• Title/Summary/Keyword: Clinical pathology

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A Case of Pure Red Cell Aplasia (순수적혈구형성부전증 1 례)

  • Choi, Myung-Sook;Lee, Chae-Hoon;Cheon, Chang-Ho;Kim, Kyung-Dong;Kim, Chung-Sook;Hyun, Myung-Soo
    • Journal of Yeungnam Medical Science
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    • v.5 no.2
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    • pp.239-246
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    • 1988
  • Pure red cell aplasia is uncommon disorder characterized by finding of anemia, absence of nucleated red blood cell in the marrow, absence of reticulocytes in the peripheral blood and normal peripheral platelet and leukocytes counts. We experienced one case of pure red cell aplasia associated with hemolytic anemia characterized by hemoglobinuria, reticulocytopenia, and erythroid hypoplasia of the bone marrow. The cause of the illness was not definitely identified, but we concluded that this patient had simultaneous occurence of PRCA and hemolytic anemia following administration of diphenylhydan. toin after craniotomy rather than virus or bacteria induced. The simultaneous occurance of PRCA and hemolytic anemia is uncommon and the mechanism for diphenylhydantoin induced PRCA and hemolytic anemia is unclear.

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Cytologic Features of Metastatic Retroperitoneal Seminoma - A Case Report - (후복막강에 전이한 정상피종의 세포학적 소견 - 1예 보고 -)

  • Kwon, Mi-Seon;Seo, Eun-Joo;Kim, Young-Shin;Kang, Chang-Suk;Shim, Sang-In
    • The Korean Journal of Cytopathology
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    • v.6 no.1
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    • pp.71-75
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    • 1995
  • A fine needle aspiration biopsy specimen of a retroperitoneal mass in a 26-year-old man who had had an orchiectomy for seminoma was submitted for cytologic evaluation. Cytologic features of the specimen included uniform neoplastic cells found singly or in groups of several cells intermingled with lymphocytes in a characteristic foamy, lacelike background. These cells varied from 10 to 20 m in diameter. The nuclei were round to ovoid with fine or reticular chromatin and one or more prominent nucleoli. The poorly defined cytoplasm stained pale-blue or blue with cytoplasmic vacuoles. The cytologic appearance was consistent with seminoma. Documented reports of the cytological appearance of seminoma are rare. The diagnosis of primary gonadal seminoma by fine needle aspiration biopsy is probably not indicated since the treatment of a primary gonadal tumor, regardless of its histogenesis, requires surgical resection. However, fine needle aspiration biopsy is extremely valuable in the diagnosis of extragonadal as well as metastic and recurrent seminoma.

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Fine Needle Aspiration Cytology of Mucinous Cystic Carcinoma of the Pancreas - A Case Report - (췌장의 점액 낭샘암종의 세침흡인 세포소견 -1예 보고-)

  • Lee,, Kyung-Ji;Lee, Kyo-Young;Kang, Chang-Suk;Shim, Sang-In;Lee, Ah-Won
    • The Korean Journal of Cytopathology
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    • v.16 no.2
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    • pp.88-92
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    • 2005
  • Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.

Epithelial-Myoepithelial Carcinoma of the Parotid Gland - Report of a Case Misinterpreted as Pleomorphic Adenoma on Fine Needle Aspiration Cytology - (이하선의 상피-근상피암종 - 세침흡인 세포검사에서 다형성선종으로 오진된 1 예 보고 -)

  • Kim, Dong-Chul;Lee, Kyo-Young;Kang, Cang-Suk;Shim, Sang-In;Lee, Ah-Won
    • The Korean Journal of Cytopathology
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    • v.13 no.1
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    • pp.42-46
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    • 2002
  • Epithelial-myoepithelial carcinoma(EMC) is a rare, low grade malignant tumor of the salivary glands. The EMC has a distinctive histological appearance comprising ductal structures with an inner epithelial cell component and an outer layer of myoepithelial cells which show plump clear cytoplasm. The cytologic features of the EMC have been rarely described. A correct cytological diagnosis to this rare tumor is difficult with high false negative rate. We report a case of EMC in which fine needle aspiration cytologic findings were misinterpreted as a pleomorphic adenoma.

Isolation of Vibrio vulnificus from Shellfish (어패류에서의 Vibrio vulnificus 분리)

  • Chong, Yun-Sop;Chun, Myung-Sook;Chung, Hae-Kyung;Kwon, Oh-Hun;Lee, Samuel Y.
    • The Journal of the Korean Society for Microbiology
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    • v.19 no.1
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    • pp.73-77
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    • 1984
  • Vibrio vulnificus is an organism capable of causing septicemia and wound infection in compromised patients. The source of infection is known to be raw oysters and others. The prevalence of the organism in Korean sea water and shellfish is not known. The authors surveyed shellfish and other specimens obtained mainly from a market in Seoul and from ones in Inchon. Five cultures of V. vulnificus were isolated from oyster and clam samples. Two isolates had typical characteristics of the strains isolated from patients, i.e., definite hemolysis and typical biochemical reactions. However, other 2 isolates were sucrose positive, although the identity were confirmed by Center for Disease Control. We do not know wether such strains are pathogenic or not. For the isolation of V. vulnificus from environmental samples, TCBS agar and VV agar were not very selective or differential. We isolated our strains with the use of OF-lactose agar and SPS agar. However OF-lactose agar did not support good growth of V. vulnificus, while SPS agar did not suppress other vibrios.

