• Journal of Korean Medicine Rehabilitation
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• v.27 no.4
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• pp.21-31
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• 2017

Objectives This study aimed to review manual therapies for mononeuropathies of upper limb through domestic and foreign studies designed for human body. Methods We searched databases (KMbase, OASIS, RISS, NDSL, KISS, KoreaMed, MEDLINE/Pubmed, CENTRAL, EMBASE) on the 1st to 31th of July 2017 to find related literatures that published after 2000. Results Twenty-eight studies were finally included. Of these, 13 articles were published after 2010. Twenty-two studies were clinical trials and 6 were observational studies. Carpal tunnel syndrome were the most researched type of diseases (85.7%). Most frequently used method of manual therapies was neurodynamic mobilization (35.7%). Pain scales and questionnaires were generally employed for evaluation. Significantly effective studies were 72.2% in controlled trials and 90% in the studies without control group. Conclusions In this study, we reviewed literatures concerning manual therapies on mononeuropathies of upper limb. Further studies are needed on the various diseases of mononeuropathies of upper limb to retain the evidence for the effectiveness of manual therapies.

• Journal of Korean Medicine Rehabilitation
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• v.25 no.4
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• pp.47-54
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• 2015

Objectives This study aimed to research current trends of acupuncture treatment of whiplash associated disorder (WAD). Methods Clinical studies about acupuncture therapy on WAD were searched in 7 databases. The included studies were classified according to their publication dates, methods, interventions, outcome measures. Interventions were analyzed by accompanied intervention, acupoint, acupuncture retaining time and treatment period. Results 14 articles were included. The number of studies on acupuncture for WAD shows increasing tendency since 1990. The included studies consist of 6 randomized controlled trials (RCTs), 2 non-randomized controlled trials (nRCTs), 2 cohort studies, 1 before and after study, 1 case study and 2 case reports. Most studies used visual analogue scale (VAS) as primary outcome. Conclusions This review demonstrates that further clinical studies need to be carried out under the formal clinical practice guidelines of acupuncture therapy for WAD in order to support clinical treatment objectively.

• Journal of Oriental Neuropsychiatry
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• v.20 no.4
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• pp.79-89
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• 2009

Objectives : To address suitable method for designing clinical trial intervening Traditional Korean Herbal Medicine on General anxiety disorder through the recent clinical research in Chinese Herbal Medicine. Methods : Randomized, controlled trials(RCTs) of treatment of general anxiety disorder intervening herbal medicine were searched through CNKI databases. We examined several item of studies and evaluated using Jadad scale. We searched articles in CNKI with the key word "General anxiety disorder or 廣範性焦慮症", among them we selected the clinical trial studies related with herbal medicine except for case reports, studies of acupuncture therapy or west medicines. Results : 11 RCT studies of herbal medicine met inclusion criteria. The Studies used CCMD-3, HAMA as inclusion tool and mainly HAMA as a evaluation tool. Studies were progressed for 2-8 weeks, mostly used various positive control. Experiment medicine were mainly 理氣劑, 安神劑. In most studies, experiment group made similar or higher efficacy in comparison with control group. Mean Jadad score of studies was $1.3{\pm}0.67$, and only one study was double-blinded among 11 studies. Conclusions : RCT studies on general anxiety disorder of chinese herbal medicine tend to focus on investigating effect of herbal medicine through setting positive control group with CCMD-3 and HAMA. But, most studies had low quality of trial, for lack of pattern identification, evaluation and inclusion tool of chinese medicine. Clinical trials of general anxiety disorder should provide good quality by randomization, double-blinding, and multi-site trial.

• Journal of Acupuncture Research
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• v.32 no.1
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• pp.97-107
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• 2015

Objectives : The purpose of this study is to explore the antitumor mechanism and effects of tetrodotoxin through a literature review of experimental and clinical studies. Methods : Medical databases, including The Cochrane Library, Pubmed, NDSL, RISS4u and National Assembly Library, were searched for relevant articles published from January 1, 2000 to October 31, 2014 using the keywords 'tetrodotoxin', 'cancer' and 'tumor'. The results were classified into experimental studies(in vitro and in vivo) and clinical studies. Analysis of the results was conducted on several research areas including the mechanism, antitumor effect and adverse effects of tetrodotoxin(TTX). Results : A total of 34 experimental studies(32 in vitro and 2 in vivo) and 3 clinical studies were found in the search. Most of the experimental studies suggested blocking of voltage-gated sodium channels in metastasis of tumor cells as the main antitumor mechanism of TTX. The most common type of cancers mentioned in the experimental studies were prostate and breast cancer. All of the clinical studies were on the application of TTX on moderate to severe cancer-related pain. No adverse effects of TTX were reported in in vivo studies but mild to moderate adverse events were reported in clinical studies. Conclusions : The results show that tetrodotoxin, which is the main component of Tetraodontidae(commonly known as pufferfish) poison, could be clinically used for antitumor therapy. However, further studies should be conducted on its safety.

• The Journal of Internal Korean Medicine
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• v.42 no.6
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• pp.1184-1198
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• 2021

Objectives: The aim of this study was to investigate the latest clinical studies on Korean medicine treatment of post-concussion syndrome (PCS) in the Chinese National Knowledge Infrastructure Database (CNKI). Methods: We searched the last 10 years of clinical studies discussing Oriental medicine-based treatments for PCS in the CNKI database. The search focused on the authors, publication year, type of study, purpose of the study, method and duration of treatment, evaluation criteria, and results of each article. Results: Of the 22 selected studies, 1 was a non-randomized controlled trial (nRCT), 2 were case series, and 19 were randomized controlled trials (RCTs). Treatments included oral herbal medicine in 16 studies, oriental medicine through external use in 2 studies, acupuncture in 3 studies, and traditional Chinese medicine injection in 2 studies. The most frequently used herb was Cnidii Rhizoma (川芎). All 22 studies confirmed the efficacy of Oriental medicine treatments. Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for PCS. The results of this study could be used as basic data for further PCS studies.

