• Interdisciplinary Bio Central
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• 제2권3호
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• 전자공학회논문지SC
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• 제48권5호
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• pp.45-51
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• 2011

본 논문에서는 비교사학습법을 통해 영상의 방대한 정보를 효율적으로 모델링 하는 방법을 제안하고자 한다. 여기서 이동궤적들은 자연어 처리에 사용되는 알고리즘인 잠재 디리클레 할당 모형(Latent Dirichlet Allocation)에 의해 직진, 좌회전, 우회전등 각 상황 별로 주제에 따라 그 영역을 효과적으로 분류할 수 있다. LDA를 이용해 주제별로 의미 있는 영역을 분류한 후, 각 주제별로 분류된 궤적을 관측열로 보고 은닉 마르코프 모델(Hidden Markov Model)의 바움-웰치 알고리즘을 사용하여 학습한다. 전향 알고리즘을 사용하여 입력된 행동과 학습된 행동을 비교함으로써 영상내의 행동이 정상인지 비정상인지를 효과적으로 판단할 수 있다. 실험결과 다양한 영상에 대해 의미있는 주제별로 영역이 잘 분류되며 추적에러로 인한 궤적의 노이즈에도 강인하게 물체의 무단횡단, 신호위반과 같은 상황을 효과적으로 탐지하는 것을 확인할 수 있다.

• 대한가정학회지
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• 제45권3호
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• pp.109-120
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• 2007

The purposes of this study were to provide evidence concerning the effects of Emotional Leadership and examine the impacts of Emotional Leadership on employee-related variables which were 'job satisfaction', 'organizational commitment', 'organizational performance', 'turnover intention'. A survey was conducted from August 23 to November 3, 2005 to collect data from kitchen staff(N=611). Statistical analyses were completed using SPSS Win(12.0) for descriptive analysis, reliability analysis, factor analysis, t-test, correlation analysis, cluster analysis and AMOS(5.0) for structural equation modeling. Kitchen staffs gave high point to their leader in the Emotional Leadership competence 'Optimism: seeing the upside in events' and 'Adaptability: flexibility in handing change' and gave lower point in the Emotional Leadership competence 'Inspirational leadership: guiding and motivating with compelling vision'. Employees' job satisfaction on 'coworker' were relatively high. However, the extents of satisfaction on 'payroll', 'promotion', 'work environment' were relatively low. The organizational commitment score was higher at 'loyalty' factor than 'commitment' factor. the test of hypothesis using structural equation modeling found that Emotional Leadership produced positive effects on job attitude and job performance. In conclusion, this study has identified that the Emotional Leadership effects on their organizational performance and attitudes toward their job.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5493-5498
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• 2015

Due to the lack of nationwide population-based cancer registration, the total cancer prevalence in Iran is unknown. Our previous work in which we used a basic network scale-up (NSU) method, failed to provide plausible estimates of total cancer prevalence in Kerman. The aim of the present study was to estimate total and partial prevalence of cancer in southeastern Iran using an adapted version of the generalized network scale-up method. A survey was conducted in 2014 using multi-stage cluster sampling. A total of 1995 face-to-face gender-matched interviews were performed based on an adapted version of the NSU questionnaire. Interviewees were asked about their family cancer history. Total and partial prevalence were estimated using a generalized NSU estimator. The Monte Carlo method was adopted for the estimation of upper/lower bounds of the uncertainty range of point estimates. One-yr, 2-3 yr, and 4-5 yr prevalence (per 100,000 people) was respectively estimated at 78 (95%CI, 66, 90), 128 (95%CI, 118, 147), and 59 (95%CI, 49, 70) for women, and 48 (95%CI, 38, 58), 78 (95%CI, 66, 91), and 42 (95%CI, 32, 52) for men. The 5-yr prevalence of all cancers was estimated at 0.18 percent for men, and 0.27 percent for women. This study showed that the generalized familial network scale-up method is capable of estimating cancer prevalence, with acceptable precision.

