• Physical Therapy Rehabilitation Science
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• 제11권2호
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• pp.154-164
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• 2022

Objective: The purpose of this study is to select a cognitive training game that can evaluate five cognitive domains and to study their validity with existing cognitive evaluation tools. Design: Methods: Delphi survey was conducted through the 2nd questionnaire for 30 experts to select games suitable for training 5 cognitive domains. Five cognitive training games and Mini Mental State Examination - Korea(MMSE-K), and cognitive impairment screening test(CIST) were conducted for 82 elderly in the community. Pearson correlation analysis was performed to find out the correlation of the three tests. The ROC curve was used to calculate the selection criteria for the game results for the screening evaluation of the presence or absence of mild cognitive impairment. Results: The coefficient of variation to evaluate the stability of the Delphi survey was less than 0.50 in most game items. The 'correct answers' and 'level' of the five final selected game items showed a statistically significant positive correlation with the CIST and MMSE-K scores. CIST score and 'time' of all game items except 'number making_time' showed a statistically significant negative correlation. Conclusions: The validity of the cognitive training program using smart devices was evaluated, and the criteria for classifying the cognitive domain and distinguishing the presence or absence of cognitive impairment were confirmed.

• 한국노년학
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• 제37권4호
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• pp.813-833
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• 2017

본 연구의 목적은 노인의 인지기능 향상 프로그램에 대한 선행연구의 결과를 인지기능장애집단과 일반집단으로 구분하고 메타분석을 이용하여 집단 간 효과크기를 비교해 보고자 하였다. 최근 5년간 국내에서 보고된 인지기능 향상 프로그램 선행연구 중에서 86편을 선정하고 메타분석을 사용하여 효과크기를 요약하였다. 연구결과, 전체평균 효과크기는 두 집단 모두 큰 효과크기를 보였다. 중재유형별 효과크기는 인지기능장애집단은 운동 중재가 높았고, 일반집단은 운동과 인지기반 중재가 유사하게 나타났다. 성별 효과크기는 인지기능장애집단은 여성으로만 구성한 경우가 높았고, 일반집단은 혼성이 높았다. 집단크기에 대한 효과크기는 인지기능장애집단은 20명, 일반집단은 21~40명이 높게 나타났다. 총회기수는 두 집단 모두 32회 이상이 높았고, 주회기수는 인지기능장애집단은 3회, 일반집단은 4~6회, 활동시간은 인지기능장애집단 55~60분, 일반집단 70~180분으로 나타나 일반집단은 회기수와 활동시간이 많을수록 효과크기가 높게 나타났다. 본 연구는 인지기능장애집단과 일반집단 간 인지기능 향상 프로그램 유형과 활동요소들에 대한 효과크기를 비교 분석함으로써 추후 프로그램 개발에 필요한 기초자료를 제공하였다는데 의의가 있을 것이다.

• 한국산학기술학회논문지
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• 제20권6호
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• pp.531-540
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• 2019

본 연구는 요양시설노인의 사회적 지지(MOS-SSS)와 인지기능장애(MMSE-K)정도와의 관련성을 규명할 목적으로 D 광역시의 일부 장기요양시설에 입소하고 있는 65세 이상 노인 372명을 대상으로 2018년 10월에 조사원이 조사대상 요양시설을 직접 방문하여 면접 조사를 실시하였다. 연구결과, 조사대상 노인들의 인지기능장애정도는 사회적지지가 낮은 군일수록 유의하게 높았다(p<0.001). 인지기능장애 점수와 사회적지지 점수 간의 상관관계에서는 유의한 양의 상관관계(r=0.250, p<0.001)를 보여, 사회적 지지가 낮을수록 인지기능장애 정도가 높아지는 것으로 나타났다. 로지스틱 회귀분석 결과, 확정적 인지기능장애가 나타날 위험비는 사회적지지 총점이 매우 높은 군(Q4)보다 낮은 군(Q1)에서 2.8배(ORs=2.75, 95% CI=1.40~5.79) 유의하게 증가하였으며, 위계적 다중회귀분석 결과에서도 사회적 지지가 낮을수록 인지기능장애가 높아지는 것으로 나타났다. 이 같은 연구결과는 요양시설 노인의 인지기능장애는 사회적 지지가 낮을수록 높아지는 것을 시사하고 있어 요양시설 노인의 인지기능을 증진시키기 위한 방안의 하나로 사회적 지지를 향상시키기 위한 구체적인 방안을 모색할 필요가 있다고 생각된다.

