• Title/Summary/Keyword: Coated core

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Stability Improvement of Esomeprazole Magnesium Dihydrate Enteric-Coated Tablet by Adding Alkalizing Agents (에스오메프라졸 마그네슘 이수화물을 함유하는 장용성 제제의 안정성 개선)

  • Cho, Young Ho;Jeon, Hyo Bin;Lee, Jong-Hwa;Lee, Gye Won
    • KSBB Journal
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    • v.32 no.2
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    • pp.108-116
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    • 2017
  • Omeprazole, a benzimidazole derivative, suppresses gastric acid secretion by inhibiting $H^+/K^+$ ATPase in gastric parietals cells, and by reducing $H^+$ concentration. To improve stability of esomeprazole magnesium dihydrate (ESMD), enteric-coated preperation was composed of core tablet, subcoating and enteric coating layer. We were evaluated in vitro dissolution characteristics between test and reference ESMD preparation and stability. We could prepare enteric-coated formulation of ESMD by controlling disintegrating agent and coating ratio which could rapidly dissolved in neutral or alkali medium. The formulation D5 with crospovidone of 1.25% and coating ratio of 16.25% had a similar dissolution behavior compare to reference preparation. Difference factor ($f_1$) and similarity factor ($f_2$) were 0~15 and 50~100 and there was no significant difference in bioequivalence between formulations. The content and dissolution rate of formulation D5 were $96.54{\pm}0.21$ and $78.56{\pm}0.87%$ without change of color in accelerated condition ($40^{\circ}C$, RH 75%, high density polyethylene (HDPE) container) for 6 months. This study concluded that our enteric coated preparation of ESMD could be an useful method to improve stability of unstable drug without direct contact with coating material.

Characteristics according to the spot at the beginning of the fault current (개선된 자속구속형 전류제한기의 사고 시점에 따른 사고전류제한 특성)

  • Kim, Yong-Jin;Du, Ho-Ik;Lee, Dong-Hyeok;Han, Sang-Chul;Lee, Jeong-Phil;Han, Byoung-Sung
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2010.06a
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    • pp.189-189
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    • 2010
  • The Improved flux-lock type superconducting fault current limiter(SFCL) is composed of a series transformer and superconducting unit of the YBCO coated conductor. The primary and secondary coils in the transformer were wound in series each other through an iron core and the YBCO coated conductor was connected with secondary coil in parallel. In a normal condition, the flux generated from a primary coil is cancelled out by its structure and the zero resistance of the YBCO thin films. When a fault occurs, the resistance of the YBCO coated conductor was generated and the fault current was limited by the SFCL. In this paper, we investigated the fault current limiting characteristics through the spot at the beginning of the fault current in the Improved flux-lock type SFCL. The experiment results that the fault current limiting characteristics was difference according to the point of a fault current started. Through the analysis, it was shown that shorter the time of a phase transition.

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Synthesis of FDR-SPC Resin and PIV Measurement for Frictional Drag-reduction (마찰저항 저감을 위한 고분자 수지 합성 및 PIV 유동장 계측)

  • Chung, Sungwoo;Kim, Eunyoung;Chun, Ho Hwan;Park, Hyun;Lee, Inwon
    • Journal of the Korean Society of Visualization
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    • v.12 no.1
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    • pp.49-53
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    • 2014
  • In this study, a novel FDR-SPC is first synthesized in this study. The drag reducing functional radical such as PEGMA (Poly(ethylene) glycol methacrylate) has been utilized to participate in the synthesis process of the SPC. The types of the baseline SPC monomers, the molecular weight and the mole fraction of PEGMA were varied in the synthesis process. The resulting SPCs were coated to the substrate plates for the subsequent hydrodynamic test for skin friction measurement. In a low-Reynolds number flow measurement using PIV (Particle Image Velocimeter), a significant reduction in Reynolds stress was observed in a range of specimen, with the maximum drag reduction being 15.9% relative to the smooth surface.

Preparation of Cu-Ag Powder having Core-Shell Structure by Electroless Plating Method (무전해 도금법을 이용한 코어 셸 구조의 Cu-Ag분말 제조)

  • Kim, Jong-Wan;Lee, Huk-Hee;Won, Chang-Whan
    • Journal of Surface Science and Engineering
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    • v.42 no.1
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    • pp.47-52
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    • 2009
  • Cu-Ag powder having Core-Shell structure was prepared from by electroless plating method using agents such as $AgNO_3$, $NH_{4}OH$, Hydroquinone. Ag coated copper powders were analyzed using scanning electron microscopy(SEM) and energy dispersive X-ray spectrometer(EDX). The silver coating layer of copper powder was affected from various reaction conditions such as molar ratio of $NH_{4}OH$, $AgNO_3$, and pulp density. Free silver was generated below 0.1M or 0.3M and above of $NH_{4}OH$ mole ratio. Silver coating layer thickened as addition of $AgNO_3$. When the pulp density reached 12% with 0.2M $NH_{4}OH$, and 0.15M $AgNO_3$ at $4^{\circ}C$, silver was homogeneously distributed around the copper particles and free silver particles were not generated.

