• Integrative Medicine Research
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• 제7권1호
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• pp.95-102
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• 2018

Background: Hypertension is a major cause of cardiovascular disease and associated mortality, and postmenopausal women are at a high risk of hypertension. We aim to investigate the hypotensive effect and safety of acupuncture, focusing on postmenopausal women with prehypertension and stage 1 hypertension. In addition, we aim to investigate whether the effect of acupuncture treatment differed, depending on Sasang Constitution and cold-heat pattern. Methods: This study is designed as an intervention cohort study. Two hundred postmenopausal women aged <65 years with prehypertension or stage 1 hypertension living in Daejeon city in Korea will be recruited, and randomly assigned to either an acupuncture or no-treatment control group. The intervention will consist of four sessions; one session will include acupuncture performed 10 times for 4 weeks. There will be a 20-week observation period after each session, and the total study duration will be 96 weeks. Acupuncture will be applied at the bilateral Fengchi (GB20), Quchi (LI11), Zusanli (ST36), and Sameumgyo (SP6) acupoints. The effect of acupuncture will be evaluated by comparing the change in systolic and diastolic blood pressure between the acupuncture and control groups every 4 weeks until the end of the study. Discussion: To evaluate the success of blood pressure management, long-term observation is required, but no long-term studies have been conducted to evaluate the effect of acupuncture on blood pressure in postmenopausal women. To our knowledge, this study will be the first long-term study to investigate this issue for more than 6-8 weeks.

• Journal of Plant Biotechnology
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• 제35권4호
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• pp.307-316
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• 2008

식물에서 전이인자를 이용한 삽입 변이체의 유전자 기능분석 연구가 최근 가장 활발하게 이루어지고 있다. 본 연구에서는 동진벼의 Ac/Ds 삽입 변이체인 F2 세대 30,000 계통을 이용하여 고염과 저온에 민감한 계통과 내성이 있는 계통을 대량 스크리닝을 통해 선발하였다. 첫 번째 스크리닝에서 선발한 212 계통을 Southern blot 분석을 통해 Ds의 삽입여부 및 copy 수를 꽉인하고 표현형과 비교하여 고염과 저온에서 총 19 계통을 선발하였고, 이 중 copy 수가 하나인 계통은 13 계통이었다. 선발한 계통을 FSTs 분석을 통해 Ds의 삽입위치 및 knock-out유전자를 확인하고 염기서열 정보를 이용하여 벼 전체 염기서열 정보와 상동성 비교분석 결과 세포의 신호전달 과정과 조절 관여하는 유전자 그룹인 transpoter, protease family protein and apical meristem family protein, 삼투압조절에 관여하는 유전자 그룹인 heat shock potein, O-methyltransferase, glyceraldehyde-3-phosphate dehydrogenase and drought stress Induce protein 그리고 식물의 소포유통(vesicle trafficking)에 관여하는 유전자 SYP 5 family protein로 구분할 수 있었다. 선발된 19개 유전자의 발현 분석을 위해 9종류 비생물학적 스트레스 하에서 RT-PCR을 수행한 결과 이들 knock-out 유전자는 비생물학적 스트레스에 각각 다른 발현 패턴을 보였다. 이 연구의 결과는 삽입 변이체를 통한 유전자의 기능분석에 있어서 비생물학적인 스트레스의 응답 반응계에 관여하는 유전자를 연구하는데 유용할 것이라고 생각된다.

• 대한한방내과학회지
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• 제31권1호
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• pp.1-10
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• 2010

