• Journal of Acupuncture Research
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• v.35 no.1
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• pp.28-36
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• 2018

Background: This study investigated the effects of acupuncture at Sobu (HT8) and Haenggan (LR2) on scopolamine-induced, cognitively impaired rats. Methods: Scopolamine-treated Sprague-Dawley rats were divided into 6 groups; normal, control, HT8, LR2, HT8 + LR2 and sham group. Cognitive impairment was induced by scopolamine, in control, and then in HT8, LR2, HT8 + LR2 and sham groups. Acupuncture treatment was performed at HT8, LR2, HT8 + LR2, and a random acupoint, respectively, every other day for 2 weeks. After each treatment, behavior change was observed and the rats were sacrificed. The change in brain-derived neurotrophic factor, glutathione peroxidase, and superoxide dismutase activity was evaluated by polymerase chain reaction. Results: Latency time to target in Morris Water-Maze test for the HT8 + LR2 group showed a significant decrease compared with control (p<0.05). Target crossing times and time zone ratios in Morris Water-Maze test for HT8 + LR2 group showed a significant increase compared with control (p<0.01). In the Y-Maze test the HT8 + LR2 group showed a significant increase compared with control (p<0.05). Brain-derived neurotrophic factor, glutathione peroxidase, and superoxide dismutase, in the HT8 + LR2 group, showed a significantly increased level compared with control (p<0.05). Neural activity of acetylcholine esterase in HT8 + LR2 group showed a significant decrease compared with the control group (p<0.01), choline acetyltransferase activity in the HT8 + LR2 group showed a significant increase compared with control (p<0.05). Conclusion: Acupuncture at HT8 + LR2 restored scopolamine-induced cognitive impairment, suggesting acupuncture could be an alternative to improve cognitive function.

• Sleep Medicine and Psychophysiology
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• v.2 no.2
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• pp.129-132
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• 1995

The goal of neuropsychological tests is to identify the neuropsychological dysfunction in psychiatric disorders such as organic mental disorders and schizophrenia, to develop the exe-cutive and monitor treatment plan and to make a cognitive rehabilitation program. Also, it will provide a more useful information that neurpsychological tests will be applied to neurotic out-patients in combination with conventional psychological test. However, many researches should be performed to further clarify the usefulness of neuropsychological test in neurosis.

• Journal of Home Health Care Nursing
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• v.18 no.1
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• pp.40-47
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• 2011

Purpose: This study investigated changes in neurocognitive function over a 2-month period of board game therapy in patients with schizophrenia. Method: Twenty-one schizophrenic patients treated with board game therapy and nineteen control schizophrenic patients were evaluated with neuropsychological and clinical tests, such as the Wisconsin Card Shorting Test (WCST). The same tests were re-administered after 2 months of board game therapy. Results: At the first series of neuropsychological tests, no difference was seen in performance, demographical aspects, or clinical severity among both patient groups. After 2 months, the group receiving board game therapy showed significant improvement of WCST performances compared to the controls. However, no difference was observed in clinical symptoms between the groups. Conclusion: The results of cognitive enhancement in patients playing board games indicates that board game play, easily used in an inpatient setting, is a promising tool for executive function improvement in chronic schizophrenic patients.

• Sleep Medicine and Psychophysiology
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• v.3 no.1
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• pp.25-30
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• 1996

Personality can be understood in terms of cognitive and informational modulation. Augmenting and reducing evoked potential (AREP) has been known as the one of method to test this cognitive characteristic. Especially, many studies have been performed on the relationship between AREP and the Zuckerman Sensation Seeking Scale (SSS) and the Eysenck Personality Questinnaire (EPQ), which are well known as the psychological tests of personality. Generally sensation seekers tend to be augmenters and low sensation seekers tend to the rend to be reducers of EP. However, there are some reports that EP reducers are more extraverted on the EPQ and more sensation-seeking on the SSS than EP augmenters. These results may imply regulatory function of brain can be different depending on brain areas. According to the result of author's studies it can be assumed that frontocentral area works consistently with personality trend whereas right posterior temporal area performs inhibitory regulation against personality trend.

• Journal of Korean Public Health Nursing
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• v.26 no.1
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• pp.158-173
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• 2012

Purpose: This study was conducted in order to investigate factors related to depression of elderly women in a Metropolitan city. Methods: Subjects included 118 elderly women older than 65 years of age. Structured questionnaires were used for data collection, and descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and hierarchical regression analysis were performed for data analysis. Results: A significant difference in depression was observed according to number of chronic diseases(F=4.963, p=.001). Significant factors influencing depression included number of chronic diseases (${\beta}$=.265, p<.01), cognitive function (${\beta}$=.290, p<.01), quality of sleep(${\beta}$=.212, p<.01), and nutritional state (${\beta}$=.161, p<.05). These factors explained 54.2% of the variance. Conclusion: Findings of this study suggest the need for development of nursing strategies to decrease the incidence of depression in elderly women.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.07a
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• pp.681-683
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• 2022

