• Journal of Preventive Medicine and Public Health
• /
• 제27권1호
• /
• pp.84-106
• /
• 1994

Hyperbaric oxygen (HBO) therapy for carbon monoxide (CO) poisoning eventually inducing the hypoxia-reoxygenation condition, may produce oxygen free radicals, which forms 8-hydroxydeoxyguanosine (8-OH-dG) by attacking C-8 position of deoxyguanosine (dG) in DNA. Effects of oxygen partial pressure or duration of HBO therapy with or without CO poisoning on the tissue 8-OH-dG formation were investigated. Male Sprague-Dawley rats were grouped and exposed to air (control group), 4000 ppm of CO for 10 to 30 minutes (CO only group), air for 30 minutes after 30 minute exposure to 4000 ppm of CO(CO-air exposure group), HBO after 30 minute exposure to 4000 ppm of CO(CO-HBO group), or HBO therapy fo. $10{\sim}120$ minutes(HBO only group). The 8-OH-4G concentrations in the brain and the lung tissues were measured with high performance liquid chromatography and electrochemical detector (ECD). Average concentrations of the 8-OH-dG of each group were statistically compared. In the brain tissues, 8-OH-dG concentrations of the CO only group, the CO-air exposure group, and the CO-HBO group did not significantly differ from those of the control group. Similar insignificance was also found between the CO-HBO group and the HBO only groups. No appreciable dose-response relationship was observed between the 8-OH-dG concentration and the oxygen partial pressure or the duration of HBO. However, the 8-OH-dG concentrations of the 30 minute CO only group were higher than those of the CO-air exposure group (p-value<0.05). In the lung tissues, there were no significant differences between the 8-OH-dG concentrations of the control group and those of the CO only group, the CO-air exposure group, and the CO-HBO group. However, mean 8-OH-dG concentration of the CO-air exposure group was significantly higher than that of the CO only group under the same CO exposure condition(p-value<0.05). With the duration of CO exposure, the 8-OH-dG concentrations of the lung tissues decreased significantly (p-value<0.05). The concentrations of 8-OH-dG in the lung tissues proportionally increased with the duration of HBO, but no such relation was observed with the oxygen partial pressure. These results suggest that the brain may be more resistant to oxygen free radicals as compared with the lungs, and that oxygen toxicity following HBO may be affected by factors other than oxygen free radicals.

• 한국대기환경학회지
• /
• 제11권4호
• /
• pp.323-329
• /
• 1995

The number of motor vehicles in Korea has increased to about 4 million, and the exhaust gases of these vehicles have become a more threatening factor to public health. Traffic policemen are one of the highest health risk groups since they work on roadsides where they are exposed to high levels of air pollutants. The health effects on them due to air pollution were determined by measuring personal carbon monoxide(CO) exposure and carboxyhemoglobin(COHb) level in blood. Thirty-one traffic policemen in Seoul volunteered to be subjects of the study. In October 1992, personal CO exposure was measured by a CO passive sampler. The subjects wore the CO passive sampler for 8 hours while on duty. The exposed samples were analyzed by gas chromatography. Blood samples from each subject were collected just after the exposure sampling, and were analyzed within 3 hours of blood collection by a CO-oximeter. The activities of the subjects were recorded by the subject in 30 minute intervals using an activity log sheet containing location and time spent. Personal CO exposure were ranged between 0.1 and 14.5ppm, eith an average of 5.9ppm. Carboxyhemoglobin levels ranged from 1.1% to 6.9%, with an average of 3.6%. policemen on duty outdoors had significantly higher CO exposures and COHb levels than policemen on duty indoors(p<0.01). Personal CO exposure and COHb were positively correlated, although the coefficient was not significant. The relationship between CO level and COHb level was confounded by smoking status. Among smokers, COHb level was significantly higher as CO exposure and hours worked outdoors increased.