Objectives : It is necessary that the international classification of diseases (ICD) be examined in order to comprise the third revision of the Korean Classification of Disease on Oriental Medicine (KCD-OM) and disease classification in the oriental internal medicine field. It is essential that the selection, classification and definition of disease and pattern names of oriental concepts in internal medicine be clear. Since 2008, the fifth revision of the Korean Classification of Disease (KCD-5) has been used in Korea. It was required to use the reference classification from the Oriental medicine area based on the ICD-10. Methods : In this review, the necessity for, meaning of and content of the third revision are briefly described. The ICD system was reviewed and KCD-OM was reconstructed. How diagnosis in the oriental internal medicine area had changed is discussed. Review and Results : In 1973, the disease classification of oriental medicine was established the basis on the contents of Dongeuibogam. It was irrespective of the ICD. As to the classification system in the Oriental internal medicine field, systemic disease was comprised of wind, cold, warm, wet, dryness, heat, spirit, ki, blood, phlegm and retained fluid, consumptive disease, etc. Diseases of internal medicine comprised a system according to the five viscera and the six internal organs and followed the classification system of Dongeuibogam. The first and second revisions were of the classification system based on the curriculum in 1979 and 1995. In 1979, in the first revision, geriatric disease and idiopathic types of disease were deleted, and skin disease was included among surgery diseases. This classification was expanded to 792 small classification items and 1,535 detailed classification items to the dozen disease classes. In 1995, in the second revision, it was adjusted to 644 small classes and 1,784 detailed classification items in the dozen disease classes. KCD-OM3 did KCD from this basis. It added and comprised the oriental medical doctor's concept names of diseases considering the special conditions in Korea. KCD-OM3 examined the KCD-OMsecond revised edition (1994). It improved the duplex classification, improper classifications, etc. It is difficult for us to separate the disease names and pattern names in oriental medicine. We added to the U code and made one classification system. By considering the special conditions in Korea, 169 codes (83 disease name codes, 86 pattern name codes) became the pre-existence classification and links among 306 U codes of KCD-OM3. 137 codes were newly added in the third revision. U code added 3 domains. These are composed of the disease name (U20-U33, 97 codes), the disease pattern name (U50-U79, 191 codes) and the constitution pattern name of each disease (U95-U98, 18 codes). Conclusion : The introduction of KCD-OM3 conforms to the diagnostic system by which oriental medical doctors examine classes used with the basic structure of the reference classification of WHO and raises the clinical study and academic activity of the Korean oriental medicine and makes the production of all kinds of nation statistical indices possible. The introduction of KCD-OM3 promotes the diagnostic system by which doctors of Oriental medicine examine classes using the association with KCD-5. It will raise the smoothness and efficiency of oriental medical treatment payments in the health insurance, automobile insurance, industrial accident compensation insurance, etc. In addition, internationally, the eleventh revision work of the ICD has been initiated. It needs to consider incorporating into the International Classification of Diseases some of every country's traditional medicine.

• 한국자기학회지
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• 제9권4호
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• pp.190-195
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• 1999

최대 출력 3.5kW인 고주파에 의한 알곤 플라즈마 분위기에서 제작한 Fe1-xCox(x=0.2와 0.4)계와 25$\mu\textrm{m}$의 철 박막의 자기적인 성질을 상온에서의 X선 회절과 진동시료자력계를 이용한 자기이력곡선 측정 방법을 사용하여 연구하였다. arc로에서 제작된 시룐느 삼단계 처리 가공하였다. 첫째는 수압기로 9,000N/$\textrm{cm}^2$의 압력을 가하여 알약 형태로 만들었다. 이 단계는 압연기로 눌러 얇은 sheet로 만들었다. 삼단계는 시료는 질소 가스 분위기에서 90$0^{\circ}C$로 열처리하였다. 일단계 시료의 X선 회절결과는 시료가 균질이며 각 시료는 철과 동일한 bcc 결정구조를 갖는 단일결저상(single crystal phase)임을 보였다. 철 박막은 43 Oe의 항자력과 인가자기장에 대한 자화, 즉 초기 기울기는 0.328 emu/gOe를 나타냈다. 이단계 시료에서는 Co량이 증가함에 따라 항자력과 포화자화값은 증가하였다. 반면 초기 기울기는 감소하였다. 이는 항자력의 증가로 인해서 계면이동이 억제되었음을 의미한다. 삼단계 시료에서 두 시료 모두 포화자화값은 증가하였다. 반면 이들 시료의 항자력은 감소하였다. 3단계 시료의 포화자화의 열처리로 인한 시료의 X선 회절강도 변화와 연관이 있어 보인다. 또한 몇 개의 자기 매개변수를 단순모형을 써서 계산하여 다른값과 비교하였다.

