• Nutrition Research and Practice
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• v.16 no.2
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• pp.173-193
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• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.558-576
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• 2020

The purpose of the research was to verify the mediating effect of social support and cognitive emotional regulation strategy when office worker's emotional expressive ambivalence influences on interpersonal stress. A survey was conducted with 422 office workers from August to September of 2018. SPSS, AMOS and Mplus were used for descriptive statistics, correlation analysis, verification of structural equation modeling and mediated effect. There was a partial mediating effect in emotional expressive ambivalence of self-defense model, a complete mediating effect in relational emotional expressive ambivalence model. In both self-defense and relational emotional expressive ambivalence model, double mediation effect of passing through support and cognitive emotional regulation strategy in the relationship between emotional expressive ambivalence and interpersonal stress was significant. This study sought ways to reduce interpersonal stress by increasing the level of perception of social support and using adaptive cognitive emotional control strategies for office workers.

• Nutrition Research and Practice
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• v.18 no.4
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• pp.464-478
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• 2024

BACKGROUND/OBJECTIVES: Chronic alcohol consumption causes oxidative stress in the body, which may accumulate excessively and cause a decline in memory; problem-solving, learning, and exercise abilities; and permanent damage to brain structure and function. Consequently, chronic alcohol consumption can cause alcohol-related diseases. MATERIALS/METHODS: In this study, the protective effects of Phyllostachys edulis (Carrière) J. Houz (PE) against alcohol-induced neuroinflammation and cognitive impairment were evaluated using a mouse model. Alcohol (16%, 5 g/kg/day for 6 weeks) and PE (100, 250, and 500 mg/kg/day for 21 days) were administered intragastrically to mice. RESULTS: PE showed a protective effect against memory deficits and cognitive dysfunction caused by alcohol consumption, confirmed through behavioral tests such as the T-maze, object recognition, and Morris water maze tests. Additionally, PE attenuated oxidative stress by reducing lipid oxidation, nitric oxide, and reactive oxygen species levels in the mice's brains, livers, and kidneys. Improvement of neurotrophic factors and downregulation of apoptosis-related proteins were confirmed in the brains of mice fed low and medium concentrations of PE. Additionally, expression of antioxidant enzyme-related proteins GPx-1 and SOD-1 was enhanced in the liver of PE-treated mice, related to their inhibitory effect on oxidative stress. CONCLUSION: This suggests that PE has both neuroregenerative and antioxidant effects. Collectively, these behavioral and histological results confirmed that PE could improve alcohol-induced cognitive deficits through brain neurotrophic and apoptosis protection and modulation of oxidative stress.

• Journal of Korean Academy of Nursing
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• v.42 no.1
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• pp.56-65
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• 2012

Purpose: This study was done to evaluate the effects of cognitive behavioral therapy in a victimized community district and to determine if the program is an effective nursing intervention to reduce posttraumatic stress disorder symptom, depression and state anxiety. Methods: A nonequivalent control group design was used for the study. The participants, 32 elementary school students, were selected from grades 4, 5, 6 and each student was assigned to either the experimental (16) or control (16) group. Cognitive behavioral therapy was used as the experimental treatment from April 9 to May 28, 2009. The experimental group received cognitive behavior therapy intervention 8 times. Data analysis was done using ANCOVA with SPSS 17.0. Results: After the intervention, the experimental group showed significantly lower levels of posttraumatic stress disorder symptoms than the control group. Conclusion: The findings from this study suggest that cognitive behavioral therapy is an effective nursing intervention to decrease the level of mental health problems of children in victimized district. Further research is required in order to identify the continuous effects of cognitive behavioral therapy.

• Korean Journal of Human Ecology
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• v.20 no.6
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• pp.1093-1107
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• 2011

The purpose of this study was to examine the effect of stress types and coping styles on the relationship quality with mothers-in-law perceived by sons-in-law. The data was collected from 300 sons-in-law aged 20~49 by using a survey questionnaire. The main results of this study were as follows: first, factor analysis yielded 4 types of coping(cognitive understanding coping, avoidant coping, direct behavior coping, and indirect behavior coping) and 7 types of stress(despising poor ability and condition, interference in daily life, son-in-law discrimination, wife discrimination, uncomfortable interaction, differences in lifestyle, and excessive demand). Second, the total stress perceived by sons-in-law in the relationship with their mothers-in-law was affected by avoidant coping and cognitive understanding coping. Finally, the relationship quality between mothers-in-law and sons-in-law was influenced by avoidant coping, uncomfortable interaction stress, direct behavior coping, differences in lifestyle stress, son-in-law discrimination stress, interference in daily life stress, frequency of meeting, cognitive understanding coping, indirect behavior coping, and age. Consequently, it was confirmed that sons-in-law's coping styles with stress from their mothers-in-law was more influential than the amount of stress perceived by sons-in-law on the relationship quality with their mothers-in-law. Especially, 'avoidant coping' among 4 styles of coping and 'uncomfortable interaction stress' among 7 types of stress influenced the relationship quality between mothers-in-law and sons-in-law the most.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.3
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• pp.11-23
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• 2023

