• 한국약용작물학회지
• /
• 제27권2호
• /
• pp.115-125
• /
• 2019

Background: Glycyrrhiza radix (licorice root) have been used as an oriental medicine material for long time, and its protective effects on oxidative stress, inflammation and cognition deficit have been recently reported. However, the cultivation of Glycyrrhiza species as medicinal crops is associated with some problems such as low productivity and early leaf fall, etc. To resolve this problems, Glycyrrhiza cultivars have been developed by direct hybridization of each Glycyrrhiza species by Korean researchers. The present study was conducted to compare the Glycyrrhiza cultivar radix (Dagam, Sinwongam and Wongam) for their anti-oxidation, anti-inflammation, and cognition improvement effects and levels of liquiritin, isoliquiritigenin and licochalcone in order to select an excellent cultivar as a material resource. Methods and Results: For evaluating the inhibitory efficacies of the Glycyrrhiza cultivar extracts on oxidative stress and inflammation in BV2 cells, we measured their reactive oxygen species (ROS) production and nitric oxide (NO) release after treating them with lipopolysccharide. The scavenging activities on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxynitrite ($NOO^-$) radicals were evaluated. Cell proliferation and N-methyl-D-aspartate receptor (NMDAR) inhibition were analyzed. The total phenol, liquiritin, isoliquiritigenin and licochalcone A content in the extracts of the three culivars were quantified. Furthermore, the correlation coefficient between the activities and contents of total phenol, liquiritin, isoliquiritigenin and licochalcone A were also calculated. The results indicated that Sinwongam exhibited potent anti-oxidant, anti-inflammatory and NMDAR inhibititory activities. Sinwongam also showed higher total phenol and licochalcone A contents than the other cultivars. Among the three cultivars, Dagam exhibited a positive effects on NO release inhibition, cell proliferation and contents of liquiritin and isoliquiritigenin. Conclusions: Sinwongam is expected to be the most useful resource as a functional material for anti-oxidation/anti-inflammation and cognition improvement among the three studied licorice cultivars.

• 한국산학기술학회논문지
• /
• 제21권8호
• /
• pp.537-545
• /
• 2020

본 연구는 회복기 단계에 있는 뇌혈관 질환자를 대상으로 가상현실 콘텐츠를 활용한 인지재활프로그램의 임상적 적용 효과를 알아보았다. 연구방법은 회복기 단계의 뇌혈관 질환자 34명을 대상으로 대조군(16명)과 실험군(18명)으로 나눈 후에 가상현실 콘텐츠 기반의 인지재활프로그램을 적용한 후, 인지기능과 일상생활활동 능력, 상지기능에서의 효과를 비교하고자 하였다. 대조군에는 보편적인 재활치료 프로그램을 실시하고, 실험군에서는 보편적인 재활치료 프로그램과 가상현실 콘텐츠 기반의 인지재활프로그램을 제공하였다. 두 집단 모두 하루 2회(1회 30분씩)씩, 주 5회, 4주간(총 20회기) 실시하였다. 중재 결과, 두 집단 모두 일상생활활동 능력이 모두 유의미하게 향상되었지만(p<.05), 실험군에서의 변화량이 대조군보다 5점정도 더 향상되었다(p<.05). 인지기능에서도 실험군과 대조군이 유의미한 차이를 보였고(p<.05), 변화량에서 실험군이 대조군보다 2점정도의 변화 수치를 보였다(p<.05). 상지기능에서는 대조군과 실험군 간의 유의마한 차이는 없었고(p>.05), 전후 변화량을 비교한 결과 실험군이 대조군보다 0.7점정도 유의미한 변화폭을 보였다(p<.05). 가상현실 콘텐츠를 활용한 인지재활프로그램이 일반적인 재활치료 프로그램에 비해서 일상생활활동 능력과 인지기능에서의 유의미한 향상 폭의 차이가 있다는 것을 확인하는 연구였다.

