• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1819-1823
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• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

• Journal of Convergence for Information Technology
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• v.10 no.5
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• pp.51-59
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• 2020

The purpose of this study was to find out a correlation of clinical nurse's character, clinical practice stress, stress coping and factor affecting nursing professional value on nursing students in Korea, and to use it as a basic data in developing nursing professional value promotion programs for nursing students. The study was composed of 145 students who were studying in fourth year student at colleges. Data were collected from May to June, 2019. Data analysis included an independent t-test, ANOVA, Pearson correlation coefficients and multiple regression using the SPSS program. As a result of this study, nursing professional value of those was significantly correlated with clinical nurse's character, clinical practice stress and stress coping. In a regression analysis, nursing professional value accounted for 38.2%(F=43.973, p=.000), of the variance of clinical nurse's character and stress coping. The most significant factor affection the success of nursing professional value was stress coping(β=.508, p=.000). The result of the study indicates the importance of developing clinical nurse's character and applying variety stress coping method for positive nursing professional value of nursing students.

• Journal of KIISE:Software and Applications
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• v.37 no.12
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• pp.871-881
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• 2010

Objective: A clinical contents model is an essential data model to exchange clinical data, among existing computer systems and enhance consistency of necessary data, in terms of its meaning and reusability. However, there has not been a domestic case where such clinical model is developed till present. Methods and Results: This research is based on determining principles of developing clinical information model which is a specified model of Health level 7 Reference Information Model and attempts to identify clinical contents with types of ENTITY-ATTRIBUTE-VALUE, based on terminology standard by clinicians and domain modelers. Conclusion: This model is projected to be utilized in the next generation of EMR as core contents.

• Journal of Oriental Neuropsychiatry
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• v.23 no.4
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• pp.11-36
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• 2012

Objectives : Sleep Disorders are very common in clinical stages and there are many reports and papers regarding this subject. I try to understand the present state of sleep research in JON (The Journal of Oriental Neuropsychiatry) for the benefits of clinical practice. Methods : We searched and read every article on JON from 1990 to 2012 and selected ones that are related to Sleep Disorder; then analyzed the data to 5 categories, like literature study, case study, Clinical Data-Analysis study, experimental study, and clinical trial. Results : 1. We Found 41 articles relating to sleep disorder in JON form 1999 to 2012, and there were 9 literature studies, 13 case studies, 13 Clinical Data-Analysis studies, 4 experimental studies, and 2 clinical trials. 2. There were Sa-Am Acupuncture Method, Pharmacopuncture, electroacupuncture, and Auricular acupuncture to treat Sleep Disorder. 3. There were many additional treatments like Purgative Therapy, etc. 4. They reported the ordinary sleep pattern of Soeumin and Soyangin, too. 5. In the experimental study, they reported several herbs, herbal prescription on the expression of melatonin receptors, and Punsimgeimgamibang on insomnia, anxiety, emotionality in rats. 6. There were 2 clinical trials, one for Hwabyung-patient with insomnia by acupuncture treatment and another for insomnia in the elderly by ETF-I program. 7. There were 2 case of other sleep disorder (enuresis, sleepwalking) and 2 literature study of dream. Conclusions : In JON regarding sleep disorder, the majority was due to insomnia. Therefore, we also have to expand our sight into other sleep diseases. We need more clinical trials and experimental researches for the construction of EBM Sleep Disorder in Oriental Neuropsychiatry.

• Korean Journal of Clinical Pharmacy
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• v.33 no.3
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• pp.178-185
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• 2023

Objective: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease. Both tralokinumab and dupilumab have been recommended in the European Guideline for the treatment of adult patients with severe AD. In Korea, dupilumab has been approved for patients with moderate to severe AD, and reimbursed for those with severe AD. Since there is no clinical trial directly comparing tralokinumab and dupilumab, we conducted indirect comparison to assess the clinical usefulness in patients with AD. Methods: We selected clinical trials for indirect comparison through a systematic literature review. Individual patient data were available for the tralokinumab clinical trial, and aggregated data were available for the dupilumab clinical trial. Therefore, we employed the Matching-Adjusted Indirect Comparison (MAIC) method. The treatment efficacy was assessed based on whether patients achieved a 75% reduction on the Eczema Area and Severity Index (EASI 75) after drug administration. Results: The difference in the proportion of patients achieving EASI 75 between tralokinumab and dupilumab was 4.7% (95% CI: -7.9 to 17.3). Considering the non-inferiority margin for the EASI 75 achievement rate is -10%, tralokinumab is deemed non-inferior to dupilumab as the lower bound of the CI for the difference in the EASI 75 achievement rate between tralokinumab and dupilumab was within -10%. Conclusion: We conducted a MAIC analysis comparing tralokinumab and dupilumab based on EASI 75 achievement. The findings of this study show that tralokinumab is non-inferior to dupilumab and can be implemented in Korean clinical settings with a therapeutic position comparable to dupilumab.

