• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.21 no.2
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• pp.121-127
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• 2010

Background and Objectives : Unilateral vocal fold paralysis is generally treated using injection laryngoplasty or voice therapy. However, the decision of treatment method is dependent on clinician's preference and hospital facilities without specific criteria. The purpose of the study was to examine factors predictive of voice therapy outcome in patients with unilateral vocal fold paralysis. Materials and Method : 38 patients diagnosed as unilateral vocal fold paralysis, aged from 24 to 81 years and undergone voice therapy more than 1 month were included. After 3 to 12 (mean 5.1) sessions of voice therapy, subjects had divided into responder group (RG, 28 patients) and non-responder group (NRG, 10 patients) according to G scale change. Paramters of perceptual assessment, acoustic and aerodynamic measure, and videostroboscopy were compared between two groups, and factors predictive of voice therapy result were analyzed. Results : RG patients showed significantly reduced rough, breathy, asthenic voice after voice therapy. Change of MPT and MFR was more substantial in RG than in NRG. By videostroboscopy, RG patients showed significantly more mucosal wave symmetry, glottal closure, reduced glottal gap index during the closed phase of phonation, while NRG patients showed more occurrences of abnomal supraglottic activities during phonation (p < 0.05). Poor outcome of voice therapy significantly associated with increased asthenic scale, short MPT, and less glottal closure (p=0.02). In addition, 90% of patients with MPT more than 5 seconds were in RG, whereas 56% of patients with MPT less than 5 secondes were in RG. Conclusion : Voice therapy is useful for large proportion of patients with unilateral vocal fold paralysis as an initial treatment method. However, patients with large asthenia scale, large glottic gap or MPT less than 5 seconds tend to have poor voice therapy outcome, and early injection laryngoplasty maybe recommended for these patients.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.9 no.1
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• pp.30-35
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• 2013

The four principles of treatment of odontogenic infection are as follows : (1) removal of the cause, (2) establishment of drainage, (3) institution of antibiotic therapy, and (4) provision of supportive care, including proper rest and nutrition. A separate incision is required to establish drainage, especially in the case of extensive fascial space infections. There are four principle causes for active bleeding in the immediate incision & drainage phase; (1) vascular wall alteration (infection, scurvy, chemicals), (2) disorder of platelet function, (3) thrombocytopenic purpuras, (4) disorders of coagulation (liver disease, anticoagulation drug). If the hemorrhage from incision & drainage site is aggressive, the site must be packed with proper wet gauze and wound closure & drainage dressing are applied. The specific causes of bleeding may be associated with hypoxia, changes in the pH of blood & chemical changes affecting vascular contractility and blood clotting. This is a case report of bleeding control by the circumferential suture & drainage on active bleeding incision & drainage site of temporal space abscess due to advanced odontogenic infection in a multiple medically compromised disabled patient.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.3
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• pp.215-226
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• 2017

This paper presents numerical results of the performance of a marin propeller in cavitating and non-cavitating flow conditions. The geometry and experimental validation data of the propeller are provided in Potsdam Propeller Test Case(PPTC) in the framework of the second International Symposium on Marine Propulsors 2011(SMP'11) workshop. The PPTC includes open water tests, velocity field measurements and cavitation tests. The present numerical analysis was carried out by using the Reynolds averaged Navier-Stokes(RANS) method on a wall-resolved grid ensuring a y+=1, where the SST k-${\omega}$ model was mainly used for turbulence closure. The influence of the turbulence model was investigated in the prediction of the wake field under a non-cavitating flow condition. The propeller tip vortex flows in both cavitating and non-cavitating conditions were captured through adaptation of additional grids. For the cavitation flows at three operation points, Schnerr-Sauer's cavitation model was used with a Volume-Of Fluid(VOF) approach to capture the two-phase flows. The present numerical results for the propeller wake and cavitation predictions including the open water performance showed a qualitatively reasonable agreement with the model test results.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.6
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• pp.431-436
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• 2009

