• 대한상한금궤의학회지
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• v.5 no.1
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• pp.1-17
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• 2013

Objective : The purpose of this study is to help korean medical doctors write case reports based on Shanghanlun six clinical patterns and provisions accurately and effectively. Methods : To achieve the purpose of this study, we reviewed Shanghanlun six clinical patterns and provisions. After this, we formed a case report form according to the importance of Korean medical terms in Shanghanlun. Results : Through this study, we got the consistency and unity of case reports based on Shanghanlun six clinical patterns and provisions. Conclusions : This case report form is designed for gathering clinical data which are organized clearly according to the diagnostic system based on Shanghanlun six clinical patterns and provisions.

• Journal of Interdisciplinary Genomics
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• v.1 no.2
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• pp.15-18
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• 2019

Gaucher disease (GD) is an autosomal recessive inborn error of metabolism resulting from a deficiency in ${\beta}$-glucocerebrosidase (GBA) activity that leads to the accumulation of glucocerebroside in macrophages in multiple organs, such as the bone marrow, liver, spleen, and brain. GD can be classified into three clinical types: type 1 (non-neuropathic form, OMIM #230800); type II (acute neuropathic form, OMIM #230900); and type III (chronic neuropathic form, OMIM #231000). Type III is the subacute form of neuropathic GD. The best available treatment for GD is long-term enzyme (imiglucerase) replacement therapy (ERT) performed every two weeks. This report describes the long-term clinical course of a patient with type III GD who was treated with ERT for 18 years.

• Journal of Genetic Medicine
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• v.10 no.2
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• pp.113-116
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• 2013

Alexander disease is a rare degenerative leukodystrophy caused by dominant mutations in glial fibrillary acidic protein (GFAP). The neonatal form of Alexander disease may manifest as frequent and intractable seizures or obstructive hydrocephalus, with rapid progression leading to severe disability or death within two years. We report a case of a 50-day-old male who presented with intractable seizures and obstructive hydrocephalus. His initial magnetic resonance imaging (MRI) suggested a tumor-like lesion in the tectal area causing obstructive hydrocephalus. Despite endoscopic third ventriculostomy and multiple administrations of antiepileptic drugs, the patient experienced intractable seizures with rapid deterioration of his clinical status. After reviewing serial brain MRI scans, Alexander disease was suspected. Subsequently, we confirmed the de novo missense mutation in GFAP (c.1096T>C, Y366H). Although the onset was slightly delayed from the neonatal period (50 days old), we concluded that the overall clinical features were consistent with the neonatal form of Alexander disease. Furthermore, we also suspected that a Y366 residue might be closely linked to the neonatal form of Alexander disease based on a literature review.

• IMMUNE NETWORK
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• v.9 no.5
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• pp.158-168
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• 2009

Tumor therapy using cytokines has been developed for last two decades. Several recombinant cytokines and tumor cell vaccines produced by cytokine gene transfer have been in clinical trials, but several side effects hamper routine clinical applications. Many cytokines are originally expressed as membrane-bound form and then processed to secretory form exerting paracrine effects. Though functional differences of these two types of cytokines are elusive yet, the membrane-bound form of cytokine may exert its effects on restricted target cells as a juxtacrine, which are in physical contacts. With the efforts to improve antitumor activities of cytokines in cancer patients, developing new strategies to alleviate life-threatening side effects became an inevitable goal of tumor immunologists. Among these, tumor cell vaccines expressing cytokines as membrane-bound form on tumor cell surface have been developed by genetic engineering techniques with the hope of selective stimulation of the target cells that are in cell-to-cell contacts. In this review, recent progress of tumor cell vaccines expressing membrane-bound form of cytokines will be discussed.

• The korean journal of orthodontics
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• v.34 no.6 s.107
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• pp.481-487
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• 2004

The purpose of this study was to clarify morphologic characteristics between mandibular clinical arch forms in Koreans with normal occlusions. The study included data from 102 Koreans. The most facial portion of 13 proximal contact areas was digitized from photocopied images of the mandibular dental arches. Clinical bracket points were calculated for each tooth based on mandibular tooth thickness data. Four linear and two proportional measurements were taken. The dental arches were classified into ovoid, square and tapered forms. The frequency distributions of the three mandibular arch form classifications were determined and compared between male and female subjects. No significant differences in arch form size were found between the sexes. However, there were a few differences in molar width. It was useful to classify mandibular clinical arch forms present in normal occlusion samples into ovoid, square and tapered categories. The frequency of the ovoid form was the highest, and that of the square form was the second highest. The tapered arch form was found in less than 10 percent of subjects. No significant differences in their frequency distributions and dimensions were shown between males and females.

• The Journal of KAIRB
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• v.1 no.2
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• pp.30-42
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• 2019

