• 제목/요약/키워드: Colitis, Ulcerative

검색결과 204건 처리시간 0.023초

Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

  • Basturk, Ahmet;Artan, Reha;Yilmaz, Aygen;Gelen, Mustafa T.
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제21권3호
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    • pp.163-169
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    • 2018
  • Purpose: The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences. Methods: This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined. Results: In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03). Conclusion: The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.

The improving effects of Saengmaeksan on ulcerative colitis

  • Kim, Min-Cheol;Kim, Su-Jin;Choi, In-Young;Ki, Ji-Ye;Kim, Dae-Seung;Jeon, Yong-Deok;Bae, Go-Eun;Choi, Sun-Kyung;Jeong, Hyun-Ja;Park, Yun-Jum;Kim, Hyung-Min;Um, Jae-Young;Hong, Seung-Heon
    • Advances in Traditional Medicine
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    • 제10권2호
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    • pp.116-122
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    • 2010
  • Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.

흰쥐의 합곡부위(合谷部位)에 황련약침(黃連藥鍼)이 TNBS로 유발된 대장염(大腸炎)에 미치는 영향(影響) (Effects of Rhizoma Coptidis Herbal Acupuncture applied to HapGok $(LI_4)$ on TNBS-induced Colitis in rats)

  • 도진우;안성훈;구성태;백대봉;김경식;손인철
    • Korean Journal of Acupuncture
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    • 제21권2호
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    • pp.95-110
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    • 2004
  • Objectives : Ulcerative colitis and Crohn's diseases are chronic inflammatory disease of the gastrointestinal tract identified mainly for diarrhea, stomachache, hemafecia. The source and pathologic mechanism about ulcerative colitis and Crohn's disease are still unknown but stress, infection, a genetic factor, environmental factors etc. may be the cause of chronic inflammatory disease of the gastrointestinal tract recently. Methods : Because ulcerative colitis and Crohn's disease is recognized as Ha-ri(下痢) or Jang-Byok(腸?) in Oriental Medicine, Rhizoma Coptidis Herbal acupunctures were injected in hapgok $(LI_4)$ which is used to treat intestinal disease in clinic. All animals were subjected to the injection of saline $(300\;{\mu}l,\;500\;{\mu}l)$ for a study control and TNBS $(300\;{\mu}l,\;500\;{\mu}l)$ into the lumen of the colon, 8cm proximal to the anus through the intestine. Rhizoma Coptidis Herbal (20 mg/ml, 0.4 ml) acupuncture solution was injected to the $LI_4$ (both hands) at the secondary injection time of TNBS in rats. And body weight, RBC count, WBC count, total protein, Paw edema rate, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels were observed to study the effects of Rhizoma Coptidis Herbal acupuncture in hapgok $(LI_4)$. Results : In results, Rhizoma Coptidis Herbal acupuncture in hapgok $(LI_4)$ on TNBS-induced colitis reduced the rate of weight loss but had no effect on RBC and WBC count. And it reduced total protein concentration, paw edema, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels. Conclusion : Data suggest that injection of Rhizoma Coptidis herbal acupuncture solution into hapgok has significant therapeutic effect on the colitis.

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Panax ginseng: a candidate herbal medicine for autoimmune disease

  • Lee, Joon-Il;Park, Kyoung Sun;Cho, Ik-Hyun
    • Journal of Ginseng Research
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    • 제43권3호
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    • pp.342-348
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    • 2019
  • Panax ginseng Meyer (P. ginseng; Korean ginseng) is well known for its medicinal properties. It can alleviate pathological symptoms, promote health, and prevent potential diseases via its anti-inflammatory, antioxidant, homeostatic, and other positive effects on biological metabolism. Although many studies have determined effects of P. ginseng on various diseases, such as cardiovascular, neurological, and immunological diseases, little is known about the effect of P. ginseng on autoimmune diseases. Here, we review a few reports about effects of P. ginseng on autoimmune diseases (e.g., multiple sclerosis, Crohn's disease, ulcerative colitis, atopic dermatitis, and rheumatoid arthritis) and suggest the possibility of P. ginseng as a candidate herbal medicine to prevent and treat autoimmune diseases as well as the need to study it.

Effects of Korean Radish on DSS-Induced Ulcerative Colitis in Mice

  • Kim, Hyun-Kyoung
    • International Journal of Advanced Culture Technology
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    • 제6권4호
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    • pp.97-108
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    • 2018
  • The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling moleculesthrough suppression both mitogen-activated protein kinases(MAPK) and nuclear factor-kappa B ($NF-{\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine.

궤양성 대장염의 한약치료에 대한 국내 연구동향 분석 - 오아시스 검색을 중심으로 (A Review of Recent Domestic Research on Herbal Medicine Treatments for Ulcerative Colitis: A Focus on OASIS Platform Research)

  • 최새롬;이지윤;박상민;신재욱;백지훈;이민주;이은지
    • 대한한방내과학회지
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    • 제44권6호
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    • pp.1256-1270
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    • 2023
  • Objectives: This study analyzes domestic research trends on herbal medicine treatments for ulcerative colitis (UC) by examining 28 selected domestic papers using the Oriental Medicine Advanced Searching System (OASIS) as the main search source. Methods: A total of 28 domestic papers were selected on the OASIS platform as the main search source using the keywords "(궤양성 대장염) or (궤양성 대장병)" and "(한약) or (한의학)". Results: There were 11 case report studies and 17 case-control studies published from 2002 to 2022. All the case-control studies only dealt with mice and did not include human subjects. The most common pathologies were damp heat and Changpung. Hwangryunhaedok-tang was the most frequently prescribed herbal formula, and Coptidis Rhizoma was the most commonly used herb across all studies. The results showed that many studies demonstrated the significant effects of herbal treatment. Conclusion: Herbal medicine may exhibit therapeutic effects on various aspects of UC. However, evidence-based studies, such as clinical trials involving human subjects, are needed.