong Gwang;Lee, Cheon Su;Park, Seon Ho
    • Bulletin of the Korean Chemical Society
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    • v.22 no.4
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    • pp.372-374
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    • 2001
  • Three simple carboxamides incorporating the phenethylamine moiety have been isolated from strain XR-NC of a symbiotic bacterium Xenorhabdus nematophilus. Their structures were identified by spectroscopic data and synthesis. The compounds exhibited significant cytotoxicities against human cancer-cell line, viz. the gastric adenocarcinoma, colon adenocarcinoma and lung adenocarcinoma.