In pharmaceutical clinical trials as human material research, the collection, use, storage and provision of human materials must be in accordance with the criteria stipulated in 「Bioethics and Safety Act」, except in the case that some criteria about it is in the law related to clinical trials such as 「Pharmaceutical Affairs Act」 and 「Enforcement Rule on Safety of Drugs, etc.」 so these take precedence over. Under 「Bioethics and Safety Act」, the core aspect of the legal standard for obtaining informed consent is the use of statutory form . The use of statutory form ensure that both those who obtain informed consent and those who give it can know the contents contained this form as well as recognize its importance. Thus, the person who has the right to informed consent can sign the statutory form after correct understanding of the contents. In reality, however, some researchers and IRB members determine that only the main informed consent form is to be used because most of contents on statutory from are included in the main informed consent form. Some other researchers and IRB members judge that the use of statutory form is not needed if human materials may only be used for laboratory testing and the rest will not be stored and provided for future use. Most of these determination and judgement is based on the interpretation of the Korea National Institute for Bioethics Policy(hereafter, KoNIBP) on IRB Information Portal Site. But, it is questionable whether the KoNIBP's interpretation is legally valid and the KoNIBP is the legal entity having authority to interpret existing statute. In some cased not only using the main informed consent form including enough information about the collection, use, storage and provision of human materials but also collecting necessary minimum human materials, and discarding the rest, unusing the statutory form may not cause the problem to respect and protect the research participant's rights. Therefore, the provision stipulating the criteria about the use of statutory form as the legal standard of obtaining informed consent that applies all human material research without exception should review to revise. At least, straighten out the confusion surrounding whether or not the statutory form is to be used, before the revision of related provision, considering the logical opinions of some researchers and IRB Members, the Ministry of Health and Welfare as the legal entity having authority to interpret existing statute should represent its opinion about permission of the acceptable exceptions.

• The Journal of Korean Medicine
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• v.40 no.1
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• pp.1-11
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• 2019

Objectives: The aim of this study is to introduce the Clinical presentation and announce the importance of developing Clinical presentation of Korean medicine and suggest about development direction of Clinical presentation of Korean medicine. Methods: To Investigate the Clinical presentation used in western medicine. I think that Clinical presentation of Korean medicine is a systematic list of Korean medicine symptoms and a standard syndrome differentiation and treatment(辨證論治). So I would like to offer "PangYakHapPyon(方藥合編)" as a basis for developing Clinical presentation of Korean medicine. Results: The clinical presentation term has become widespread in use at Calgary Medical college. Calgary Medical college created a list of 120 clinical presentations In 1991. In Korea, 101 clinical presentations were made in 2016. "PangYakHapPyon(方藥合編)" has been used effectively for over 130 years and widely used in the public. In addition, "PangYakHapPyon(方藥合編)" is summarized in the symptoms and prescriptions that occur frequently in Korea. Conclusions: For the globalization and standardization of Korean medicine, Clinical presentation of Korean medicine should be developed. The overall form of Clinical presentation of Korean medicine uses the form of Clinical presentation of Canada and a standard syndrome differentiation and treatment(辨證論治) for diagnosis and treatment is based "PangYakHapPyon(方藥合編)".

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.714-720
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• 2012

With the help of information technology, it is the most important to collect clinical data correctly in clinical trials. For this, recently, in many pharmaceutical companies and Clinical Research Organizations (CRO) have tried to adopt an Electronic Case Report Form (eCRF) system. The eCRF system is a computerized system designed for collecting and managing clinical data in clinical trials. Although the eCRF is recognized as a significant system for clinical trials, until now there are no widely useable, due to the huge effort and expense at the initiatory stage of adopting eCRF system. In this study, we inquired the use of eCRF system developed for clinical trial at Korea Institute of Oriental Medicine. Especially, we focused on the time required for entering clinical data into the eCRF, hours of use, and the number of queries according to the time flow.

• Clinical and Experimental Pediatrics
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• v.48 no.4
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• pp.443-447
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• 2005

Castleman's disease is a rare non-neoplastic lymphoproliferative disorder of unknown etiology. It is divided into three histologic subtypes; hyaline-vascular(HV), plasma cell(PC) type and mixed type (HV-PC). It has two clinical expressions. The localized form, which presents as a slow growing mass, has a relatively benign clinical course. The multicentric form is multilocated and holds significant morbidity. The mainstay of treatment of the localized form is surgical resection. The multicentric form requires medical treatment comprising prednisolone and other immunosuppressor drugs. The disease in children seems to have a more favorable course than in adults. We report a 13-year-old boy with Castleman's disease of multicentric form who was successfully treated with prednisolone and intravenous immunoglobulin.

• Journal of Sasang Constitutional Medicine
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• v.24 no.4
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• pp.17-27
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• 2012

Objectives : This study proposes developing Sasang Medical Diagnosis Program using Facial form for increase in Sasang Constitution Diagnosis objectivity and putting the Diagnosis Program into practical use. The author presents a review of extant research on Sasang constitution diagnosis utilizing facial feature analysis and suggests an agenda for further research. Methods : For this thesis, a collection of dissertations on the subject of 'Usage of facial form for constitution diagnosis' published until September of 2012 such as RISS4U, OASIS, KISTI, Korean TK were reviewed. The final 33 dissertations were classified into two categories, basic or clinical research and then analyzed. Results : 9 out of 33 dissertations were of basic research and 24 were of clinical research. 1) As result of review of references, a uniform tendency was found in facial form according to Sasang Constitution. 2) In the grade of practical use, facial element is repeatedly used and the facial element of important use has constitutional differences. 3) Standard faces per Sasang Constitution were derived as result of 2-dimensional research. 4) 3-dimensional research focused on improvement of accuracy and reliability of 3D-AFRA, and there has been an attempt to develop a prototype for identification. Conclusions : For practical use of facial feature in Sasang Constitution Diagnosis, 1) Standardization of diagnosis through establishing Sasang Medical Diagnosis clinical protocol must be preceded. After the standardization, practical purpose and direction of facial form in general may be decided. 2) Information on high quality facial form of constitutional and conditional patients must be collected to form extensive database. 3) Subdivided symptomatology, as well as Sasang Constitution must be considered for diagnosis in order for diagnosis technique to acquire clinical practicality.