• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2016년도 제53차 동계학술대회논문집 24권1호
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• pp.247-248
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• 2016

본 논문에서는 치매 등 인지기능 저하에 따른 질병을 예방하기 위한 기능성 퍼즐 게임을 설계하고 구현하였다. 치매 등 인지기능 저하에 따른 질병은 고령층에서 주로 나타난다. 이에 따라 게임의 UI와 규칙은 가급적 단순해야 하며, 동시에 기억력과 판단력, 반응속도는 향상시킬 수 있도록 해야 한다. 본 논문에서는 고령층에서도 쉽게 조작할 수 있도록 UI를 단순화시켰으며, 순간적인 인지능력과 단기기억력 및 판단력을 향상시킬 수 있는 색맞추기 퍼즐게임을 설계하고 구현하였다.

• Journal of Nutrition and Health
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• 제16권4호
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• pp.253-262
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• 1983

A survey was undertaken to investigate relationship between nutritional status and physical growth and behavior of school children. Dietary intakes, environmental factors, physical growth, personality, and cognitive development were measured in 323 children of 4 th and 6th grader in the urban and rural arcas. The results are summarized as follows : 1) The average intakes of the food groups and nutrients except ascorbic acid were lower in rural children. Comparing the intakes of the rural children with RDA of the Korean children, 64.0% of them in protein, 99.3% in calcium, 84.6% in iron, and 73.5% in riboflavin consumed less than 75% of RDA. Environmental factors were significantly related to the nutrient intakes 2) Height, weight, and head circumference were significantly related to the nutrient intakes. Retarded growth due to malnutrition was supposed in the $rural^{1)}$ area. 3) Some domains of personality were significantly related to nutrient intakes. 4) Environmental factors, physical growth, and nutrient intakes made independent contribution to variation in cognitive performance and their relative importance depended on the particular cognitive domain when stepwise multiple regression analyses were undertaken. Environmental stimulation was largely associated with verbal usage, and economic status and nutrient intakes with numerical reasoning. Above findings support that nutritional deprivation retards brain growth and performance on various cognitive dimensions of children. Therefore, amelioration of the several adverse social, economical, environmental influences as well as the improvement of dietary intake is required to bring about a substantial enhancement of the physical growth and the mental development of children.

• 대한물리의학회지
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• 제7권1호
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• pp.11-20
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• 2012

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

• 한국통신학회논문지
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• 제35권9A호
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• pp.859-867
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• 2010

본 논문에서는 새로운 스펙트럼 검출 시스템을 제안한다. 먼저 융합 센터(Fusion Center : FC)에서 1차 사용자의 신호를 수신하고, 이를 이용하여 1차 사용자의 유무를 판단한다. 그러나 이 과정에서 최종 1차 사용자의 유무를 판단하지 못한다면, 각 2차 사용자들의 Local observation 결과를 필요로 한다. 이때 융합 센터(Fusion Center : FC)는 각 2차 사용자의 신호 중 에너지가 가장 큰 2차 사용자의 Local observation의 결과만을 수신하며, 수신한 FC는 최종 결정값을 각 2차 사용자에게 송신한다. 본 논문을 통해 제안하는 기법은 단 하나의 2차 사용자가 스펙트럼 검출에 참여하기 때문에 불필요한 스펙트럼 검출로 인한 비트수를 줄일 수 있다. 그러므로 1차 사용자의 유무를 판단하는 과정에서의 2차 사용자의 전력과 불필요한 Local observation전송으로 인한 대역폭의 소모를 줄일 수 있다. Monte-Carlo 시뮬레이션을 통해 본 논문에서 제안하는 기법의 검출 확률, 오 경보 확률 등을 구함으로서 기존의 기법보다 우수한 성능을 보이는 것을 증명한다.

