• Title/Summary/Keyword: Coherence imaging

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Three-dimensional Imaging with an Endoscopic Optical Coherence Tomography System for Detection of Airway Stenosis (기도협착 측정을 위한 내시경 광 결맞음 단층촬영법을 이용한 3차원 이미징)

  • Kwon, Daa young;Oak, Chulho;Ahn, Yeh-Chan
    • Korean Journal of Optics and Photonics
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    • v.30 no.6
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    • pp.243-248
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    • 2019
  • The respiratory tract is an essential part of the respiratory system involved in the process of respiration. However, if stenosis occurs, it interferes with breathing and can even lead to death. Asthma is a typical example of a reversible cause of airway narrowing, and the number of patients suffering from acute exacerbation is steadily increasing. Therefore, it is important to detect airway narrowing early and prevent the patient's condition from worsening. Optical coherence tomography (OCT), which has high resolution, is suitable for observing the microstructure of tissues. In this study we developed an endoscopic OCT system. We combined a 1300-nm OCT system with a servo motor, which can rotate at a high speed. A catheter was pulled back using a linear stage while imaging with 360° rotation by the motor. The motor was selected considering various requirements, such as torque, rotational speed, and gear ratio of pulleys. An ex vivo rabbit tracheal model was used as a sample, and the sample and catheter were immobilized by acrylic structures. The OCT images provided information about the structures of the mucosa and submucosa. The difference between normal and stenosed parts in the trachea was confirmed by OCT. Furthermore, through a three-dimensional (3-D) reconstruction process, it was possible to identify and diagnose the stenosis in the 3-D image of the airway, as well as the cross-sectional image. This study would be useful not only for diagnosing airway stenosis, but also for realizing 3-D imaging.

Evaluation of Morphological Changes in Degenerative Cartilage Using 3-D Optical Coherence Tomography

  • Youn, Jong-In
    • Journal of the Optical Society of Korea
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    • v.12 no.2
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    • pp.98-102
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    • 2008
  • Optical Coherence Tomography (OCT) is an important noninvasive medical imaging technique that can reveal subsurface structures of biological tissue. OCT has demonstrated a good correlation with histology in sufficient resolution to identify morphological changes in articular cartilage to differentiate normal through progressive stages of degenerative joint disease. Current OCT systems provide individual cross-sectional images that are representative of the tissue directly under the scanning beam, but they may not fully demonstrate the degree of degeneration occurring within a region of a joint surface. For a full understanding of the nature and degree of cartilage degeneration within a joint, multiple OCT images must be obtained and an overall assessment of the joint surmised from multiple individual images. This study presents frequency domain three-dimensional (3-D) OCT imaging of degenerative joint cartilage extracted from bovine knees. The 3-D OCT imaging of articular cartilage enables the assembly of 126 individual, adjacent, rapid scanned OCT images into a full 3-D image representation of the tissue scanned, or these may be viewed in a progression of successive individual two-dimensional (2-D) OCT images arranged in 3-D orientation. A fiber-based frequency domain OCT system that provides cross-sectional images was used to acquire 126 successive adjacent images for a sample volume of $6{\times}3.2{\times}2.5\;mm^3$. The axial resolution was $8\;{\mu}m$ in air. The 3-D OCT was able to demonstrate surface topography and subsurface disruption of articular cartilage consistent with the gross image as well as with histological cross-sections of the specimen. The 3-D OCT volumetric imaging of articular cartilage provides an enhanced appreciation and better understanding of regional degenerative joint disease than may be realized by individual 2-D OCT sectional images.

Incoherent imaging method for high-contrast cylindrical cavity by using frequency-averaged electric field intensity pttern (주파수평균된 전계전력패턴을 사용한 high-contrast 원기둥 공동의 incoherent 영상법)

  • 강진섭;라정웅
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.35D no.2
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    • pp.1-12
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    • 1998
  • In this paper, an incoherent imaging of a high-contrast cylindrical cavity illuminated by the time-harmonic cylindrical wave is obtained ia the back-projections of he incoherent intensity patterns, which si acquired by averaging out the multi-frequency intensities of the total electric field scattered from this object in the cross-borehole measurement configuration. Multi-freuqncy effect is shown numerically and is intepreted analytically by the mutual coherence function defined in the is frequency domain. This imaging method is validated by imaging high-contrast cylindrical cavidities and the conditions to get better image are investigated.

