• Journal of Chest Surgery
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• 제32권9호
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• pp.823-826
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• 1999

주대동맥폐동맥간 부행혈관, 심실중격결손과 폐동맥 형성부전이 동반된 6개월된 환아에서 Clamshell 절개 를 통한 일차 완전교정술을 시행하였다. 수술 후 특별한 합병증은 없었으며, 초음파 검사상 남아있는 심실중 격결손이나 의미있는 폐동맥 협착 소견을 보이지 않았다. 이러한 질환의 수술적 접근에 \ulcorner폐로 공급되는 혈 류의 형태에 따라 다양한 방법이 존재하는데, 최근 들어서는 일차 완전교정술에 대한 여러 형태의 수술방법 이 제시되고 있으며, 그 적용 또한 확대되고 있다. 본 증례의 경우 Clamshell 절개 방법을 적용함으로써 종격 동내 병변에 대한 접근이 용이하였으며, 수술 결과 및 합병증 등의 측면에서도 일차 완전교정술의 한 방법 으로 고려해 볼만하다고 여겨진다.

• 대한한의진단학회지
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• 제23권1호
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• pp.9-18
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• 2019

Objectives The authors feel the Qi(氣) through the training, and diagnose and treat our patients through the feeling. In order to utilize the Qi-daignosis, we try to summarize the authors's training process by examining what and how to use the Qi-daignosis. Methods The authors have gathered empirical parts of the psychological part and the various methods of training, through what they need most and how to train them. And we want to describe them in order of importance. Result First of all, with psychological sense of securit you should practice trainingy. It should be able to maintain the unity of the body through relaxation on the basis of 'no thinking only watching'. You must concentrate your energy through concentration and strengthen your inner work. Then you can feel the flow of energy inside your body and you can feel the interaction between the outside and your body. Conclusion By doing this, you naturally begin to apply the Qi-daignosis to your patients. It is not only possible for some doctors with specific abilities. Anyone can feel the Qi(氣) through clinical training and use the Qi-daignosis.

• Annals of Clinical Neurophysiology
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• 제4권1호
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• pp.38-43
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• 2002

Background & Purpose : Dynamic susceptibility contrast MR imaging, one method of perfusion MRI, was developed to define cerebral hemodynamic status with good anatomical resolution. The authors investigated hemodynamic parameters using this imaging method, in an effort to identify hemodynamic changes on the remote crossed cerebellum of patients with a supratentorial infarct. Methods : Dynamic susceptibility contrast MR imaging was performed in 15 patients with only unilateral supratentorial infarcts. Imaging was obtained at the anatomic level of the cerebellum. rCBF, rCBV, MTT and TP were determined over both cerebellar hemispheres of interest. Results : The rCBF and rCBV values of the contralateral cerebellar hemisphere were significantly more decreased than those of the ipsilateral cerebellar hemisphere in 12 patients(p=0.028, 0.033). MTT and TP values of the contralateral and ipsilateral cerebellar hemispheres didn't reveal any differences(p=0.130, 0.121). Conclusions : The results of this work suggest that the region which are remote from the ischemic brain lesion shows no changes of MTT or TP but show decrease of rCBF and rCBV, mean to diaschisis, it also demonstrates that perfusion MRI is an easily available method to evaluate the hemodynamic status of the brain.

• 디지털융복합연구
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• 제16권4호
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• pp.195-203
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• 2018