• 한국컴퓨터정보학회논문지
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• 제23권11호
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• pp.229-238
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• 2018

The purpose of this study is to investigate the mediating effect of learners' learning flow in the effect of presence on academic achievement in web-based e-learning. For this purpose, this study analyzed the influencing relationship between the each factor based on the structural model with the learning flow as a mediator variable. Based on existing theoretical studies, learning satisfaction and academic achievement, which represent learning outcomes, are set as dependent variables, and teaching presence, cognitive presence, and social presence are set as independent variables. Data collected from a total of 256 e-learning learners were used in the analysis of this study. According to the results of the analysis, teaching presence, cognitive presence, and social presence were found to have a significant effect on academic achievement when a learning flow is a mediator variable. Concretely, teaching presence, cognitive presence, and social presence have a positive effect on the learning flow, while learning flow has a positive effect on learning satisfaction. On the other hand, learning flow has a negative effect on academic achievement. As a result of verifying the mediating effect of learning flow on the relationship between presence, learning satisfaction, and academic achievement, there was meditating effect in the aggregate. This study implies that in order to increase the level of learning satisfaction and academic achievement, it is necessary to make the teaching-learning design in the provision of contents and materials for e-learning so that the learner can feel the presence. The results of this study can be used as a basic data for seeking support and promotion strategies for enhancement of future learning flow and presence.

• 과학교육연구지
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• 제47권2호
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• pp.192-210
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• 2023

이 연구는 인지적 도제 모델의 교수 단계와 교수방법을 적용하여 Rapid-cycling Brassica rapa (RcBr)를 활용한 식물 분자생물학 실험 프로그램을 개발하여 그의 적용 효과를 알아보고자 하였다. 개발된 프로그램은 예비교사의 분자생물학 실험에 관한 전문성 제고를 위하여 'purple RcBr과 non-purple RcBr 개체의 DFR 유전자 확인'과 'DNA 프로파일링 방법을 이용한 RcBr 개체의 유전적 다형성 부위 확인'의 두 가지 실험 주제를 선정하여 총 8차시로 구성하였다. 개발된 프로그램은 충북 H 대학교 생물교육 전공 2학년 18명을 대상으로 적용하여 분자생물학 지식과 기술 활용에 관한 인지기능과 영역 일반적 메타인지 기능의 향상 효과를 알아보았으며, 개발된 프로그램에서 제공된 수업흐름도 작성 과제의 분석을 통하여 프로그램의 효과를 검증하고자 하였다. 개발된 인지적 도제 모델 기반의 RcBr 식물 프로그램은 예비교사의 분자생물학 지식 및 기술 활용에 관한 인지기능 향상에 효과적이었다. 예비교사의 선행 실험 경험에 따라 고차적 인지기능 향상에 차이를 보였는데, 선행 실험 경험이 없는 예비교사의 고차적 인지기능 향상에 특히 효과적이었다. 개발된 프로그램은 또한 영역 일반적 메타인지 기능 중 메타인지적 지식의 과제와 메타인지적 조절의 계획, 점검, 평가 부분의 하위요소에 있어 유의미한 향상 효과를 보여주었다. 이는 프로그램의 차시별 자기평가 활동이 예비교사의 메타인지적 조절 기능 향상에 도움을 주었기 때문으로 생각한다. 이 연구에서 개발된 인지적 도제 모델의 식물 프로그램은 예비교사의 분자생물학 실험에 관련된 핵심역량을 키우는데 이바지한 것으로 나타났으므로 후속 연구에서 이 교수·학습 자료를 재구성하여 과학교사 연수나 고등학생들에게 적용하여도 메타인지 기능의 향상 효과를 기대할 수 있을 것이다.

• 한국농공학회논문집
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• 제63권2호
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• pp.19-31
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• 2021