• 대한간호학회지
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• 제45권1호
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• pp.118-128
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• 2015

Purpose: Evidence suggests that some patients with breast cancer experience cognitive difficulties following chemotherapy. This longitudinal study was done to examine the prevalence of cognitive impairment and trajectory of cognitive function over time in women with breast cancer, who received adjuvant chemotherapy. Methods: Participants were 137 patients with breast cancer. They completed neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function before adjuvant therapy (pretest), toward the end of adjuvant therapy (posttest), and 6 months after the completion of adjuvant therapy (follow-up test). Of the patients, 91 were treated with adjuvant chemotherapy and 46 patients who did not receive chemotherapy made up the comparison group. A reliable-change index and repeated-measure ANOVA were used for statistical analyses. Results: At the posttest point, over 30% of patients showed complex cognitive impairment and reported greater difficulty in subjective cognitive function. At the follow-up test point, 22.0% of patients exhibited complex cognitive impairment and 30.8% of patients complained of subjective cognitive impairment. Repeated-measure ANOVA showed significant decreases after receiving chemotherapy followed by small improvements 6 months after the completion of chemotherapy in cognitive domains of change for attention and concentration, memory, executive function, and subjective cognitive function. Conclusion: These results suggest that chemotherapy in patients with breast cancer may be associated with objective and subjective cognitive impairments. Further studies are needed to explore the potential risk factors and predictor of chemotherapy-related cognitive changes. Also nursing interventions for prevention and intervention of cognitive impairments should be developed and tested.

• 대한간호학회지
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• 제42권5호
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• pp.644-658
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• 2012

Purpose: The purpose of this study was to evaluate the cognitive effects of chemotherapy in patients with breast cancer. Methods: Using several databases, prospective studies were collected up to August 2011. Of 2,106 publications identified, 12 met the inclusion criteria, and 8 studies were used to estimate the effect size of chemotherapy on cognitive impairment. Results: Twelve studies were done since 2005 and most of the research was performed in Europe or North America. Eight studies were used to generate effect size across the cognitive domains of attention/concentration, verbal and visual memory, executive function, visuospatial skill, language, and subjective cognitive function. Each of the cognitive domains showed small effect sizes (-0.02 ~ -0.26), indicating diminished cognitive function for the chemotherapy group compared with non-chemotherapy groups. Conclusion: Finding suggests that breast cancer patients who undergo chemotherapy may experience mild cognitive decline. Further study is needed to generate knowledge and guideline for interventions to address chemotherapy related cognitive impairment in these patients.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.178-185
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• 2018

노인 운전자가 스스로 운전능력을 점검하는 자가-보고식 평가는 운전 중 사고 또는 사고위험성을 사전에 대비할 목적으로 사용된다. 지역사회에 거주하는 정상노인의 다수가 경도인지장애로 인해 인지기능 저하를 경험할 수 있으며, 이들의 저하된 인지기능은 노인 운전자용 자가-보고식 평가 수행에 영향을 미치는 변수가 될 수 있다. 따라서 본 연구를 통해 지역사회에 거주하는 경도인지장애 노인 운전자가 자가-보고식 평가를 수행하는 데 있어 영향을 미치는 인지기능을 확인하였다. 지역사회에 거주하는 노인 운전자 103명의 Korean Version of the Montreal Cognitive Assessment 평가결과를 바탕으로 경도인지장애와 정상 노인을 분류하였다. 그리고 두 집단의 자가-보고식 평가인 Korean-Drivers 65 plus 점수를 비교하였고, 이 평가 결과에 영향을 미치는 인지기능을 분석하였다. 그 결과 경도인지장애 그룹이 정상 그룹과 비교하여 유의하게 낮은 평가수행 결과를 보였으며, 경도인지장애 노인 운전자의 자가-보고식 평가 결과는 시공간 실행력 및 지연 회상력과 유의한 상관성이 확인되었다. 회귀분석을 통해 자가-보고식 평가 수행에 영향을 미치는 인지기능을 확인한 결과 시공간 실행력이 가장 영향력인 높은 변수로 확인되었다. 지연 회상력 또한 부분적 영향이 확인되었지만 경도인지장애 노인 운전자의 자가-보고식 평가 결과를 변질 시키는 수준은 아닌 것으로 확인되었다.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.31-40
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• 2023