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The Development of Double Clad Fiber and Double Clad Fiber Coupler for Fiber Based Biomedical Imaging Systems

  • Ryu, Seon-Young;Choi, Hae-Young;Ju, Myeong-Jin;Na, Ji-Hoon;Choi, Woo-June;Lee, Byeong-Ha
    • Journal of the Optical Society of Korea
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    • v.13 no.3
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    • pp.310-315
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    • 2009
  • We report the fabrication of double clad fiber (DCF) and DCF coupler, suitable for fiber based imaging systems requiring the dual-channel transmission. Unlike the conventional DCF which uses silica for both cladding layers, the proposed DCF uses a low-index polymer for its outer-cladding layer coated over the conventional silica inner-cladding layer. The DCF is drawn with a conventional SMF preform but a low-index polymer coating is used for both jacket and outercladding of the fiber. To achieve the cladding mode coupling, a DCF coupler is fabricated by simply twisting two pieces of the proposed DCF after removing the polymer-coating at contacting regions. A cladding mode coupling ratio of 30% was achieved with a contact length of 16 cm. The proposed DCF and DCF coupler were employed in a composite optical coherence tomography (OCT) and fluorescence spectroscopy (FS) system, and both OCT images and FS signal from a plant tissue are measured simultaneously.

A Study on the Interferometer Configuration for Improvement of Signal-to-Noise Ratio of Optical Coherence Tomography System (OCT 시스템의 SNR 향상을 위한 간섭계 개선에 관한 연구)

  • Yang, Sung-Kuk;Park, Yang-Ha;Chang, Won-Suk;Oh, Sang-Ki
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.18 no.5
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    • pp.126-131
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    • 2004
  • As a noninvasive imaging method, optical coherence tomography system has been extensively studied because it has some advantages such as imaging of high resolution, low cost, and compact size configuration. In order to improve the SNR of OCT system, two types of interferometers were configured and then, we compared simulation with measurement of reference sample. In the OCT system is configured with Michelson interferometer, the contrast of cross-sectional image is reduced with low SNR detection which is due to loss of feedback interference signal from light source part. Also, in order to image measured data with real time, image processing program is constructed. From results of simulation, it is confirmed that improved Michelson interferometer is improved about 10[dB] with a 50 : 50 fiber coupler. And from the measurement of reference sample, about 5[dB] is improved with a 50 : 50 fiber coupler. It is confirmed that the OCT system is configured with the improved Michelson interferometer which has a good distinctive cross-sectional image due to higher contrast.

Ultrahigh-Resolution Spectral Domain Optical Coherence Tomography Based on a Linear-Wavenumber Spectrometer

  • Lee, Sang-Won;Kang, Heesung;Park, Joo Hyun;Lee, Tae Geol;Lee, Eun Seong;Lee, Jae Yong
    • Journal of the Optical Society of Korea
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    • v.19 no.1
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    • pp.55-62
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    • 2015
  • In this study we demonstrate ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) with a linear-wavenumber (k) spectrometer, to accelerate signal processing and to display two-dimensional (2-D) images in real time. First, we performed a numerical simulation to find the optimal parameters for the linear-k spectrometer to achieve ultrahigh axial resolution, such as the number of grooves in a grating, the material for a dispersive prism, and the rotational angle between the grating and the dispersive prism. We found that a grating with 1200 grooves and an F2 equilateral prism at a rotational angle of $26.07^{\circ}$, in combination with a lens of focal length 85.1 mm, are suitable for UHR SD-OCT with the imaging depth range (limited by spectrometer resolution) set at 2.0 mm. As guided by the simulation results, we constructed the linear-k spectrometer needed to implement a UHR SD-OCT. The actual imaging depth range was measured to be approximately 2.1 mm, and axial resolution of $3.8{\mu}m$ in air was achieved, corresponding to $2.8{\mu}m$ in tissue (n = 1.35). The sensitivity was -91 dB with -10 dB roll-off at 1.5 mm depth. We demonstrated a 128.2 fps acquisition rate for OCT images with 800 lines/frame, by taking advantage of NVIDIA's compute unified device architecture (CUDA) technology, which allowed for real-time signal processing compatible with the speed of the spectrometer's data acquisition.

Fourier Domain Optical Coherence Tomography for Retinal Imaging with 800-nm Swept Source: Real-time Resampling in k-domain

  • Lee, Sang-Won;Song, Hyun-Woo;Kim, Bong-Kyu;Jung, Moon-Youn;Kim, Seung-Hwan;Cho, Jae-Du;Kim, Chang-Seok
    • Journal of the Optical Society of Korea
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    • v.15 no.3
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    • pp.293-299
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    • 2011
  • In this study, we demonstrated Fourier-domain/swept-source optical coherence tomography (FD/SS-OCT) at a center wavelength of 800 nm for in vivo human retinal imaging. A wavelength-swept source was constructed with a semiconductor optical amplifier, a fiber Fabry-Perot tunable filter, isolators, and a fiber coupler in a ring cavity. Our swept source produced a laser output with a tuning range of 42 nm (779 to 821 nm) and an average power of 3.9 mW. The wavelength-swept speed in this configuration with bidirectionality is 2,000 axial scans per second. In addition, we suggested a modified zero-crossing method to achieve equal sample spacing in the wavenumber (k) domain and to increase the image depth range. FD/SS-OCT has a sensitivity of ~89.7 dB and an axial resolution of 10.4 ${\mu}m$ in air. When a retinal image with 2,000 A-lines/frame is obtained, an acquisition speed of 2.0 fps is achieved.