• Journal of Pharmaceutical Investigation
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• 제30권3호
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• pp.179-189
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• 2000

Clebopride malate(Cm) is a new benzamide drug which has a potent central antidopaminergic activity possessing antiemetic and anxiolytic properties. A purpose of this study was to assess the feasibility of formulating sustained release preparation by dispersing a drug in hydrophilic polymeric matrices and double layered tablets(DLT), using HPMC, carbopol, PEO, PVP/VA and other polymers as a rate controlling barrier. The matrix and DLT showed optimum dissolution pattern up to 8 hours and the contents of polymer were optimized at 30% level in this preparation. After an oral administration in beagle dog, Cm concentration was determined by use of GC-ECD and pharmacokinetic parameters were calculated by Vallner's method. The AUC of DLT showed similar results and the duration of action was increased 55% compared to that of regular release dosage form. The calculated absorption rate effectiveness(ARE) and controlled release effectiveness(CRE) for DLT increased 50% compared to that of matrix, the overall effectiveness(E) of this product appears to be about 70%. in vivo effectiveness test, DLT showed significant differences from control on antiemetic action of Cm. In consequence, it was possible to conclude that double layered tablet might be a good candidate for the sustained release dosage forms.

• Journal of Yeungnam Medical Science
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• 제4권1호
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• pp.59-63
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• 1987

1. 기능성 소화기 장애증상이 있고 GET의 지연을 보였던 환자들의 GET 평균치는 22.49분으로 정상군 9.6분보다 유의하게 증가되어 있었으며 이를 환자수는 44명으로 88%에 해당하였다. 2. GFT지연군 15명에게 1단간 Cleboril을 투이한 결과 유의한 GET단축이 관찰되었으며 이중 11명(73%)에서는 현저한 단축소견이 있었다. 3. 기능성 소화기 장애증상을 호소하는 환자에서의 GET측정은 건강염려환자를 선별하는데 유용할 뿐만 아니라 간기능검사, 상부위상관, X-선촬영, 위내시경검사 및 경구담낭조영술 등에서 정상으로 확인된 환자에서 잠복된 소화기성 질환을 발견하는데도 유용하게 이용될 수 있을 것으로 사료된다.