• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6347-6350
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• 2013

Post-transplant lymphoproliferative disorder (PTLD) is a common complication of therapeutic immunosuppression after organ transplantation. Gene expression profile facilitates the identification of biological difference between Epstein-Barr virus (EBV) positive and negative PTLDs. Previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. The aim of this study is to investigate the gene expression difference between EBV positive and negative PTLDs through partial least squares (PLS) based analysis. With a microarray data set from the Gene Expression Omnibus database, we performed PLS based analysis. We acquired 1188 differentially expressed genes. Pathway and Gene Ontology enrichment analysis identified significantly over-representation of dysregulated genes in immune response and cancer related biological processes. Network analysis identified three hub genes with degrees higher than 15, including CREBBP, ATXN1, and PML. Proteins encoded by CREBBP and PML have been reported to be interact with EBV before. Our findings shed light on expression distinction of EBV positive and negative PTLDs with the hope to offer theoretical support for future therapeutic study.

• Education of Primary School Mathematics
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• v.18 no.3
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• pp.203-216
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• 2015

This study analyzed changes of representations which had come up in the problem-solving process of math-gifted 6th grade students that ACODESA had been applied. The class was designed on a ACODESA procedure that enhancing the use of varied representations, and conducted for 40minutes, 4 times over the period. The recorded videos and interviews with the students were transcribed for analysing data. According to the result of the analysis, which adopted Despina's using type of representation, there appeared types of 'adding', 'elaborating', and 'reducing'. This study found that there is need for a class design that can make personal representations into that of public through small group discussions and confirmation in the problem-solving process.

• Journal of Korea Multimedia Society
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• v.15 no.1
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• pp.148-165
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• 2012

Applying maintenance simulation using virtual mockup in product design phase enables maintainability test before prototyping physical products, and it is expected to reduce product development costs. The simulation results can be reused as contents of service manuals and RAM (Reliability, Availability, Maintainability) analysis data. Maintenance simulation should provide realistic representation of physical property of virtual product, assembly relation between parts and manipulation process to verify feasibility of product design. The simulation system should be extended to collaborative virtual environment to perform collaborative maintenance procedures. In this paper, the three layered system architecture and the physics based collaborative interaction technique are proposed to extend current maintenance simulation into collaborative virtual environment. The proposed system was implemented as ViMMS (Virtual Mockup Maintenance Simulation system), and compared with case study results of VADE (Virtual Assembly Design Environment). As a result, the ViMMS encompassed broader range of maintenance tasks by using physics based collaborative interaction technique.

• Structural Engineering and Mechanics
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• v.54 no.2
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• pp.305-317
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• 2015

Optimal sensor placement (OSP) is an integral component in the design of an effective structural health monitoring (SHM) system. This paper describes the implementation of a novel collaborative-climb monkey algorithm (CMA), which combines the artificial fish swarm algorithm (AFSA) with the monkey algorithm (MA), as a strategy for the optimal placement of a predefined number of sensors. Different from the original MA, the dual-structure coding method is adopted for the representation of design variables. The collaborative-climb process that can make the full use of the monkeys' experiences to guide the movement is proposed and incorporated in the CMA to speed up the search efficiency of the algorithm. The effectiveness of the proposed algorithm is demonstrated by a numerical example with a high-rise structure. The results show that the proposed CMA algorithm can provide a robust design for sensor networks, which exhibits superior convergence characteristics when compared to the original MA using the dual-structure coding method.

• The Journal of the Korea Contents Association
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• v.5 no.4
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• pp.122-132
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• 2005

CVE(Collaborative Virtual Environment) is the virtually shared area where people cannot come together physically, but wish to discuss, collaborate on, or even dispute certain matters. In CVEs, in habitants are usually represented by humanoid embodiments, generally referred to as avatars. But most current graphical CVE systems fail to reflect the natural relationship between the avatar's gesture and the conversation that is taking place. More than 65% of the information exchanged during a person to person conversation is carried on the nonverbal band. Therefore, it is expected to be beneficial to provide such communication channels in CVEs in some way. To address this issue, this study proposes a scheme to represent avatar's gestures that can support the CVE users' communication. In the first level, this study classifies the non-verbal communication forms that can be applicable to avatar gesture design. In the second level, this study categorizes the body language according to the types of interaction with verbal language. And in the third level, this study examines gestures with relevant verbal expressions according to the body parts-from head to feet. One bodily gesture can be analyzed in the description of gesture representation, the meaning of gesture and the possible expressions, which can be used in gestural situation.

