• Journal of KIISE:Computer Systems and Theory
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• v.31 no.1_2
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• pp.125-134
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• 2004

Recently, an on-chip compressed cache system was presented to alleviate the processor-memory Performance gap by reducing on-chip cache miss rate and expanding memory bandwidth. This research Presents an extended on-chip compressed cache system which also significantly expands main memory capacity. Several techniques are attempted to expand main memory capacity, on-chip cache capacity, and memory bandwidth as well as reduce decompression time and metadata size. To evaluate the performance of our proposed system over existing systems, we use execution-driven simulation method by modifying a superscalar microprocessor simulator. Our experimental methodology has higher accuracy than previous trace-driven simulation method. The simulation results show that our proposed system reduces execution time by 4-23% compared with conventional memory system without considering the benefits obtained from main memory expansion. The expansion rates of data and code areas of main memory are 57-120% and 27-36%, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4331-4338
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• 2014

$N^1$-(2, 5-dimethoxyphenyl)-$N^8$-hydroxyoctanediamide (N25) is a novel SAHA cap derivative of HDACi, with a patent (No. CN 103159646). This invention is a hydroxamic acid compound with a structural formula of $RNHCO(CH_2)6CONHOH$ (wherein R=2, 5dimethoxyaniline), a pharmaceutically acceptable salt which is soluble. In the present study, we investigated the effects of N25 with regard to drug distribution and molecular docking, and anti-proliferation, apoptosis, cell cycling, and $LD_{50}$. First, we designed a molecular approach for modeling selected SAHA derivatives based on available structural information regarding human HDAC8 in complex with SAHA (PDB code 1T69). N25 was found to be stabilized by direct interaction with the HDAC8. Anti-proliferative activity was observed in human glioma U251, U87, T98G cells and human lung cancer H460, A549, H1299 cells at moderate concentrations ($0.5-30{\mu}M$). Compared with SAHA, N25 displayed an increased antitumor activity in U251 and H460 cells. We further analyzed cell death mechanisms activated by N25 in U251 and H460 cells. N25 significantly increased acetylation of Histone 3 and inhibited HDAC4. On RT-PCR analysis, N25 increased the mRNA levels of p21, however, decreased the levels of p53. These resulted in promotion of apoptosis, inducing G0/G1 arrest in U251 cells and G2/M arrest in H460 cells in a time-dependent and dose-dependent manner. In addition, N25 was able to distribute to brain tissue through the blood-brain barrier of mice ($LD_{50}$: 240.840mg/kg). In conclusion, our findings demonstrate that N25 will provide an invaluable tool to investigate the molecular mechanism with potential chemotherapeutic value in several malignancies, especially human glioma.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.9-12
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• 2008

The semi-rigid joint is the shape of middle that can supplement the defect of pin joints and accept the good point of rigid joints. Recently, a study on the pin joints is activated in the country, but because the study on semi-rigid joints is not many, this study tried to prove with producing test model of three shape. The test models are rigid joint HI-R, semi-rigid joint HI-S, pin joint HI-P. As a result of the test, respectively HI-R, HI-S, HI-P appeared shear failure of joint, flexure failure of the top fixing, flexure failure of the lower part slipping stair slab, and the maximum strength is measured to 51.74, 51.4, 24.63kN, the stiffness is appeared 1.58, 1.19, 0.37 respectively, The yield strength is respectively kept 44.5, 47.3, 24kN, and ductility ratio is appeared to 3.31, 2.32, 1.54, when is based on KBC code, sag of the acting service load is appeared that HI-P model is over the standard. When is based on distribution of bars strain ratio, HI-S seems similar behavior incipiently, but after the yield, the semi-rigid joint was able to be judged better than pin joint because of the stress allotment of joint internal elements.