• 방송공학회논문지
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• 제25권5호
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• pp.734-741
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• 2020

본 논문은 인간과 공존하고 커뮤니케이션하며, 인간에게 심리적 안전거리(사회적 거리) 침해에 따른 스트레스를 유발하지 않는 소셜로봇을 위한 새로운 보행자 회피 알고리즘을 제안한다. 보행자 모델을 새롭게 정의하기 위해 보행자의 걸음걸이 특성(직진성, 속도)에 따라 보행자를 클러스터링하며 보행자 클러스터별 사회적 거리를 정의한다. 정의된 사회적 거리를 포함하도록 보행자(장애물) 모델링을 하고, 새롭게 정의된 보행자 모델에 상용화된 장애물 회피, 경로계획 알고리즘을 적용해 통합된 주행 알고리즘을 완성한다. 새로운 알고리즘의 효과를 검증하기 위해, 상용화된 대표적 두가지 장애물회피 경로계획 알고리즘인 DWA 알고리즘과 TEB 알고리즘을 활용한다. 본 논문의 핵심 알고리즘인 새로운 보행자 모델을 적용한 경우와 적용하지 않은 경우로 구분하여 그 효용성을 평가한다. 그 결과, 새롭게 제안된 알고리즘이 이동시간의 손실 없이 보행자의 스트레스 지수를 현격하게 줄일 수 있음을 보인다.

• 정보처리학회논문지D
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• 제11D권3호
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• pp.717-730
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• 2004

최근 들어 원 사이트 개인화(Web Personalization)에 관한 연구가 활발히 진행되고 있다. 웹 개인화는 클러스터링과 같은 데이터 마이닝 기법을 이용하여 가 사용자에게 가장 흥미를 가질만한 URL 집합을 예측하는 것이라 할 수 있다. 기존의 클러스터링을 이용한 방식에서는 웹 트랜잭션들을 웹 사이트의 각 URL들에 방문했는지 안했는지를 나타내는 비트 벡터(bit vector)로 표현하였다. 그리고 이들 비트 벡터의 방문 패턴이 일치하는 정도에 따라 유사성을 결정하였다. 하지간 이것은 유사한 성향을 가지는 웹 트랜잭션을 클러스터링 하는데 있어 사용자의 흥미를 배제하고 단순히 방문 여부만을 반영하게 되는 문제점이 발생하게 된다. 즉 방문 목적 또는 성향이 유사하지 않은 웹 트랜잭션들을 같은 그룹으로 분류할 가능성이 존재하게 된다 이에 본 논문에서는 기존의 비트 벡터를 이용한 트랜잭션 모델을 사용자의 흥미도(Interestingness)를 반영할 수 있도록 보완하여 새로운 점 트랜잭션 모델을 제시하고 흥미가중치를 적용한 유사도 비교방법을 제안한다. 그리고 성능평가를 통하여 제안만 방법이 기졸 방법에 비해 클러스터링의 정확성을 높임을 보인다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2010년도 학술발표회
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• pp.268-272
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• 2010

The research presented here represents a collaborative effort with the SFWMD on developing scenarios for future climate for the SFWMD area. The project focuses on developing methodology for simulating precipitation representing both natural quasi-oscillatory modes of variability in these climate variables and also the secular trends projected by the IPCC scenarios that are publicly available. This study specifically provides the results for precipitation modeling. The starting point for the modeling was the work of Tebaldi et al that is considered one of the benchmarks for bias correction and model combination in this context. This model was extended in the framework of a Hierarchical Bayesian Model (HBM) to formally and simultaneously consider biases between the models and observations over the historical period and trends in the observations and models out to the end of the 21st century in line with the different ensemble model simulations from the IPCC scenarios. The low frequency variability is modeled using the previously developed Wavelet Autoregressive Model (WARM), with a correction to preserve the variance associated with the full series from the HBM projections. The assumption here is that there is no useful information in the IPCC models as to the change in the low frequency variability of the regional, seasonal precipitation. This assumption is based on a preliminary analysis of these models historical and future output. Thus, preserving the low frequency structure from the historical series into the future emerges as a pragmatic goal. We find that there are significant biases between the observations and the base case scenarios for precipitation. The biases vary across models, and are shrunk using posterior maximum likelihood to allow some models to depart from the central tendency while allowing others to cluster and reduce biases by averaging. The projected changes in the future precipitation are small compared to the bias between model base run and observations and also relative to the inter-annual and decadal variability in the precipitation.

