• 대한의용생체공학회:의공학회지
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• 제24권6호
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• pp.515-522
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• 2003

인두는 구강과 식도, 비강과 폐의 중간에서 능동적으로 구강을 통해 섭취되는 음식물과 비강을 통해 흡입되는 공기의 통로역할을 하는 주요한 기관이다. 본 연구는 유한요소기법을 이용한 인두의 3차원 구조의 재구성 과정을 거쳐 인두의 생체역학모델을 구현하였으며, 연하곤란환자의 인두근육의 주요부분에 대한 구조적 변형특성을 3가지로 분류하여 유한요소기법을 이용하여 인두내의 압력에 대한 형상의 변형을 관찰 후 최적화 과정을 거쳐 각 부분에서의 추정 압력 구배를 측정하여 연하과정에서 내부에 생성되는 압력의 연속적인 압력분포를 추정하였다. CT에 의한 인두의 변형 형상을 추정하여 임의 압력에 의한 인두구조의 변형 형상을 유한요소 해석에 의해 계산한 후 비교하여 실제 인두강 내에 형성되는 압력을 추정하였다. 재료적 특성은 인두의 기능이상 시 근조직경화가 발생, 즉 stiffness 가 증가하는 것으로 가정하여 응력-변형률 관계에 있어서 각각 $25\%,\;50\%,\;75\%$씩 증가시켜 분석하였다. 이러한 인두의 생체역학모델은 인두기능장애를 가진 환자의 치료 계획 수립에 도움이 되는 유용한 자료를 제공 할 것으로 생각된다.

• 한국재난정보학회 논문집
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• 제19권4호
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• pp.976-983
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• 2023

연구목적: 지진하중을 받는 교량 구조물의 동적 거동은 지진파의 특성 혹은 재료 및 기하학적 특성과 같은 많은 불확실성에 영향을 받는다. 하지만 모든 불확실성 인자가 교량 구조물의 동적 거동에 중요한 영향을 미치진 않는다. 영향성이 낮은 불확실성 인자까지 고려한 확률론적 내진성능 평가는 많은 계산비용이 요구되기 때문에 교량의 동적 거동에 미치는 영향을 고려하여 불확실성 인자는 식별되어야 한다. 따라서 본 연구는 I형 곡선 거더를 갖는 단경간 교량의 동적 거동에 영향을 미치는 주요 매개변수를 식별하기 위해 전역민감도 분석을 수행하였다. 연구방법: 지진파의 불확실성과 곡선 교량의 재료 및 기하학적 불확실성을 고려하여 유한요소 해석을 수행하였으며 해석결과를 기반으로 대리모델을 작성하였다. 결정계수와 같은 성능평가지료를 이용하여 대리모델을 평가하였으며 최종적으로 대리모델 기반의 전역 민감도 분석을 수행하였다. 연구결과: 지진하중을 받는 I형 곡선 거더의 응력응답에 가장 큰 영향을 미치는 불확실성 인자는 최대지반가속도(PGA), 교각의 높이(h), 강재의 항복응력(fy) 순으로 나타났다. PGA, h, fy의 주효과 민감도 지수는 각각 0.7096, 0.0839, 0.0352로 나타났으며 총 민감도 지수는 각각 0.9459, 0.1297, 0.0678로 나타났다. 결론: I형 곡선 거더의 응력응답은 입력운동의 불확실성에 대한 영향성이 지배적이며 각 불확실성 인자 사이의 교호작용에 큰 영향을 받는다. 따라서 입력운동의 개수 및 intensity measure과 같은 입력운동의 불확실성에 대한 추가적인 민감도 분석과 곡선거더의 개수 및 곡률과 같은 구조적 불확실성까지 고려한 총 민감도 분석은 필요하다.

• Tuberculosis and Respiratory Diseases
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• 제69권1호
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• pp.16-23
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• 2010