• Journal of the Korea Concrete Institute
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• v.29 no.3
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• pp.275-281
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• 2017

This study examined the effect of water-to-binder ratio (W/B) and phosphate-to-binder ratio (P/B) on the flow, setting time, compressive strength development, and pH variation of magnesium-potassium phosphate composites, MKPC mortars. Ten mortars mixtures were prepared with the W/B varying from 20% to 40% at each P/B of 0.3 or 0.5. The hydration products and microstructural pore distribution of the MKPC pastes were investigated using X-ray diffraction (XRD), scanning electron microscope (SEM) and mercury intrusion porosimetry (MIP). The initial flow and setting time of MKPC mortars tended to decrease with an increase of P/B, indicating that the final setting time was shortened by approximately 24% when P/B increased from 0.3 to 0.5. The slope of the early-strength development measured in the MKPC mortars was considerably higher than that of cement concrete specified in code provisions. For obtaining a relatively good 28-day strength (above 30 MPa) and a near neutral pH (below 9.0) in MKPC mortars, the P/B and W/B need to be selected as 0.5 and 30%, respectively. The strubite-K crystal increased with the increases of P/B and W/B, which leads to the decrease of the macro-capillary pores.

• Journal of the Korea Concrete Institute
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• v.17 no.3 s.87
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• pp.375-384
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• 2005

The effects of bar deformation properties on bond of steel reinforcing bars to concrete are experimentally studied to predict the bond strength. Based on the previous research about high relative rib area, bond strength between reinforcing bars and concrete can be improved by the control of rib height and spacing. But, the equations in Korean code provisions to estimate development and splice length do not include these specifications of reinforcing bars. So the purpose of this paper is to determine the effect of relative rib area to the bond strength. This paper describes 2 kinds of experimental researches. Thirty beam-end specimens were tested to investigate the effects of bar size and relative rib areas ranging from 0.112 to 0.162. And, twelve lap-splice beam specimens were tested to the same variables. Each test results are normalized and compared with the proposed equations of ACI 408 committee. The results show that bond strength is increased as bar size and the relative rib area(Rr) increase. The distribution of flexural cracks and failure aspect do not appear to be affected by $R_r$.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.2
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• pp.161-168
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• 2011

The heating, ventilating, air conditioning (HVAC) system is a very important part of an automotive vehicle: it controls the microclimate inside the passenger's compartment and removes the frost or mist that is produced in cold/rainy weather. In this study, the numerical analysis of the defrost duct in an HVAC system and the de-icing pattern is carried out using commercial CFX-code. The mass flow distribution and flow structure at the outlet of the defrost duct satisfied the duct design specification. For analyzing the de-icing pattern, additional grid generation of solid domain of ice and glass is pre-defined for conductive heat transfer. The flow structure near the windshield, streakline, and temperature fields clearly indicate that the de-icing capacity of the given defrost duct configuration is excellent and that it can be operated in a stable manner. In this paper, the unsteady changes in temperature, water volume fraction, and static enthalpy at four monitoring points are discussed.

• Tunnel and Underground Space
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• v.23 no.4
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• pp.297-307
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• 2013

In this study, the thermal analysis is carried out for a result of borehole heater test using ABAQUS ver 6.10 based on finite element analysis code. Thermal-mechanical rock properties as determined by laboratory tests before the in situ test and characteristics of the atmosphere at the test section are used as the initial condition. When comparing the results of the in situ test and thermal analysis, the temperature of C3 observation hole that is 0.9 m away from the heater showed very similar patterns and figures (about $1.3^{\circ}C$ difference). But the results of the A and B observation hole showed a significant difference around $15^{\circ}C{\sim}20^{\circ}C$. To find the reason for these results, the over-coring is carried out for the A1 and B1 observation holes. As a result of checking the excavated rock core with the naked eye, there is no problem on the number and position of the sensor as the test plan. However the state of cement injection in the observation hole is poor.

