• Korean Journal of Acupuncture
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• v.23 no.3
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• pp.51-54
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• 2006

Objectives : To express an opinion on the controversy about the cold exposure as one of the risk factors of Bell's palsy. Results & Conclusions : It is widely assumed that there is a causal relationship between Bell's palsy and herpes family virus. Regarding cold exposure as one of the risk factors of Bell's palsy, however, some physicians do not accept that cold exposure could be one of the risk factors of Bell's palsy. There is no evidence supporting the hypothesis that the virus causes Bell's palsy, and it has yet to be confirmed. As there are some experimental and clinical reports suggesting that Bell‘s palsy is related to the cold exposure, we cannot exclude the possibility that the cold exposure may be one of the important risk factors of Bell's palsy. It would be necessary to undertake further studies to determine this.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.3
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• pp.506-514
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• 2020

Objective: We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods: Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6℃) or warm (28℃) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers. Results: Prenatal Cu exposure increased ewe plasma triiodothyronine (T₃) and thyroxine concentration (T₄) (p<0.01) but prenatal Cu exposure had no effect on lamb plasma concentrations of T₃, T₄, glucose, or nonesterified fatty acid concentration (p≥0.08). The high level of prenatal Cu exposure depressed 48-h rectal temperature (p = 0.03). Cold exposure decreased BAT norepinephrine (NE) and increased BAT dopamine (p≤0.01), but prenatal Cu exposure had no effect on BAT cytochrome C oxidase activity or BAT NE or dopamine (p≥0.07). However, BAT of lambs from high-Cu ewes maintained higher uncoupling protein-1 (UCP1) gene expression than BAT of lambs from low- and medium-Cu ewes following warm or cold exposure in environmental chambers (p = 0.02). Cold exposure caused near depletion of BAT lipid by 48 h (p<0.001), increased BAT cytochrome c oxidase activity (p<0.01), and depressed plasma fatty acid concentrations (p<0.001). Conclusion: Although prenatal Cu exposure increased BAT UCP1 expression during warm and cold exposure, prenatal cold Cu exposure depressed 48-h rectal temperature. Cold exposure decreased BAT lipid content by over 80% and decreased lamb plasma fatty acid concentration by over 40%, indicating that fuel reserves for thermogenesis were nearly depleted by 48 h of cold exposure.

• Asian-Australasian Journal of Animal Sciences
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• v.7 no.3
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• pp.357-362
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• 1994

Five adult sheep were exposed to intermittent cold for 12 h (18:00-06:00) at an air temperature of $5{\pm}1^{\circ}C$ followed by 12 h (06:00-18:00) at $25{\pm}2^{\circ}C$ over a period of 8 days continuously. Carotid artery blood (Tc), mean skin (Ts) and mean body (Tb = 0.86 Tc + 0.14 Ts) temperatures, heat production rate (HP), respiratory evaporative heat loss, respiration rate (RR) and volume were measured before and after exposure. Tc during the 12 h cold period of intermittent cold exposure was similar to that during the corresponding period in the warm environment, while Tc in the $25^{\circ}C$ of intermittent cold was higher (p < 0.05) than that in the corresponding period in the warm environment. Ts during the cold period markedly decreased (p < 0.001) by about $9^{\circ}C$ when compared with that in the corresponding time period in the warm environment, while Ts during the $25^{\circ}C$ period of intermittent cold recovered to a similar level to that in the warm environment. Tb was lower (p < 0.001) during the cold period of intermittent cold, whereas a slight increase in Tb during the $25^{\circ}C$ period of intermittent cold was significant (p < 0.05) when compared with the value during the similar period in the warm environment. HP was greatly increased (p < 0.001) by cold exposure, followed by an immediate decrease during the first one hour of the 12 h warm period, reaching a similar level to that in the warm environment. A lower (p < 0.05) RR was observed during both the cold and $25^{\circ}C$ period of intermittent cold than during the corresponding periods in the warm environment. The results of the present investigation clearly show that the body temperature of sheep increased during a 12 h warm period following 12 h of exposure to cold. These results suggest that during a warm period of an intermittent cold exposure cycle, heat could be shored in the animal body.