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Production of recombinant nucleocapsid protein of Newcastle disease virus in Escherichia coli for a diagnostic ELISA

  • Kim, Hyun-Il;Park, Kyoung-Phil;Park, Chan-Hee;Cho, Hyun-Ah;Yang, Ho-Suk;Hahn, Tae-Wook
    • Korean Journal of Veterinary Research
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    • v.49 no.1
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    • pp.39-44
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    • 2009
  • Transmission of avian viruses both bird-to-bird and from birds to non-avian species is a major health concern. Newcastle disease virus (NDV) is an economically important avian virus that poses substantial risks to the poultry industry. Rapid and sensitive diagnostic methods, such as the enzymelinked immunosorbent assay (ELISA), are required to track such infections. To develop an ELISA for detecting anti-NDV antibody in avian sera, the nucleocapsid protein (NCP) gene of the NDV La Sota strain was cloned and expressed in Escherichia coli and the 513-amino acid recombinant NCP was purified by Ni-NTA affinity chromatography. To evaluate its ability to replace NDV whole virus antigen as a coating antigen, NCP-coated and whole NDV-coated ELISAs were tested and compared using a panel of NDV positive antisera from chickens. Results using purified NCP were highly correlated with those obtained using whole NDV (r= 0.927), demonstrating that recombinant NCP expressed in Escherichia coli is a suitable substitute antigen for whole NDV in a diagnostic ELISA.

A Literature Study On Physiology, Pathology and Clinical Applications for TCM Cosmetology (중의미용(中醫美容)의 생리병리, 임상응용에 관한 문헌고찰)

  • Yang, Mi-Sung;Shin, Mi-Sook
    • Korean Journal of Acupuncture
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    • v.26 no.4
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    • pp.107-118
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    • 2009
  • Objectives : This study was performed to investigate physiology, pathology and clinical applications for cosmetology in Traditional Chinese Medicine. We hope most clinicians practicing cosmetic acupuncture to understand theoretical background well and to treat cosmetic diseases more diversely by this paper. Methods : We collected useful informations from 35 papers in Chinese at website www.cnki.net about TCM treatments including acupuncture, moxibustion and herbal medicine. And we could see important factors connected with physiology, pathology and clinical applications within this field. Conclusions : Liver, lung, stomach, mental disorders and yin-deficiency constitution were connected each other in cosmetic physiology. Blood stasis and congestion were thought highly in cosmetic pathology. In clinical applications, wet cupping therapy on the acupoints located in the back line of Governor Vessel(GV), ear-acupuncture, acupuncture using local facial acupoints, pharmacopuncture, moxibustion were used diversely for each case with cosmetic disorders. Especially, local acupoints and remote acupoints were selected at the same time for wrinkle care. And studies on plastic surgery sequelae, dark skin, acne and melasma were more published than those on wrinkle care.

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Fine Needle Aspiration Cytology of Ameloblastoma - A Case Report- (사기질모세포종의 세침흡인 세포학적 소견 - 1예 보고-)

  • Lee, Hee-Jeong;Kim, Byung-Kee;Kang, Chang-Suk;Jung, Eun-Sun
    • The Korean Journal of Cytopathology
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    • v.13 no.2
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    • pp.70-73
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    • 2002
  • Utilization of fine needle aspiration cytology (FNAC) in the diagnosis of odontogenic tumors seems to have little attention. Ameloblastoma is the most common epithelial odontogenic tumor. However, the cytologic findings of ameloblastoma are described recently. We report a case of ameloblastoma diagnosed by FNAC. The aspirated blood-tinged mucoid fluid from maxillary mass showed a few clusters of tumor cells with distinct two-cell population: basaloid cells with palisading arrangement and squamous cells with more abundant and eosinophilic cytoplasm. Nuclear atypism, pleomorphism or mitosis were absent. A few keratinized bodies in the tumor cell clusters and the third component, stellate cells were also characteristic.

Canine Multicentric Large B Cell Lymphoma with Increased Mott Cells Diagnosed by Flow Cytometry

  • Yang, Yeseul;Jung, Jae-Ha;Hwang, Sung-Hyun;Kim, Yongbaek
    • Journal of Veterinary Clinics
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    • v.38 no.1
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    • pp.36-40
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    • 2021
  • A 12-year-old dog was referred due to multiple superficial lymphadenopathy. On cytology, each lymph node showed different cell populations where some of them consisted of intermediate to large lymphocytes with frequent Mott cells. Presence of Mott cells along with immature lymphocytes made the cytological diagnosis challenging, and therefore, supplementary diagnostic tests including PCR for Antigen Receptor Rearrangement (PARR) assay and flow cytometry were performed. This case report illustrates the value of flow cytometry in the diagnosis of lymphadenopathy with ambiguous cytologic findings.