• Journal of Korean Neurosurgical Society
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• 제54권5호
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• pp.390-398
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• 2013

Objective : We determined whether the relationship between the neuropsychological performance of patients with mild traumatic brain injury (TBI) and their psychopathological characteristics measured by disability evaluation are interrelated. In addition, we assessed which psychopathological variable was most influential on neuropsychological performance via statistical clustering of the same characteristics of mild TBI. Methods : A total of 219 disability evaluation participants with mild brain injury were selected. All participants were classified into three groups, based on their psychopathological characteristics, via a two-step cluster analysis using validity and clinical scales from the Minnesota Multiphasic Personality Inventory (MMPI) and Symptom Checklist-90-revised (SCL-90-R). The Korean Wechsler Adult Intelligence Scale (K-WAIS), Korean Memory Assessment Scale (K-MAS) and the Korean Boston Naming Test (K-BNT) were used to evaluate the neurocognitive functions of mild TBI patients. Results : Over a quarter (26.9%) experienced severe psychopathological symptoms and 43.4% experienced mild or moderate psychopathological symptoms, and all of the mild TBI patients showed a significant relationship between neurocognitive functions and subjective and/or objective psychopathic symptoms, but the degree of this relationship was moderate. Variances of neurocognitive function were explained by neurotic and psychotic symptoms, but the role of these factors were different to each other and participants did not show intelligence and other cognitive domain decrement except for global memory abilities compared to the non-psychopathology group. Conclusion : Certain patients with mild TBI showed psychopathological symptoms, but these were not directly related to cognitive decrement. Psychopathology and cognitive decrement are discrete aspects in patients with mild TBI. Furthermore, the neurotic symptoms of mild TBI patients made positive complements to decrements or impairments of neurocognitive functions, but the psychotic symptoms had a negative effect on neurocognitive functions.

• Journal of Ginseng Research
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• 제40권1호
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• pp.55-61
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• 2016

Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of $K^+$ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.135-145
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• 2006

Background: Parkinson's disease is movement disorder due to dopaminergic deficiency. It has been noted that cognitive dysfunction also presented on Parkinson's disease patients. But, it is not clear whether such a cognitive dysfunction was a dopaminergic dysfunction or cholinergic dysfunction. Using linear and non-linear analyses, we analysed the effect of cognitive and motor symptom on EEG change. Methods: EEGs were recorded from patients with Parkinson's disease and essential tremor, and normal controls during rest. We calculated the power spectrum, correlation dimension and Lyapunov exponent by using 'Complexity'program. The power spectrum, correlation dimension, and Lyapunov exponent were compared between Parkinson's disease patients and essential tremor patients. Results: Theta power was increased in Parkinson's disease patient group. Correlation dimension was increased in Parkinson's disease patients. Positive correlation was noted between MMSE and correlation dimension, and negative correlation was noted between MMSE and Lyapunov exponent. Lyapunov exponent was decreased in Parkinson's disease patient. Conclusions: We conclude that the state of Parkinson's disease patient is characterized by increased correlation dimension and decreased Lyapunov exponent.

• 고령자･치매작업치료학회지
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• 제12권2호
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• pp.107-115
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• 2018

목적 본 연구의 목적은 집단작업치료 프로그램이 경도인지장애(MCI)를 가진 노인의 우울증과 삶의 질에 미치는 영향을 알아보고자 한다. 연구방법 경도인지장애 노인은 간이정신상태검사(Mini Mental State Examination-Dementia Screening, MMSEDS)를 기준으로 선정하였다. 대상자들의 집단작업치료 프로그램은 다양한 인지 영역으로 구성되어 6주 동안 12회 수행되었다. 노인우울증 척도 (SGDS-K)와 삶의 질 (QOL)을 사용하여 중재 전 후의 대상자의 우울증과 삶의 질을 평가하였다. 연구결과 경도인지장애(MCI) 노인은 집단 작업치료 중재 프로그램 후 노인우울증 척도 (SGDS-K)와 삶의 질(QOL)에서 통계학적으로 유의하게 향상되었다(p<0.05). 특히 삶의 질 평가 (QOL)중 일부 항목은 통계적으로 유의한 차이가 있었지만, SGDS-K와 QOL의 결과는 상관관계를 보이지 않았다(p>0.05). 결론 경도인지장애(MCI)를 가진 노인의 경우, 집단작업치료 프로그램을 6주 동안 시행했을 때 삶의 질(QOL)과 우울 증상은 중재 전 후비교에서 통계적으로 유의한 변화를 보였다.

