• Journal of the Korean Applied Science and Technology
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• v.37 no.2
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• pp.354-361
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• 2020

The purpose of this study was to investigate the effects of regular taekwondo training on neurotrophic factors and cognitive function in obese middle-aged women. Thirty-three middle-aged women with obesity were selected for this study and randomly assigned into a control group(CG, n=18) and an taekwondo group(TG, n=15). The TG performed taekwondo training 5 times weekly for 16 weeks, while the CG did not exercise training. Serum brain-derived neurotrophic factor(BDNF), vascular endothelial growth factor(VEGF), and insulin-like growth factor-1(IGF-1) levels were analyzed and Stroop Color and Word tests were performed before and after the intervention. The serum BDNF and IGF-1 levels were significantly increased in the TG after the intervention(p<.05). On the other hand, no statistically significant differences were found in the serum VEGF levels, or in the Stroop Color and Word Test scores(p>.05). These results suggest that regular taekwondo training may be affects levels of peripheral neurotrophic factors but not cognitive function in obese middle-aged women.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.513-518
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• 2014

Purpose: This study was to investigate color distortion by colors and luminous transmittance of lenses with word-color test included in computerized neurocognitive function test (CNT). Methods: 32 subjects aged $21.97{\pm}1.58$ years with no ocular disease and color vision deficiency were selected. Four colors of tinted lenses, which were red, green and blue included in the primary colors of light and pink, and word-color test in CNT to evaluate changes in cognitive function by color distortion were used. Results: Response time was not significantly increased in green, blue, and pink among four colors, but significantly increased in only red color. And response time was significantly increased below 46% of luminous transmittance in red color. Conclusions: It should be cautious and careful of the red-tinted lens choice because red color with below 46% of luminous transmittance can distort colors of objects, and it could be related to safety problem. It is suggested that word-color test could be extensively used for further studies on color recognition.

• Korean Journal of Biological Psychiatry
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• v.22 no.3
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• pp.140-148
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• 2015

Objectives The aim of this study is to investigate the correlation between degenerative changes in brain [i.e., global cortical atrophy (GCA), medial temporal atrophy (MTA), white matter hyperintensities (WMH)] and neurocognitive dysfunction in Korean patients with Alzheimer's disease. Methods A total of 62 elderly subjects diagnosed with Alzheimer's disease were included in this study. The degenerative changes in brain MRI were rated with standardized visual rating scales (GCA or global cortical atrophy, MTA or medial temporal atrophy, and Fazekas scales) and the subjects were divided into two groups according to the degree of degeneration for each scale. Cognitive function was evaluated with Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) and several clinical features, including apolipoprotein E ${\varepsilon}4$ status, lipid profile and thyroid hormones, were also examined. Chi-square test and Fisher's exact test were performed to analyze the relationship between the degree of cerebral degeneration and neurocognitive functions. Results Demographic and clinical features, except for the age, did not show any significant difference between the two groups divided according to the degree of cerebral degenerative changes. However, higher degree of GCA was shown to be associated with poorer performance in verbal fluency test, word list recall test, and word list recognition test. Higher degree of MTA was shown to be associated with poorer performance in Mini-Mental State Examination in the Korean Version of CERAD Assessment Packet (MMSE-KC), word list recognition test and construction praxis recall test. Higher degree of white matter hyperintensities was shown to be associated with poorer performance in MMSE-KC. Conclusions Our results suggest that severe brain degeneration shown in MRI is associated with significantly poorer performance in neurocognitive tests in patients with Alzheimer's disease. Moreover, the degree of GCA, MTA and white matter hyperintensities, represented by scores from different visual rating scales, seems to affect certain neurocognitive domains each, which would provide useful information in clinical settings.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.483-489
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• 2018

Driving behaviors are reported to be vulnerable to safe driving in unexpected situations or driving in the city due to deterioration of physical and cognitive functions in elderly drivers. The purpose of this study was to investigate the difference in driving behaviors according to age of self-drivers and to identify changes in physical function related to driving caused by normal aging. The subjects of the study included 75 healthy adults (21 persons aged 20-39 years, 40 persons 40-64 years, 14 persons 65 years old) who were self-driving and possessed a driver's license. Data included sex, dominant hand, medication, exercise, age, and driving time obtained by a self-reported questionnaire. In addition, this study measured steering, acceleration and braking using a Driver Test Station. Results of the study showed there was no significant difference in power test according to age group, but the total time of the timer test and the emergency brake test significantly differed according to age. The timer test and emergency brake test were completed fastest in young adults between 20 and 39 years old and completed slowest in elderly people 65 years old or over. Based on our study results, it is suggested that normal aging affects the perceptual-cognitive processes associated with driving behaviors.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6201-6213
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• 2015

The purpose of this study was to investigate the effect of Reality Orientation Therapy and Spaced Retrieval Therapy of the applied of CERAD-K type cognitive rehabilitation program for mild Alzheimer's patients. The tool used to this study was CERAD-K neuropsychological test consists of Boston Naming, a simple mental status, the word list recall, and configure behavior. A non-equivalent control group pretest-posttest design was used. The participants were 85 mild Alzheimer's patients (experimental group: 32, control group: 53) who registered G Health Center, in Gyeonggi province. Those Data were collected from 10:00 to 11:00, 14:00 to 15:00, twice a week on Tuesday and Friday, 8 session, from September 1 to September 30, 2014. Control group was participated daily routine program only in the G public health center.The data were analyzed using SPSS WIN 21.0 program. The results of this study were as follows;Boston Naming(F=3.22, p<.001), simple mental status(F=5.92, p<.001), and configure behavior(F=4.67, p<.001) were accepted, but word list recall(F=.75 p>.05) was not accepted. The study findings indicate that the Reality Orientation Therapy and Spaced Retrieval Therapy of the applied of CERAD-K type cognitive rehabilitation program is effective and can be recommended as intervention for mild Alzheimer's patients.