• Journal of Radiation Protection and Research
• /
• 제16권2호
• /
• pp.7-16
• /
• 1991

감마선 조사선량의 국가표준을 확립하기 위하여 Co-60 감마선에 대한 조사선량률 절대 측정을 수행하였고 그 값이 갖는 오차한계를 분석 평가하였다. 측정기로는 고순도 흑연으로 제작된 원통형 이온전리함을 사용하였고 이온화 전류 측정은 vibrating reed 증폭기를 사용한 전하모드법에 의해 수행되었으며 관련 물리상수 및 각종 관련 보정인자를 평가하여 이온화 전류 측정값으로부터 조사선량률을 결정하였다.

• Safety and Health at Work
• /
• 제11권1호
• /
• pp.33-40
• /
• 2020

Background: Exploratory study to investigate whether co-exposure to physical wrist stressors and chemicals is associated with carpal tunnel syndrome (CTS) in French male farmers and agricultural workers. Methods: Cross-sectional study of 711 men aged 30-65 years and working as either farmers or agricultural workers in 2009-2010 within a cohort covered by the French Agricultural Workers' and Farmers' Mutual Benefit Fund. CTS and exposure to physical wrist stressors and chemicals were assessed using a self-administered questionnaire. Associations between CTS and personal/medical factors, exposure to physical wrist stressors, exposure to chemicals, and co-exposure to physical wrist stressors and chemicals were studied using multivariate logistic regression models. Results: Forty-four men {5.6% [95% confidence interval (CI) 4.0-7.7]} reported that they had suffered from unilateral/bilateral CTS during the last 12 months. CTS was associated with age, current smoking [odds ratio (OR) = 2.1 (1.0-4.5)], and exposure to physical wrist stressors [OR = 2.6 (1.1-5.9)]. An association was found between CTS and co-exposure to physical wrist stressors and chemicals [OR = 3.3 (0.8-14.3), p = 0.044] in comparison with the no-exposure group. Conclusions: This exploratory study shows an association of CTS with exposure to biomechanical wrist stressors in male farmers and agricultural workers and suggests an association of CTS with co-exposure to physical wrist stressors and chemicals. Owing to the limitations of the study, this result must be confirmed by a prospective study with objective assessments of the outcome and exposure before drawing conclusions on the possible synergistic effects of mechanical stressors and chemicals on the impairment of the median nerve.

• Annals of Occupational and Environmental Medicine
• /
• 제34권
• /
• pp.19.1-19.9
• /
• 2022

Background: It is widely known that carbon dioxide (CO₂) arc welding generates carbon monoxide (CO). However, to the best of our knowledge, no case reports have been published regarding CO poisoning in CO₂ arc welders. Therefore, we aimed to report a case of CO poisoning-induced encephalopathy in a CO₂ arc welder in the Republic of Korea to inform about the dangers of CO exposure among CO₂arc welders. Case presentation: A 40-year-old man working as a CO₂ arc welder for 15 years visited a local hospital with a tremor, involuntary urination, and speaking gibberish, on April 9, 2019. He stated that he had intermittent headache and forgetting symptoms for the last 5 years, and had been lost on the way to work several times. On April 9, 2019, he was diagnosed with CO poisoning-induced encephalopathy through brain magnetic resonance imaging. He received hyperbaric oxygen therapy, and some of his symptoms improved. According to the exposure assessment of his work environment, he was continuously exposed to high concentrations of CO for 15 years while operating CO₂ arc welding machines. Conclusions: After evaluating the patient's work environment and evaluating his medical history, we concluded that his encephalopathy was caused by CO exposure during CO₂ arc welding. Thus CO₂ arc welders must be aware of the risk of CO poisoning and strive to avoid CO exposure.

• 대한방사선방어학회:학술대회논문집
• /
• 대한방사선방어학회 2009년도 추계 학술발표
• /
• pp.208-209
• /
• 2009

• 한국버섯학회지
• /
• 제2권2호
• /
• pp.45-48
• /
• 2004

The effect of $CO_2$ concentration (500, 3,000, $6,000{\mu}{\ell}/{\ell}$) on the mycelial growth and fruit body primordium formation of Ganoderma lucidum on nutrient agar medium was examined. Optimum $CO_2$ concentration for vegetative growth was above $3,000{\mu}{\ell}/{\ell}$. Fruit body initiation was accelerated at higher than $3,000{\mu}{\ell}/{\ell}$ $CO_2$ exposure but the maximum number and size of primordia, and primordium color were not influenced by $CO_2$ concentrations. Whereas each atypical fruiting structure forming stock culture showed different fruiting time under each concentration of $CO_2$ exposure.

