• 제목/요약/키워드: Clinical value

검색결과 3,111건 처리시간 0.031초

수정 델파이 기법을 이용한 의약품의 DDD(일일상용량) 결정과 항생제 사용량 분석: WHO 일일상용량이 없는 항생제를 중심으로 (Determination of Defined Daily Dose of Medicines using Nominal Group Technique and Analysis of Antibiotics Use in National Insurance Claim Data: Focused on Antibiotics without DDD of WHO)

  • 김동숙;김남순;이숙향
    • 한국임상약학회지
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    • 제17권1호
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    • pp.19-32
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    • 2007
  • Objectives : It is necessary to monitor consumption of drugs in order to enhance promote appropriate use of drugs. Defined Daily Dose(DDD) of World Health Organization(WHO) has been used for evaluating the amount of medicine use. However, DDD of some drugs must be determined for drugs in Korea which are not listed by WHO. Our formulary follows ourself classification and DDD of some drugs must be determined since they exist only in Korea. This study was aimed to determine DDD value using RAND Appropriateness Methods and evaluate the amount of antibiotics use using DDD value. Methods : J01 antibiotics of WHO anatomical therapeutic chemical(ATC) classification were extracted from drug formulary. Antibiotics list without DDD was identified to determine their DDD with comprehensive review of references and recommendation of experts. defined. Review of reference was executed. of Expert panels were comprised of clinical pharmacist and clinical doctors. Modified Delphi Method was applied by survey and consensus meeting. Amount of antibiotic use was calculated by DDD/1000 inhabitants/day in the national level using health insurance claim data. Results : The result of 1 round, DDD values of 28 ingredients were determined from the first round of consensus meeting. With 2nd round meeting, 3 ingredients were deleted and DDD of 17 ingredients were decided. Analysis of antibiotic use in health insurance claim data showed 22.97 DDD/1000 inhabitants/day in 2003 year. Conclusion : This study can contribute to the establishment of DDD assignment and thus quantifying drug uses.

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양도락의 진단적 활용에 대한 문헌 고찰 - 국내문헌을 중심으로 - (Ryodoraku Application for Diagnosis : a Review of Korean Literature)

  • 노승희;김건형;윤영진;양기영;김재규;이병렬;임윤경
    • Korean Journal of Acupuncture
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    • 제28권4호
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    • pp.125-135
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    • 2011
  • Objectives : This study is aimed to evaluate the diagnostic value of Ryodoraku for traditional Korean medicine practice reported in the Korean literature. Methods : A search of seven Korean databases was performed up to May 2011 using the search term 'Ryodoraku(in Korean)'. All clinical studies on diagnostic Ryodoraku characteristics were included. Results : The search yielded 59 studies, of which 5 were considered suitable for this analysis. Four were observational studies. Only one was a controlled trial. Average Ryodoraku score(RS), mean values for each measure point, physiologic limit, number of Pyesaek and Gyeokcha, and pattern classification were used as references for the analysis. Correlations were observed between average RS and idiopathic Parkinson's disease, some sub-groups of respiratory disease, chronic low back pain, and menopause. Some mean values for measure points showed particularly high or low tendencies in patients with idiopathic Parkinson's disease, chronic low back pain, and menopause. Positive correlations were observed between the number of Pyesaek and H-Y stage in idiopathic Parkinson's disease and F2(肝) and the modified Kupperman's index with menopausal women. The four classes, organized based on Ryodoraku pattern, showed differences in various characteristics. Conclusions : Since only five studies met the experimental conditions, this evaluation of the diagnostic value of Ryodoraku in various situations is limited. Future studies should be conducted using various physiologic and pathologic situations.

요추 추간판 탈출증 환자의 보존적 치료결과와 흡연의 상관성에 대한 임상적 고찰 (A Clinical Study for Patients with Lumbar Disc Herniation: Association Between Clinical Outcomes of Conservative Treatment and Cigarette Smoking)

  • 반효정;김석;윤현석;김한겸;김선민;김지용;김태헌;박병윤
    • 척추신경추나의학회지
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    • 제5권2호
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    • pp.17-32
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    • 2010
  • Objectives : To investigate the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc. Methods : We reviewed 74 male patients with lumbar herniated disc who were hospitalized at the Jaseng Oriental Medicine Hospital. 74 patients were divided into 2 groups(smokers, non-smokers) and we measured age, ODI score, SF-36 score, VAS. Results : Between smokers and non-smokers, statically significant differences were found in clinical symptoms on the time of 6 months later, effective scores of treatments, value of ODI and value of VAS on the time of 6 months later. And in these values of measurements, non-smokers were higher than those of smokers. Conclusion : These results suggest that possibility of the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc.

