• Advances in pediatric surgery
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• v.12 no.1
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• pp.11-16
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• 2006

Inguinal hernia is one of the most common surgical diseases in pediatric patients. But the management of the side opposite the clinically apparent inguinal hernia, the "silent side" is controversial. Four hundred fifty-eight cases of pediatric inguinal hernias, operated by one pediatric surgeon at the Divisionof Pediatric Surgery, Department of Surgery, Chonbuk National University Hospital from January 1998 to December 2002, were reviewed retrospectively to determine the characteristics and significances of the silk-glove test on the side opposite the clinically apparent inguinal hernia. Males were preponderant as 2.8:1. Allhernias were of the indirect type and were repaired by high ligation of the sac. There were 238 (52.0 %) right sided hernias, 160 (35.0 %) were on the left and 60 (13.0%) were bilateral. The number of patients with a positive silk-glove sign on the contralateral side was 158(39.7 %), and 133 of these had a contralateral patent processus vaginalis. Positive predictive value of Silk-glove test was 84.2 % (133/158). The silk-glove test is a simple, safe, and relatively accurate method for contralateral exploration in the unilateral inguinal hernias in children.

• Progress in Medical Physics
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• v.15 no.1
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• pp.39-44
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• 2004

The energy distributions for clinically used electron beams from measured and calculated mono energetic depth dose values were calculated. The energy distributions having the minimum difference between the measured and reduced values of depth dose are determined by iterations based on least square method. The nominal energies of 6, 9, 12, 15 MeV clinical electron beams were examined. The Monte Carlo depth dose calculations with determined energy distributions were peformed to evaluate those distributions. In a comparison of the calculated and measured depth dose data, the standard errors are estimated within $\pm$ 3% from surface to R$_{80}$ depth and within $\pm$4% from the surface to near the range for all electron beams. This can be practically applied to determine the energy distributions for clinically used electron beams.

• Journal of Genetic Medicine
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• v.10 no.2
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• pp.81-87
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• 2013

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension. PHA is a heterogeneous disorder both clinically and genetically and can be divided into three subgroups; PHA type 1 (PHA1), type 2 (PHA2) and type 3 (PHA3). PHA1 and PHA2 are genetic disorders, and PHA3 is a secondary disease of transient mineralocorticoid resistance mostly associated with urinary tract infections and obstructive uropathies. PHA1 includes two different forms with different severity of the disease and phenotype: a systemic type of disease with autosomal recessive inheritance (caused by mutations of the amiloride-sensitive epithelial sodium channel, ENaC) and a renal form with autosomal dominant inheritance (caused by mutations of the mineralocorticoid receptor, MR). In the kidneys, the distal nephron takes charge of the fine regulation of water absorption and ion handling under the control of aldosterone. Two major intracellular actors necessary for the action of aldosterone are the MR and the ENaC. Impairment of the intracellular aldosterone signal transduction pathway results in resistance to the action of mineralocorticoids, which leads to PHA. Herein, ion handling the distal nephron and the clinico-genetic findings of PHA are reviewed with special emphasis on PHA type 1.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1633-1637
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• 2012

Introduction: The incidence of oral premalignant and malignant lesions is on the rise due to an increased number of people taking in tobacco and alcohol related habits. Material and Methods: 1028 patients with tobacco, alcohol and areca nut habits attending our Department of Oral Medicine and Radiology formed the study sample. An interviewer based questionnaire was used to record the habit details. All the patients were then examined clinically for the presence of lesions. Chi square and Fisher exact tests were used to assess the statistical significance of the study parameters. Results: Males had a higher prevalence and comprised 87.9% of the sample. The commonest habit in this study sample was smoking (39.2%) followed by smokeless tobacco use (28.1%). Out of the 1028 patients with habits 40% had no clinically detectable changes in their mucosa. Of the mucosal changes leukoplakia (14%) was the commonest. Conclusions: This study provided information about the habit trends in the patients visiting this institution. The study may serve as a useful tool in educating the patients about the deleterious effects of oral tobacco, alcohol and betel exposure.

• Health Policy and Management
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• v.24 no.4
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• pp.357-366
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• 2014

Background: The objective of this study was to evaluate the efficiency of an emergency ambulance system and to investigate socio-economic and clinical characteristics associated with emergency ambulance service. Methods: Based on 2011 Korea health panel, unmet need and inappropriate use of emergency ambulance service were measured by Gibson in 1977. Furthermore, the factors associated with unmet need and inappropriate use of emergency ambulance service were identified by Fisher's exact tests and multiple logistic regression models. Results: Unmet need, defined as the proportion of emergency patients who clinically need ambulance transportation but do not receive it, was found to be 59.8%. Inappropriate use, defined as the proportion of emergency patient receiving ambulance care who did not clinically need it, was found to be 37.2%. There were statistically significant differences between appropriate and inappropriate groups in overall variables of socio-economic and clinical characteristics. Specifically, gender, age, relationship to household, and reasons of visiting emergency department (accident/disease) were statistically significant factors associated with appropriate use of emergency ambulance service. Conclusion: Unmet ambulance need is a useful measure for patients needs assessment, and inappropriate ambulance use is a valid criteria in judging the efficiency of emergency ambulance system. To improve and understand emergency ambulance system, unmet need and inappropriate use of emergency ambulance service should be more concerned.