Relationship Between AC and DC Magnetic Properties of an Iron-Based Amorphous Alloy for High Frequency Applications

  • Choi, Y.S.;Noh, T.H.;Lim, S.H.
    • Journal of Magnetics
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    • v.1 no.1
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    • pp.24-30
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    • 1996
  • The relationship between effective permeability and the remanence ratio of an Fe-based amorphous alloy (Metglas 2605S3A) is investigated over a wide frequency range, in an effort to understand magnetization behavior of the alloy. In the frequency range from 1 to 200 kHz, the permeability is maximum at the remanence ratio of 0.4-0.5 and, at frequencies over 500 kHz, the correlation with negative coefficients emerges indicating that the permeability decreases with the remanent ratio, except for the ribbon coated with an insulating layer of MgO which exhibits both high values of the effective permeability and remanence ratio. It is considered from the correlation results that the boundary at which the dominant magnetization mechanism changes from domain wall motion to spin rotation is near 500 kHz. The core loss is also investigated as a function of annealing time when the samples are annealed at a fixed temperature of $435^{\circ}C$. The core loss in most cases decreases with the annealing time, the degree of the loss may consist of the hysteresis loss and anomalous eddy current loss. The two loss components are considered to be of similar magnitudes at low frequencies while, at high frequencies, the dominant contribution to the total loss is the anomalous loss.

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Photoluminescence Imaging of SiO2@ Y2O3:Eu(III) and SiO2@ Y2O3:Tb(III) Core-Shell Nanostructures

  • Cho, Insu;Kang, Jun-Gill;Sohn, Youngku
    • Bulletin of the Korean Chemical Society
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    • v.35 no.2
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    • pp.575-580
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    • 2014
  • We uniformly coated Eu(III)- and Tb(III)-doped yttrium oxide onto the surface of $SiO_2$ spheres and then characterized them by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction crystallography and UV-Visible absorption. 2D and 3D photoluminescence image map profiles were reported for the core-shell type structure. Red emission peaks of Eu(III) were observed between 580 to 730 nm and assigned to $^5D_0{\rightarrow}^7F_J$ (J = 0 - 4) transitions. The green emission peaks of Tb(III) between 450 and 650 nm were attributed to the $^5D_4{\rightarrow}^7F_J$ (J = 6, 5, 4, 3) transitions. For annealed samples, Eu(III) ions were embedded at a $C_2$ symmetry site in $Y_2O_3$, which was accompanied by an increase in luminescence intensity and redness, while Tb(III) was changed to Tb(IV), which resulted in no green emission.

In-Situ Synthesis of PS/(-)Silica Composite Particles in Dispersion Polymerization Using An ($\pm$) Amphoteric Initiator

  • Hwang, Deok-Ryul;Hong, Jin-Ho;Lee, Jeong-Woo;Shim, Sang-Eun
    • Macromolecular Research
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    • v.16 no.4
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    • pp.329-336
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    • 2008
  • Core/shell ($\pm$)PS/(-)silica nanocomposite particles were synthesized by dispersion polymerization using an amphoteric initiator, 2,2'-azobis [N-(2-carboxyethyl)-2,2-methylpropionamidine] ($HOOC(CH_2)_2HN$(HN=) $C(CH_3)_2CN$=NC $(CH_3)_2C$(=NH)NH $(CH_2)_2COOH$), VA-057. Negatively charged (-6.9 mV) silica was used as the stabilizer. The effects of silica addition time and silica and initiator concentrations were investigated in terms of polymerization kinetics, ultimate particle morphology, and size/size distribution. Uniform hybrid microspheres with a well-defined, core-shell structure were obtained at the following conditions: silica content = 10-15 wt% to styrene, VA-057 content=above 2 wt% to styrene and silica addition time=0 min after initiation. The delay in silica addition time retarded the polymerization kinetics and broadened the particle size distribution. The rate of polymerization was strongly affected by the silica content: it increased up to 15 wt% silica but then decreased with further increase in silica content. However, the particle size was only marginally influenced by the silica content. The zeta potential of the composite particles slightly decreased with increasing silica content. With increasing VA-057 concentration, the PS microspheres were entirely coated with silica sol above 1.0 wt% initiator.