• Journal of Ginseng Research
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• 제47권4호
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• pp.524-533
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• 2023

Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.871-879
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• 2024

Our group had isolated Bifidobacterium breve strain BS2-PB3 from human breast milk. In this study, we sequenced the whole genome of B. breve BS2-PB3, and with a focus on its safety profile, various probiotic characteristics (presence of antibiotic resistance genes, virulence factors, and mobile elements) were then determined through bioinformatic analyses. The antibiotic resistance profile of B. breve BS2-PB3 was also evaluated. The whole genome of B. breve BS2-PB3 consisted of 2,268,931 base pairs with a G-C content of 58.89% and 2,108 coding regions. The average nucleotide identity and whole-genome phylogenetic analyses supported the classification of B. breve BS2-PB3. According to our in silico assessment, B. breve BS2-PB3 possesses antioxidant and immunomodulation properties in addition to various genes related to the probiotic properties of heat, cold, and acid stress, bile tolerance, and adhesion. Antibiotic susceptibility was evaluated using the Kirby-Bauer disk-diffusion test, in which the minimum inhibitory concentrations for selected antibiotics were subsequently tested using the Epsilometer test. B. breve BS2-PB3 only exhibited selected resistance phenotypes, i.e., to mupirocin (minimum inhibitory concentration/MIC >1,024 ㎍/ml), sulfamethoxazole (MIC>1,024 ㎍/ml), and oxacillin (MIC >3 ㎍/ml). The resistance genes against those antibiotics, i.e., ileS, mupB, sul4, mecC and ramA, were detected within its genome as well. While no virulence factor was detected, four insertion sequences were identified within the genome but were located away from the identified antibiotic resistance genes. In conclusion, B. breve BS2-PB3 demonstrated a sufficient safety profile, making it a promising candidate for further development as a potential functional food.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.112.2-112
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• 2003

Levels of blister rust infection (from Cronartium ribicola) varied in western white pine(Pinus monticola Dougl.) seedlings grown in two nurseries in northern Idaho. This observation suggested the potential importance of environmental components operating on the blister rust pathosystem. In an experiment designed to test the influence of environmental conditions at two nurseries, seedlings of a single genetic source were unintentionally held in cold storage for 6 months longer at one nursery than at the other. Subsequently, these seedlings, which had been growing under nursery conditions for 7 months or 1 month, were inoculated with blister rust spores on September 9th, 1999. Infection efficiency measured on the seedlings with only 1 month of growth was 70X greater than on the seedlings that had 7 months for their new growth to mature. Results from this nursery test and infection levels of northern Idaho resistant selections in mild climates suggest that expression of genes related to rust resistance in western white pine can be manipulated by regulation of phonology. If so, several new molecular tools may be employed to enhance our understanding of environmental regulation of genes for blister rust resistance.

• Journal of Welding and Joining
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• 제30권2호
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• pp.76-80
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• 2012

In this study, the effect of the welding current on the hardness characteristics and microstructure in the resistance spot welding of 1GPa grade cold-rolled DP steel was investigated, Also, correlation between the hardness and microstructure was discussed. In spite of the change in the welding current, the hardness distributions near weld was similar. the hardness in the HAZ and the fusion zone was higher than that of the base metal and the hardness in the fusion zone was variated with the location. Especially, the hardness of HAZ adjacent to the base metal showed maximum value, and softening zone in the base metal adjacent to HAZ was found. With the increasing of welding current, there were no difference in maximum hardness and average hardness in the fusion zone were, but the hardness of the softening zone reduced. The difference in the hardness in each location of weld due to grain size of prior austenite. The softening of the base metal occurred by tempering of the martensite.

• 한국작물학회:학술대회논문집
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• 한국작물학회 1998년도 추계 학술대회지
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• pp.22-34
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• 1998

Coarse grain crops including maize, sorghum, buckwheat, fox-tail millet, pearl millet, proso millet and barnyard millet have been used as health food, feed and industrial materials in Korea for a long time. Korean ancestors thought and treated them as the very important good crops for human health and the crops have served as a dish made with all the grains, particularly in January 15 of the lunar month in korea because the grains make the five viscera of heart, liver, spleen, lungs and kidneys and the six entrails of gall bladder, stomach, small and large intestines, the paunch, the bladder, and the bowels strong and build healthy body. Thus, the objectives of the paper were to review and summarize the results obtained from the quality breeding and functional researches worldwide on nutrition, utilization and medical action of the coarse grain crops. Maize grain, fresh ear and green fodder yields have increased since 1960s in Korea. Agronomic traits improvements also occurred for cold tolerance, disease and insect resistance, resistance to barrenness, resistance to loding, pollen production, grain and seed yields, and eating quality. For buckwheat, improved summer buckwheat varieties produced more rutin for vegetable and grain than autumn varieties in Korea