본 연구는 수면의 질, 우울, 불안, 인지기능을 확인하고 이들의 상관관계를 알아보는 서술적 상관관계연구 연구이다. K도 G시, D시에 위치한 10곳의 경로당에서 65세 이상 일반노인 130명을 대상으로 설문조사를 통해 자료를 수집하였다. 수집된 자료는 SPSS WIN 20.0 프로그램을 이용하여 대상자의 일반적 특성의 빈도, 백분율을 산출하였고 대상자의 수면의 질, 불안, 우울, 인지정도의 평균, 표준 편차을 산출하였으며, 대상자의 일반적 특성에 따른 수면의 질, 불안, 우울, 인지정도를 t-test와 one-way ANOVA로 분석하였으며, 대상자의 수면의 질, 불안, 우울, 인지정도의 상관관계 검정은 Pearson's correlation coefficient를 실시하였다. 연구결과는 수면의 질, 불안, 우울, 인지기능의 상관관계는 불안과 수면의 질(p=-.422), 우울과 수면의 질(p=-.552)간에 유의한 음의 상관관계가 있는 것으로 나타났고, 불안과 우울은 유의한 양의 상관관계가 있는 것으로 나타났다. 노인이 지각하는 수면의 질과 우울, 불안, 인지기능의 정도를 파악하고 노인수면증진을 위한 간호중재 개발에 기초자료가 될 수 있을 것이다.

• Sleep Medicine and Psychophysiology
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• v.6 no.2
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• pp.149-157
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• 1999

A Computerzed Neuropsychological Test(CNT) system using multimedia and object oriented technologies are developed for clinical application in psychiatry. The developed system is composed of 14 neuropsychologial tests which are capable of evaluation of various cognitive functions and functional localization of brain. The system employs Microsoft Window based graphic user interface for easy operation and it has a touch screen and a mouse as input devices from the patient. Speech perception test, color word test, verbal memory test, contingent continuos performance test, and trail making test were translated into korean language, so that usefulness of tests was maximized. Through the results of utilization of this system in the cases of patients with head trauma and psychiatric desorder, this system can be proved to be useful in the evaluation of cognitive function and functional localization of brain.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.2
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• pp.45-60
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• 2008

Objectives : Sopung-tang(Shufeng-tang) is a famous herbal prescription that treated ischemic brain injury. This study was designed to evaluate the effects of Sopung-tang(Shufeng-tang) on congnition and motor function recovery after ischemic brain injury in rats. Methods : Male rats were divided into 4 groups. Those rats caused ischemic brain injury by occlusion of MCA as Longa method. Control group I was per os normal saline for 7 days after ischemic brain injury. Control group II was per os normal saline for 14 days after ischemic brain injury. Experimental group I(Ex I) was taken with Sopung-tang(Shufeng-tang) for 7 days after ischemic brain injury. Experimental group II(Ex II) was taken with Sopung-tang(Shufeng-tang) for 14 days after ischemic brain injury. The author carried out neurological, cognitive motor behavior tests and histological assessment. Neurological motor behavior tests consist of limb placement test, beam-walking test and horizontal wire test. Morris water maze test was used for cognitive motor behavior test. In the histological assessment test, TTC(2,3,5-triphenylteterazolium chloride) staining, Hematoxylin & Eosin staining and immunohistochemical staining were experimented. Results : 1. In neurological motor behavior tests, motor function recovery was significantly increased in the experimental groups as compared with control groups(p<0.05). Especially Ex II was significantly increased as compared with Ex I(p<0.05). 2. In Morris water maze test, congnitive motor function recovery was significantly increased in the experimental groups as compared with control group(p<0.05). Especially Ex II was significantly increased as compared with Ex I(p<0.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially most immune reaction was experimented in the EX II. Conclusions : According to the above results, Sopung-tang(Shufeng-tang) can treat on the congnition and motor function recovery after ischemic brain injury in rats. And it is effective method in expression of BDNF in hippocampus.

• Membrane and Water Treatment
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• v.14 no.3
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• pp.141-146
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• 2023

Algal organic matters (AOMs) are challenging to remove using traditional water treatment methods. Additionally, they are recognized as disinfection by product (DBP) precursors during the chlorination process. These compounds have the potential to seriously harm aquatic creatures. Despite the fact that AOMs and DBPs formed from algae can harm aquatic species by impairing their cognitive function and causing behavioral problems, only a few studies on the effects of AOMs and associated DBPs have been conducted. To assess the impact of extracellular organic materials (EOMs) produced by three different hazardous algal species and the chlorinated EOMs on zebrafish, this study used fish acute embryo toxicity (FET) and cognitive function tests. With rising EOM concentrations, the embryo's survival rate and mental capacity both declined. Of the three algal species, the embryo exposed to Microcystis aeruginosa EOM exhibited the lowest survival rate. On the other hand, the embryo exposed to EOMs following chlorination demonstrated a drop in CT values in both the survival rate and cognitive ability. These findings imply that EOMs and EOMs treated with chlorine may have detrimental effects on aquatic life. Therefore, an effective EOM management is needed in aquatic environment.

• The Journal of the Korea Contents Association
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• v.12 no.5
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• pp.280-292
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• 2012

Cognitive-pragmatic language ability decreases during the normal aging process. Evaluating the ability might be useful in testing predicting cognitive level and diseases such as dementia. The aim of this study is to analyze various assessment protocols for normal aging, and evaluate the content validity of the currently developing cognitive-pragmatic language test domains and items. Content Validity Index(CVI) was calculated based on ratings judged by 17 experts including speech-language pathologists and clinical psychologists. As a result, it was found that CVIs of all 7 domains including attention, memory, organization, reasoning, problem solving, executive function, pragmatic language were above .75. It was concluded that the test items contained the appropriate content validity to assess cognitive-pragmatic language for normal aging.