• Journal of the Korea Concrete Institute
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• v.25 no.5
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• pp.497-508
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• 2013

This paper introduces a numerical model which can evaluate the fire-resistant capacity of reinforced concrete members. On the basis of the transient heat transfer considering the heat conduction, convection and radiation, time-dependent temperature distribution across a section is determined. A layered fiber section method is adopted to consider non-linear material properties depending on the temperature and varying with the position of a fiber. Furthermore, effects of non-mechanical strains of each fiber like thermal expansion, transient strain and creep strain are reflected on the non-linear structural analysis to take into account the extreme temperature variation induced by the fire. Analysis results by the numerical model are compared with experimental data from the standard fire tests to validate an exactness of the introduced numerical model. Also, time-dependent changes in the resisting capacities of reinforced concrete members exposed to fire are investigated through the analyses and, the resisting capacities evaluated are compared with those determined by the design code.

• Journal of Radiation Protection and Research
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• v.24 no.4
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• pp.215-223
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• 1999

Characteristics of radiation field in the steam generator(S/G) water chamber of a PWR were investigated and the anticipated effective dose rates to the worker in the S/G chamber were evaluated by Monte Carlo simulation. The results of crud analysis in the S/G of the Kori nuclear power plant unit 1 were adopted for the source term. The MCNP4A code was used with the MIRD type anthropomorphic sex-specific mathematical phantoms for the calculation of effective doses. The radiation field intensity is dominated by downward rays, from the U-tube region, having approximate cosine distribution with respect to the polar angle. The effective dose rates to adults of nominal body size and of small body size(The phantom for a 15 year-old person was applied for this purpose) appeared to be 36.22 and 37.06 $mSvh^{-1}$) respectively, which implies that the body size effect is negligible. Meanwhile, the equivalent dose rates at three representative positions corresponding to head, chest and lower abdomen of the phantom, calculated using the estimated exposure rates, the energy spectrum and the conversion coefficients given in ICRU47, were 118, 71 and 57 $mSvh^{-1}$, respectively. This implies that the deep dose equivalent or the effective dose obtained from the personal dosimeter reading would be the over-estimate the effective dose by about two times. This justifies, with possible under- or over- response of the dosimeters to radiation of slant incidence, necessity of very careful planning and interpretation for the dosimetry of workers exposed to a non-regular radiation field of high intensity.

• Journal of Radiation Protection and Research
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• v.45 no.2
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• pp.69-75
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• 2020

Background: Dose conversion coefficients (DCCs) have been commonly used to estimate radiation-dose absorption by human organs based on physical measurements of fluence or kerma. The International Commission on Radiological Protection (ICRP) has reported a library of DCCs, but few studies have been conducted on their applicability to non-Caucasian populations. In the present study, we collected a total of 8 Korean pediatric and adult voxel phantoms to calculate the organ DCCs for idealized external photon-irradiation geometries. Materials and Methods: We adopted one pediatric female phantom (ETRI Child), two adult female phantoms (KORWOMAN and HDRK Female), and five adult male phantoms (KORMAN, ETRI Man, KTMAN1, KTMAN2, and HDRK Man). A general-purpose Monte Carlo radiation transport code, MCNPX2.7 (Monte Carlo N-Particle Transport extended version 2.7), was employed to calculate the DCCs for 13 major radiosensitive organs in six irradiation geometries (anteroposterior, posteroanterior, right lateral, left lateral, rotational, and isotropic) and 33 photon energy bins (0.01-20 MeV). Results and Discussion: The DCCs for major radiosensitive organs (e.g., lungs and colon) in anteroposterior geometry agreed reasonably well across the 8 Korean phantoms, whereas those for deep-seated organs (e.g., gonads) varied significantly. The DCCs of the child phantom were greater than those of the adult phantoms. A comparison with the ICRP Publication 116 data showed reasonable agreements with the Korean phantom-based data. The variations in organ DCCs were well explained using the distribution of organ depths from the phantom surface. Conclusion: A library of dose conversion coefficients for major radiosensitive organs in a series of pediatric and adult Korean voxel phantoms was established and compared with the reference data from the ICRP. This comparison showed that our Korean phantom-based data agrees reasonably with the ICRP reference data.