The Ministry of Maritime Affairs and Fisheries has been promoting the 'Fishing Village Specialization Capacity Enhancement Project' to pursue sustainable development of villages such as income generation by using local tangible and intangible resources led by local residents at the village level since 2013. For the fishing village-Specialization capacity enhancement project, six training sessions (mainly in the village unit) are selected by the public offering method, and the project (income generating business, village development project, etc.) is developed for the selected village residents. It has a process of establishing a village project plan (a preliminary plan for village development or a sixth preliminary industrialization plan) based on the training of experts 5 times, practice or excursion 1 time). In this study, four villages in Gangwon-do fishing villages (two coastal villages and two inland water villages) were surveyed on the perception and satisfaction of fishing village development projects before and after training. The survey analysis was conducted by dividing the analysis of resident capacity and satisfaction into personal, interpersonal, and social dimensions. The survey was conducted by distributing a survey before and after training, and a 1:1 survey was conducted according to the residents' cognitive status. Based on the survey, factor analysis, reliability analysis, and analysis using the corresponding sample t-test showed an increase of 0.02 for Yangyang Mulchi fishing village, 0.11 for Samcheok Jangho fishing village, and 0.36 for Hongcheon River fishing industry, but Yanggu Jinmok fishing industry was -0.29, unlike other regions. As a result of this analysis, it has been empirically proven that provision of training projects through resident participation is a very important factor for the success of the fishing village project. Therefore, rather than fostering local leaders, training and community activities to strengthen personal capacities of residents participating in the project, it is necessary to operate the software business with a focus.

• 한국보육학회지
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• 제19권2호
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• pp.85-100
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• 2019

본 연구의 목적은 유아교육과 신입생들을 위한 감사증진 프로그램이 예비유아교사의 감사성향, 공감능력, 그리고 학과만족에 미치는 영향을 알아보고자 하는 것이다. 연구대상은 경기도에 소재한 3년제 전문대학교 유아교육과에 재학 중인 신입생 55명이며, 이들 중 28명은 실험집단에, 27명은 비교집단에 배치되었다. 실험집단에 속한 유아교육과 신입생들은 2018년 14학기 동안 인지, 정서, 행동적 영역이 통합되어 구성된 감사증진 프로그램을 경험하였다. 본 프로그램의 효과를 검증하기 위해서 프로그램 실시 사전과 사후에 유아교육과 신입생들의 감사성향, 공감능력, 학과만족 검사를 실시하여 SPSS WIN 20.0을 활용한 공변량분석을 실시하였다. 분석결과, 유아교육과 신입생을 위한 감사증진 프로그램은 예비유아교사의 감사성향, 공감능력, 학과만족에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구의 결과는 유아교육과 신입생의 학과적응과 학습 지속력 향상을 위한 프로그램의 구체적 방법론을 제시하였다는 데에 의의가 있다.

• Molecules and Cells
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• 제39권10호
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• pp.762-767
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• 2016

Fasciclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule (NCAM), plays a critical role in synaptic stabilization and plasticity. Although this molecule undergoes constitutive cycling at the synaptic membrane, how its membrane trafficking is regulated to ensure proper synaptic development remains poorly understood. In a genetic screen, we recovered a mutation in Drosophila mical-like that displays an increase in bouton numbers and a decrease in FasII levels at the neuromuscular junction (NMJ). Similar phenotypes were induced by presynaptic, but not postsynaptic, knockdown of mical-like expression. FasII trafficking assays revealed that the recycling of internalized FasII molecules to the cell surface was significantly impaired in mical-like-knockdown cells. Importantly, this defect correlated with an enhancement of endosomal sorting of FasII to the lysosomal degradation pathway. Similarly, synaptic vesicle exocytosis was also impaired in mical-like mutants. Together, our results identify Mical-like as a novel regulator of synaptic growth and FasII endocytic recycling.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.232-238
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• 2014

Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Ab). Specific mechanisms underlying the development of the disease have not yet been fully understood. In this study, we investigated effects of 4-O-methylhonokiol on memory dysfunction in APP/PS1 double transgenic mice. 4-O-methylhonokiol (1 mg/kg for 3 month) significantly reduced deficit in learning and memory of the transgenic mice, as determined by the Morris water maze test and step-through passive avoidance test. Our biochemical analysis suggested that 4-O-methylhonokiol ameliorated $A{\beta}$ accumulation in the cortex and hippocampus via reduction in beta-site APP-cleaving enzyme 1 expression. In addition, 4-O-methylhonokiol attenuated lipid peroxidation and elevated glutathione peroxidase activity in the double transgenic mice brains. Thus, suppressive effects of 4-O-methylhonokiol on $A{\beta}$ generation and oxidative stress in the brains of transgenic mice may be responsible for the enhancement in cognitive function. These results suggest that the natural compound has potential to intervene memory deficit and progressive neurodegeneration in AD patients.