• Archives of Plastic Surgery
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• v.35 no.2
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• pp.121-126
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• 2008

Purpose: Poly-N-acetyl glucosamine(PGlcNAc) nanofiber-based materials, produced by a marine microalga, have been characterized as effective hemostatic and angiogenic agents. The similarity between PGlcNAc patch and the natural extracellular matrix allows it to support new healthy tissue growth in an injured area and to encourage fluid absorption. In this study, we hypothesized that a poly-N-acetyl glucosamine fiber patch(PGlcNAc patch) may enhance wound healing in the db/db mouse. Methods: PGlcNAc patches were applied on one square centimeter, full-thickness, skin wounds in the db/db mouse model. Wounds(n=15 per group) were dressed with a PGlcNAc nanofiber patch for 1 hour(1 h), 24 hours(24 h) or left untreated(NT). After the application time, patches were removed and wounds were allowed to heal spontaneously. The rate of wound closure was evaluated by digital analysis of unclosed wound area in course of time. At day 10, wounds(n=7 per group) were harvested and quantified with immunohistochemical markers of proliferation(Ki-67) and vascularization (platelet endothelial cell adhesion molecule, PECAM-1). Results: Wounds dressed with PGlcNAc patches for 1 hour closed faster than control wounds, reaching 90% closure in 16.6 days, nine days faster than untreated wounds. Granulation tissue showed higher levels of proliferation and vascularization following 1 h treatment than the 24 h and NT groups. In addition to its hemostatic properties, the PGlcNAc material also appears to accelerate wound closure in healing-impaired genetically diabetic mice. Conclusion: This material, with its combination of hemostatic and wound healing properties, has the potential to be effective agent for the treatment of complicated wounds.

• Journal of KIISE:Databases
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• v.37 no.4
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• pp.197-202
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• 2010

Recent studies on change detection for RDF data are focused on not only the structural difference but also the semantic-aware difference by computing the closure of RDF models. However, since these techniques which take into account the semantics of RDF model require both RDF models to be memory resident, or they use a forward-chaining strategy which computes the entire closure in advance, it is not efficient to apply them directly to detect changes in large RDF data. In this paper, we propose a scalable change detection technique for RDF data, which uses a backward-chaining inference based on relational database. Proposed method uses a new approach for RDF reasoning that computes only the relevant part of the closure for change detection in a relational database. We show that our method clearly outperforms the previous works through experiment using the real RDF from the bioinformatics domain.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.165-176
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• 2015

A numerical analysis was conducted to investigate the inlet buzz and combustion oscillation in an axisymmetric ramjet engine with wedge-type flame holders. The physical model of concern includes the entire engine flow path, extending from the leading edge of the inlet center-body through the exhaust nozzle. The theoretical formulation is based on the Farve-averaged conservation equations of mass, momentum, energy, and species concentration, and accommodates finite-rate chemical kinetics and variable thermo-physical properties. Turbulence closure is achieved using a combined scheme comprising of a low-Reynolds number k-${\varepsilon}$ two-equation model and Sarkar's compressible turbulence model. Detailed flow phenomena such as inlet flow aerodynamics, flame evolution, and acoustic excitation as well as their interactions, are investigated. Mechanisms responsible for driving the inlet buzz are identified and quantified for the engine operating at subcritical conditions.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.81-86
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• 2001

Interfacial pressure jump terms based on the physics of phasic interface and bubble dynamics are introduced into the momentum equations of the two-fluid model for bubbly flow. The pressure discontinuity across the phasic interface due to the surface tension force is expressed as the function of fluid bulk moduli and bubble radius. The consequence is that we obtain from the system of equations the real eigenvalues representing the void-fraction propagation speed and the pressure wave speed in terms of the bubble diameter. Inversely, we obtain an analytic closure relation for the radius of bubbles in the bubbly flow by using the kinematic wave speed given empirically in the literature. It is remarkable to see that the present mechanistic model using this practical bubble radius can indeed represent both the mathematical well-posedness and the physical wave speeds in the bubbly flow.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.55-58
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• 2009