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Clinical Outcomes after Spinal Cord Stimulation According to Pain Characteristics

  • Ha, Jong-Ho;Huh, Ryoong;Kim, Shin-Gyeom;Im, Soo-Bin;Jeong, Je Hoon;Hwang, Sun-Chul;Shin, Dong-Seong;Kim, Bum-Tae;Chung, Moonyoung
    • Journal of Korean Neurosurgical Society
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    • 제65권2호
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    • pp.276-286
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    • 2022
  • Objective : Spinal cord stimulation (SCS) is an effective treatment for chronic neuropathic pain. However, its clinical efficacy in regard to specific types of pain has not been well studied. The primary objective of this study was to retrospectively analyze the clinical outcomes of paddle-type SCS according to the type of neuropathic pain. Methods : Seventeen patients who underwent paddle-lead SCS at our hospital were examined. Clinical outcomes were evaluated pre- and postoperatively (3 months, 1 year, and last follow-up) using the Neuropathic Pain Symptom Inventory (NPSI). The NPSI categorizes pain as superficial, deep, paroxysmal, evoked, or dysesthesia and assess the duration of the pain (pain time score). Changes in NPSI scores were compared with change in Visual analogue scale (VAS) scores. Results : After SCS, the pain time score improved by 45% (independent t-test, p=0.0002) and the deep pain score improved by 58% (independent t-test, p=0.001). Improvements in the pain time score significantly correlated with improvements in the VAS score (r=0.667, p=0.003, Spearman correlation). Additionally, the morphine milligram equivalent value was markedly lower after vs. before surgery (~49 mg, pared t-test, p=0.002). No preoperative value was associated with clinical outcome. Conclusion : The NPSI is a useful tool for evaluating the therapeutic effects of SCS. Chronic use of a paddle-type spinal cord stimulation improved the deep pain and the pain time scores.

Clinical comparison of marginal fit of ceramic inlays between digital and conventional impressions

  • Franklin Guillermo Vargas-Corral;Americo Ernesto Vargas-Corral;Miguel Angel Rodríguez Valverde;Manuel Bravo;Juan Ignacio Rosales Leal
    • The Journal of Advanced Prosthodontics
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    • 제16권1호
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    • pp.57-65
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    • 2024
  • PURPOSE. The aim of this stuldy was to compare the clinical marginal fit of CAD-CAM inlays obtained from intraoral digital impression or addition silicone impression techniques. MATERIALS AND METHODS. The study included 31 inlays for prosthodontics purposes of 31 patients: 15 based on intraoral digital impressions (DI group); and 16 based on a conventional impression technique (CI group). Inlays included occlusal and a non-occlusal surface. Inlays were milled in ceramic. The inlay-teeth interface was replicated by placing each inlay in its corresponding uncemented clinical preparation and taking interface impressions with silicone material from occlusal and free surfaces. Interface analysis was made using white light confocal microscopy (WLCM) (scanning area: 694 × 510 ㎛2) from the impression samples. The gap size and the inlay overextension were measured from the microscopy topographies. For analytical purposes (i.e., 95-%-confidence intervals calculations and P-value calculations), the procedure REGRESS in SUDAAN was used to account for clustering (i.e., multiple measurements). For p-value calculation, the log transformation of the dependent variables was used to normalize the distributions. RESULTS. Marginal fit values for occlusal and free surfaces were affected by the type of impression. There were no differences between surfaces (occlusal vs. free). Gap obtained for DI group was 164 ± 84 ㎛ and that for CI group was 209 ± 104 ㎛, and there were statistical differences between them (p = .041). Mean overextension values were 60 ± 59 ㎛ for DI group and 67 ± 73 ㎛ for CI group, and there were no differences between then (p = .553). CONCLUSION. Digital impression achieved inlays with higher clinical marginal fit and performed better than the conventional silicone materials.

Health-Related Quality of Life and Nutritional Status Are Related to Dietary Magnesium Intake in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

  • Afsane Ahmadi;Mohammad Hassan Eftekhari;Zohreh Mazloom;Masoom Masoompour;Mohammad Fararooei;Morteza Zare;Najmeh Hejazi
    • Clinical Nutrition Research
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    • 제11권1호
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    • pp.62-73
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    • 2022
  • An insufficient intake of magnesium may be associated with the development of chronic obstructive pulmonary disease (COPD). We aimed to determine the relationship between health related quality of life (QoL), anthropometric indices and nutritional status with dietary magnesium intake in COPD patients. Sixty-one COPD patients participated in this cross-sectional study. QoL and nutritional status were assessed. Furthermore, body composition, calf circumference, and muscle strength were measured; equations were used to calculate fat-free mass index, body mass index, and muscle mass value. Dietary magnesium intake was assessed by three 24-hours recalls and magnesium intake was categorized as ≤ 188.08 mg/day (A group) and > 188.08 mg/day (B group). The χ2, independent-sample t-test and Mann-Whitney test were used for statistical analysis. The p values less than 0.05 were considered significant. Of QoL assessments the total and impact mean scores of St. George's respiratory questionnaire in the B group were significantly lower than the means of the A group (p value = 0.007 and 0.005, respectively). The instrumental activity of daily living score was significantly improved in patients with higher consumption of dietary magnesium (p = 0.02). Participants had a significantly lower mean score of patient-generated subjective global assessment in the B group compared to the A group (p = 0.003). Higher intake of dietary magnesium can lead to improve QoL and nutrition status.