• The Korean Journal of Community Living Science
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• v.18 no.4
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• pp.599-607
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• 2007

We analyzed the effects of regular Jjimjilbang (Korean sauna) exposure on the cold tolerance in young and elderly females. Subjects were young (n=7) and elderly (n=7) females who had never had Jjimjilbang exposure experience. The Jjimjil training group was exposured in the Jjimjilbang 19 times per week. Jjimjibang exposure was limited to three times per day. Jjimjil activity was taken freely. To prove the effects of the cold tolerance, subjects were exposed to cold air ($12{\pm}1^{\circ}C,\;60{\pm}10%$RH). In these conditions, subjects were exposed for 30 minutes at which time rectal temperature, skin temperatures, clothing microclimate, energy expenditure, blood pressure and subjective sensation were measured. To prove the effects of the local cold tolerance, vascular hunting reaction was observed measuring the finger skin temperature while the left middle finger tip was immersed in cold water of $0^{\circ}C$ for 30 minutes. The results are as follows. According to repeated Jjimjil exposure, rectal temperature changes, peripheral temperature and energy expenditure were increased gradually in the cold climate chamber. Blood pressure, subjective sensation and vascular hunting reactions did not show any significant difference. In conclusion, regular Jjimjilbang exposure has negative effects on the ability of the body to improve its regulation of temperature especially in cold tolerance.

• The Korean Journal of Pharmacology
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• v.17 no.2
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• pp.37-45
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• 1981

The importance of thyroid hormones for the survival of rats in the cold is along-established fact. Hypothyroid animals are unable to survive in a cold environment. It was also reported that acute exposure of rats, guinea pigs and rabbits to cold produced an increased secretion of TSH and thereby thyroid hormone secretion within 10 to 30 min, but this increase of thyroid activity disappeared quite rapidly during warming. However, in human study no significant difference was found in the concentration of $T_4$, TSH and cortisol between summer and winter. But plasma $T_3$ concentration was increased significantly in winter in 56 adult men. On the other hand, it has been also known that catecholamines are important in the maintenance of body temperature of rat exposured to cold. Abundant evidences suggest that the sympathetic nervous system is involved in the activation of nonshivering thermogenesis and that thyroid hormone metabolism and secretion are influenced by catecholamines and consequently by the activity of the sympatheticadrenal system. Many of the metabolic effects of catecholamines are associated with an increase in the level of cAMP mediated through activation of adenylate cyclase which converts ATP to cAMP. Other studies have shown that thyroid hormones affect the amount of adenylate cyclase present in the adipose tissue. On the other hand. it was also reported that a particulate cAMP phosphodiesterase activity in fat cells was modulated by the action of thyroid hormones. The objective of the present study was to determine the interaction between thyroid activity and cyclic nucleotides during acute exposure to cold. Albino rats weighing around 200 g were used as the experimental animal. The room temperature group was kept at $25^{\circ}C$ and the cold-exposured group was kept at $4^{\circ}C$ for 1 week or 2 weeks. Each group was subdivided into three subgroups; control, KI, and MTU group. At the end of experiment the animals were etherized and blood was taken from abdominal aorta for $T_4,\;T_3$ and cyclic nucleotides. The determinations of $T_3,\;T_4$ and cyclic nucleotides were carried out with a radioimmunoassay(RIA) method. The results were summerized as followings. 1) A significant increase of thyroid weight was observed in rats exposured to cold for 2 weeks. Furthermore, in rats administered MTU while to exposure to cold the thyroid weight was also increased significantly. 2) After 2 weeks $T_3$ concentration in the plasma of cold-exposured rats was significantly increased in KI group and MTU group as well as in control group. On the contrary, after 2 weeks of cold exposure $T_4$ level was decreased in control group. 3) In the case of cyclic nucleotides, plasma cAMP was increased in the control group after 1 or 2 weeks of cold exposure. However, cAMP level in plasma was rather significantly decreased in KI group and MTU group as well as in control group.