Sodium polyacrylate based hydrogel patch was prepared and its wound healing efficacy in comparison with control groups was evaluated in thermal burn wound ($200^{\circ}C$, 10 sec burn) and excision wound rat model. Cytotoxicity of gamma irradiated (25 kGy) hydrogel patch was investigated in human fibroblasts and showed no significant cytotoxicity. Wound closure rates (H50%) in hydrogel patch group and BAND-$AID^{(R)}$ treated group were faster than that of control group (uncovered open wound). Hydrogel patch showed an enhancement in wound healing process.

• Journal of the Korean Society of Hazard Mitigation
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• v.4 no.2 s.13
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• pp.53-59
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• 2004

The mechanism of manhole bursting which occurs at excess rainfall events Is studied by using both the physical model and the numerical model (SWMM ; Storm Water Management Model). The result of numerical simulation to steep pressure rising agrees well with that of the physical model at the sewer system under surcharged flow. A cause of manhole bursting is an expansion and spout of the condensed all at manhole that results from the surcharged flow and press wave propagation caused by gate operation or closure of conduit at pumping station.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.7 s.94
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• pp.1668-1677
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• 1993

The objective of this paper is to develop a computational model for predicting the fatigue propagation of collinear multiple surface cracks under constant amplitude and variable amplitude loadings. After examining fatigue crack growth behavior for CT specimens and single surface crack specimens, empirical equations of(11) and(12) are proposed for the prediction of fatigue life in a multiple surface crack geometry. The accuracy of the proposed model is verified using a life prediction computer program. Several case studies were performed to check the accuracy of the proposed model and to verify the usefulness of the developed program. Good agreement is observed between the numerical results based on the proposed model and the published experimental data.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.6
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• pp.1541-1546
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• 1993

To extend the widely used Gibson and Launder's second order closure model to the low-Reynolds-number region near a wall, modifications have been made for velocity pressure-gradient interaction and dissipation terms in the stress equations, and also for the dissipation rate equation. From the computation of fully developed plane channel flow, it is found that the results with present model agree well with the data of direct numerical simulation in the predictions of stress components. And, the computed mean velocity profile coincides with the universal velocity law.

• Plant Journal
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• v.14 no.1
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• pp.42-46
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• 2018

The flow and heat transfer characteristics inside a solar chimney power plant system are analyzed in this article. 3-D model with the $k-{\varepsilon}$ turbulence closure was developed. In this model, to solve the radiative transfer equation the discrete ordinates radiation model was implemented, using a two-band radiation model. To simulate radiation effects from the sun's rays, the solar ray tracing algorithm was coupled to the calculation via a source term in the energy equation. Simulations were carried out for a system with the geometry parameters of the Manzanares power plant. Based on the numerical results, the velocity and temperature distributions were illustrated and the results were validated by comparing with experimental data of the Manzanares prototype power plant. Moreover, temperature profile of the ground surface of the system was illustrated.

• Journal of Ship and Ocean Technology
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• v.5 no.1
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• pp.38-54
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• 2001

A finite difference method for calculating turbulent flow and surface wave fields around a ship model is evaluated through the comparison with the experimental data of a Series 60 $C_B$=0.6 ship model. The method solves the Reynolds-averaged Navior-Stokes Equations using the non-staggered grid system, the four-stage Runge-Kutta scheme for the temporal integration of governing equations and the Bladwin-Lomax model for the turbulence closure. The free surface waves are captured by solving the equation of the kinematic free-surface condition using the Lax-Wendroff scheme and free-surface conforming grids are generated at each time step so that one of the grid surfaces coincides always with the free surface. The computational results show an overall close agreement with the experimental data and verify that the present method can simulate well the turbulent boundary layers and wakes as well as the free-surface waves.