• Journal of Oriental Neuropsychiatry
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• v.28 no.4
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• pp.303-318
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• 2017

Objectives: To establish a base for further research by reviewing studies on traditional Chinese medicine treatment for Tourette Syndrome. This is the purpose of this study. Methods: Clinical studies involving the effects of traditional Chinese medicine treatment for Tourette Syndrome, published January 2010~June 2017, were obtained from CNKI, Pubmed. Selected Studies were evaluated by the Jadad Scale. Results: Among a total of 252 articles, 39 articles that meet the criteria were selected. 'Diagnostic and Statistical Manual for Mental Disorders, 4th edition (DSM-IV)' was most frequently used as diagnosis criteria. 'Yale Global Tic Severity Scale (YGTSS)' was primarily used for outcome measurements. Most of the studies showed effective results of traditional Chinese medicine therapy. However, the quality of a selected clinical studies was low. Conclusions: Despite several limitations, various studies to prove limited yet effective traditional Chinese medicine treatment on Tourette Syndrome provides much significance. Subsequent studies conducted by the complementary systematic review and well-designed clinical trials using the methodological quality will be needed to more firmly validate the effect of traditional Chinese medicine therapy.

• Herbal Formula Science
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• v.27 no.1
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• pp.87-100
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• 2019

Objective : This study's purpose was to review the clinical studies of Mahwang-tang (MHT). Method : We searched ten clinical studies of MHT using KISS, RISS, NAVER, PUBMED, Science Direct. Ten papers were sorted by 4 topics, as influenza, pediatric febrile symptoms, contact dermatitis, and adjuvant for chronic hepatitis C. At last we analyzed if these papers are consistent with the keywords of Shanghanlun provisions about MHT. Results : When summarizing these papers again by topic, there were 4 studies on influenza, 1 study on pediatric febrile symptoms, 1 study on contact dermatitis and 4 studies as an adjuvant for chronic hepatitis C. Conclusion : These studies were consistent with terms such as fever, headache, aversion to wind, body pain, pain in the lumbar, articular pain written in Shanghanlun provisions. In addition to this, research on anti-depressive effects of MHT is proceeding systematically. However, studies on nosebleeds and pulses are still underdeveloped and further studies are needed.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.14 no.1
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• pp.99-118
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• 2019

Objectives : The purpose of this study was to analyze trends of posture pattern in Korean literature. Methods : We searched four Korean databases (NDSL, RISS, OASIS, and KISTI) and classified the studies according to publication year and the study type. Additionally, we analyzed clinical research papers according to the predominant reported posture pattern, the type of study, assessment for clinical outcomes. Results : In total, 50 published studies were included in our analysis, and we determined the following: By study type, there were 37 interventional studies, 6 observational studies and 7 non-clinical research papers. In the interventional studies, the most common posture pattern was the forward head posture pattern, which was investigated in 22 studies. As a tool for evaluating posture pattern, cervical vertebral angle and the height of the scapula inferior angle are used most. Conclusions : Although this study has provided insight into the commonly investigated posture patterns types in Korean clinical studies, further research is required and future studies should include randomized controlled trials and systematic reviews in their analyses.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.3
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• pp.35-48
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• 2022

Objectives The purpose of this study is to review relevant clinical studies to investigate the effectiveness of herbal medicines for IgA (Immunoglobulin A) nephropathy in children. Methods Studies on herbal treatment for IgA nephropathy were searched and analyzed through electronic databases such as PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang, CiNii, J-STAGE, Oriental Medicine Advanced Searching Integrated System and Science ON. Studies included Randomized controlled trials and case series. Results We selected nine studies and analyzed the findings. In most studies, improvement of IgA nephropathy was observed after treatment, and was evaluated using factors as 24 hour urine protein, hematuria, Scr (serum creatinine) and BUN (blood urea nitrogen). The most commonly used herbs for IgA nephropathy were Poria cocos (茯苓), Astragalus membranaceus (黃芪), and Rehmannia glutinosa (生地黃). Conclusions Based on the results of the clinical studies, we identified that herbal medicine is an effective treatment for IgA nephropathy. However, additional systematic clinical studies are necessary to prove its effect and safety.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.1
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• pp.78-90
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• 2022

Objectives The purpose of this study is to review relevant clinical studies to investigate the effectiveness of herbal medicines for night terror in children. Methods Studies on herbal treatment for night terrors were searched and analyzed through electronic databases such as PubMed, China National Knowledge Infrastructure, Wanfang, CiNii, J-STAGE, Oriental Medicine Advanced Searching Integrated System and Science ON. Studies included Randomized controlled trials, case series, and case reports. Results A total of 25 studies were selected and analyzed. In most studies, improvement of night terrors was observed after treatment, such as high total effectiveness. In one study, the frequency of night terrors was decreased significantly in herbal medicine group. Conclusions Based on the results of the clinical studies, we identified that herbal medicine is an effective treatment for night terror. But it is considered necessary to prove the effect and safety through additional systematic clinical studies.