• 한방재활의학과학회지
• /
• 제30권2호
• /
• pp.105-123
• /
• 2020

Objectives This study was conducted to verify the effectiveness of east-west integrative rehabilitation therapy on activity of daily living and cognitive functional recovery in stroke patients by comparing with integrative rehabilitation therapy group and conventional rehabilitation therapy group in a single institution. Methods The medical records of 106 stroke patients hospitalized in Department of Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital from January 1, 2017 to February 28, 2019 were reviewed. After screening and dividing it into conventional rehabilitation (CR) group and integrative rehabilitation (IR) group, Korean version of Modified Barthel Index (K-MBI), functional independence measure (FIM), clinical dementia rating-sum of boxes (CDR-SB) were statistically analyzed. Results IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.001) and there was a statistically significant difference in K-MBI and CDR-SB score changes than CR group (p<0.05). And chronic patient of IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.01) and there was a statistically significant difference in CDR-SB score changes than CR group (p<0.05). In particular, the earlier the treatment initiation time, the more the improvement in function and when the treatment started within 2 years from the onset and patients took acupuncture and pulsed electromagnetic therapy, all scales significantly improved (p<0.001). Conclusions IR showed more improvement on activities of daily life and cognitive functional recovery than CR in this study.

• 대한지구과학교육학회지
• /
• 제4권1호
• /
• pp.12-19
• /
• 2011

This study aimed to analyze the teachers' cognitions about the primary science textbooks(experiment and observation) used in elementary schools. This study surveyed 211 teachers in Seoul and Gyeonggi province. The data were statistically analyzed by SPSS WIN 10.0. The results of this study are as follows : Most of the teachers showed positive opinions on the directions of the compilation of experiment and observation textbook. Teachers used experiment and observation textbook as summary notes, experiment reports and evaluating methods. The experiment and observation textbooks should be compiled and reorganized in order as follows : Lesson introduction, inquiry activities, and intensive and supplementary activities which are followed by space of description in experiment and observation textbook.

• 한국엔터테인먼트산업학회논문지
• /
• 제13권7호
• /
• pp.521-529
• /
• 2019

본 연구는 지역사회 치매노인이 선택한 선택형 인지자극치료가 치매노인의 인지, 일상생활활동의 독립 수준 및 우울에 미치는 효과를 알아보고자 하였다. 프로그램은 2019년 3월 4일부터 2019년 4월 26일까지 주 1회 50분씩 총 7회기를 진행하였다. 연구결과, 선택형 인지자극치료는 실험군의 인지기능, 일상생활활동 독립수준을 향상시켰고, 우울을 감소시켰다. 또한 대조군의 결과와 비교하였을 때, 인지기능에서 유의한 차이를 보였다. 따라서 본 연구의 선택형 인지자극치료는 치매노인의 인지기능을 파악하고 흥미를 유발하면서 효과가 입증된 인지과제를 제시하여 대상자들에게 선택하게 하였다. 이후 대상자들의 인지기능 수준에 따른 활동의 난이도 등을 고려하여 회기별 활동을 구성하여 인지기능의 향상을 이끌었다. 또한, 흥미를 느끼고 선택한 활동에 지속해서 적극 참여함으로써 성공을 경험하였고, 이를 통해 일상생활활동의 자발성과 우울감소에 긍정적 영향을 미쳤을 것으로 사료된다.

• 성인간호학회지
• /
• 제27권2호
• /
• pp.211-222
• /
• 2015

Purpose: This study was conducted to test the model for sleep in community-dwelling older adults. The hypothetical model based on a senescent sleep model was constructed using the multiple influencing factors of sleep and associated adverse outcomes of changes in sleep in the older adults. Methods: Data were collected from 203 community-dwelling older adults living in Korea, and analyzed using IBM SPSS 21.0 and AMOS 21.0. Results: Increased age and multiple comorbidities were associated with decreased physical activities. Decreased physical activities were associated with smaller social networks, and smaller social networks were associated with higher level of loneliness. Multiple comorbidities, decreased physical activities, larger social networks, and higher level of loneliness were associated with maladaptive sleep hygiene. Decreased physical activities, higher level loneliness, and shorter actual sleep duration were associated with worse sleep quality. Smaller social networks and shorter actual sleep duration were associated with lower cognitive functions. Smaller social networks, higher loneliness, and worse sleep quality were associated with more severe depressive symptoms. Conclusion: These findings suggest that the sleep improvement interventions not only with physical perspectives but psychosocial ones for older adults may improve depressive symptoms as well as sleep quality.

