• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.116-134
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• 2005

Although the parallel prescription of Sopoongsangagambang (SG) administration along with external treatment such as spraying or ointment application on the skin is clinically used for the treatment of atopic dermatitis (AD), molecular mechanism underlying its effectiveness is unknown. Thus in the present study, diverse immune responses in terms of chemical mediators related to AD were investigated using an atopic mouse model NC/Nga after SG administration and external treatment (ET), and major findings are summarized as follows. 1. The clinical severities in 16 and 20 week old NC/Nga mice with SG and ET treatment were decreased to 72.2% and 62.3% respectively compared to the control NC/Nga mice with no drug treatment. 2. IgE, IL-4, IL-5, IL-6, IL-13, IgM, IgG1 and IgG2a levels in the serum of SG and ET treated NC/Nga mouse group were significantly decreased compared to the untreated control mice. In contrast, $IFN-{\gamma}$ showed a significant increase in the experimental group compared to the untreated control group. 3. The spleen weight of SG and ET treated NC/Nga mice was significantly decreased compared to the untreated control group. 4. The B/T ratio in the lymph node of SG and ET treated NC/Nga mice was increased compared to the untreated control group. $CD4^+\;and\;CD8^+$ cell numbers in the lymph node of SG and ET treated NC/Nga mice were significantly increased compared to the untreated control group, but $CD69^+\;and\;CD11a^+$ cells were significantly decreased. 5. mRNA expression levels of IL-4, IL-5, and CCR3 in the skin tissues of SG and ET treated NC/Nga mice were significantly decreased, and expression levels of IL-6, IL-13, $CD69^+/CD3{\varepsilon}^+\;and\;CD19^+/CD44^+$ in the skin tissues of SG and ET treated NC/Mga mice were significantly decreased compared to the untreated control group. $IFN-{\gamma}$ mRNA expression levels were increased compared to the untreated control group. 6. Histological observation of the ear and neck skin tissues showed that the extents of inflammation and infiltrated immune cells in the epidermis and dermis of SG and ET treated NC/Nga mice were highly reduced compared to the untreated control group. 7. Lymphokine assay showed a significant decrease in IL-4 levels in SG and ET treated NC/Nga mice compared to the untreated control group, but the levels of $IFN-{\gamma}$ secretion were significantly increased drug treated NC/Nga mice.

• Journal of Veterinary Clinics
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• v.34 no.6
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• pp.449-453
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• 2017

A 3-year-old castrated male Maltese dog, weighing 4.8 kg was referred with hindlimb ataxia and right forelimb proprioceptive deficits were shown for 20 months. Chiari-like malformation and syringomyelia diagnosed through MRI at a local animal hospital and Knuckling of right forelimb and reluctance to walk were managed with steroid. The medical management was getting ineffective to manage for the symptoms one month before referred. Physical and neurological examinations, radiography, computed tomography, and magnetic resonance imaging were performed and diagnoses of caudal occipital malformation syndrome (COMS) and subsequent syringomyelia (SM) were made. Given that pharmacological treatment was previously ineffective, surgical intervention was recommended. Foramen magnum decompression with duraplasty using $Lyoplant^{(R)}$ was performed. Three days post-surgery, the dog showed improved gait and activity. After 2 months, the dog received no additional prescription medications. At the 12-month follow-up after surgery, the dog showed no clinical problems or recurrences, despite complete cessation of pharmacological treatment. In present report, we applied $Lyoplant^{(R)}$ as a dural graft has been carried out in a dog with COMS. Surgical decompression with $Lyoplant^{(R)}$ was an effective long-term (12-month) treatment for COMS without the need for any pharmacological treatment.

• The korean journal of orthodontics
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• v.35 no.6 s.113
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• pp.459-474
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• 2005