• 한국농공학회지
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• 제26권2호
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• pp.106-124
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• 1984

Monthly streanflow of watersheds is one of the most important elements for the planning, design, and management of water resources development projects, e.g., determination of storage requirement of reservoirs and control of release-water in lowflow rivers. Modeling of longterm runoff is theoretically based on water-balance analysis for a certain time interval. The effect of the casual factors of rainfall, evaporation, and soil-moisture storage on streamflow might be explained by multiple regression analysis. Using the basic concepts of water-balance and regression analysis, it was possible to develop a generalized model called the Regionalized Regression Model for Monthly Streamflow in Korean Watersheds. Based on model verification, it is felt that the model can be reliably applied to any proposed station in Korean watersheds to estimate monthly streamflow for the planning, design, and management of water resources development projects, especially those involving irrigation. Modeling processes and properties are summarized as follows; 1. From a simplified equation of water-balance on a watershed a regression model for monthly streamflow using the variables of rainfall, pan evaporation, and previous-month streamflow was formulated. 2. The hydrologic response of a watershed was represented lumpedly, qualitatively, and deductively using the regression coefficients of the water-balance regression model. 3. Regionalization was carried out to classify 33 watersheds on the basis of similarity through cluster analysis and resulted in 4 regional groups. 4. Prediction equations for the regional coefficients were derived from the stepwise regression analysis of watershed characteristics. It was also possible to explain geographic influences on streamflow through those prediction equations. 5. A model requiring the simple input of the data for rainfall, pan evaporation, and geographic factors was developed to estimate monthly streamflow at ungaged stations. The results of evaluating the performance of the model generally satisfactory.

• 한국재난정보학회 논문집
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• 제18권4호
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• pp.891-898
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• 2022

연구목적: 건설산업의 전 분야 및 전 단계에 대한 BIM 도입 의무화가 머지않아 시행될 만큼 BIM 업무의 실질적인 생산성 향상을 위한 기술 확보 방안이 필요하기 때문에 연구에서는 엔지니어가 BIM기반 설계 과정에서 건설기준을 검증할 수 있도록 BIM 모델링 절차별로 제작되는 주요 객체에 대해 자동으로 관련 건설기준을 검증할 수 있는 방안을 제시하였다. 연구방법: BIM기반 도로 설계 업무를 대상으로 모델링 업무 절차를 정의하고, 각 단계에서 도출되는 BIM 모델별로 관련 설계기준을 데이터베이스로 구축하는 방안을 마련하였다. 그리고 BIM기반 설계기준 검토 자동화 시스템 개발을 위한 프로세스도 제시하였다. 연구결과: Civil3D 및 Dynamo를 활용하여 BIM기반 설계기준 검토 자동화 모듈을 개발하고, 시범적용을 통해 설계과정에서 제작되는 BIM 객체의 건설설계기준 충족여부를 자동으로 신속하게 제공할 수 있음을 확인하였다. 결론: BIM기반 설계기준 검토 자동화 기술은 BIM 모델 제작 업무의 생산성 향상과 BIM 모델의 품질확보가 가능하다.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2008년도 추계학술논문발표회 논문집
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• pp.165-172
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• 2008

위험물저장 탱크기초의 결함으로 인한 인화성물질의 유출사고는 산업단지의 대형화재를 야기시킬 수 있으므로 탱크기초의 설계 및 시공단계에서 세심한 주의를 기울여야 한다. 본 연구에서는 위험물저장탱크 기초의 설계 및 시공 가이드라인을 제시하기 위하여, 대표적인 탱크기초 유형을 분류하고 각 유형에 따른 대표단면을 모델링한 수치해석(3D FEM)을 수행하였으며, 수치해석 결과로 나타난 탱크기초의 응력 및 침하분포를 비교 평가하여 각 기초 유형별로 위험물저장탱크 설계 및 시공단계에서 유의 하여야할 사항을 검토하였다.