• 동의생리병리학회지
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• 제21권1호
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• pp.1-9
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• 2007

${\ulcorner}$Hamsansachon Dongyi Suse Bowon Gabogubon${\lrcorner}$ , discovered in 2000, can give very precious information in order to study the formation and development process of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Dircourse on the Constitutional Symptoms and Disease${\lrcorner}$ . I examined, by comparison, changes in understanding pathology explained in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Discourse on the Constitutional Symptoms and Disease${\lrcorner}$ of Gabobon and Sinchukbon, and consequently tried to define the concept of Dispositional Symptom(Dispositional disease) as below, in a point of view that ‘Dispositional Symptom(Dispositional disease)’ should be the key word in explaining the changes in understanding of pathology. Dispositional Symptom(dispositional disease) is a new concept that was first troduced in the Kyongjabon, not found in the Gabobon, and that played a key role in editing ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Discourse on the Constitutional Symptom and Disease${\lrcorner}$ . Dispositional Symptom(dispositional disease) means an innate temperament or a pathological tendency, which is already constructed in the system of an individual, prior to expression of specific diseases and symptoms, and can be a primary basis to tell the susceptibility and developing pattern of a certain disease, to decide how to treat and forecast the prognosis. Sinchukbon inductively categorized symptoms of the dispositional symptom (dispositional disease) into the concept of ‘Eight principles’, or eight standards of diagnosis, such as superficies-interior, cold-heat, and weakness-strength.

• Asian-Australasian Journal of Animal Sciences
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• 제16권7호
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• pp.952-961
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• 2003

In the first part of the study, rates of estrus occurrence and success of A.I. service in the Thai-native and Friesian crossbred, and purebred Friesian cows fed in the National Dairy Training and Applied Research Institute in Chiang Mai, Thailand were traced monthly throughout a year. An electric fan and a water sprinkler cooled the stall for the purebred cows during the hot season (March-September). Both rates in pure Friesians were at their highest in the cold-dry season (October- February), but they decreased steadily during the hot-dry season (March-May) and were at their lowest in the hot-wet season (June-September). Seasonal change of a similar pattern was observed in the incidence of estrus, but not in the success rate of insemination in the crossbred cows. By the use of reproductive data, compiled in the same institute, on the 75 % cross- and purebred Friesian cows, and climatological data in Chiang Mai district, effects of ambient temperature and humidity on the reproductive traits of cows were examined by regression analysis in the second half of the study. Significant relationships in the crossbred, expressed by positive-linear and parabola regressions, were found between reproductive parameters such as days to the first estrus (DTFE), A.I. service (DTFAI), and conception, the number of A.I. services required for conception and some climatic factors. However, regarding this, no consistent or intelligible results were obtained in purebred cows, perhaps because electric fans and water sprinklers were used for this breed in the hot season. Among climatic factors examined, the minimum temperature (MINT) in early lactation affected reproductive activity most conspicuously. As the temperature during one or two months prior to the first estrus and A.I. service rose, DTFE and DTFAI steadily became longer, although, when MINT depleted below $17-18^{\circ}C$, the reproductive interval tended to be prolonged again on some occasions. The maximum temperature also affected DTFE and DTFAI, but only in limited conditions. The effect of humidity was not clear, although the inverse relationship between DTFE and minimum humidity during 2 months before the first estrus in the crossbred seemed to be significant. Failure to detect any definite effect of climate on the reproductive traits of pure Friesians seemed to indicate that forced ventilation by electric fans and water sprinklers were effective enough to protect the reproductive ability of this breed from the adverse effects of a hot climate.