Background: Most lung cancer patients receive systemic chemotherapy at an advanced stage disease. Cisplatin-based chemotherapy is the main regimen for treating advanced lung cancer. Recently, autophagy has become an important mechanism of cellular adaptation under starvation or cell oxidative stress. The purpose of this study was to determine whether or not autophagy can occurred in cisplatin-treated lung cancer cells. Methods: H460 cells were incubated with RPMI 1640 and treated in $5{\mu}M$ or $20{\mu}M$ cisplatin concentrations at specific time intervals. Cells surviving cisplatin treatment were measured and compared using an MTT cell viability assay to cells that underwent apoptosis with autophagy by nuclear staining, apoptotic or autophagic related proteins, and autophagic vacuoles. The development of acidic vascular organelles was using acridine orange staining and fluorescent expression of GFP-LC3 protein in its transfected cells was observed to evaluate autophagy. Results: Lung cancer cells treated with $5{\mu}M$ cisplatin-treated were less sensitive to cell death than $20{\mu}M$ cisplatin-treated cells in a time-dependent manner. Nuclear fragmentation at $5{\mu}M$ was not detected, even though it was discovered at $20{\mu}M$. Poly (ADP-ribose) polymerase cleavages were not detected in $5{\mu}M$ within 24 hours. Massive vacuolization in the cytoplasm of $5{\mu}M$ treated cells were observed. Acridine orange stain-positive cells was increased according in time-dependence manner. The autophagosome-incorporated LC3 II protein expression was increased in $5{\mu}M$ treated cells, but was not detected in $20{\mu}M$ treated cells. The expression of GFP-LC3 were increased in $5{\mu}M$ treated cells in a time-dependent manner. Conclusion: The induction of autophagy occurred in $5{\mu}M$ dose of cisplatin-treated lung cancer cells.

• Journal of Preventive Medicine and Public Health
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• 제38권4호
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• pp.391-400
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• 2005

Objective : This study examined the socioeconomic differentials for the health and health related behaviors among South Korean middle school students. Methods : A nationwide cross-sectional interview survey of 3,449 middle school second-grade students and their parents was conducted using a stratified multi-stage cluster sampling method. The response rate was 93.3%. The socioeconomic position indicators were based on self-reported information from the students and their parents: parental education, father's occupational class, monthly family income, out-of-pocket expenditure for education, housing ownership, educational expectations, educational performance and the perceived economic hardships. The outcome variables that were measured were also based on the self-reported information from the students. The health measures included self-rated health conditions, psychological or mental problems, the feelings of loneliness at school, the overall satisfaction of life and the perceived level of stress. The health related behaviors included were smoking, alcohol drinking, sexual intercourse, violence, bullying and verbal and physical abuse by parents. Results : Socioeconomic differences for the health and health related behaviors were found among the eighth grade boys and girls of South Korea. However, the pattern varied with gender, the socioeconomic position indicators and the outcome measures. The prevalence rates of the overall dissatisfaction with life for both genders differed according to most of the eight socioeconomic position indicators. All the health measures were significantly different according to the perceived economic hardship. However, the socioeconomic differences in the self-rated health conditions and the psychosocial or mental problems were not clear. The students having higher socioeconomic position tended to be a perpetrator of bullying while those students with lower socioeconomic position were more likely to be a victim. Conclusions : The perceived economic hardships predicted the health status among the eighth graders of South Korea. The overall satisfaction of life was associated with the socioeconomic position indicators. Further research efforts are needed to explore the mechanisms on how and why the socioeconomic position affects the health and health related behaviors in this age group.

• 혜화의학회지
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• 제9권1호
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• pp.201-214
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• 2000

Precise and detailed clinical research and evaluation based on objective standards are imperative factors in securing reliability of a clinical test. Built on this principle, this clinical test has been conducted during the period between March 1999 and March 2000 dealing with 31 outpatients treated with ShiHo-GuizhiTang or ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions at the Sung-bo ORIENTAL MEDICAL CLINIC. A variety of information relating to those patients has been collected and analyzed under such criteria as precise diagnoses and their clinical effectiveness. The analysis was duly based on "The theory of cold syndrome". Then, the 31 patients' individual clinical information was compared one another by breaking down the results into sub-categories including gender, age, disease, main symptom, blood pressure, pulse beats, syndrome of abdomen, treatment period, modify and mixed prescription, and evaluation. The result of this clinical test can be summarized as follows: First, ShiHo-GuizhiTang appears to be more frequently prescribed in the case of female patients than in the case of male patients despite the fact that it does not necessarily need to be applied only to female. In addition, the numbers of prescriptions of ShiHo-GuizhiTang in the two age groups consisting of elementary school children and economically active adults respectively were the highest among other age groups. Second, ShiHo-GuizhiTang proved to be most effective in treatment for respiratory ailments and arthritis. Third, ShiHo-GuizhiTang brought down blood pressure of hypertension patients and at the same time benefited patients with normal or lower-than-normal blood pressure who were vulnerable to diseases due to low disease-resistance. Fourth, ShiHo-GuizhiTang was effective in the case of frequent pulse(rapid pulse) and thereby indicating the fact it carries Taiyang superficies syndrome. 지맥 arises from suppressed immune responses owing to adrenocortical hormones. ShiHo-GuizhiTang controls and revitalizes those suppressed immune systems which stem from slow pulse and, as a consequence of that process, helps them return to normal condition of pulse. Fifth, from the standpoint of syndrome of abdomen, feeling of obstruction in the epigastrium serves as an important standard in the process of diagnosing diseases and evaluating effectiveness of treatments. Sixth, according to the results of the clinical test with the 31 patients, a total of 81 percent of test subjects benefited from the treatment. The figure is the sum of 52 percent of I-class (both main symptom and accompanying symptoms had been eliminated) and 29 percent of II-class (part of main symptom and accompanying symptoms had been eliminated) respectively. All told it is safe to say that ShiHo-GuizhiTang can elect to be a viable clinical treatment. In conclusion, it is estimated that this clinical study has drawn up guidelines for objective diagnostic standards and evaluation on specific treatments' effectiveness. This will lead to more general application of ShiHo-GuizhiTang. On top of that, this study could also provide an opportunity to stress the significance of ShiHo-GuizhiTang and ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions as an alternative treatment for collagen disease which comes from environmental degradation and pollution.