There are five principal causes for excessive bleeding in the immediate postextraction phase ; (1) Vascular wall alteration (wound infection, scurvy, chemicals, allergy) (2) Disorders of platelet function (genetic defect, drug-aspirin, autoimmune disease) (3) Thrombocytopenic purpuras (radiation, leukemia), (4) Inherited disorders of coagulation (hemophilia, Christmas disease, vitamin deficiency, anticoagulation drug-heparin, coumarin). If the hemorrhage from postextraction wound is unusually aggressive, and then dehydration and airway problem are occurred, the socket must be packed with gelatine sponge(Gelfoam) that was moistened with thrombin and wound closure & pressure dressing are applied. The thrombin clots fibrinogen to produce rapid hemostasis. Gelatine sponges moistened with thrombin provide effective coagulation of hemorrhage from small veins and capillaries. But, in dental alveoli, gelatine sponges may absorb oral microorganisms and cause alveolar osteitis (infection). This is a case report of bleeding control by continuous rubber strip & iodoform gauze drainage (without gelfoam packing) of active bleeding infection sites of three teeth extraction wounds in a 46-years-old female patient with advanced liver cirrhosis.

• Journal of Microbiology and Biotechnology
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• v.27 no.1
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• pp.26-35
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• 2017

The hydrolysis of proteins constitutes an invaluable tool, granting access to a variety of peptide fragments with potentially interesting biological properties. Therefore, a hemoglobin (Hb) hydrolysate of Crocodylus siamensis was generated by digestion under acidic conditions. The antibacterial and antioxidant activities of the Hb hydrolysate were assessed in comparison with intact Hb. A disc diffusion assay revealed that the Hb hydrolysate exhibited antibacterial activity against eight strains of gram-positive bacteria and showed a higher efficacy than intact Hb. Moreover, the antioxidant activity of intact Hb and its hydrolysate was evaluated using ABTS and DPPH radical scavenging assays. The Hb hydrolysate exhibited free radical scavenging rates of 6-32%, whereas intact Hb showed a slightly higher activity. In addition, non-toxicity to human erythrocytes was observed after treatment with quantities of Hb hydrolysate up to $10{\mu}g$. Moreover, active fragmented Hb (P3) was obtained after purifying the Hb hydrolysate by reversed-phase HPLC. Scanning electron microscopy demonstrated the induction of bacterial cell membrane abnormalities after exposure to P3. Antibacterial and antioxidant activities play crucial roles for supporting the wound healing activity. Consequently, an in vivo mice excisional skin wound healing assay was carried out to investigate the effects of intact Hb treatment on wound healing in more detail. The results clearly demonstrate that intact Hb is capable of promoting 75% wound closure within 6 days. These findings imply that intact Hb of C. siamensis and its acid hydrolysate may serve as valuable precursors for food supplementary products benefitting human health.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.1
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• pp.111-117
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• 2010

A three-dimensional numerical model is employed to investigate wave deformation due to a submerged structure. The three-dimensional numerical model solves the spatially averaged Navier-Stokes equations for two-phase flows. The LES(large-eddy-simulation) approach is adopted to model the turbulence effect by using the Smagorinsky SGS(sub-grid scale) closure model. The two-step projection method is employed in the numerical solutions, aided by the Bi-CGSTAB technique to solve the pressure Poisson equation for the filtered pressure field. The second-order accurate VOF(volume-of-fluid) method is used to track the distorted and broken free surface. A simple linear wave is generated on a constant depth and compared with analytical solutions. The model is then applied to study wave deformation due to a submerged structure and the predicted results are compared with available laboratory measurements.

• Clinical and Experimental Pediatrics
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• v.51 no.4
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• pp.355-361
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• 2008

Pollen is very important causing factor for allergy such as allergic rhinitis, allergic conjunctivitis, and asthma, and pollen allergy has a remarkable clinical impact all over Korea. The main pollination period covers about half the year, from spring to autumn, and the distribution of airborne pollen taxa of allergological interest is related to pollen season dynamics. Korean academy of pediatric allergy and respiratory diseases (KAPARD) has evaluated the pollen characteristics and nationwide pollen count for over 10 years since 1997. Airborne particles carrying allergens were collected daily from nationwide 8 stations (Seoul, Guri, Cheongju, Daegu, Kwangju, Busan, Kangneung, and Jeju) by using 7 days-Burkard sampler (Burkard Manufacturing Co Ltd, Hertfordshire, UK) in South Korea (July 1, 1997-June 30, 2007). They were counted and recorded along with the meteorological factors daily. Tree pollen is a major airborne allergen in spring, grass is most common in summer, and weed pollen is major pollen in autumn in Korea. There has two peak seasons for pollen allergy, as summer and autumn. There is some evidence suggesting that the prevalence of allergic diseases in Korea has been on the increase in the past decade. However, recent findings of the phase I and II studies of the international Study of Asthma and Allergies in Childhood (ISAAC) study showed the absence of increases or little changes in prevalence of asthma symptoms and diagnosis rates in Korea, whereas the prevalence of allergic rhinitis and atopic dermatitis were increased. We reported the evidence that sensitization rate to weed pollen has been increased yearly since 1997 in childhood. Climate change and air pollution must be the major causing factors for the increase of pollen counts and sensitization rate to pollen. Climate change makes the plants earlier pollination and persisting pollination longer. In conclusion, data on pollen count and structure in the last few years, the pathogenetic role of pollen and the interaction between pollen and air pollutants with climate change gave new insights into the mechanism of respiratory allergic diseases in Korea.