• 한국노년학
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• v.40 no.3
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• pp.429-442
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• 2020

The purpose of this research was to examine changes in the physical fitness, activities of daily living performance, and cognitive status of the frail elderly by combined exercise programs. The combined exercise program consisted of an aerobic exercise for the elderly and a four-color ladder exercise for improving of cognitive ability and physical fitness. Twenty-one frail elderly participated in this study, they were divided into 12 exercise groups and nine control groups. The exercise group conducted the combined exercise program of 60 minutes, twice a week, for10 weeks, while the control group maintained their normal lives. Strength, flexibility, agility, coordination, ADL and MMSE-K were measured. Exercise group showed significant improvement in grip strength compared to control group. In addition, ADL showed significant improvement only in the exercise group. The results of this study showed that participation in the combined exercise program of the el derl y was effective in improving the grip strength, and in preventing various physical functions and cognitive conditions decline.

• The Journal of Korean Physical Therapy
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• v.26 no.3
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• pp.147-155
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• 2014

Purpose: This study was to determine the effects of before and after application of silicone sleeve on balance and muscle strength in anterior cruciate ligament (ACL) reconstruction patients. Methods: 13 subjects who had one or more months after ACL surgery were involved. Dynamic balance, timed up and go (TUG), stair step, vertical jump, proprioception and isokinetic knee strength were measured while subjects under taped, untapped and silicone sleeve conditions. Results: For 30 seconds one-leg standing, there was a significant improvement under silicone sleeve on operated side with eyes open and both taping and silicone sleeve revealed similar effects with eyes closed (p<0.01). Application of silicone sleeve showed significant effects in proprioceptive function on the operated side compared to both taping and none (p<0.05). For stair step test, TUG and vertical jump was a tendency to improve after application of silicone sleeve, but no significant different. Muscle strength on operated side of quadriceps and hamstring was significantly improved compared with none or taping(p<0.05). Conclusion: Silicone sleeve application for ACL reconstruction patients was effective immediately on improving strength and balance. Therefore, depending on the intended use and the disease is considered appropriate use of silicone sleeve will be able to help prevention and functional movement.

• Journal of Nutrition and Health
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• v.39 no.3
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• pp.219-224
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• 2006

This study was performed to determine the effect of soy isoflavones on brain development and function in rats. Forty Sprague-Dawley male rats were provided diets containing different levels of soy isoflavones for 6 weeks; 0 ppm (control), 50 ppm (low isoflavone intake; LI), 250 ppm (medium isoflavone intake; MI) and 500 ppm (high isoflavone intake; HI). Learning ability was evaluated by a Y-shaped water maze and the activity of acetylcholinesterase in brain was assayed after decapitation. Food intake and body weights as well as weights of brain, liver, spleen, heart and kidney showed no significant difference among the four groups, which means 500 ppm of isoflavones is safe. In the water maze test, the frequency of error counted when rats entered one end of the alley without platform was significantly lower in the HI group than in the control group, and the escape latency as swim time taken to escape on the hidden platform was significantly shorter in the HI group than in the LI and control groups. The activity of acetylcholinesterase of the brain was significantly higher in the HI and MI groups than in the control group. Therefore, the results indicate that isoflavones may improve the cognitive function without adverse effects.

• The Korean Journal of Rehabilitation Nursing
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• v.9 no.1
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• pp.72-80
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• 2006

Purpose: This study was conducted to examine the effect of multidimensional program on cognition, physical function and depression among institutionalized elderly and the relationship between study variables and resident's characteristics and health related variables. Method: This study involved a one group pre and post test, comparison of variables over a 12 month period. To investigate this research question, data of 114 residents of a nursing home were analyzed. Results: There was statistically significant difference in MMSE-K (t=-2.63, p=.010), ADL (t=-2.85, p=.005), and depression (t=4.66, p=.000) before and after program participation. Conclusion: These results indicate that, for a year their regular involvement in a broad spectrum of multidimensional program activities can improve in cognitive, physical and emotional perspectives, but the level of IADL decreased significantly (t=-6.72, p=.000). Further testing is required with the control group, to compare with community resident elders in order to explore the effects on social skill of elderly.

• International Journal of Control, Automation, and Systems
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• v.6 no.4
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• pp.559-570
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• 2008

This paper proposes an improved particle swarm optimization named PSO with Controllable Random Exploration Velocity (PSO-CREV) behaving an additional exploration behavior. Different from other improvements on PSO, the updating principle of PSO-CREV is constructed in terms of stochastic approximation diagram. Hence a stochastic velocity independent on cognitive and social components of PSO can be added to the updating principle, so that particles have strong exploration ability than those of conventional PSO. The conditions and main behaviors of PSO-CREV are described. Two properties in terms of "divergence before convergence" and "controllable exploration behavior" are presented, which promote the performance of PSO-CREV. An experimental method based on a complex test function is proposed by which the proper parameters of PSO-CREV used in practice are figured out, which guarantees the high exploration ability, as well as the convergence rate is concerned. The benchmarks and applications on FCRNN training verify the improvements brought by PSO-CREV.