• Journal of Intelligence and Information Systems
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• v.12 no.2
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• pp.1-15
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• 2006

Currently the mobile web service is growing with a tremendous speed and mobile contents are spreading extensively. However, it is hard to search what the user wants because of some limitations of cellular phones. And the music is the most popular content, but many users experience frustrations to search their desired music. To solve these problems, this research proposes a hybrid recommendation system, MOBICORS-music (MOBIle COntents Recommender System for Music). Basically it follows the procedure of Collaborative Filtering (CF) system, but it uses Contents-Based (CB) data representation for neighborhood formation and recommendation of new music. Based on this data representation, MOBICORS-music solves the new item ramp-up problem and results better performance than existing CF systems. The procedure of MOBICORS-music is explained step by step with an illustrative example.

• The Mathematical Education
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• v.44 no.4 s.111
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• pp.627-651
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• 2005

This study was conducted to attain an in-depth understanding of students' mathematical representations and to present the educational implications for teaching them. Twelve mathematical tasks were developed according to the six types of problems. A task performance was executed to 151 third graders from four classes in DaeJeon and GyeongGi. We analyzed the types and forms of representations generated by them. Then, qualitative case studies were conducted on two small-groups of five from two classes in GyeongGi. We analyzed how individuals' representations became elaborated into group representation and what patterns emerged during the collaborative small-group learning. From the results, most students used more than one representation in solving a problem, but they were not fluent enough to link them to successful problem solving or to transfer correctly among them. Students refined their representations into more meaningful group representation through peer interaction, self-reflection, etc.. Teachers need to give students opportunities to think through, and choose from, various representations in problem solving. We also need the in-depth understanding and great insights into students' representations for teaching.

• International Journal of CAD/CAM
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• v.3 no.1_2
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• pp.67-75
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• 2003

Viewpoint-dependent feature-based modelling in computer-aided design is developed for the purposes of supporting engineering design representation and automation. The approach of this paper uses a combination of a multi-level modelling approach. This has two stages of mapping between models, and the multi-level model approach is implemented in three-level architecture. Top of this level is a feature-based description for each viewpoint, comprising a combination of form features and other features such as loads and constraints for analysis. The middle level is an executable representation of the feature model. The bottom of this multi-level modelling is a evaluation of a feature-based CAD model obtained by executable feature representations defined in the middle level. The mappings involved in the system comprise firstly, mapping between the top level feature representations associated with different viewpoints, for example for the geometric simplification and addition of boundary conditions associated with moving from a design model to an analysis model, and secondly mapping between the top level and the middle level representations in which the feature model is transformed into the executable representation. Because an executable representation is used as the intermediate layer, the low level evaluation can be active. The example will be implemented with an analysis model which is evaluated and for which results are output. This multi-level modelling approach will be investigated within the framework aimed for the design automation with a feature-based model.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.4
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• pp.169-177
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• 2009

Concurrent Engineering (CE) has presented new possibilities for successful product development by incorporating various product life-cycle functions from the earlier stage of design. In the product design, geometric representation is vital not only in its traditional role as a means of communicating design information but also in its role as a means of externalizing designer's thought process by visualizing the design product. During the last dozens of years, there has been extraordinary development of computer-aided tools intended to generate, present or communicate 3D models. However, there has not been comparable progress in the development of 3D-CAD systems intended to represent and manipulate a variety of product life-cycle information in a consistent manner. In the previous research, the authors proposed a novel concept called Minus Volume (MV) to incorporate various design information relevant to product life-cycle functions. This paper proposes the use of the MV concept for the collaborative design environment, where many team members are geographically distributed over the networked environment, including Internet, Intranet, WWW, etc. A prototype 3D-CAD system is implemented based on the MV concept and illustrated with the successful implementation of collaborative design example.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.7
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• pp.2399-2413
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• 2021

A recommendation system is an information filter tool, which uses the ratings and reviews of users to generate a personalized recommendation service for users. However, the cold-start problem of users and items is still a major research hotspot on service recommendations. To address this challenge, this paper proposes a high-efficient hybrid recommendation system based on Fuzzy C-Means (FCM) clustering and supervised learning models. The proposed recommendation method includes two aspects: on the one hand, FCM clustering technique has been applied to the item-based collaborative filtering framework to solve the cold start problem; on the other hand, the content information is integrated into the collaborative filtering. The algorithm constructs the user and item membership degree feature vector, and adopts the data representation form of the scoring matrix to the supervised learning algorithm, as well as by combining the subjective membership degree feature vector and the objective membership degree feature vector in a linear combination, the prediction accuracy is significantly improved on the public datasets with different sparsity. The efficiency of the proposed system is illustrated by conducting several experiments on MovieLens dataset.