• Proceedings of the KSRS Conference
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• v.1
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• pp.21-24
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• 2006

Processes controlling the interannual variation of mixed layer temperature (MLT) averaged over the NINO3 domain ($150-90^{\circ}W$, $5^{\circ}N-5^{\circ}S$) are studied using an ocean data assimilation product that covers the period of 1993 to 2003. Advective tendencies are estimated here as the temperature fluxes through the domain's boundaries, with the boundary temperature referenced to the domain-averaged temperature to remove the dependence on temperature scale. The overall balance is such that surface heat flux opposes the MLT change but horizontal advection and subsurface processes assist the change. The zonal advective tendency is caused primarily by large-scale advection of warm-pool water through the western boundary of the domain. The meridional advective tendency is contributed mostly by Ekman current advecting large-scale temperature anomalies though the southern boundary of the domain. Unlike many previous studies, we explicitly evaluate the subsurface processes that consist of vertical mixing and entrainment. In particular, a rigorous method to estimate entrainment allows an exact budget closure. The vertical mixing across the mixed layer (ML) base has a contribution in phase with the MLT change. The entrainment tendency due to temporal change in ML depth is negligible comparing to other subsurface processes. The entrainment tendency by vertical advection across the ML base is dominated by large-scale changes in wind-driven upwelling and temperature of upwelling water. Tropical instability waves (TIWs) result in smaller-scale vertical advection that warms the domain during La Ni? cooling events. When the advective tendencies are evaluated by spatially averaging the conventional local advective tendencies of temperature, the apparent effects of currents with spatial scales smaller than the domain (such as TIWs) become very important as they redistribute heat within the NINO3 domain. However, such internal redistribution of heat does not represent external processes that control the domain-averaged MLT.

• Journal of the Society of Naval Architects of Korea
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• v.45 no.1
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• pp.29-41
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• 2008

The present paper provides a CFD analysis of diffraction problem for a ship with forward speed using an unsteady RANS simulation method, a WAVIS code. The WAVIS viscous solver adopting a finite volume method has second order accuracy in time and field discretizaions for the RANS equations. A two phase level-set method and a realizable ${\kappa}-{\varepsilon}$ turbulence model are adopted to compute the free surface and to meet the turbulence closure, respectively. To validate the capability of the present numerical methods for the simulation of an unsteady progressive regular wave, computations are performed for three grid sets with refinement ratio of ${\sqrt{2}}$. The main simulation is performed for a DTMB5512 model with a forward speed in a regular head sea condition. Validation of the present numerical method is carried out by comparing the present CFD results with available unsteady experimental data published in the 2005 Tokyo CFD Workshop: resistance, heave force, pitch moment, unsteady free surface elevations and velocity fields.

• Journal of the Korea Society for Simulation
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• v.21 no.2
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• pp.19-30
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• 2012

In recent decades, it has been known that the Discrete Event System Specification, or DEVS, formalism provides sound semantics to design a modular and hierarchical model of a discrete event system. In spite of this benefit, practitioners have difficulties in applying the semantics to real-world systems modeling because DEVS needs to specify a large size of sets of events and/or states in an unstructured form. To resolve the difficulties, this paper proposes an extension of the DEVS formalism, called the Structured DEVS formalism, with an associated graphical representation, called the DEVS diagram, by means of structural representation of such sets based on closure property of set theory. The proposed formalism is proved to be equivalent to the original DEVS formalism in their model specification, yet the new formalism specifies sets in a structured form with a concept of phases, variables and ports. A simplified example of the structured DEVS with the DEVS diagram shows the effectiveness of the proposed formalism which can be easily implemented in an objected-oriented simulation environment.