• Molecules and Cells
• /
• v.43 no.2
• /
• pp.198-202
• /
• 2020

Comprehensive inhibition of RUNX1, RUNX2, and RUNX3 led to marked cell suppression compared with inhibition of RUNX1 alone, clarifying that the RUNX family members are important for proliferation and maintenance of diverse cancers, and "cluster regulation of RUNX (CROX)" is a very effective strategy to suppress cancer cells. Recent studies reported by us and other groups suggested that wild-type RUNX1 is needed for survival and proliferation of certain types of leukemia, lung cancer, gastric cancer, etc. and for their one of metastatic target sites such as born marrow endothelial niche, suggesting that RUNX1 often functions oncogenic manners in cancer cells. In this review, we describe the significance and paradoxical requirement of RUNX1 tumor suppressor in leukemia and even solid cancers based on recent our findings such as "genetic compensation of RUNX family transcription factors (the compensation mechanism for the total level of RUNX family protein expression)", "RUNX1 inhibition-induced inhibitory effects on leukemia cells and on solid cancers through p53 activation", and "autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells". Taken together, these findings identify a crucial role for the RUNX cluster in the maintenance and progression of cancers and suggest that modulation of the RUNX cluster using the pyrrole-imidazole polyamide gene-switch technology is a potential novel therapeutic approach to control cancers.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.50 no.1
• /
• pp.51-63
• /
• 2013

Recently with base apply MANET with the application for the service discovery and delivery which are various techniques are being proposed the result of such MANET base research techniques from actual inside. This dissertation proposes T-Chord(Trustworthy-based Chord) Ring system for MANET to guarantees from such requirements. T-Chord Ring system in order to manage Efficiently the services which the mobile nodes provide is the service discovery system which uses P2P overlay network Technique in mobile environment. The system which is proposed MANET communications in order to accomplish a service discovery operation with physical network class and logical network class will be able to minimize problems from about MANET service discoveries, and uses the dispersive hash table technique for a service discovery and effectiveness of service discovery improves and will be able to guarantee the expandability of network size. The mobile nodes(mobile device) have a mobility from MANET and operate with service request node, service provide node and service transmit node. The mobile nodes will be able to elect cluster header using Trustworthy that was evaluated service request, provision and delivery in each other. The system which is proposed a service discovery and a delivery efficiently will compose the cluster head which will grow of P2P overlay networks and will be able to accomplish. The system which proposes from dissertation is composed of Trustworthy evaluations of MANET mobile nodes, service information collection which is dispersed and P2P overlay networks that composed of Chord algorithm modules which provide O(Log N) efficiencies. The system comparison evaluation analyzes an efficiency from the expandability side of effectiveness and the network of service discovery technique and the service discovery message over head, service discovery and delivery of former times and service discovery and delivery is excellent gives proof from MANET.

• Korean Journal of Medicinal Crop Science
• /
• v.10 no.5
• /
• pp.333-339
• /
• 2002

This study was conducted to obtain the basic data for practical use of the Polygonatum genetic resources. The 20 collections were analyzed by principal component analysis of 8 characters and cluster analysis. In the principal analysis, the first, the second and the third components contributed 54.10%, 18.95% and 11.62% of the variations, respectively. The cumulative contribution from the first to the third principal components was 84.68%. The first principal component was related to shape and size of plant, and assimilatory, reserve and reproductive organs. The second principal component was related to growth and development of plant, and reserve organ. And the third principal component was related to growth and development of plant. Based on cluster analysis, the 20 collections were classified into 4 distinct groups with the average distance greater than 0.7 between groups. Group I was Polygonatum sibiricum $D_{ELAR}$ and Group II included P. odoratum var. pluriflorum $O_{HWI}$, P. odoratum var. pluriflorum $O_{HWI}$ for 'Variegatum' Y. Lee, for. nov., P. odoratum var. thunbergii $H_{ARA}$ and P. odoratum var. maximowiczii $K_{OIDZ}$. GroupIII was P. involucratum $M_{AXIM}$, P. desoulavyi $K_{OMAROV}$ and P. humile $F_{ISHER}$ ex. $M_{AXIM}$. And GroupIV included P. lasianthum var. coreanum $N_{AKAI}$ and P. inflatum $K_{OMAROV}$.