본 연구에서는 우리나라 치과임상에서 사용되고 있는 치과인상재의 종류 및 채득 방법에 대해 조사해보기 위해 실시되었으며, 설문조사는 전국치과병(의)원 치과의사를 대상으로 기관당 1부씩 자기기입식 방법을 통해 조사하였으며, 수집된 자료는 SPSS 20.0을 사용하여 통계 처리하여 분석하였다. 그 결과 인상재의 종류별 진료 내용에서는 대부분의 진료에서 부가중합형 인상재의 사용빈도가 가장 높았다. 인상채득방법은 점도에 분류에 의한 light body와 heavy body를 사용하는 흐름성이 다른 인상재를 한번에 채득하는 방법을 가장 선호하는 것을 확인할 수 있었고, 임플란트 인상채득방법에는 직접법과 간접법 모두 흐름성이 다른 두 가지 고무인상재를 한번에 채득하는 방법이 가장 선호되었다. 일반적인 특성에 따른 주조수복재와 보철물의 인상채득방법에서는 각각 연령과 임상경력에서 통계적으로 유의한 차이를 보였다. 본 연구결과는 임상에서 주로 사용되고 있는 인상재의 종류를 파악해보고 치과전문가에게 요구되는 인상재의 선호도에 따른 이론과 실무에 대한 업무개발에 도움이 될 수 있으리라 판단된다.

• Clinical and Experimental Pediatrics
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• 제45권2호
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• pp.183-191
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• 2002

목 적 : 본 연구에서는 임상적으로 XLA로 진단받고 현재 치료 중인 한가족 3명 환아의 가계를 대상으로 말초혈액 단핵구의 Btk 단백질 발현과 Btk 유전자 변이를 분석하고자 하였다. 방 법 : 환아 말초혈액 단핵구의 Btk 발현도를 항 Btk 항체를 이용한 유세포계측을 통해 분석하고 PCR-SSCP 및 직접 염기서열 분석에 의해 Btk 유전자 변이를 분석하였다. 결 과 : 유세포 계측 및 PCR-SSCP에 의하여 가계내의 환자 3명 및 보인자 4명을 확인하였으며 환아들의 단핵구의 Btk 발현도를 조사한 결과 2.7% 미만으로 건강인에 비해 매우 유의한 감소를 나타내었다. 유전자 변이 분석 결과 Btk 유전자 exon 3에서 점돌연변이($T{\rightarrow}C$)가 발견되어 61번째 아미노산의 치환이 일어난 과오돌연변이를 확인할 수 있었다. 동일한 유전형을 지닌 3명의 환아들은 임상적으로 매우 다양한 표현형을 나타내었다. 특히 환아들의 혈청 IgG level이 낮을수록 임상 양상은 심한 소견을 보였다. 결 론 : 본 연구 결과를 종합해 볼 때 임상적으로 XLA로 진단된 환아와 가족에 대한 항 Btk 항체를 이용한 유세포계측 및 PCR-SSCP 방법은 XLA 환아 및 보인자의 진단에 매우 유용하며 신속하게 적용될 수 있는 기법으로 생각된다. 또한 분자유전학 기법을 이용하여 환아의 유전자 변이를 검색한 결과 Btk의 PH 도메인 내 한개의 과오돌연변이를 검색하여 XLA를 최종 확진할 수 있었다.

• IMMUNE NETWORK
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• 제5권1호
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• pp.11-15
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• 2005

Background: Throughtout the last three decades, the therapy of leukemias and lymphoma has set the stage for curative cancer therapy in systemic malignant disease. This was the result of an integrated work of basic reaserch and clinical investigators leading to more aggressive albeit tolerable protocol of chemotherapy and radiotherapy. High dose therapy marks the most elaborated strategies in this field today. However, intensification of conventional therapeutic modalities as mentioned has to be based on new approaches and the exploration of new antineoplastic mechanisms. This insight has resulted in immune therapy of cancer. Among the cells of the immune system, natural killer (NK) cells and T cells are of major interest for the development of therapeutic strategies. Methods: Cytotoxicity to target cells was measured by LDH release method, Characterization of activated lymphocyte was measured by Flow cytometry analysis. Anti-CD3, 16, 56 monoclonal antibody and IL-2 were used for the activation of NK and T cell. The analysis of effect of activated lymphocyte, in vivo, were used by Balb/c nude mouse. Results and Conclusion: Cytotoxicity to K562 cells was significantly higher in the mixture group of NK and T cells than that of a group of activating T cells. The survivors and the rate of reduction of size of tumor craft of nude mouse group treatment with activated lymphocyte was higher than that of the group without treatment with activated lymphocyte. Therefore, this results are suggested that the activated lymphocytes by anti-CD3, CD16 and CD56 can reduce the malignancy effect of lymphoma.