Making a precise and ideal set-up model is an essential part in the indirect bonding procedure for lingual orthodontic treatment. To evaluate the accuracy of the making a set-up model, 22 adult patients who received lingual orthodontic treatment with 4 bicuspid extractions were selected, and 3 sets of dental models (before, set-up, and after treatment) were measured using the set-up model gauge, an instrument for measuring the inclination and angulation of the clinical crowns on the dental model. Two sets of lateral cephalograms (before and after) from each patient were also evaluated. The mean difference between the before treatment model and the set-up model was $-3.93{\pm}6.98^{\circ}$ for the inclination and $1.87{\pm}5.79^{\circ}$ for the angulation. And the mean difference between the set-up model and the after treatment model was $-4.31{\pm}5.91^{\circ}$ labiolingually and $-2.16{\pm}3.27^{\circ}$ mesiodistally, The after treatment model differed from the before treatment model about $-8.24{\pm}5.39^{\circ}$ in inclination. There were no significant difference between the measured gauge that measured from the dental model using the set-up model gauge and the calculated gauge angle measured from the lateral cephalogram using constructed points and lines. Using the set-up model gauge, it is possible to evaluate the study model 3-dimensionally in relation with the patient's lateral cephalogram and establish whether the doctor's prescription or overcorrection is built in the set-up model precisely.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.325-331
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• 2015

Purpose: This study was to find the correlation between exophthalmetry and visual functions. Methods: Exophthalmetry and visual functions of 200 adults without ophthalmophathy and general disease were examined. Exophthalmetry were measured with Hertel's exophthalmometer. Visual functions (myopia, distance exophoria, near exophoria, near point of convergence, near point of accommodation) were measured for three times. Results: The exophthalmetry was $13.59{\pm}1.10mm$. Myopia, distance exophoria, near exophoria, near point convergence, and near point accommodation were measured as $-2.48{\pm}1.91D$, $3.51{\pm}1.78{\Delta}$, $5.73{\pm}2.44{\Delta}$, $9.63{\pm}2.82cm$, and $21.73{\pm}10.28cm$. With increasing exophthalmetry, the unaided visual acuity, myopia and astigmatism were decreased. On the other hand, distance exophoria, distance esophoria, near exophoria, near point of convergence and near point of accommodation were significantly increased, while exophthalmetry was increased. Conclusions: The relationship between visual functions and exophthalmetry were found to be statistically significant. It could be used as the clinical criteria for prescription of binocular inspections.

• Journal of radiological science and technology
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• v.25 no.1
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• pp.63-71
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• 2002

The aim of this study Is to develop a simple and fast method which computes in-vivo doses from transmission doses measured doting patient treatment using an ionization chamber. Energy fluence and the dose that reach the chamber positioned behind the patient is modified by three factors: patient attenuation, inverse square attenuation. and scattering. We adopted a straightforward empirical approach using a phantom transmission factor (PTF) which accounts for the contribution from all three factors. It was done as follows. First of all, the phantom transmission factor was measured as a simple ratio of the chamber reading measured with and without a homogeneous phantom in the radiation beam according to various field sizes($r_p$), phantom to chamber distance($d_g$) and phantom thickness($T_p$). Secondly, we used the concept of effective field to the cases with inhomogeneous phantom (patients) and irregular fields. The effective field size is calculated by finding the field size that produces the same value of PTF to that for the irregular field and/or inhomogeneous phantom. The hypothesis is that the presence of inhomogeneity and irregular field can be accommodated to a certain extent by altering the field size. Thirdly, the center dose at the prescription depth can be computed using the new TMR($r_{p,eff}$) and Sp($r_{p,eff}$) from the effective field size. After that, when TMR(d, $r_{p,eff}$) and SP($r_{p,eff}$) are acquired. the tumor dose is as follows. $$D_{center}=D_t/PTF(d_g,\;T_p){\times}(\frac{SCD}{SAD})^2{\times}BSF(r_o){\times}S_p(r_{p,eff}){\times}TMR(d,\;r_{p,eff})$$ To make certain the accuracy of this method, we checked the accuracy for the following four cases; in cases of regular or irregular field size, inhomogeneous material included, any errors made and clinical situation. The errors were within 2.3% for regular field size, 3.0% irregular field size, 2.4% when inhomogeneous material was included in the phantom, 3.8% for 6 MV when the error was made purposely, 4.7% for 10 MV and 1.8% for the measurement of a patient in clinic. It is considered that this methode can make the quality control for dose at the time of radiation therapy because it is non-invasive that makes possible to measure the doses whenever a patient is given a therapy as well as eliminates the problem for entrance or exit dose measurement.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5019-5024
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• 2015