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.84-86
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• 2016

Globus pharyngeus or globus sensation is the painless sensation of a lump in the throat and may be described as a foreign body sensation, a tightening or choking feeling. It is often associated with persistent clearing of the throat, chronic cough, hoarseness, and catarrh. Its etiology remains unclear ; however, laryngopharyngeal reflux may play a role in a subset of patients. Psychogenic problems have often been thought to cause or trigger the globus sensation. Personality studies have found higher levels of alexithymia, neuroticism, and psychological distress (including anxiety, low mood, and somatic concerns) and lower levels of extraversion in patients presenting with globus. Globus patients with laryngopharyngeal reflux exhibited weaker psychological symptoms than non- laryngopharyngeal reflux globus patients, and globus patients who did not respond to proton pump inhibitor had significantly higher anxiety scores. In cases with negative clinical investigations and consistent globus symptom, other treatment strategies, including speech therapy, antidepressants, and cognitive-behavioral therapy, should be considered.

• 한국주거학회논문집
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• 제15권5호
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• pp.59-67
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• 2004

This study was intended to suggest the design guidelines of the space for the elderly with dementia. To achieve this, the behavioral characteristics of the elderly with dementia were grasped, and the design cases which were considered and reflected of the behavioral characteristics of the elderly with dementia were examined. Then, the effective space design guidelines which met the behavioral characteristcs of the elderly with dementia were suggested. The behaviors of the elderly with dementia were categorized into cognitive, emotional, and functional behavior. The positive influences of space design on dementia symptom were founded in the planned living environments, accessible and visible location of common space such as living room, soft and homelike interior finishes and lighting, and healing garden. Therefore, the space design for the elderly with dementia should be done on the basis of the dementia symptoms and healing effects.

• 수면정신생리
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• 제2권1호
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• pp.44-54
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• 1995

It is very difficult to evaluate sleep disorders by simple history taking, because which covers very comprehensive areas such as psychobiosocial fields. Although polysomnography is used for the method of final diagnosis, systemic history taking and sleep question-aires are still critically important especially in evaluation of insomnia. Proper informations through sleep questionnaires can provide very precise data for effective treatment as well as exact diagnosis. Sleep questionnaires consist of largely four kinds of questionnaires, which are screening questionnaire of sleep disorders, sleep diary and questionnaire of sleep hygine, diagnostic questionnaire for specific sleep disorder and questionnaire of special symptoms of sleep disorders including insomnia, daytime sleepiness, cognitive function, mental symptom and personality, parasomnia, physical illness and sexual function. However, for more conclusive diagnosis especially in excessive daytime sleepiness nocturnal polysomnography and multiple sleep latency test should be performed.

• 생물정신의학
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• 제13권1호
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• pp.38-42
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• 2006

The case of a 66- year-old woman with coexisting idiopathic basal ganglia calcification(IBGC) and dementia was presented. The calcification was detected in bilateral basal ganglia, dentate nucleus, and thalamus by brain imaging. Serum calcium and phosphorus levels were normal. The underlying diseases of calcification of basal ganglia such as parathyroid dysfunction and other infectious, toxic, or metabolic illness were excluded. The patient had memory impairment and frontal executive dysfunction without aphasia, agnosia, apraxia, and visuospatial impairment in neuropsychological test. It suggested that the cognitive impairment might be due to the dysfunction of frontal-subcortical circuit.

• The Korean Journal of Pain
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• 제25권2호
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• pp.75-80
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• 2012

Hypnosis is an altered state of consciousness that comprises of heightened absorption in focal attention, dissociation of peripheral awareness, and enhanced responsiveness to social cues. Hypnosis has a long tradition of effectiveness in controlling somatic symptoms, such as pain. Pain, the most common symptom in clinical practice, is a multi-dimensional experience, which includes sensory-discriminative, affective-emotional, cognitive and behavioral components. There is a growing recognition for hypnosis and related techniques in pain management. Psychological approaches to pain control, such as hypnosis, can be highly effective analgesics, but are underused in Korea. In this article, we would like to review the basic concepts of hypnosis, the mechanism, and the outcome data of the analgesic effects of hypnosis, and also, its limitations.

• International journal of advanced smart convergence
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• 제8권2호
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• pp.126-131
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• 2019

This study investigated the relationship between depressive symptoms and interests of workers in their 30s to 40s. This study recruited 49 workers who fit the selection criteria. Descriptive, frequency, and regression analyses were performed. To describe participant characteristics and the classification of depression and interest, descriptive and frequency analyses were used. The effect of interest patterns on depressive symptoms was analyzed using a multiple regression analysis, specifying the significance level at 0.05. The results of this study showed that half of the respondents, who were in their 30s and 40s, experienced depression. In addition, this study indicated that interest of workers in their 30s to 40s in daily, cognitive, physical, and social activities in the present was lower than that in the past. This interest level affected depression in past and present interest (p<0.05). This study investigated the relationship between interest and depression of workers in their 30s to 40s and suggest that interest in various areas may help prevent depression.