• 한국대기환경학회지
• /
• 제6권1호
• /
• pp.97-102
• /
• 1990

A pilot field study was conducted to measure indoor and personal exposure to carbon monoxide (CO) levels using personal monitors from January to February in 1989. The principal objectives of the study was to design and evaluate the research protocol and the instrumentation performance for application to the conduct of a large-scale personal monitoring program. The mean CO concentrations in kitchen and in bedroom were 23.4 and 11.9 ppm, respectively, while mean concentration of personal CO exposure was 18.9 ppm. It was found that the mean CO concentrations in kitchen exceeded 20 ppm of the Korea ambient CO standard(8-hr average) not to be exceeded more than three times per year. The results suggest that indoor CO levels in Korean houses appear to be affected by use of coal briquette for heating any cooking.

• Toxicological Research
• /
• 제34권3호
• /
• pp.211-220
• /
• 2018

Early life exposure to aflatoxin B1 (AFB1) and low protein diet through complementary foods during weaning is common in parts of Africa and Asia. This study evaluated the effect of co-exposure to AFB1 and low protein diet on the extrahepatic tissues of rats. Twenty-four three-week old weanling male albino rats were used for this study and were randomly assigned into four groups: group 1 served as control and was fed normal protein diet (20% protein), group 2 was fed low protein diet (5% protein), group 3 was fed normal protein diet + 40 ppb AFB1 while group 4 received low protein diet + 40 ppb AFB1, all for eight weeks. Afterward, biomarkers of anemia (packed cell volume (PCV), hemoglobin) and kidney function (urea, uric acid, and creatinine) were determined in the blood while biomarkers of oxidative stress were determined in the tissues spectrophotometrically. Co-exposure to AFB1 and low protein diet significantly (p < 0.05) decreased body weight gain and PCV, increased biomarkers of kidney functions and induced oxidative stress in the tissues studied. There was significant (p < 0.05) reduction in glutathione concentration while TBARS was significantly increased in the tissues. Co-exposure to AFB1 and low protein diet had additive effects on decreasing the weight gain and potentiation effect of kidney dysfunction in the rats. The co-exposure also decreased antioxidant enzymes and increased oxidant status in the tissues. Our results demonstrate that this co-exposure has deleterious health effects on extrahepatic tissues and should be a public health concern especially in developing countries where AFB1 contamination is common.

• Journal of Preventive Medicine and Public Health
• /
• 제24권4호
• /
• pp.507-515
• /
• 1991

백서 주령이 일산화탄소(CO) 폭로후 carboxyhemoglobin (HbCO) 형성 및 해리에 미치는 영향을 관찰하기 위하여 주령 1주, 2주, 6주 및 10주의 Sprague-Dawley계 백서에 일산화탄소를 폭로시킨 후 HbCO를 측정하여 다음과 같은 결론을 얻었다. 1. CO에 급성으로 폭로된 후 형성되는 HbCO의 농도는 백서 주령에 따라 유의한 차이를 보였으며, 이는 1주군에서 현저히 높았고, 폭로후 120분이 경과되어도 다른 주령군에 비하여 유의하게 높았다. 2. CO에 폭로되지 않은 백서에서의 HbCO농도는 각 주령군마다 유의한 차이를 보였으며, 비폭로군에서 얻어진 주령별 평균 HbCO농도를 CO폭로후 얻어진 개개의 관측치에서 뺀 후 이를 비교한 결과 1.에서와 같은 차이를 보이지 않았다. 3. CO폭로후 경과시간과 HbCO 농도와의 관계를 알아보는 회귀분석에서 폭로후 경과시간은 HbCO농도에 유의한 영향을 미치며, HbCO가 해리되는 속도는 주령 1주군에서 유의하게 높았다.