Background: The purpose of this study was to assess the dosimetric and clinical feasibility of volumetric modulated arc based hypofractionated stereotactic radiotherapy (RapidArc) treatment for large acoustic schwannoma (AS >10cc). Materials and Methods: Ten AS patients were immobilized using BrainLab mask. They were subject to multimodality imaging (magnetic resonance and computed tomography) to contour target and organs at risk (brainstem and cochlea). Volumetric modulated arc therapy (VMAT) based stereotactic plans were optimized in Eclipse (V11) treatment planning system (TPS) using progressive resolution optimizer-III and final dose calculations were performed using analytical anisotropic algorithm with 1.5 mm grid resolution. All AS presented in this study were treated with VMAT based HSRT to a total dose of 25Gy in 5 fractions (5fractions/week). VMAT plan contains 2-4 non-coplanar arcs. Treatment planning was performed to achieve at least 99% of PTV volume (D99) receives 100% of prescription dose (25Gy), while dose to OAR's were kept below the tolerance limits. Dose-volume histograms (DVH) were analyzed to assess plan quality. Treatments were delivered using upgraded 6 MV un-flattened photon beam (FFF) from Clinac-iX machine. Extensive pretreatment quality assurance measurements were carried out to report on quality of delivery. Point dosimetry was performed using three different detectors, which includes CC13 ion-chamber, Exradin A14 ion-chamber and Exradin W1 plastic scintillator detector (PSD) which have measuring volume of $0.13cm^3$, $0.009cm^3$ and $0.002cm^3$ respectively. Results: Average PTV volume of AS was 11.3cc (${\pm}4.8$), and located in eloquent areas. VMAT plans provided complete PTV coverage with average conformity index of 1.06 (${\pm}0.05$). OAR's dose were kept below tolerance limit recommend by American Association of Physicist in Medicine task group-101(brainstem $V_{0.5cc}$ < 23Gy, cochlea maximum < 25Gy and Optic pathway <25Gy). PSD resulted in superior dosimetric accuracy compared with other two detectors (p=0.021 for PSD.

• Journal of Korean Medical classics
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• v.21 no.2
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• pp.1-20
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• 2008

The Song Dynasty(宋代) period gained the summit in the developmental phase of the history in pediatrics. In 1076, Taeuiguk(太醫局) was founded and Sobangmaek(小方脈) was the one of nine branch in Taeuiguk(太醫局). As a result, educational agency and system was arranged in the field of pediatrics. At the same time, pediatrics have furnished with foundation to develop independent field in medical science. Especially, Byeonjeungnonchi(辦證論治) system is established in pediatrics science according to the compilation of "Soayakjeungjikgyeol(小兒藥證直訣)" by Jeoneul(錢乙). Children's doctors, Jeoneul(錢乙), Jinmunjung(陳文中) and Donggeup(董汲) arranged clinically theories, so they made that age the peak of the pediatrics. Looking at the developmental part of theory in pediatrics of the Song Dynasty period, Jeoneul(錢乙), who was the representative children's doctor in Song Dynasty period, insisted that children had formed Ojang-yukbu(五臟六腑) in the physiological part but they were not perfect like adult's. Therefore they had to consider the poor part in children's body, and then they had to cure them. 'Byeonjeung(變蒸)' was considered to be normal physiological phenomenon. Also he insisted that Yukeum(六淫), 'Pung, Han, Seo, Seup, Jo, Hwa(風, 寒, 暑, 濕, 燥, 火)' and 'Gyeong, Pung, Gon, Cheon, Heo(驚, 風, 困, 喘, 虛)' are the main cause of the children's five vital organ's pathology Like this, his academic thought, which lay emphasized on children's spleen and stomach and Ojangbyeonjeung(五臟辦證) main principles, affected on doctors, Donggeup(董汲), Yeomhyochung(閣孝忠), Yubang(劉肪), Jang-wonso(張元素), Idong-won(李東垣), Manjeon(萬全). Bangje(方劑) fields of pediatrics had developed so fast and "Taepyeongsunghyebang(太平聖惠方)" contained about 2689 kinds of children's prescription. According to this, there are so many kinds of medicinal shape, for example 'Hwan, San, Go, Dan(丸, 散, 膏, 丹)', which cured children' s disease. Through this, we find that the shape of medicine about the children's diseases had developed to the more simple direction, taking account of the children's clinical trait.

• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.337-380
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• 1996

'Nei Jing(內徑)' first defined the interrelationship of the true and tile false between evil factor affecting health(雅氣) and vital essence energy(精氣). According to 「'Nei Jing(內徑)', the above interrelationship is explained as 'If state of evil domination is considered as sthenia-syndrome(雅氣盛則實), if the consumption of healthy energy Is considered as asenia-syndrome(精氣尊則虛): 'Nei Jing(內徑)', proposed major features of the medicall treatment by 'regluate the vatal energy of asthenia and sthenia, treat the sthenia-syndrome by purgation, and treat the asenia-syndrome by therapy of invigoration(調其氣之虛實, 實則瀉之, 虛則補之): The above interrelationship was interpreted as 'treat the asthenia-syndrome of child organ by invigorating the mother organ(虛者補其母)'in the 69th of 'The Classic on Difficulty',(難經 六十九難). Go-Mu(高武) of Myung-dynasty describe therapy for invigoration and purgation of itself-meridian(自經 補瀉法), which locating acupuncture points according to the Therorr of Five Element in the five shu points of itself-meridian(自經 五유穴), based on the generation in the ${\ulcorner}$A Synthetical Book of Acupuncture and Moxibustion(針灸聚英)${\lrcorner}$, Sae-hyun Jang(張世賢) further extended location acupuncture points of the five shu points to the other-meridian in the ${\ulcorner}$Gyeo Jung Do Ju Nan Gyung(校正圖註難經)${\lrcorner}$ Sa-Ahm's 5 Element Acupuncture Method(舍嚴五行鍼法) was originated in 1644, the middle of the Yi-dynasty. It linked the reinforcing and reducing in acupuncture therapy which incorporated tlle asthenia-syndrome and sthenia-syndrome of the hollow organs, based on principle of the Yin Yang 5 Element Theory(陰陽五行學說), not only to the generation in the 5 element(相生關係) but also to the restriction in the 5 element(相剋關係). Furthermore it was devised for the medical treatment by comning therapy for invigoration and purgation of itself-meridian(自經 補瀉法) with that of the other-meridian. Even though many original forms(正形) of the therapy for invigoration and purgation of the Yin Yang 5 Element Theory comply with the principle of the generation and the restriction based on the principle of the Yin Yang 5 Element Theory are abailable, variational forms(變形) are also recognized by examining the nature of the Sa-Ahm's 5 Element Acupuncture Method(舍嚴五行鍼法), For this reason, it is very difficult to understand the Sa-Ahm's 5 Element Acupuncture Method(舍嚴五行鍼法) thoroughly. therefore, those variational forms are obstacles for the beginners to study the Sa-Ahm's 5 Element Acupuncture Method. In order to understand the principle of the practical clinical application of the Sa-Ahm's 5 Element Acupuncture Method, this study investigated which principle was based on the variations of the locating acupuncture points' method for the acupuncture prescription.

• Advances in Traditional Medicine
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• v.10 no.2
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• pp.116-122
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• 2010

Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.

• Clinical and Experimental Pediatrics
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• v.50 no.4
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• pp.381-385
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• 2007

Purpose : Traditional herbal medicines may be overused in Korea. Expenditures and inaccuracies of hospital prescription are increasing gradually. So we investigated the frequency and nature of herbal medicine use among elementary school pupils. Methods : We interviewed students of three elementary schools located in Gwangju with survey papers. We analyzed 905 returned surveys. Results : They consisted of 421 males and 484 females. Five hundred ninety (65.2 percent) of pupils who have taken herbal medicines since birth. First grade made up 74.1 percent, 2nd grade 63.0 percent, 3rd grade 64.8 percent, 4th grade 63.3 percent, 5th grade 65.5 percent, and sixth grade 61.9 percent, respectively. The mean frequency of herbal medicine use was 3.2 times. 6th grade was 3.3 times, 5th grade 3.9 times, 4th grade 3.7 times, 3rd grade 2.7 times, 2nd grade 2.7 times, and 1st grade 2.6 times, respectively. The mean cost of herbal medicine use was from 50,00-100,000 won. The mean age of pupils who took their 1st herbal medicine was 55 months, 6th grade 67 months, 5th grade 58 months, 4th grade 54 months, 3rd grade 55 months, 2nd grade 51 months, and 1st grade 47 months. The most common reason of herbal medicine use was "looking weak, without disease." The rate of elementary pupils who had good effects was 63.7 percent; the rate of side effects was 4.5 percent. Conclusions : The rate of elementary pupils who took herbal medicines was high and gradually higher in lower grades. So, clinicians have to cope directly with this situation and to educate parents about herbal medicines.