• Advances in nano research
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• 제9권2호
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• pp.123-131
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• 2020

Conventional fabrics that have modified in to conductive fabrics using conductive nanomaterials have novel applications in different fields. These of fabrics can be used as heat generators with the help of the Joule heating mechanism, which is applicable in thermal therapy and to maintain the warmth in cold weather conditions in a wearable manner. A modified fabric can also be used as a sensor for body temperature measurements using the variation of resistance with respect to the body temperature deviations. In this study, polyol synthesized silver nanowires (Ag NWs) are incorporated to commercially available cotton fabrics by using drop casting method to modify the fabric as a thermogenic temperature sensor. The variation of sheet resistance of the fabrics with respect to the incorporated mass of Ag NWs was measured by four probe technique while the bulk resistance variation with respect to the temperature was measured using a standard ohm meter. Heat generation profiles of the fabrics were investigated using thermo graphic camera. Electrically conductive fabrics, fabricated by incorporating 30 mg of Ag NWs in 25 ㎠ area of cotton fabric can be heated up to a maximum steady state temperature of 45℃, using a commercially available 9 V battery.

• 설비공학논문집
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• 제23권6호
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• pp.421-429
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• 2011

Experimental and theoretical studies on cooling performance of two-channel thermoelectric air-cooling system in parallel flow are conducted. The effects of operating temperature to physical properties of thermoelectric module (TEM) are experimentally examined and used in the analysis of an air-cooling system considering thermal network and energy balance. The theoretical predicted temperature variation and cooling capacity are in good agreement with measured data, thereby validating analytic model. The heat absorbed rate increases with increasing the voltage input and decreasing thermal resistance of the system. The power consumption of TEM is linearly proportional to mean temperature differences due to variations of the physical properties on operation temperature of TEM. Furthermore thermal resistance of hot side has greater effects on cooling performance than that of cold side.

• Journal of Advanced Marine Engineering and Technology
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• 제18권2호
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• pp.54-63
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• 1994

Mg thin films were prepared on SPCC(cold-rolled steel) substrates by vasuum evapoaration and ion-plating. The influence of argon gas pressure and substrates bias voltage on the crystal orientation and morphology of the film was determined by using X-ray diffraction and scanning electron micrography (SEM), respectively. And the effect of crystal orientation and morphology of the Mg thin films on corrosion behavior was estimated by measuring the anodic polarization curves in deaerated 3% NaCl solution. The crystal orientation of the Mg films deposited at high argon gas pressure exhibited a (002) preferred orientation, regardless of the substrate bias voltage. Film morphology changed from a columnar to a granular structure with the increase of argon gas pressure. The morphology of the films depended not only on argon gas pressure but also bias voltage ; i.e., the effect of increasing bias voltage was similar to that of decreasing argon gas pressure. The influences of argon gas pressure and bias voltage were explained by applying the adsorption inhibitor theory and the sputter theory. And also, this showed that the corrosion resistance of the Mg thin films can be changed by controlling the crystal orientaton and morphology.

• Journal of Power Electronics
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• 제7권1호
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• pp.38-43
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• 2007

An External Electrode Fluorescent Lamp (EEFL) has longer lifespan, higher power efficiency and higher luminance than a Cold Cathode Fluorescent Lamp (CCFL). Moreover, it is easy to drive them in parallel. Therefore, the EEFL is expected to quickly replace the CCFL in LCD backlight systems. However, the EEFL has more complex characteristics than the CCFL with a resistive component, because it has both a resistive component by plasma and a capacitive component by external electrode. In this paper, values of resistance and capacitance are measured at several power levels and at several operating frequencies. They are expressed by a numeral formula based on a linear approximation that represents the equivalent resistance and capacitance as a function of power. Then we made block diagram of the equivalent circuit model using numerical expressions. Simulation waveforms and experimental results are presented to verify the feasibility of the equivalent model.

• 열처리공학회지
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• 제31권1호
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• pp.12-17
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• 2018

We investigated the corrosion behavior of commercially pure cold working processed (CP)-Ti with coarse-grained (CG) microstructure heat-treated at $400^{\circ}C$ and $600^{\circ}C$, respectively. It is observed that corrosion resistance of as-received CP-Ti heat-treated at $400^{\circ}C$, at which recrystallization proceeds, is largely improved. Interestingly, the mechanical property of CP-Ti sample at $400^{\circ}C$ was scarcely deteriorated. It is attributed to the decrease of the defects such as strain variance and dislocation density. On the other hand, the annealing treatment at $600^{\circ}C$ of CP-Ti plate causes to grain growth with the noticeable reduction of mechanical property. Hence, it is considered that defect density such as strain and dislocation density is important microstructural parameter for the improvement of corrosion resistance. The introduction of proper annealing treatment can help to improve corrosion resistance without scarifying mechanical property of CP-Ti.