• Journal of the Korean Data and Information Science Society
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• v.26 no.3
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• pp.695-706
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• 2015

The purpose of this study was to examine the relationship among self-leadership, critical thinking disposition, satisfaction of clinical practice and clinical practice competency of nursing students. Participants were 199 baccalaureate nursing students (3rd and 4th grades) in 2 cities. The data was collected by questionnaires and were analyzed with the SPSS/Win 21.0 program, using descriptive statistics, Pearson's correlation coefficient and multiple regression. Significant positive correlations were among self-leadership, critical thinking disposition, satisfaction of clinical practice and clinical practice competency. The regression model explained 30.4% of satisfaction of clinical practice. The significant predictors of satisfaction of clinical practice were clinical experience, satisfaction of major, self-leadership and critical thinking disposition. The regression model explained 23.7% of clinical practice competency. Health status, self-leadership and critical thinking disposition were factors influencing clinical practice competency. It should strengthen self-leadership and encourage critical thinking disposition to improve nursing students' satisfaction of clinical practice and clinical practice competency.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.12 no.2
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• pp.195-205
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• 2005

Purpose: This study was done to use preceptorship in an ordered elective clinical nursing practice and to evaluate the effects on student nurses, nurses managers and preceptors. Method: The participants in this study were 208 students who were majors in the department of nursing, G college located in Inchon Metropolitan City, 54 nurse managers and 187 preceptors from 11 general hospitals. The instrument was a questionnaire which included general characteristics of participants, and 21 items to evaluate the ordered elective clinical nursing practice on a scale of 1 to 4. Data were collected from October 23 to November 7. 2004. Data analysis was done using SPSS WIN with the following statistics: frequency, percentage, mean, standard deviation, and ANOVA. Results and Conclusions: The results of data analysis were as follows: There were meaningful differences in the evaluation scores of the ordered elective clinical nursing practice with preceptors between students ($3.33{\pm}.39$) and nurse managers ($3.33{\pm}.28$) and preceptors ($3.23{\pm}.38$). Evaluation scores for the ordered elective clinical nursing practice with preceptors were categorized as follows: necessity and appropriateness, practice control and management, material for practice, practice report assignment and evaluation, practice ability improvement and connection with getting a job, and contribution to the hospitals.

• Journal of Korean Biological Nursing Science
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• v.12 no.1
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• pp.63-72
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• 2010

Purpose: The purpose of this study is to assess the effects of raloxifene in prevention of cardiovascular disease in postmenopausal women. Methods: A systematic literature review was conducted. Data sources: The existing literature from 1986 to 2009 was searched electronically using the data base of Medline with the key words of hypertension, obesity, diabetes, cholesterol, lipid, myocardial infarction, coronary events with combination of raloxifene. Study selection: The criteria for inclusion in the review were 1) an randomized clinical trial (RCT), 2) postmenopausal women, 3) English or Korean language. Finally, 15 articles were included in the review. Data extraction: Findings from the studies were organized according to the results of lipid profile changes by two authors. Results: Among 15 articles, 12 studies reported the beneficial effects of raloxifene on LDL cholesterol and 9 studies on total cholesterol in the postmenopausal women. Conclusion: The consistent results on reduction of LDL cholesterol and total cholesterol in raloxifene using postmenopausal women were confirmed. However, the effect of raloxifene on other components of lipid profile and endothelial function were still remaining controversial.

• Journal of East-West Nursing Research
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• v.29 no.1
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• pp.78-85
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• 2023

Purpose: This study aims to examine factors affecting nursing professionalism among nursing students. Methods: Data were collected using a structured questionnaire from July to August, 2022. The participants were a total of 266 students in the 3^rd and 4^th grades located in A and C cities. T-test, ANOVA, Scheffe' test, Pearson's correlation coefficient and multiple regression were used for data analysis using SPSS 24.0 program. Results: The average score for clinical competency was 4.05±0.59 (out of 5), confidence in essential nursing skill was 3.52±0.64 (out of 5), and nursing professionalism was 4.11±0.52 (out of 5). There was a positive correlation between clinical competency and confidence in essential nursing skills with nursing professionalism. The factors influencing nursing professionalism were clinical competency and grade, which explained 30% of nursing professionalism. Conclusion: The results of this study may be used as basic data for developing educational methods to improve nursing professionalism.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.366-370
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• 2005

Tissue microarry is one of the high throughput technologies in the post-genomic era. Using tissue microarray, the researchers are able to investigate large amount of gene expressions at the level of DNA, RNA, and protein The important aspect of tissue microarry is its ability to assess a lot of biomarkers which have been used in clinical practice. To manipulate the categorical data of tissue microarray, we applied Bayesian network classifier algorithm. We identified that Bayesian network classifier algorithm could analyze tissue microarray data and integrating prior knowledge about gastric cancer could achieve better performance result. The results showed that relevant integration of prior knowledge promote the prediction accuracy of survival status of the immunohistochemical tissue microarray data of 18 tumor suppressor genes. In conclusion, the application of Bayesian network classifier seemed appropriate for the analysis of the tissue microarray data with clinical information.