• 디지털산업정보학회논문지
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• 제11권4호
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• pp.113-127
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• 2015

An interface in smart device environment is changing to TUI(touch user interface) environment where a system is being controlled by physical touch, differently from a system controlled through conventional mouse and keyboard. What is more important than anything else in this TUI environment is to implement interface in consideration of learn ability and cognitive constructivism according to user's experience. Therefore, now is the time when it is necessary to carry out various studies on smart content design process going a step farther together with discussing the details of user's experience factor. Hence, this study was intended to look into what effect a user's experiential traits had on the production of contents for the purpose of measures for improving TUI user satisfaction in order to effectively realize contents in smart environment. Results were yielded by using a statistical empirical analysis such as cross-tabulation analysis according to important variable and user, paired t-test, multiple response analysis, and preference frequency analysis of user preference on the basis of a survey. As a result, a system was presented for implementing DFSS(Design For Six Sigma) process. TUI experience factor can be divided into direct habitual experience, direct learning experience, indirect habitual experience, and indirect learning experience. And in the results of study, it was possible to find that the important variables of this study had a positive effect on the improvement of use satisfaction with contents on the whole according to the user convenience of smart contents. This study is expected to have a positive effect on efficient smart device-based contents production by providing objective information according to empirical analysis to smart media-based developer and designer and presenting a model for improving the changed TUI usability.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.422-433
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• 2018

Objective: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain function in a bottom-up manner. Here, the changes in the response of the hypothalamic-pituitary-adrenal axis and inflammation-related markers in the brain in colitis were studied. Methods: Dextran sodium sulfate (DSS) was used to generate a mouse model of colitis. Mice were treated with DSS for 3 or 7 days and sacrificed. We analyzed the gene expression of brain-derived neurotrophic factor (BDNF), cyclooxygenase 2 (COX-2), and glial fibrillary acidic protein (GFAP), and the expression of GFAP, in the hippocampus, hypothalamus, and amygdala. Additionally, the levels of C-reactive protein (CRP) and serum cortisol/corticosterone were measured. Results: Alteration of inflammatory-related markers varied depending on the brain region and exposure time. In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS. However, in the hypothalamus, COX-2 mRNA was upregulated only 3 days after treatment. In the amygdala, BDNF and COX-2 mRNAs were downregulated. CRP and corticosterone expression increased with DSS treatment at day 7. Conclusion: IBD could lead to neuroinflammation in a bottom-up manner, and this effect varied according to brain region. Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment. Therefore, early and active intervention is required to prevent psychological and behavioral changes caused by IBD, and region-specific studies can help understand the precise mechanisms by which IBD affects the brain.

• 대한한의학방제학회지
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• 제27권2호
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• pp.121-136
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• 2019

Objective : To investigate the effect of sihogayonggolmoryeotang (SY) on Single Prolonged Stress(SPS)-induced Post Traumatic Stress Disorder(PTSD). Method : To confirm the effects of SY on SPS-induced PTSD, Changes in body weight, sucrose intake open field test(OFT) and forced swimming test(FST)were observed. After behavioral tests, the plasma corticosterone(CORT) from the abdominal aorta, serotonin(5-HT) from prefrontal cortex, hippocampus, amygdala and striatum, norepinephrine(NE) and dopamine(DA) from hippocampus was measured by ELISA. mRNA expression of brain-derived neurotrophic factor(BDNF) and cAMP response element-binding protein(CREB) in hippocampus was measured by RT-PCR. Result : Weight change and sucrose intakes of rats in 14th day after the administration of SY were significantly increased in the SPS + SY450 group compared to the SPS group (p<0.05). Numbers of crossing in the central zone in the OFT were significantly increased in the SPS + SY450 group (p<0.05) compared with the SPS group. The immobility time of FST was significantly decreased in SPS + SY450 group compared with SPS group (p<0.05). The change of plasma CORT concentration was significantly decreased in SPS + SY450 group compared with that in SPS group (p<0.05). The change of 5-HT concentration was significantly increased in the SPS + SY450 group at hippocampus and amygdala compared with the SPS group (p<0.05). The concentration of DA was significantly increased in the SPS + SY450 group compared with the SPS group (p<0.05). The expression of BDNF and CREB were significantly increased in SPS + SY450 group compared with the SPS group (p<0.05). Conclusion : SY administration lowered the increase of CORT caused by PTSD and increases the 5-HT concentration and reversed the decreased expression of NE and DA and BDNF and CREB by PTSD. It is postulated that SY is effective in treating PTSD by restoring cognitive function, memory impairment, unstable emotional disturbances.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권12호
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• pp.5723-5743
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• 2018