• 대한예방한의학회지
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• 제5권2호
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• pp.8-28
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• 2001

This investigation grasps the level and relevant elements of performance of health promotional activities for the elderly in Korea. It provides fundamental data on health promoting projects targeting the elderly population from farming villages. Hence, this study gropes for an effective approach and measures of health promoting programs. The program needs to be developed with a focus on elderly people from farming villages. In addition, it was carried out in order to provide basic data for development of health projects for local communities. Data gathering was based on survey data targeting patients from the free clinic service. Service was rendered for the residents of farming villages, and conducted at the Offices of CheonBuk Province from October 2000 to December 2000. Analytical results were used to examine the health promotional method for the elderly in the aspect of Oriental Medicine. SPSS 9.0 version as well as T-test and ANOVA were used for survey data analysis. Piersons correlation coefficient was utilized for the relationship for each area, obtaining the following analytical results. 1. The average score for the activities of health promotion was 2.28. Looking at each subcategory, stress management was the highest at 3.65; interpersonal relationship, 3.00; nutrition, 2.55; health responsibility, 2.15; self-realization, 2.03; and exercise was the lowest at 1.89. 2. With respect to lifestyle of the health promotion secondary to general features of elderly people from farming villages, the level of activities of health promoting lifestyle was shown to be higher for males than that of females. Self-realization area was high among males in detailed particulars while the level of execution was high as age decreases in the stress area. 3. Regarding health promoting life style secondary to socioeconomic characteristics, the level of execution was higher for the individuals with a higher level of education and further utilization of spare time. With respect to occupation, the level was highest for people from the fishery. The level decreased in the order of other occupations such as trade, unemployed and agriculture, which was shown to be the lowest. In detailed particulars, it revealed that higher the individuals educational level, the higher the self-realization and stress management areas. The level of interpersonal relationship was the highest among people with little or no education. With respect to self-realization area, the level was highest among the cases where one paid living expenses along with their children. The lowest level of living expenses was seen in the cases where an individual pays for living expenses by himself/herself. There were significant results in all areas except for nutrition areas depending on occupation. The fishery was shown to be the highest. The level of activities was higher as one utilizes more spare time in all areas except for the area of interpersonal relationship.

• Asian-Australasian Journal of Animal Sciences
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• 제20권5호
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• pp.761-767
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• 2007

This study was conducted to determine the effects of exogenous zinc-metallothionein (Zn-MT) on anti-oxidative function and pork quality. After feeding a corn-soybean meal-based diet for two weeks, 48 pigs ($Duroc{\times}Landrace{\times}Chinese\;Black Pig$) were assigned randomly to four groups. Pigs in Group 1 were maintained under non-stress conditions, whereas pigs in Groups 2, 3 and 4 were aggressively handled for 25 min to produce stress. Pigs in Groups 1, 2, 3, and 4 received intramuscular administration of saline (control group; CON), 0 (negative control group; NCON), 0.8 (low dose group; LOW), and 1.6 (high dose group; HIGH) mg rabbit liver Zn-MT per kg body weight, respectively. Pigs were slaughtered at 3 and 6 h post-injection. Zn-MT treatment increased (p<0.05) the activities of superoxide dismutase (SOD) and glutathione-peroxidase (GSH-PX) while decreasing the concentration of malondialdehyde (MDA) in liver. These responses were greater (p<0.05) at 6 h than at 3 h post Zn-MT injection. Zn-MT treatment increased (p<0.05) hepatic SOD mRNA levels in a time and dose-dependent manner and decreased (p<0.05) serum glutamate-pyruvate transaminase and lactate dehydrogenase activities (indicators of tissue integrity). Zn-MT administration decreased (p<0.05) lactate concentration and increased (p<0.05) pH and water-holding capacity in the longissimus thorasis meat. Collectively, our results indicate that intramuscular administration of Zn-MT to pre-slaughter stressed pigs improved tissue anti-oxidative ability and meat quality.

