• 생약학회지
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• 제52권4호
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• pp.208-211
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• 2021

Four compounds were isolated from 90% ethanol extract of the stem of Clematis heracleifolia. On the basis of spectral data, the structure of isolated compounds were identified as sitosterone (1), β-sitosterol (2), scoparone (3) and octadecanoyl caffeate (4), respectively. Sitosterone (1) and octadecanoyl caffeate (4) are isolated from this plant for the first time.

• 생약학회지
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• 제46권1호
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• pp.6-11
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• 2015

To clarify chemical constituents of Clematis heracleifolia, isolation and structure elucidation of the underground parts of C. heracleifolia were performed. Five compounds were isolated from $CHCl_3$ and n-BuOH soluble fraction of this plant. On the basis of spectral and physico-chemical data, the structure of isolated compounds were identified as coniferyl alcohol (1), scoparone (2), (+)-lariciresinol (3), phytosterols (4), and daucosterol (5), respectively. All compounds are isolated from this plant for the first time. To evaluate anti-acetylcholinesterase activity of the isolated compounds, compounds 1, 2, 3, and 5 were tested inhibition activity against acetylcholinesterase. Among tested compounds, daucosterol (5) showed acetylcholinesterase inhibitory activity with $IC_{50}$ value of $6.1{\mu}M$.