• 한국보건간호학회지
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• 제28권1호
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• pp.114-126
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• 2014

Purpose: The purpose of this study was to determine the accuracy and satisfaction with IVIC300 (Intravenous infusion controller). Method: The subjects consisted of 90 nurses and 100 patients. Data collected during July 2013 were analyzed using descriptive statistics, t-test, ANOVA, and $X^2$-test (Chi-Square). Result: The error value of IVIC300 was less than that of Dosi-flow. Differences of error values according to variable of fluid infusion (needle's gauge, patient's moving, patient's calls, and nurse's arabitary calls) were not significant. The mean scores for satisfaction with IVIC300 of nurses ($3.67{\pm}.76$), patients ($3.75{\pm}.63$) were above average. Satisfaction with IVIC300 of nurses differed significantly according to age, work unit, and clinical career. Satisfaction with IVIC300 of patients was not significantly different according to general characteristics. Conclusion: These findings indicate that it is proven the accuracy of IVIC300, and is considered individual characteristics in use IVIC300.

• 대한의용생체공학회:의공학회지
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• 제23권2호
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• pp.131-137
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• 2002

이동 작동기형 인공 심장의 원격 모니터링을 위한 시스템을 설계, 구현하였다 동물 실험이나 환자에의 임상 실험 후 인공 심장 동작 상황에 대한 원격 모니터링은 필수적이다. 본 논문에서는 담당자가 환자로부터 멀리 떨어진 곳에 있을 때에도 인터넷을 통해 간편하게 인공 심장의 동작 상황과 혈류역학 정보를 확인할 수 있는 시스템을 제안하여 그 성능을 확인하였다. 기존의 시스템과 쉽게 연결하여 사용할 수 있도록. 또 쉬운 관리와 기능 향상을 위하여 COM(Component Object Model) 기술 기반의 콤포넌트 모듈로 데이터 전송 부분을 구현하였고. 범용의 브라우저를 이용하여 인터넷에 연결, 확인토록 자바 애플릿을 이용하여 실행되도록 하였다. 또한 정해진 룰에 따라 판단하여 인공 심장의 이상 동작시 관리자에게 알려주도록 하였다. 구현된 시스템을 1개월 이상 생존하는 동물에 적용하여 본 결과 아무런 문제없이 정상 동작함을 확인하였다.

• Journal of Korean Neurosurgical Society
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• 제63권2호
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• pp.137-152
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• 2020

In spite of the developing endovascular era, large (15-25 mm) and giant (>25 mm) wide-neck cerebral aneurysms remained technically challenging. Intracranial flow-diverting stents (FDS) were developed to address these challenges by targeting aneurysm hemodynamics to promote aneurysm occlusion. In 2011, the first FDS approved for use in the United States market. Shortly thereafter, the Pipeline of Uncoilable or Failed Aneurysms (PUFS) study was published demonstrating high efficacy and a similar complication profile to other intracranial stents. The initial FDA instructions for use (IFU) limited its use to patients 22 years old or older with wide-necked large or giant aneurysms of the internal carotid artery (ICA) from the petrous segment to superior hypophyseal artery/ophthalmic segment. Expanded IFU was tested in the Prospective Study on Embolization of Intracranial Aneurysms with PipelineTM Embolization Device (PREMIER) trial. With further post-approval clinical data, the United States FDA expanded the IFU to include patients with small or medium, wide-necked saccular or fusiform aneurysms from the petrous ICA to the ICA terminus. However, IFU is more restrictive in South Korea than in United States. Several systematic reviews and meta-analyses have sought to evaluate the overall efficacy of FDS for the treatment of cerebral aneurysms and consistently identify FDS as an effective technique for the treatment of aneurysms broadly with complication rates similar to other traditional techniques. A growing body of literature has demonstrated high efficacy of FDS for small aneurysms; distal artery aneurysms; non-saccular aneurysms posterior circulation aneurysms and complication rates similar to traditional techniques. In the short interval since the Pipeline Embolization Device was first introduced, FDS has been firmly entrenched as a powerful tool in the endovascular armamentarium. As new FDS are developed, established FDS are refined, and delivery systems are improved the uses for FDS will only expand further. Researchers continue to work to optimize the mechanical characteristics of the FDS themselves, aiming to optimize deploy ability and efficacy. With expanded use for small to medium aneurysms and posterior circulation aneurysms, FDS technology is firmly entrenched as a powerful tool to treat challenging aneurysms, both primarily and as an adjunct to coil embolization. With the aforementioned advances, the ease of FDS deployment will improve and complication rates will be further minimized. This will only further establish FDS deployment as a key strategy in the treatment of cerebral aneurysms.