• 대한통합의학회지
• /
• 제9권3호
• /
• pp.9-18
• /
• 2021

Purpose : In this study, we applied a computerized cognitive rehabilitation program (CoTras-C) for children with cerebral palsy. Research was conducted to investigate the impact of upper limb function, sensory function, and activities of daily living. Methods : The study period lasted 10 weeks from October 2019 to December 2019. The study subjects were 12 subjects according to the selection criteria, and a computerized cognitive rehabilitation program (CoTras-C) was conducted twice a week for 30 minutes before and after the application of basic occupational therapy. Results : As a result of the computerized cognitive rehabilitation program, scores of upper limb function (QUEST), sensory function (SSP-2), and daily life activity (WeeFIM) were significantly improved (p>.05). From the result of examining the motor area, improvement in fine-motor function and protective extension through touch pad or controller operation was found. It also showed improvement in activities of daily living including motor and activities of daily living including social cognition. In the sensory function evaluation, it was not significant in movement sensitivity. Significant differences were shown in the items excluding olfactory/taste sensitivity. Conclusion : The application of the computerized cognitive rehabilitation program (CoTras-C) showed significant results in upper limb function, sensory function, and daily life activities of children with brain lesions. Based on these results, future studies need to generalize the study by expanding the age or population of children with brain lesions, or by expanding the diversity of diseases and environments.

• 대한간호학회지
• /
• 제47권1호
• /
• pp.1-13
• /
• 2017

Purpose: The purpose of this study was to examine the effects of a cognitive training program on neurocognitive task performance and activities of daily living (ADL) in patients who had a stroke. Methods: The research design for this study was a nonequivalent control group non-synchronized design. Patients were assigned to the experimental (n=21) or control group (n=21). The experimental group received a 4-week cognitive training program and usual care (i.e., rehabilitation service), while the control was received usual care only. Cognitive function was measured with a standardized neurocognitive test battery and ADL was assessed at baseline and one and two months after completion of the intervention. Repeated measures ANOVA was used to determine changes in cognitive function and ADL over 2 months. Results: The interaction of group and time was significant indicating that the experimental group showed improvement in attention, visuospatial function, verbal memory, and executive function compared to the control group which had a sustained or gradual decrease in test performance. A significant group by time interaction in instrumental ADL was also found between the experimental group with gradual improvement and the control group showing no noticeable change. Conclusion: Findings show that the cognitive training program developed in this study is beneficial in restoring cognitive function and improving ADL in patients following a stroke. Further study is needed to investigate the long-term relationship between cognitive training participation and cognitive improvement and effective functioning in daily living.

• 대한통합의학회지
• /
• 제4권3호
• /
• pp.49-59
• /
• 2016

Purpose : The study was aimed to evaluate the improvement of cognitive and hand functions after the application of a complex rehabilitation intervention program on patients with mild cognitive impairment (MCI) and dementia who were living a regional community from. Methods : Subjects who were living in a regional sanatorium or who were outpatients of a community health center were enrolled from 2012. 2 to 2013.2 All subjects were enforced 8 cycles of a complex rehabilitation intervention program including RON dance, physical activity using therabands, reality awareness training, space retrieval training and handicraft activities. Results : There were significant improvement in LOTCA-G cognitive function and JTHFT hand function test after the application of a complex rehabilitation intervention program. Conclusion : The result shows a significant improvement in cognitive and hand functions after the application of a complex rehabilitation intervention program in patients with MCI and dementia. Therefore the authors suggest the vast studies of the cognitive function program development and hand function vitalization by the application of a complex rehabilitation intervention program.

• International Journal of Advanced Culture Technology
• /
• 제9권1호
• /
• pp.196-202
• /
• 2021

Currently, as Korea enters into a fast aging society, the problem of dementia population is increasing. In this paper, we intend to contribute to the improvement of welfare for the elderly by developing virtual reality technology and related interface technology to effectively perform hand movements known as effective methods for preventing and treating dementia. As the content of the research and development of this paper, it is designed to be easy for the elderly to use and stimulate brain function by applying VR technology using sensors, and to activate mental and physical activities for the elderly who are marginalized in terms of cultural welfare. We intend to develop by classifying the types of games and contents that can induce them. As a result of this thesis, we developed contents using virtual reality to improve cognitive abilities for elderly people with poor cognitive ability to activate the brains of users' cognition, memory, and attention to prevent and treat dementia I want to contribute.