• 한국터널지하공간학회 논문집
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• 제19권1호
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• pp.11-27
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• 2017

서울시 등의 국내 주요 도심은 지역적 팽창에 따라 도로망 체계가 급격하게 발전하였고 도시민이 안락하고 풍요로운 생활을 영위하도록 전력, 통신, 상수도, 하수도, 냉 난방관로, 가스관 등이 무분별하게 개별 매설되었으며 비효율적으로 개별 관리되고 있다. 국토계획법에서는 Life-Line을 공동 수용함으로써 도로의 반복 굴착을 줄이고 도시 미관의 개선, 포장 내구성 향상에 따른 주행성능 향상 그리고 원활한 교통소통 등을 기대하는 도시계획 시설물로 공동구를 정의하고 있다. 최근 기존 도심지의 재정비 측면에서 쾌적한 도시공간 조성, 지하공간 이용 효율과 도로관리 효율 향상, 지진 및 도로함몰에 대한 재난안전성, 스마트 그리드와 전기자동차 보급과 같은 미래 생활환경 변화에 대한 신속한 대응 등을 기대할 수 있는 기존 도심지의 공동구 설치 필요성이 증가하고 있으나 국내에 설치된 모든 공동구는 신도시 개발에 따라 계획된 Life-Line을 모두 수용하도록 설치한 개착식 공동구 형태이다. 기존 도심지에서는 현재 가동중인 모든 Life-line을 모두 수용할 수 없으므로 도심지 유형별 공동구 설치 타당성 평가시스템을 활용한 설계용량 최적화 등의 새로운 연구가 필요하다. 본 연구는 신도시 공동구를 탈피하고 기존 도심지를 대상으로 평가지표에 의한 정량적 평가모델을 제시 하는 등 유형별 타당성 평가시스템을 세분화하며 정량적 평가시스템의 구현이 가능한 프로그램을 개발해 궁극적으로 도심지 공동구 활성화에 기여하고자 한다.

• 대한한방소아과학회지
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• 제32권3호
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• pp.100-118
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• 2018

Objectives The purpose of this study is to analyze some of the TCM (traditional Chinese medicine) clinical research literatures about pediatric night crying in order to learn clinical application of Korean medicine treatment for pediatric night crying. Methods We searched clinical trial literatures about TCM treatment of pediatric night crying from the CNKI (China National Knowledge Infrastructure) (January 2000 to June 2018). We analyzed the literature in regards to the treatment methods and the results. Results Among the 459 searched studies, 13 randomized controlled trials and 41 case studies were selected and analyzed. In most of the studies, the effectiveness of TCM in treating patients was significantly high, so we confirmed the effectiveness of TCM on pediatric night crying. The most commonly used pattern differentiations (辨證) were Spirit damage due to fright and fear (驚恐傷神), Spleen deficiency and cold (脾虛寒) and Heart fire heat (心火熱). Methods of treatment include herbal medicines (internal medicine and external application), massage therapy (Tuina methods), acupuncture and other treatments (bloodletting). The most commonly used herb medicines were Cicadidae Periostracum (蟬?), Poria Cocos (茯?), Glycyrrhizae Radix (甘草), Uncariae Ramulus et Uncus (釣鉤藤), Junci Medulla (燈心草), Fossilia Ossis Mastodi (龍骨), Atractylodis Rhizoma Alba (白朮), Cinnabaris (朱砂), and Coptidis Rhizoma (黃連). The most commonly used massage methods were Clearing Liver Channel (淸肝經), Clearing Heart Channel (淸心經), Kneading $Xi{\check{a}}oti{\bar{a}}nx{\bar{i}}n$ (?小天心), Supplementing Spleen Channel (補脾經), Clearing $Ti{\bar{a}}nh{\acute{e}}shu{\check{i}}$ (淸天河水), and Rubbing Abdomen (摩腹). Conclusions Based on the results of clinical studies from China, the use of Korean medicine for the treatment of pediatric night crying has been shown to be effective in relieving symptoms. Based on the results of this study, it is possible to widen the scope of Korean medicine by additionally reviewing clinical and experimental studies on pediatric night crying.