• Biomolecules & Therapeutics
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• v.18 no.1
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• pp.1-15
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• 2010

Progress in the development of DNA vaccines and their delivery strategies has been made since their initial concept as a next generation vaccine. Since DNA vaccine includes non-infectious DNA parts of pathogens, it can't cause disease yet it closely mimic the natural process of infection and immune responses. Despite their early promising results of controlling infectious diseases and cancer in small animal models, DNA vaccines failed to display a level of immunogenicity required for combating these diseases in humans, possibly due to their lower protein expression levels. However, increasing evidence has shown that DNA vaccines are clinically well-tolerated and safe. Furthermore, one notable advantage of DNA vaccines includes convenient utilities of plasmid DNAs coding for antigens. For instance, any emerging pathogens could be prevented easily and timely by allowing the simple exchange of antigen-encoding genes. In this review, newly developed DNA vaccine strategies, including electroporation, which has emerged as a potent method for DNA delivery, targeting infectious diseases and cancer will be discussed with a focus on any on-going DNA vaccine trials or progress made pre-clinically and in clinics.

• Journal of Technologic Dentistry
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• v.33 no.4
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• pp.313-321
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• 2011

Purpose: The purpose of this study was to compare color parameters of different fabrication method of Lava ceram powder, Lava DVS blocks, IPS e.max ceram and IPS e.max zirpress. Methods: The three available shades(A1, A2, A3.5) of Lava & Kavo zirconia blocks were examined. For each of three colors, three different thickness were tested, 5 times of measurement frequency. The measurements were made using a spectrophotometer equipped with an integrating sphere using the CIE $L^*$, $a^*$, $b^*$ colorimetric system. Results: Lava build-up group and Lava DVS group showed clinically perceived color difference, on the other hand IPS e.max build-up group and IPS e.max zirpress group did not show clinically perceived color difference to shade allowed on core. When the thickness of porcelain veneer increased from Lava and IPS e.max groups, color differences(${\Delta}E$) were decreased. Conclusion: All-ceramic system has color characteristics that clinicians have to consider when selecting materials. Also, manufacturers of different porcelain systems must make every effort to achieve color reproducibility.

• The Journal of Korean Academy of Prosthodontics
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• v.27 no.2
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• pp.249-259
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• 1989

Dental impression materials often become contaminated with patients' saliva and blood which creates the potential for cross-infection. It was the purpose of this study to investigate the effects of disinfection of three different rubber impression materials with four different disinfecting solutions. Polysulfide, vinyl polysiloxane and polyether impression materials were mixed according to the manufacturer's directions and samples were formed on a stainless steel model. On removal from the standard model, impressions were immersed in a disinfectant (acid-potentiated glutaraldehyde, phenollic compound, chlorine compound, iodophor) at room tempera tures for ten minutes. After disinfection, the distance between reference points(linear dimension) was measured using the non-contact automatic cordinate measuring projector(MZ-1, Nikon). Through statistical analyses on the data from this study,. the following conclusions were obtained. 1. Polysulfide, vinyl polysiloxane impressions were disinfected without dimensional change.(p>0.05) 2. Polyether impressions which were immersed in acid-potentiated glutaraldehyde were statistically different from control group.(p<0.05) But the amount of shrinkage(0.04%) would not be clinically significant. 3. By immersion of polysulfide, vinyl polysiloxane, polyether impressions in Banicide, Biocide, Multicide plus, sodium hypochlorite for ten minutes, clinically accurate impressions were obtained without dimensional change.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.47 no.2
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• pp.174-178
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• 2014

In this study, 6-10 clinically healthy farmed abalone, Haliotis discus hannai were obtained from Jeollanam-Do Wando Soan-myeon, Bogil-myeon, and Nohwa-eup monthly for 1 year 7 months and were examined histopathologically. As a result, the adductor muscle had severe cellular swelling and myonecrosis. These lesions were stained with hematoxylin and eosin and Giemsa. The lesions were not caused by infection of bacteria or parasites. We investigated the relationship between lesion frequency and water temperature and discovered that increased water temperature was associated with increasing lesion frequency. As water temperature is related to growth rate, increased growth rate was closely related to increased lesion frequency. We considered that these lesions could be a useful factor in measuring shellfish health.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.9 no.1
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• pp.47-52
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• 2003

Acupuncture is a complementary medical treatment whose use in cancer patients has been recommended by the American Cancer Society (ACS) for the treatment of cancer and treatment-related symptoms. Pain, nausea, breathlessness, vasomotor symptoms and limb edema have all been found to respond to this treatment modality. This has become quite familiar to many Koreans not only for pain, but also for many other health problems, both in acute and chronic conditions. Actually, acupuncture is a therapeutic technique that is part of a larger system of traditional oriental medicine. There are several styles of acupuncture. We treated one 72-year-old female patient with Dongshiqixue Acupuncture Technique who had refused surgical operation for brain meningioma showing right hemiparesis, dysarthria, headache and dizziness. During the acupuncture treatment, there were no other adverse effects. After six day's treatment, she could ambulate and make usual life all by herself. On her brain magnetic resonence image follow-up, there was no interval change in meningioma. After discharged from our hospital, she has kept up her independent daily life as before. So it is suggested that some acupuncture treatment should be effect on brain meningioma clinically.