• 한국철도학회논문집
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• 제17권3호
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• pp.193-200
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• 2014

본 연구에서는 도시철도 콘크리트궤도 장대레일에 대한 실내피로시험을 수행하였고, 장대레일 잔존수명을 표현한 파괴확률 50% S-N 선도는 적은 실험데이터에 대한 가중치 확률 해석기법을 사용하여 도출하였다. 여기서 피로시험에 사용된 레일들이 누적통과톤수가 서로 다르기 때문에 누적통과톤수를 평균하여 반복횟수를 수정하였다. 또한, 레일표면요철 및 열차속도를 고려한 레일 저부 휨응력은 기존 연구결과 도출된 레일휨응력 예측식을 사용하여 콘크리트궤도 장대레일의 잔존수명을 평가하였다. 레일 피로수명 평가결과, 레일 피로수명이 기준치에 비해 약 2억톤이상 높았다. 또한, 자갈궤도에 비해 콘크리트궤도 레일의 피로수명이 약 3억톤이상 높은 것으로 분석되었다. 따라서 도시철도에서 레일교체기준을 자갈궤도와 콘크리트궤도로 구분할 필요가 있으며, 레일연마를 통한 레일관리가 이루어진다면 기준치가 아닌 목표치로 관리할 수 있을 것으로 판단되었다.

• Child Health Nursing Research
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• 제20권4호
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• pp.314-321
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• 2014

목적 본 연구는 사회인지진로이론에 입각하여 우리나라 고등학생의 정신 건강 및 문제행동에 영향을 미치는 요인을 규명하기 위해 수행되었다. 방법 본 연구는 2013년 11월 18일부터 29일까지, S시에 소재한 인문계 고등학교 재학생 384명(남자 186명, 여자 198명)을 대상으로 한 서술적 조사연구이다. 연구도구는 개인 배경 변인, 진로 관련 변인(진로장벽, 학습경험, 자기효능감, 결과기대, 진로미결정), 정신건강 및 문제행동에 관한 자기기입식 설문지였으며 수집된 자료는 SPSS 21.0 프로그램을 활용하여 기술통계, 상관관계 및 다중 회귀분석을 하였다. 결과 다중 회귀분석 결과, 개인적 변인으로 스트레스 인지(t=5.12, p < .001)와 평상시 건강상태(t=-4.08, p <.001), 배경적 변인으로 학업성적(t=5.46, p <.001), 진로 관련 변인에서 진로장벽(t=10.57, p <.001)이 정신 건강 및 문제행동에 유의미한 영향을 미치는 요인으로 나타났다. 결론 고등학생의 정신건강 및 문제행동의 영향요인으로 개인 배경 변인과 함께 진로장벽을 확인하였다. 특히, 진로결정은 발달과정 동안 지속적으로 영향을 받으므로 진로를 선택하는 청소년 후기에 이를 고려한 예방적, 중재적 접근이 필요하다. 본 연구결과를 토대로 청소년의 정신 건강 및 문제행동 수준을 개선하기 위한 중재 개발과 학교보건 및 실무에의 적용에 기초자료로 활용될 것을 기대한다.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.212-221
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• 2020

본 연구는 병원 간호사의 인지적 정서조절전략과 전문직 삶의 질의 정도를 확인하고 전문직 삶의 질에 영향을 미치는 요인을 알아보기 위해서 수행되었다. 연구 대상자는 서울 소재 일개 대학병원에서 근무하고 있는 일반 간호사 176명으로, 2020년 3월 3일에서 16일까지 구조화된 온라인 설문지를 통하여 자료수집 하였다. 자료 분석은 SPSS WIN version 25.0 프로그램을 이용하여 기술통계, t-test, ANOVA, Pearson's correlation coefficient, Multiple regression analysis 로 분석하였다. 연구 결과, 공감만족에 영향을 미치는 요인은 적응적 인지적 정서조절전략(β=.501, p<.001)이었고, 설명력은 24.8%였다. 소진에 영향을 미치는 요인은 적응적 인지적 정서조절전략(β=-.435, p<.001), 부적응적 인지적 정서조절전략(β=.427, p<.001), 학력(학사)(β=.188, p=.046)이었으며, 설명력은 36.8%였다. 대상자의 이차 외상성 스트레스에 영향을 미치는 요인으로는 부적응적 인지적 정서조절전략(β=.502, p<.001)이었으며, 설명력은 24.4%였다. 이상의 연구결과를 토대로 적응적 인지적 정서조절전략을 습득하고 부적응적 인지적 정서조절전략을 덜 사용하도록 하는데 초점을 맞추어 병원 간호사의 전문직 삶의 질 향상을 도모하기 위한 프로그램 개발이 필요하다.