• Korean Journal of Biological Psychiatry
• /
• v.25 no.2
• /
• pp.38-43
• /
• 2018

Objectives Dopamine dysregulation has been regarded as one of the core pathologies in patients with schizophrenia. Since dopamine synthesis capacity has found to be inconsistent in patients with schizophrenia, current classification of patients based on clinical symptoms cannot reflect the neurochemical heterogeneity of the disease. Here we performed new subtyping of patients with first-episode psychosis (FEP) through biotype-based cluster analysis. We specifically suggested basal ganglia structural changes as a biotype, which deeply involves in the dopaminergic circuit. Methods Forty FEP and 40 demographically matched healthy participants underwent 3T T1 MRI. Whole brain parcellation was conducted, and volumes of total 6 regions of basal ganglia have been extracted as features for cluster analysis. We used K-means clustering, and external validation was conducted with Positive and Negative Syndrome Scale (PANSS). Results K-means clustering divided 40 FEP subjects into 2 clusters. Cluster 1 (n = 25) showed substantial volume decrease in 4 regions of basal ganglia compared to Cluster 2 (n = 15). Cluster 1 showed higher positive scales of PANSS compared with Cluster 2 (F = 2.333, p = 0.025). Compared to healthy controls, Cluster 1 showed smaller volumes in 4 regions, whereas Cluster 2 showed larger volumes in 3 regions. Conclusions Two subgroups have been found by cluster analysis, which showed a distinct difference in volume patterns of basal ganglia structures and positive symptom severity. The result possibly reflects the neurobiological heterogeneity of schizophrenia. Thus, the current study supports the importance of paradigm shift toward biotype-based diagnosis, instead of phenotype, for future precision psychiatry.

• Membrane and Water Treatment
• /
• v.13 no.5
• /
• pp.245-257
• /
• 2022

Water quality characteristics and their spatial variations in the Nakdong River were statistically analyzed by multivariate techniques including correlation analysis, CA, and FA/PCA based on water quality parameters for 17 sites over 2017-2019, yielding PI values for primary factors. Site 10 indicated the highest parameter concentrations, and results of pearson's correlation analysis suggest that non-biodegradable organic matter had been distributed on the site. Five clusters were identified in order of descending pollution levels: I (Ib > Ia) > II (IIa > IIb) > III. Spatial variations started from sub-cluster Ib in which Daegu city and Geumho-river are joined. T-P, PO4-P, SS, COD, and TOC corresponded to VF 1 and 2, which were found to be principal components with strong influence on water quality. Sub-cluster Ib was strongly influenced by NO3-N and T-N compared to other clusters. According to the PIs, water quality pollution deteriorated due to non-biodegradable organic matter, nitrogen- and phosphorus-based nutrient salts in the middle and lower reaches, illustrating worsening water pollution due to inflows of anthropogenic sources on the Geumho-river, i.e., sewage and wastewater, discharged from Site 10, at which there is a concentration of urban, agricultural, and industrial areas.

• Journal of Nutrition and Health
• /
• v.56 no.2
• /
• pp.203-216
• /
• 2023

Purpose: This study examines the weight control behavior depending on university students' motives of using social media. Methods: The participants were 447 university students in the Jeonbuk area. Collected data were analyzed using factor analysis, cluster analysis, analysis of variance, and χ² tests with SPSS v. 26.0. Considering the motives of using social media, we investigated the usage of social media, dietary behavior related to social media, and weight control behavior. Results: Using the K-clustering method, the motives to use social media were categorized into three clusters: cluster 1 was the interest-centered group, cluster 2 was the multipurpose information-seeking group, and cluster 3 was the relationship-centered group. Among the various social media sites, YouTube (86.8%), Instagram (76.1%), and Facebook (61.1%) were the most visited by the subjects. The dietary behavior related to social media in cluster 2 was significantly higher than clusters 1 and 3 (p < 0.001). Clusters 1 and 2 showed a significantly higher dissatisfaction with one's weight (p < 0.05) and consequent interest in weight control than cluster 3 (p < 0.001). Cluster 2 used weight control-related information from social media significantly more than other clusters (p < 0.05). Weight control experiences in cluster 1 and 2 were significantly higher than in cluster 3 (p < 0.001). Conclusion: Differences in dietary behavior related to social media and weight control behavior were observed between cluster types of motivation to use social media. Based on the usage motives of university students and their behaviors, we propose that educational programs should be conducted for weight control using social media.

• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.15 no.3
• /
• pp.360-370
• /
• 2008

Purpose: This study was done to identify factors (pain stress, perceived stress, pain disability, fatigue, depression) strategies used by elders to cope with pain based on their type of pain belief. Method: Data were collected from 314 elders in community settings in Seoul from September to December of 2007. Cluster analysis, t-test, and ANOVA were used to analyze data. Result: The types of pain belief were classified as the following groups: Self-blame, Enduring & Mysterious, and Short-term & Understandable. Perceived stress (t=2.36, p=.02), social support (t=2.24, p=.03), extent of pain relief (t=2.39, p=.02), and duration of pain relief (t=2.09, p=.04) were important factors for active and passive coping in the Self-blame group. Pain stress (t=2.39, p=.01) and depression (t=-3.99, p=.00) were significantly related to the active coping in the Enduring & Mysterious group. Perceived stress (t=2.55, p=.01) was an important factor in the passive coping in the Short-term & Understandable group. Conclusion: Considering different types of pain belief in elders and factors that are significantly related to different coping strategies, future nursing interventions should be population specific to encourage active coping strategies and to decrease passive coping strategies.

• Journal of Microbiology
• /
• v.40 no.3
• /
• pp.211-218
• /
• 2002

A 4.8-kb DNA fragment encoding the P-450 type hydroxylase and ferredoxin genes was cloned from Pseudonocardia autotrophica IFO 12743 that can convert vitamin D$\_$3/ into its hydroxylated active forms. In order to isolate the P-450 gene cluster in this organism, we designed PCR primers on the basis of the regions of an oxygen binding site and a heme ligand pocket that are general characteristics of the P-450 hydroxylase. Sequencing analysis of the BamHI fragment revealed the presence of four complete and one incomplete ORFs, named PauA, PauB, PauC, and PauD, respectively. As a result of computer-based analyses, PauA and PauB have homology with enoyl-CoA hydratase from several organisms and the positive regulators belonging to the tetR family, respectively. PauC and PauD show similarity with SuaB/C proteins and ferredoxins, respectively, which are composed of P-450 monooxygenase systems for metabolizing two sulfonylurea herbicides in Streptomyces griseolus PauC shows the highest similarity with another CytP-450$\_$Sca2/ protein that is responsible for production of a specific HMG-CoA reductase inhibitor, pravastatin, in S. carbophilus. Cultures of Steptomyces lividans transformant, containing the P-450 gene cluster on the pWHM3 plasmid, was unable to convert vitamin D$\_$3/ to its hydroxylated forms.

• KIPS Transactions on Computer and Communication Systems
• /
• v.3 no.3
• /
• pp.81-86
• /
• 2014

According to the development of streaming services with P2P and mobile network technologies, researches to enhance the service quality in mobile environment have been proposed. However, streaming services considering high-speed mobile environment and characteristics of heterogenous terminals have been hindered from being provided with the required quality from user because of bandwidth congestion between selfish peers of existing P2P system. It is also prone to long delay and loss in accordance with the repeated traffic amounts because there are no optimized solution for traffic localization. The structure to enhance peer contribution for service differentiation and peer selection with clustering scheme with location information of terminal can satisfy both users and service providers with service quality and efficiency. In this paper, we propose an incentive mechanism and resource distribution scheme with user contribution and traffic cost information based on user location, which make mobile users increase the satisfaction of service quality in LTE environments.

• Journal of Internet Computing and Services
• /
• v.10 no.4
• /
• pp.189-198
• /
• 2009

Unstructured peer-to-peer systems are most commonly used in today's internet. But file placement is random in these systems and no correlation exists between peers and their contents. There is no guarantee that flooding queries will find the desired data. In this paper, we propose to cluster nodes in unstructured P2P systems using the agglomerative hierarchical clustering algorithm to improve the search method. We compared the delay time of clustering the nodes between our proposed algorithm and the k-means clustering algorithm. We also simulated the delay time of locating data in a network topology and recorded the overhead of the system using our proposed algorithm, k-means clustering, and without clustering. Simulation results show that the delay time of our proposed algorithm is shorter compared to other methods and resource overhead is also reduced.