• 기본간호학회지
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• 제2권2호
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• pp.199-211
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• 1995

This study analyzed the practical education in fundamentals of nursing, for the 36 nursing schools including 12 4-year nursing schools and 24 junior college nursing schools. This survey was done from september 5th to october 5th in 1995. The results of this study were as follows : 1. Required credit in fundamentals of nursing. 1) The highest incidence of the total required credit was 7 in 4-year nursing school and 9 in junior college. 2) For the lecture course credit, the large number of 4-year nursing school gave 5 credit lessons and 6 credits provided in junior nursing colleges. 3) For the credit of practical education the major portion of 4-year nursing school gave 2 credits instruction, however junior nursing school provided 3 credits. 2. Laboratory practice in fundamentals of nursing. In laboratory practice, the ratio of instructor and student was 1 : 20 in 83.4% of the 4-year nursing school and in 66.7% of the junior nursing school. 3. Contents and hours of fundamental nursing practice. 1) In the area of health assessment and nursing process, the large number of schools allocated following hours : 6 hours for vital signs, 4 hours for nursing process, 2 hours for recording but practice for physical examination and communication was done in few schools. 2) In the area of functional health pattern, the large number of schools allocated practice hours like followings : 2 hours for I/O, 2 hours for gavage feeding, 2 hours for elimination, 6 hours for catheterization, 6 hours for bed making, 2 hours for positioning, 6 hours for personal hygiene, 2 hours for R.O.M, 4 hours for moving turning lifting, 2 hours for inhalation and suction. But C.P.R and terminally ill patient care were taught in smaller number of schools. 3) In the area of special nursing measures, the major portion of nursing schools allocated hours like followings. It consisted of 6 hours for asepsis, 16-18 hours for medication, 2 hours for heat and cold application, 2 hours for wound care. 4) 22.2% of the nursing schools had total review practice time and 36.1% of the nursing schools had the students clinical practice. Based on above mentioned results, 4-year nursing school had faithful practical education of fundamental nursing than junior nursing school. But for the contents and allocated hours for practice education, junior nursing schools were much more contents and hours than 4 year school.

• 한국식품조리과학회지
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• 제12권1호
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• pp.6-12
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• 1996

Tryptic soy broth(TSB)와 광어, 굴 homogenate에 ethanol을 함유하지 않은 경우와 5%의 ethanol(v/v)을 함유한 경우에 ethanol이 V. parahaemolyticus의 증식과 생존에 미치는 영향을 이 세균의 최적온도(35$^{\circ}C$)와 저온(-20, 5$^{\circ}C$) 및 고온(45, 5$0^{\circ}C$)에서 검토하였다. 35$^{\circ}C$에서의 V parahaemolyticus의 증식은 TSB와 광어 homogenate에서 빨랐으나 굴 homogenate에서 약간 느렸다. 5%의 ethanol 존재하에서는 TSB와 광어 homogenate에서 긴 유도기를 거친 후에 증식이 시작되었으나 굴 homogenate에서는 저장초기부터 계속 생균수가 감소하였다. 5%의 ethanol을 함유한 것과 ethanol을 함유하지 않은 액체배지에 $10^{6}$-$10^{7}$ cells/ml의 V. parahaemolyticus를 접종하여 저온(5, -2$0^{\circ}C$)과 고온(45, 5$0^{\circ}C$)에 저장하면서 ethanol에 의한 생존억제 작용을 조사하였다. 5$^{\circ}C$에서 ethanol을 함유한 것과 ethanol을 함유하지 않은 액체배지에서 시료간의 생균수는 현저한 차이가 없었으나 -2$0^{\circ}C$에서는 5%의 ethanol 존재하에서 광어와 굴 homogenate에서 V. parahaemolyticus의 생존이 TSB에 비하여 현저히 억제되었다. 45$^{\circ}C$와 5$0^{\circ}C$에서 D-value는 ethanol을 함유하지 않은 경우와 5%의 ethanol을 함유한 경우 모두에서 굴 homogenate가 TSB와 광어 homogenate에 비하여 가장 낮은 값을 나타내었다. 45$^{\circ}C$와 5$0^{\circ}C$에서 ethanol을 함유하지 않은 각 액체배지에서의 D-value는 5%의 ethanol을 함유한 각각의 액체배지에서의 D-value보다 1.9-3.5배 높은 값을 나타내었다.