• 대한간호학회지
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• 제4권1호
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• pp.1-21
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• 1974

A considerable change of the Korean nursing system has been made during the last decade not only in its philosophy but also in its function and structure to meet political and scientific need of the modern society. The main purpose of this study is to develope the new concept of comprehensive nursing care, both its Philosophy and ethics, as the basic of modern clinical nursing theory and practice. Comprehensive nursing care is the concept of human centered nursing care, and it helps a man to meet the basic physical, psychological, environmental, socioeconomic and teaching needs. It also helps him to help himself to meet these needs. This concept starts from the individualized nursing care and its ultimate goal is to improve a man to have a better position in his own community so that he may able to have a meaningful life. To accomplish this goal, an individualized nursing care plan as a nursing diagnosis and problem solving method should be set up for different patients with similar diagnosis to meet their needs, because each patient has a different social background. from this viewpoint, nursing is a science as well as abstruse humanity. The performance of comprehensive nursing care is a goal and issue of modern clinical nursing care. If nursing is a science and a profession for man, it should have ethics which recognize the dignity of man and offers infinite service voluntarily, and should be able to show leadership in carrying out the nursing responsibility. This leadership finds a person's potential and encourages him to utilize it. Such concepts should develop into a nursing ideology and this ideology should become a priority in comprehensive nursing care. The following statements are the conclusion of this study. 1) Modern nursing has been developed from disease centered nursing care to comprehensive nursing care based on humanity. The primary principle of nursing was to assist in the treatment of disease, but it has been changed to the professional nursing system independently. 2) The concept of nursing is one of continuous or endless scope of dispersion. It proves that nursing is grasping the professional responsibility to be able to coordinate scientific principles Patient health problems are according to scientific principles rather than adhering to nursing technical discipline as a daily work. 3) In chapter I and Ⅱ, the philosophy and ideology of nursing have been discussed and the flow of concept of clinical nursing and the rate of progress which emerges from naturalizing performance of the concept of comprehensive nursing in clinical nursing studied. The discussion developed the theory that a nurse should be to embody nursing ideas and objectives by establishing definite conviction of professions and study. 4) In chapter lil, nursing planning based on nursing diagnosis as a method to attain ideal nursing care for humanity with a definite idea of establishing philosophy of nursing was presented. 5) From the result of survey on patient needs about treatment and nursing, it was observed that all patient had emotional stress from unknown factors. Therefore it was concluded that nurses should not only educate the patient but also give them the opportunity to communicate freely their needs and anxieties. Furthermore complaints and doubts of the patient should be carefully noted and must be considered to meet these needs. 6) Patient teaching is the most important part of comprehensive nursing care. In chapter, Ⅲ, the important of patient teaching was emphasized by demonstrating the effect of patient teaching for diabetic patient. 7) In Chapter Ⅳ, from the result of the study on nurses attitudes to comprehensive nursing care, it was pointed that the evolution of nursing education and the establishment of a complete concept and value of comprehensive nursing was necessary.