Purpose : The stress of job-seeking college students is gradually worsening due to the continuing recession in the job market. Therefore, this study aims to verify whether intervention with an 'aromatherapy education program,' which combines theory and practice, has greater effect on stress, self-efficacy, and autonomic nervous system function than simple inhalation of essential oils in female college students preparing for employment. Methods : A single-blind, randomized controlled trial was conducted once a week for a total of 4 weeks with 29 female college students preparing for employment. Interventions included essential oil inhalation combined with an aromatherapy education program (experimental group(EG), n=14) and essential oil inhalation alone (control group(CG), n=15); measurements were taken before, immediately after, and 2 weeks after completion of the intervention. Evaluations were conducted using the job-seeking stress scale, stress VAS, self-efficacy scale, and a pulse-wave measuring instrument. Results : There were significant differences between the CG and EG groups with repeated measurements of job-seeking stress (p=.003), cognitive stress (p<.001), and self-efficacy (p<.001). There was a significant interaction between group and time. There were also significant differences between the CG and EG in terms of autonomic nervous system changes stress index(p=.047), total power(p=.029), high frequency(p=.036), and low frequency/high frequency ratio(p=.049). However, there was no significant difference in low frequency between the groups. Conclusion : The aromatherapy education program was more effective in improving job-seeking stress, cognitive stress, self-efficacy, and autonomic nervous system function than simple essential oil inhalation. For the aromatherapy education program to be useful as a complementary intervention for stress management in job seekers, it will be necessary to gather additional evidence of its efficacy by conducting follow-up studies with diverse participants and expanding the numbers, and durations, of the interventions.

• Women's Health Nursing
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• v.1 no.2
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• pp.244-259
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• 1995

This study was designed and carried out to describe the stress of the infertile women and identify its predictors. The subjects of this study, 131 infertile women, were in primary or secondary infertility. the were conveniently sampled out from the infertility clinics of K University Medical Center and C Hospital in Seoul. The data were collected by using the Infertility Stress Scale which consisted of 35 items with four dimensions(cognitive, affective, marital and social stress) from August to November 1994. The data were analyzed by using the pc-SAS program. The information was obtained of Mean, Standard Deviation, Frequencies, Percentile, t-test, ANOVA, Duncan's multiple comparison test and Multiple Regression. The results are as follows; 1. The Mean of the stress of the infertile women is 2.78. The Means of the stress in 4 dimensions are 3.81 in the cognitive dimension, 3.05 in the affective dimension, 2.06 in the marital adjustment dimension and 2.41 in the social adjustment dimension. 2. The predictors of the stress of the infertile women are their educational levels and subjective economic status. They explain 14.08% of total variance.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.225-228
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• 2018

Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.

• The Journal of the Korea Contents Association
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• v.19 no.2
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• pp.210-222
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• 2019

The purpose of this study was to identify the effectiveness of Mindfulness-Based Cognitive Therapy(MBCT) program on stress, self-esteem and depression of nursing college students. Thirty-eight students were enrolled by convenience sampling in this study and allocated to control (n=20) and experimental group (n=18). In the intervention group, Mindfulness-Based Cognitive Therapy program was applied over 8 sessions, while the control group received material of MBCT program. The data were analyzed using the Independent t- test, Chi-square test and Fisher's exact test. There was significant difference in stress and depression between the groups, but the self-esteem did not show any significant effect. The results showed that MBCT program is effective to regulate stress and depression of nursing college students and a further study is needed to explore the effect of MBCT program on stress and depression of nursing college students.

• Korean Medical Education Review
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• v.26 no.2
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• pp.140-154
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• 2024

A physician's empathy plays a crucial role in patient-centered care, and in modern medicine, patients, their caregivers, and society demand a high level of empathy from healthcare providers. The conceptualization of clinical empathy, which has emphasized cognitive empathy since the mid-20th century, has been widely accepted in medical schools and the healthcare industry without much critical ref lection. This study provides an overview of the ongoing debates on empathy versus sympathy and cognitive empathy versus affective empathy to clarify the concept of empathy. Based on recent research findings, clinical empathy is proposed to encompass three components: cognitive empathy, affective empathy, and empathic motivation. It is suggested that fully demonstrating these components requires empathic communication skills. Additionally, the cognitive characteristics of medical students and the features of the academic environment demonstrate the need for education to strengthen their empathy skills. Considering this, proposed intervention methods that medical schools can consider include utilizing tutoring programs and debriefing processes for team activities, which can facilitate problem-solving as a coping strategy for stress. Learning communities can create an environment where students can receive social support and recover from stress. Medical schools can contribute to the development of students' professional identities as practicing clinicians who embody empathy and respect by cultivating professors as positive role models. Additionally, utilizing scales to assess the empathic nature of doctor-patient communication or incorporating patients and caregivers as evaluators can actively improve empathic communication skills.