P300과 MMN(mismatch negativity)의 지형학적 상관연구 (A Topographically Correlational Study of P300 and MMN (mismatch negativity) in Healthy Subjects)

  • 김대식;김영배
    • 대한임상검사과학회지
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    • 제39권3호
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    • pp.256-263
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    • 2007
  • P300 is widely used as a neurophysiological indicator of cognitive processing, which is known as reflecting controlled processing. MMN (mismatch negativity), early response prior to P300, is known as reflecting an early stage of information processing and having involuntary attention and automatic awakening or sensory memory. This study for normal people shows that electric potential of P300 and MMN are in close correlation (r=-0.673, p<0.05). That is, it is observed that the higher negative value electric potential of MMN measured at cerebral forehead-center has, the higher value electric potential of P300 measured at cerebral center-vertex has. This fact implies that working memory for temporary storage and operation of stimuli, and involuntary attention which constitute automatic information processing, an early stage of information processing, play a crucial role in efficient information processing. On the other hand, considering that MMN of cerebral forehead-center and P300 of cerebral center-vertex are in close correlation, it is necessary to pursue further study of cerebral parts which generate P300 and MMN in information processing.

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혈청 IgE의 임상적 의의 (Clinical significance of serum IgE)

  • 정혜리
    • Clinical and Experimental Pediatrics
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    • 제50권5호
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    • pp.416-421
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    • 2007
  • Many previous studies have proved that human allergic disease resulted from the formation of antibodies belonging to a unique immunoglobulin isotype termed immunoglobulin E (IgE). Most of IgE-producing plasma cells are found in the lymphoid tissue associated with the gastrointestinal and respiratory tracts. IgE may be found free in the mucosal secretions of these tissues, bound to local mast cells, or distributed by the systemic circulation to mast cells and basophils throughout the body. Total serum IgE concentrations tend to be higher in allergic adults and children compared with non-allergic individuals, but the value of total serum IgE as a screening test for allergic disease is limited. Total serum IgE levels are related to the probability of an individual having detectable allergen-specific IgE. Allergen-specific IgE concentrations vary with a person's age, the degree and duration of the recent allergen or cross-reactive allergen exposure. The value of quantitative assays for allergen-specific IgE has been suggested in recent studies. Serum IgE increases in many non-allergic diseases, including infectious and parasitic diseases. The IgE changes appear to be specific to the infectious agents, whereas non-specific in other diseases. The increased serum IgE in some of these conditions probably results from alterations in immune function. This review summarizes the clinical significance of total and allergen-specific IgE examinations in allergic diseases.

F344와 Wistar 랫드의 계통별에 따른 혈액 및 생화학적 연구 (Hmatological and Biochemical Study of F344 and Wistar Rats)

  • 조재천;장동덕;신동환;홍충만
    • 한국수의병리학회지
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    • 제1권1호
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    • pp.46-52
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    • 1997
  • The hematology and clinical chemistry data based on the well defined normal data are essential in the safety assessment. It is important that normal values of cliniclal pathology parameters would be optimized to be accurate. So the purpose of this experiment was to compare the ranges of normal data in hematology value and serum chemistry between both sexes of F344 and Wistar rats at 5, 10, 20, 40 and 90 weeks. of age. The neutrophils eosinophils and monocytes increased with age in male Wistar rats. And serum total bilirubin and potassium were highest and alkaline phosphatase was lowest at 90 weeks in Wistar rats. As compared with Wistar rat the serum aspartate aminotransferase of F344 rats increased with age in both sexes but inorganic phosphorus decreased with age. The serum alkaline phosphatase decreased with age and potassium was highest at 90weeks. These normal data would be useful in improving the accuracy of clinical pathology value in the safety assessment.

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Full Zirconia Crown용으로 사용되는 block의 제조사의 굴곡강도와 임상작업후의 굴곡강도에 관한 연구 (The Study of Flexural Strength of Full Zirconia Crown using Block after Clinical Work)

  • 정효경;곽동주
    • 대한치과기공학회지
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    • 제33권4호
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    • pp.283-289
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    • 2011
  • Purpose: The purpose of this study was to evaluate flexural strength of full zirconia crown using block after clinical work. Methods: The three point bending test was used to measure the flexural strength of zirconia block. Statistical analysis was done using the Statistical Package for Social Sciences version 19.0 for Windows. As for the analysis methods, the study used analysis of variance, Tukey's test. Results: The ave Rage value of flexural strengths of WIELAND, Zirkonzahn, Hass, D-MAX were 516.2 MPa, 612.6MPa, 566.2MPa, 744.6MPa. The ave Rage value of Surface Roughness of WIELAND, Zirkonzahn, Hass, D-MAX were 0.39Ra, 0.33Ra, 0.33Ra, 0.47Ra. Conclusion: Flexural strength of zirconia block decreased after clinical work. Flexural strength of zirconia block is equal to or higher than flexural strength of dental metal, so zirconia block can be used as dental material.