The evolving internet-based services demand high-speed data transmission in conjunction with scalability. The next generation optical network has to exploit artificial intelligence and cognitive techniques to cope with the emerging requirements. This work proposes a novel way to solve the dynamic provisioning problem in optical network. The provisioning in optical network involves the computation of routes and the reservation of wavelenghs (Routing and Wavelength assignment-RWA). This is an extensively studied multi-objective optimization problem and its complexity is known to be NP-Complete. As the exact algorithms incurs more running time, the heuristic based approaches have been widely preferred to solve this problem. Recently the software-defined networking has impacted the way the optical pipes are configured and monitored. This work proposes the dynamic selection of path computation algorithms in response to the changing service requirements and network scenarios. A software-defined controller mechanism with a novel packet matching feature was proposed to dynamically match the traffic demands with the appropriate algorithm. A software-defined controller with Path Computation Element-PCE was created in the ONOS tool. A simulation study was performed with the case study of dynamic path establishment in ONOS-Open Network Operating System based software defined controller environment. A java based NOX controller was configured with a parent path computation element. The child path computation elements were configured with different path computation algorithms under the control of the parent path computation element. The use case of dynamic bulk path creation was considered. The algorithm selection method is compared with the existing single algorithm based method and the results are analyzed.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제12권11호
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• pp.337-346
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• 2023

고령자는 낮은 디지털 활용 역량, 주기적이고 지속적인 자가관리 유지 어려움이 있어 시간에 따른 변화에 대응해 지속적인 관리를 해줄 수 있는 돌봄 제공자용 건강관리 앱이 필요하다. 이러한 필요성을 바탕으로 본 연구에서는 고령자가 사용하기 편한 UI와 단순한 구조의 앱을 디자인하였다. 본 연구에서 개발된 앱은 돌봄 현장에서 혈압, 혈당, 심박수 등의 건강 데이터와 신체, 질병, 인지, 의사소통, 환경 등의 특이 정보들을 정기적으로 관리하도록 지원한다. 본 연구에서 개발된 앱은 건강관리 기기와의 연동을 통해 데이터를 자동 입력하고, 기록된 데이터의 자동분석과 시각화 표현이 가능하다. 건강 변화의 추세, 변동성 등의 모니터링으로 돌봄 서비스를 제공할 수 있는 지원이 가능하다. 또한 다양한 건강관리, 의료지원 플랫폼과 연계할 수 있는 확장성이 추가되어 개발되었다. 개발된 앱에 대한 효과성과 만족도가 현장 실증 결과 유의미함이 확인되었다.

• 인터넷정보학회논문지
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• 제25권2호
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• pp.57-67
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• 2024

사용자가 제스처를 통해 입력을 할 수 있는 방안들 중에서 근전도(EMG, Electromyography)를 통한 제스처 인식은 근육 내 작은 전극을 통해 사용자의 움직임을 감지하고 이를 입력 방법으로 사용할 수 있는 방법이다. EMG 데이터를 통해 사용자 제스처를 분류하기 위해서는 사용자로부터 수집된 EMG Raw 데이터를 머신러닝으로 학습하여야 하는데 이를 위해서는 EMG 데이터를 전처리 과정을 통해 특징을 추출하여야 한다. EMG 특성은 IEMG(Integrated EMG), MAV(Mean Absolute Value), SSI(Simple Sqaure Integral), VAR(VARiance), RMS(Root Mean Square) 등과 같은 수식을 통해서 나타낼 수 있다. 또한, 제스처를 입력으로 사용하기 위해서는 사용자가 입력하는 데 필요한 지각, 인지, 반응에 필요한 시간을 기준으로 제스처 분류가 가능한 시간을 알아내야 한다. 이를 위해 최대 1,000ms에서 최소 100ms까지 세그먼트 사이즈를 변화시켜 특징을 추출 후 제스처 분류가 가능한 세그먼트 사이즈를 찾아낸다. 특히 데이터 학습은 overlapped segmentation 방법을 통해 데이터와 데이터 사이 간격을 줄여 학습 데이터 개수를 늘린다. 이를 통해 KNN, SVC, RF, XGBoost 4가지 머신러닝 방식을 통해 이를 학습하고 결과를 도출한다. 실험 결과 실시간으로 사용자의 제스처 입력이 가능한 최대 세그먼트 사이즈인 200ms에서 KNN, SVC, RF, XGboost 4가지 모든 모델에서 96% 이상의 정확도를 도출하였다.

• Toxicological Research
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• 제20권3호
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• pp.251-261
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• 2004