• Journal of Advanced Marine Engineering and Technology
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• v.31 no.5
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• pp.622-629
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• 2007

Some worker is occupationally exposed to cold and freezing environment. The cold stimuli in the working environment impose physiological and psychological loads on workers to decrease the task performance. The purpose of this study is to investigate the cold stimuli of cold and freezing stores widely used in Busan can make an effect on human's physiological responses and task performance, experimentally and analytically. In the experiment, 5 workers are selected as subjects, and then their skin temperatures of hand and ear, heart rates, blood pressure, and ring test performances in cold($3^{\circ}C$) and freezing($-22^{\circ}C$) stores were measured for 21 minutes and analyzed by using statistical method. It is observed that a physiological variation and the task performance are significantly influenced by an exposure time as well as a strength of cold stimuli. Also, it is suggested the exposure limiting times for the useful manual work and the performance predict model of the ring tasks. The result of this study will be useful for a fundamental data of which design the standard task time of manual tasks and solve the job placement problem of worker selection and placement in cold environment.

• Journal of Korean Academy of Nursing
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• v.13 no.2
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• pp.87-104
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• 1983

It has been well documented that animals exposed to cold show increased activity of thyroid gland. The calorigenic action of thyroid hormone has been demonstrated by a variety of in vivo and in vitro studies. According to Edelman et al., the thyroid thermogenesis is due to activation of energy consuming processes, especially the active sodium transport by the hormone in target tissues. If so, the increase in thyroid activity during cold exposure should induce increased capacity of sodium transport in target tissue and the change in tissue metabolism should be precisely correlated with the change in Na+_K+_ATPase activity of the tissue. This possibility was tested in the present study: in one series, changes in oxygen consumption and Na+_K+_-ATPase activity of liver preparations were measured in rats as a function of thyroid status, in order to establish the effect of thyroid hormone on the tissue respiration and enzyme system in another series, the effect of cold stimulus on the serum thyroid hormone level, hepatic tissue oxygen consumption and Na+_K+_ATPase activity in rats. The results obtained are as follows: 1. The Na+_dependent oxygen consumption of liver slices, the oxygen consumption of liver mitochondria and the Na+_K+_ATPase activity of liver preparations were significantly inhibited in hypothyroidism and activated in hyperthyroidism. Kinetic analysis indicated that the Vmax. of Na+_K+_ATPase was decreased in hypothyroidism and increased in hyperth)'roidism. 2. In cold exposed rats, the serum triiodothyronine (T₃) level increased rapidly during the initial one day of cold exposure, then declined slowly to the control level after two weeks. The serum thyroxine (T₄) level decreased gradually throughout the cold exposure. Accordingly the T₃/T₄ratio increased. The mitochondrial oxygen consumption and the Na+_dependent oxygen consumption of liver slices increased during the first two days and then remained unchanged thereafter The activity of the Na+_K+_ATPase in liver preparations increased during cold exposure with a time course similar to that of oxygen consumption. Kinetic analysis indicated that the Vmax. of Na+_K+_ATPase increased. 3. Once the animal was adapted to cold, induction of hypothyroidism did not significantly alter the hepatic oxygen consumption and Na+_K+_ATPase activity. These results indicate that: 1) thyroid hormone increases capacities of mitochondrial respiration and active sodium transport in target tissues such as liver; 2) the increased T₃level during the initial period of cold exposure facilitates biosynthesis of Na+_K+_ATPase and mitochondrial enzymes for oxidative phosphorylation, leading to enhanced production and utilization of ATP, hence heat production.

• The Korean Journal of Physiology
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• v.6 no.1
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• pp.11-18
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• 1972

In an attempt to observe the Possible radioprotective actions of single or combined application of reduced glutathione (GSH) and cold exposure in mammals, the albino mouse was subjected to GSH injection, cold exposure at $-1{\pm}0.2C$ and whole-body X-irradiation with 900r either singularly or in combination, or the X-irradiation following the cold exposure and/or GSH injection. The levels of intrinsic NP-SH and NP-SS of the liver, brain and heart were measured at one hour after each application, and the results were compared with the control, i.e., non-irradiated and non-cold exposed normal animal. NP-SH was measured by the Ellman's method, and NP-SS was measured by the electrolytic reduction method described by Dohan and Woodward. The results thus obtained are summarized as follows: 1) The levels of NP-SH in the liver, brain and heart of the normal mouse was $6.35{\pm}0.61,\;2.65{\pm}0.15\;and\;3.17{\pm}0.10{\mu}\;mol/gm\;wet\;wt.$, respectively, and NP-SS was $3.09{\pm}0.11,\;2.95{\pm}0.20\;and\;0.18{\pm}0.24{\mu}\;mol/gm\;wet\;wt.$, respectively. 2) Though there were some degrees of difference among the tissues studied, a general tendency of (1) elevated NP-SH and NP-SS levels in the GSH injection group, (2) similar or slightly elevated NP-SH and NP-SS levels in the cold-exposed group, and (3) markedly decreased levels of NP-SH and NP-SS in the X-irradiated group, was observed. When GSH was injected prior to the X-irradiation, NP-SH and NP-SS in all the tissues studied showed generally higher values than in the group where the X-irradiation was given alone, and the values were close to the normal. In the group where the cold exposure was applied immediately after the X-irradiation, no significant difference was observed in the NP-SH and NP-S5 levels comparing with the X-irradiation group. On the contrary, when GSH was injected immediately prior to the X-irradiation or cold exposure, NP-SH and NP-SS levels were either similar to, or higher than, the normal value.

