• 약학회지
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• 제54권4호
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• pp.316-321
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• 2010

Adefovir dipivoxil which was originally developed by Gilead Sciences has been used as treatments of HIV and HBV, especially a therapeutics for HBeAg positive and negative chronic patients. We developed highly efficient purification method using reverse phase column chromatography for mass production and a stable amorphous Adefovir dipivoxil using solid dispersion method. Reverse phase column chromatography led to highly pure product, more than 99.7% by HPLC and can be used for mass production compared with normal column chromatography. Solid dispersion method containing watersoluble polymer and Isomalt showed improved stability of amorphous Adefovir dipivoxil against heat and moisture.

• 한국군사과학기술학회지
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• 제18권5호
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• pp.594-601
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• 2015

The purpose of this research is to propose a maintenance support system for deciding assembly sequence of the product and appropriate tools that are used to assembly and disassembly of parts in the product when geometric properties of the product. The digital maintenance system (DMS) is developed to generate the maintenance guideline and the initial experiment is conducted especially for an underwater weapon system with cylindrical structure. DMS considers four factors to find the efficient assembly and disassembly procedure automatically: (1) assembly tree, (2) properties of each part, (3) distance from the center of the product, and (4) volume. Based on the factors, DMS simulate the movement of each tool virtually and the properties of tools are investigated to find an appropriate tool for using assembly and disassembly of each part in the product. The proposed approach integrates modeling, simulation, data configuration, and virtual reality to allow a development of preliminary maintenance guidance.

• Journal of Microbiology and Biotechnology
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• 제26권5호
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• pp.953-958
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• 2016

Chitosan-based film-forming gel is regarded as a promising vehicle for topical delivery of antimicrobial agents to skin wounds, since it protects from microbial infection and the cationic polymer itself possesses antibacterial activity. In this study, possible synergistic interaction against common skin pathogens between the cationic polymer and tyrothricin (TRC), a cyclic polypeptide antibiotic, was investigated, by determining the concentration to inhibit 90% of bacterial isolates (MIC). The addition of the polysaccharide to TRC dramatically reduced the MIC values of TRC by 1/33 and 1/4 against both methicillin-resistant and methicillin-susceptible Staphylococcus aureus, respectively. The synergism of TRC and chitosan combination against both strains was demonstrated by the checkerboard method, with a fractional inhibitory concentration index below 0.5. Moreover, co-treatment of TRC and chitosan exhibited antibacterial activity against Pseudomonas aeruginosa, due to the antibacterial activity of chitosan, whereas TRC itself did not inhibit the gram-negative bacterial growth. These findings suggested that the use of chitosan-based film for topical delivery of TRC could be an alternative to improve TRC antimicrobial activity against strains that are abundant in skin wounds.

• 디지털산업정보학회논문지
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• 제6권2호
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• pp.71-80
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• 2010

This thesis is purposed on developing security product co-evaluation statistics administrate program which is can administrate or analysis CC accreditation product using by DEVS modeling via portal site of member of CCRA. Via developing security product evaluation statistics administrate program, it can analysis the trend of all countries of the world in many ways, and noticed the ways of evaluation and accreditation of most countries via scheme analysis. Except this, it can analysis the situation of accreditation trend of any countries via data analysis of ICCC 2009. Also, For trend analysis to evaluation technique of CCRA member, it analyzed up to date technology and policy of the evaluation organization and the Certification Authority of most countries. And it peformed analysis the most trend of information security of evaluation authorization in CCRA member countries. In this program, It provide the function of trend statistics analysis which can statically analyzed the evaluation accreditation trends of most countries and automatical statistics by categorization ( by Product, Class and statistics in national) and report creation functions which can easily extraction and use the needed data. It has been updated the related informations until latest accredited product using by CC(Common Criteria) portal home page's data.

• 수산경영론집
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• 제46권3호
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• pp.31-49
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• 2015

This study examines whether or not the South Korean major fishery product import markets; Frozen Pollock, Frozen Long Arm Octopus, and Frozen Hairtail are integrated. We are utilizing the Multivariate and Bivariate Johansen Co-integration test to see if the law of one price(LOP) holds in each market or not. The empirical results show that even though import prices from different countries affect each other in each South Korean major fishery product import market, there is no evidence of LOP in any fishery product import market, which means that none of the markets are integrated. Based on these results, we could expect that the three major fishery product import markets show monopolistic competition among import countries. we would also see whether or not any country plays the role of a price leader in any of the markets. Based on weak exogeneity test results, we might expect that the United States and Malaysia are price leaders in the South Korean Frozen Pollock Import Market and Frozen Long Arm Octopus Import Market, respectively; however, we need to study more on this in the future.

• 대한금속재료학회지
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• 제50권5호
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• pp.353-360
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• 2012

The corrosion product of archaeological iron objects is supposed to be removed because it causes re-corrosion. So far it is removed by scapel and sand blaster but they depend on the skill and experience of a conservator and the glass-dust of the sand blaster is harmful to humans. Therefore this study applies a laser cleaning system which is used in various industrial cleaning processes, to remove corrosion product from archaeological iron objects. In addition, this work studies the alternation of corrosion product after laser irradiation, which evaluates the reliability of the laser cleaning system. Optical microscopy, SEM-EDS, XRD, Raman have been used to observe and analyse the surface of the objects. The results show the capacity of laser cleaning some corrosion product, but blackening appears with increasing pulses and laser energy, and some corrosion products, goethite and hematite, are partially altered to magnetite. These problems, blackening and alternation of corrosion product, should be solved by further studies which find the optimal laser irradiation condition and use a wetting agent.

• 한국미생물·생명공학회지
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• 제25권1호
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• pp.106-108
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• 1997

Blue green algaes (NIES 19, 39, 46) have been cultivated to product sigle cell protein. After 7 days of cultivation under 5000 (W/M$^{2}$) of ligth intensity, final cell concentration was 2.8 (g/L) and chlorophyll a was 4.9 (mg/L). When initial concentration of NaHCOC was 1.7% and NaNO$_{3}$ was0.25%, maximum cell concentration was obtained. Spirulina platensis NIES 39 showed faster growth rate than NIES 46. While most 39 sedimented, most 46 floated.

• 한국세라믹학회지
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• 제35권9호
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• pp.899-904
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• 1998

Interface reaction between LSMC and YSZ is discussed with chemical composition of LSMC. The reac-tivity between LSMC and YSZ increased with increasing Co amount and A-site deficient perovskite is very effective on reducing reactivity. The (La0.8Sr0.2)xMn0.8Co0.2O3 (X=0.9-1) composition is not reactive with YSZ in experimental range. The electrode reaction reaction resistance increases due to reaction product.

• 대한수학회보
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• 제55권3호
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• pp.789-798
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• 2018

Let M be a compact almost $coK{\ddot{a}}hler$ 5-manifold with $K{\ddot{a}}hlerian$ leaves. In this paper, we prove that M is locally symmetric if and only if it is locally isometric to a Riemannian product of a unit circle $S^1$ and a locally symmetric compact $K{\ddot{a}}hler$ 4-manifold.

• 생약학회지
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• 제25권4호통권99호
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• pp.307-310
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• 1994

A hitherto unknown substance was isolated from the commercial sample of Aloe arborescens, which was shown to be the 4',6'-O-ethylidene-aloenin, most likely an artifact caused by hot-air drying procedure for the product preparation.