Objectives: This study investigated the effect of cognitive impairment on the association between social network properties and mortality among older Korean adults. Methods: This study used data from the Korean Social Life, Health, and Aging Project. It obtained 814 older adults' complete network maps across an entire village in 2011-2012. Participants' deaths until December 31, 2020 were confirmed by cause-of-death statistics. A Cox proportional hazards model was used to assess the risks of poor social network properties (low degree centrality, perceived loneliness, social non-participation, group-level segregation, and lack of support) on mortality according to cognitive impairment. Results: In total, 675 participants (5510.4 person-years) were analyzed, excluding those with missing data and those whose deaths could not be verified. Along with cognitive impairment, all social network properties except loneliness were independently associated with mortality. When stratified by cognitive function, some variables indicating poor social relations had higher risks among older adults with cognitive impairment, with adjusted hazard ratios (HRs) of 2.12 (95% confidence interval [CI], 1.34 to 3.35) for social nonparticipation, 1.58 (95% CI, 0.94 to 2.65) for group-level segregation, and 3.44 (95% CI, 1.55 to 7.60) for lack of support. On the contrary, these effects were not observed among those with normal cognition, with adjusted HRs of 0.73 (95% CI, 0.31 to 1.71), 0.96 (95% CI, 0.42 to 2.21), and 0.95 (95% CI, 0.23 to 3.96), respectively. Conclusions: The effect of social network properties was more critical among the elderly with cognitive impairment. Older adults with poor cognitive function are particularly encouraged to participate in social activities to reduce the risk of mortality.

• 대한물리의학회지
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• 제15권2호
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• pp.65-73
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• 2020

PURPOSE: This study examined the effects of coordinative locomotor training on the physical factors for falls in the elderly with mild cognitive impairment. METHODS: This study examined thirty subjects diagnosed with mild cognitive impairment by the radiologic findings, history, and physical examination. The subjects were assigned to a control group (n = 15) or experimental group (n = 15, coordinative locomotor training). The experimental group underwent coordinative locomotor training for four weeks, with training sessions two times per week. The control group was given a fall-prevention education for 60 minutes without coordinative locomotor training. To evaluate the physical factors for falls, the lower extremity strength and the Korean version of the Fullerton advanced balance scale and biorescue were measured for balance. These tests were conducted before and after training. RESULTS: Significant differences were observed between the two groups after the four weeks of coordinative locomotor training for the elderly with mild cognitive impairment the experimental group had a greater degree of improvement in the physical factors for falls. CONCLUSION: These findings suggest that coordinative locomotor training may have a functional effect on fall-prevention and the mobility of the elderly with mild cognitive impairment. In addition, it is expected to provide systematic and effective data that can be used as a fall prevention program for the elderly with mild cognitive impairment in each institution.

• 한국융합학회논문지
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• 제11권5호
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• pp.153-158
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• 2020

본 연구는 정상 노인과 초기 단계의 노년기 인지 장애(경도인지장애(MCI), 경도 치매)의 선별검사인 대면 이름대기와 범주 이름대기의 예측력을 파악하였다. 노년기 인지장애로 진단을 받은 340명(정상 노인 203명, MCI 106명, 경도 치매 31명)을 분석하였다. 대면 이름대기는 단축형 한국판 보스턴 이름대기 검사로 측정하였고, 범주 이름대기는 통제연상단어검사의 의미검사와 음소검사를 이용하여 측정하였다. 이름대기 검사의 예측 성능을 비교하고자 다항 로지스틱 회귀분석을 수행한 결과, 대면 이름대기와 범주 이름대기 검사 모두 일반노인에서 MCI와 경도 치매를 감별하는데 유의미한 효과가 확인되었다(p<0.05). 반면, MCI에서 경도 치매를 감별할 때, 범주 이름대기의 음소검사는 교차비가 유의미하지 않았다. 본 연구의 결과는 MCI에서 경도 치매를 감별할 때, 범주 이름대기의 총점만을 측정기준으로 분석하는 것은 유의하지 않을 가능성이 높음을 시사한다.

• 동의신경정신과학회지
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• 제29권4호
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• pp.239-253
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• 2018

Objectives: This is one of the manuals of East-West integrative medicine, which was created by the Committee on integrative medicine of Chung-Yeon Korean Medicine Hospital. To support clinical decision making and communication in the East-West cooperative treatment of mild cognitive impairment. Methods: Drafting was based on literature review from the MEDLINE, EMBASE, OASIS, and CNKI databases using search terms such as 'mild cognitive impairment', 'mild neurocognitive disorder', 'acupuncture', 'herbal medicine' and 'traditional Chinese medicine'. An amendment reflecting the goal of consultation and detailed treatment contents was made by reviewing the draft and holding discussion with the rehabilitation specialist of western medicine. The committee then agreed to adopt the manual through the process of review and feedback in addition to face-to-face discussions. Results: This manual contains the diagnosis of mild cognitive impairment, the goal of consultation, and the cooperative treatment contents of the East-West medicine for mild cognitive impairment. Conclusions: This manual provides significant information about the decision making process and contents of treatment in one medical institution for East-West cooperative treatment of mild cognitive impairment.