A large number of chemical pollutants including phthalates, alkylphenolic compounds and organochlorine pesticides have the ability to disrupt endocrine function in animals, and alter cog-nitive function. Because hormone mediated events play an important role in central nervous system development and function, the changes in cognitive function seem to be mediated by the endocrine-like action of these chemicals. The present study therefore was designed to investigate effect of bisphenol A (BPA), an endocrine disrupting chemical on neuro-behavial patterns, and expression of estrogen receptors and tyrosine hydroxylase, a limiting enzyme of dopamine synthesis pathway. BPA was treated orally for 3 weeks into 3 week old mice, and then the neuro-behavial patterns (stereo-type behaviors such as jumping rearing and forepaw tremor, climbing behavior, tail flick, rotarod and locomotor activity), and the expression of estrogen receptors and tyrosine hydroxylase were deter-mined every 3 week for 9 weeks. During the treatment of BPA, the food uptake and body weight increase were not significantly changed. BPA resulted in the increased stereotype behaviors (jump-ing, rearing and forepaw tremor) 6 or 9 weeks after treatment. The time response to tail flick and locomotor activity were decreased by the treatment of BPA, whereas the time for rotarod was increased by the treatment of BPA. The expression of estrogen receptor alpha and beta was increased in the brain and pituitary gland. Maximum expression was found in the brain after 9 week of 100 mg/kg BPA treatment and in the pituitary gland after 6 week of 100 mg/kg BPA treatment. Tyrosine hydroxylase was increased in dose and time dependent manners in the brain but no change was found in the pituitary gland. The present data show that exposure of BPA in the young mice could alter expression of estrogen receptors and dopamine synthesis pathway, thereby modulate neuro-behavial patterns (increase of stereotype behaviors but decrease locomotor activity).

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.253-261
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• 2011

Objectives : This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neuro-cognitive functions. Methods : Ninety-one subjects with ADHD (mean age 8.6${\pm}$2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects. Results : After 0.92${\pm}$0.32mg/kg/day of MCD were administered for 57.4${\pm}$7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%). Conclusion : This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.

• 대한감각통합치료학회지
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• 제16권3호
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• pp.23-33
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• 2018

목적 : 본 연구는 국내 아동 작업치료사들이 사용하고 있는 평가도구를 영역별로 구체화하여, 평가도구의 사용 동향을 파악하고자 하였다. 연구방법 : 본 연구는 아동 작업치료사를 대상으로 평가도구 사용에 대한 설문을 실시하였다. 평가도구의 하위영역은 작업수행, 일상생활활동, 교육, 놀이, 감각-지각, 운동 및 실행, 인지, 사회적 상호작용 기술, 발달, 이학적 검사로 구성하였다. 설문에 응답한 105명의 자료를 대상으로 기술통계 및 빈도분석을 사용하여 분석하였다. 결과 : 본 연구 결과는 초기 평가 시 소요되는 시간은 30~60분(41.9%)이 가장 많았으며, 재평가 주기는 3~6개월(41.0%)로 가장 많이 실시하는 것으로 나타났다. 영역 별 평가도구를 살펴보면, 작업 수행은 Canadian Occupation Performance Measure(55.2%)을, 일상생활활동은 Wee Functional Independence Measure(57.1%)을, 교육은 School Function Assessment(2.5%)를, 놀이 평가도구는 Revised Knox Preschool Play Scale(28.6%)을, 감각-지각은 Developmental Test of Visual Perception(94.3%)을, 운동 및 실행 평가도구는 Bruininks-Oseretsky Test of Motor Proficiency-2(42.9%)를, 인지 평가도구는 Lowenstein Occupational Therapy Cognitive Assessment(11.4%)를, 사회적 상호작용 기술은 Evaluation of Social Interaction(6.1%)을, 발달은 Denver Developmental Screening Test-II(92.4%)를, 이학적 검사는 임상관찰(89.5%)을 주로 사용하는 것으로 나타났다. 결론 : 본 연구를 통하여 국내 아동작업치료사들이 사용하고 있는 평가도구를 영역별로 구체적으로 파악할 수 있었으며, 이를 통해 추후 평가 교육 및 개발을 위한 기초적인 근거자료가 될 것으로 기대된다.

• 한국ITS학회 논문지
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• 제21권6호
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• pp.87-96
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• 2022

고령보행자를 포함한 교통약자는 신체적 능력이 저하되어 보행속도가 상대적으로 낮으며, 인지반응시간이 느린 특성을 가지고 있지만, 현재 교통약자를 위한 보행신호는 0.8m/s로 일률적으로 적용하고 있다. 문제점을 개선하기 위하여 스마트 횡단시스템이 개발되어 운영되고 있지만, 보행자별 적정 보행속도를 반영한 신호운영이 이루어지지 못하고 있다. 본 연구에서는 교통약자비율이 높은 지역에서 수집된 영상정보를 활용하여, 교통약자의 종류, 보행자의 수, 도로의 기하구조 등을 고려한 신경망모형과 다중회귀모형기반의 횡단속도 추정모델을 개발하였다. 이를 통해 개발된 모델을 스마트횡단시스템에 적용하여 실시간 교통약자에 따른 최적 보행신호 제공을 지원하고자 하였다. 경기도 파주시의 도시 교통 네트워크에서 수집된 실제 교통 상황 데이터 2,400개를 사용하였다. 모델의 성능은 상관계수, 평균 절대오차 등 7개의 선택된 지표를 통해 평가되었다. 다중선형회귀모델은 상관 계수가 0.652이고 MAE가 0.182였으며, 신경망모델은 상관계수가 0.823이고 MAE가 0.105로 나타나. 신경망모델이 더 높은 예측력을 보였다.