• The Korean Journal of Nuclear Medicine
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• v.21 no.2
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• pp.183-190
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• 1987

In Raynaud's phenomenon, the authors measured finger blood flow after ice water exposure by analyzing the time activity curve of radionuclide angiography on both hands. The results were as follows: 1) The digital blood flow did not decrease after ice water exposure in normal subjects. 2) In the patients with Raynaud's phenomenon, there were two groups: the one had decreased digital blood flow after cold exposure, and the other had paradoxically increased digital blood flow after cold exposure. 3) There was no difference in the digital blood flow of hand in room temperature between the normal and the patients with reduced digital blood flow after cold exposure, but the digital blood flow of the hand in room temperature was markedly reduced in the patients with paradoxically increased flow after cold exposure. 4) In the static image the difference was not significant in comparision with the dynamic study, because it represents pooling of the blood in the vein rather than flow. 5) After the treatment with nifedipine, the digital blood flow increased. In conclusion, the radionuclide angiography was useful in measuring the digital blood flow in Raynaud's phenomenon, and further studies with various drugs is expected.

• Advances in concrete construction
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• v.5 no.5
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• pp.513-537
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• 2017

In this study, the fracture toughness $K_{IC}$ of high performance concrete (HPC) was investigated by conducting three-point bending tests on a total of 240 notched beams of $500mm{\times}100mm{\times}100mm$ subjected to heating temperatures up to $450^{\circ}C$ with exposure times up to 16 hours and various heating and cooling rates. For a heating rate of $3^{\circ}C/min$, $K_{IC}$ for the hot concrete sustained a monotonic decrease trend with the increasing heating temperature and exposure time, from $1.389MN/m^{1.5}$ at room temperature to $0.942MN/m^{1.5}$ at $450^{\circ}C$ for 4-hour exposure time, $0.906MN/m^{1.5}$ for 8-hour exposure time and $0.866MN/m^{1.5}$ for 16-hour exposure time. For the cold concrete, $K_{IC}$ sustained a two-stage decrease trend, dropping slowly with the heating temperature up to $150^{\circ}C$ and then rapidly down to $0.869MN/m^{1.5}$ at $450^{\circ}C$ for 4-hour exposure time, $0.812MN/m^{1.5}$ for 8-hour exposure time and $0.771MN/m^{1.5}$ for 16-hour exposure time. In general, the $K_{IC}$ values for the hot concrete up to $200^{\circ}C$ were larger than those for the cold concrete, and an inverse trend was observed thereafter. The increase in heating rate slightly decreased $K_{IC}$, and at $450^{\circ}C$ $K_{IC}$ decreased from $0.893MN/m^{1.5}$ for $1^{\circ}C/min$ to $0.839MN/m^{1.5}$ for $10^{\circ}C/min$ for the hot concrete and from $0.792MN/m^{1.5}$ for $1^{\circ}C/min$ to $0.743MN/m^{1.5}$ for $10^{\circ}C/min$ for the cold concrete after an exposure time of 16 hours. The increase in cooling rate also slightly decreased $K_{IC}$, and at $450^{\circ}C$ $K_{IC}$ decreased from $0.771MN/m^{1.5}$ for slow cooling to $0.739MN/m^{1.5}$ for fast cooling after an exposure time of 16 hours. The fracture energy-based fracture toughness $K_{IC}$' was also assessed, and similar decrease trends with the heating temperature and exposure time existed for both hot and cold concretes. The relationships of two fracture toughness parameters with the weight loss and the modulus of rapture were also evaluated.