• 한국ITS학회 논문지
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• 제9권5호
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• pp.59-66
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• 2010

최근 서울시를 비롯한 대도시를 중심으로 자전거 전용도로가 설치되면서 자전거 이용자가 급증하는 실정이며, 이에 따라 보행자와 자전거, 자동차와 자전거간의 상충이 빈번한 실정이다. 이를 해결하기 위해서 자동차/자전거/보행자를 시 공간적으로 분리해주는 자전거 전용신호이 도입되었다. 그러나 자전거의 경우, 자동차와 속도 등의 특성이 상이하므로 자전거 이용자를 위한 별도의 신호변환시간이 필요하다. 본 논문에서는 AASHTO에서 제시한 자전거 신호등의 신호변환시간 산출공식을 이용하여 자전거의 평균속도 및 감속도 등을 현장실험을 통해 별도로 도출하여 우리나라 실정에 맞는 자전거 신호등의 신호변환시간을 제시하였다. 결과적으로, AASHTO에서 제시한 감속도값 2.0m/sec2이상의 값은 자전거 이용자의 급정지에 해당하는 값에 해당하므로 도로여건 등을 고려하여 가급적 적용하지 않는 편이 타당한 것으로 분석되었다.

• 대한교통학회지
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• 제28권1호
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• pp.97-105
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• 2010

교차로에서 신호시간 변경 시 교차로를 벗어나지 못한 차량과 대향 차량, 교차로 횡단보도의 보행자(자전거)와의 충돌을 피하기 위하여 황색신호와 별도로 전전색신호를 운영하고 있다. 외국은 전적색신호 운영이 교통사고에 미치는 영향을 분석해 오고 있다. 반면 국내의 경우에는 이와 같은 유사한 연구가 미흡한 실정이다. 본 연구에서는 국내에서 운영되는 전적색신호가 교통사고에 어떠한 영향을 미치는 지를 가설검정 통하여 평가하였다. 전적색신호를 도입한 교차로 10개소에 대하여 전 후 사고율을 분석하였다. 95% 유의 수준에서 비모수 검정을 실시한 결과 전적색신호의 도입은 교차로 안전성을 향상시키는 것으로 분석되었다. 이는 전적색신호가 신호변경 중에 교차로에 남아 있는 차량의 정리와 미리 진입하는 차량을 통제함으로써 교차로내의 직각충돌사고를 감소시켰기 때문으로 분석된다.

• Parasites, Hosts and Diseases
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• 제61권2호
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• pp.147-153
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• 2023

Lampung is a malaria-endemic region in Indonesia with an annual parasite incidence of 0.06 per 1,000 population. The socio-demographic factors, clinical conditions, and artemisinin combination therapy (ACT) types might affect parasite clearance and parasite density. This study aims to investigate factors that influence parasite clearance and parasite density in malaria patients. A retrospective analytic observational and a cross-sectional approach was used to conduct this study. A total of 66 malaria patients were examined to investigate parasite density and clearance, socio-demographic profiles, clinical conditions, and ACT types. To analyze data, univariate, bivariate, and multivariate tests were used. Age (P=0.045; r=0.238) and ACT type (P=0.021; r=0.273) were the only variables that had a significant correlation with parasite clearance. Age (P=0.003; r=0.345) had a significant correlation with parasite density. The most influential factors related to parasite clearance were the ACT type (dihydroartemisinin piperaquine) (P=0.017; odds ratio (OR) 0.109; 95.0% confidence interval (CI), 0.018-0.675) and age (P=0.030; OR 0.132; 95.0% CI, 0.021-0.823). Age (P=0.046; OR 0.320; 0.105-0.978, 95.0% CI) was the most significant variable associated with parasite density.

• 한국운동역학회지
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• 제28권2호
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• pp.79-85
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• 2018

Objective: This study aimed to create a strategic training method to enhance optimal athletic ability using information from 1H to 10H rhythmic units. Method: Top three world class athletes and three national winners of 110-m hurdle finals from the 2010 Daegu International Athletics Competition and 2017 National Athletics Championship, respectively, were selected. To analyze the kinematic variables, Dartfish 9.0 was used for two-dimensional analysis. Results: Regarding the interval time from the start to the finish line, the national athletes took less time during the pure acceleration phase (start to 1H) than the foreign athletes. The horizontal velocity increase was slower after 1H; the national athletes showed a lack of ability to accelerate at the interval phases. Moreover, the hurdle clearance time between phases was longer in the national athletes than in the foreign athletes and lacked consistency. Conclusion: The national athletes lacked the ability to accelerate at the transition, maximum rhythm, rhythm maintenance, and re-acceleration phases and showed a longer hurdle clearance time. If technical improvements and strategic training methods using rhythmic units are applied for hurdling motions, the national athlete's hurdling abilities, performance, and consistency could improve.

• 대한교통학회지
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• 제30권2호
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• pp.21-27
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• 2012

이 연구는 신호교차로의 신호운영과 교통사고의 관계를 다루고 있다. 연구의 목적은 전적색신호시간(ARCI) 운영에 따른 교통사고 감소효과를 분석하는데 있다. 이를 위해 이 연구는 청주시 37개 신호교차로를 대상으로 비교그룹 방법을 사용하여 ARCI의 교통사고 감소효과를 평가하는데 중점을 두고 있다. 주요 결과는 다음과 같다. 첫째, 교통사고 건수와 사상자 수는 ARCI 도입 전 후가 다른 것으로 평가되었다. 둘째, 교통사고 감소효과를 비교그룹방법으로 분석한 결과, 사고건수는 20.0%, 그리고 사상자 수는 28.0% 감소한 것으로 분석되었다. 마지막으로, 전적색신호시간 운영에 따른 사고건수의 감소 효과는 6.0~35.0%, 사상자 수의 감소 효과는 18.0~37.0%로 평가되었다.

• Journal of Pharmaceutical Investigation
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• 제15권3호
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• pp.113-120
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• 1985

The pharmacokinetics of lithium carbonate were investigated in rabbits with folate-induced renal failure. The blood level, the area under the blood concentration curve (AUC) and the biological half·life were increased significantly, and the urinary excretion was decreased significantly compared with those of normal rabbits. Correlation of serum creatinine concentration and AUC, biological half-life, and correlation of creatinine clearance and renal clearance of lithium carbonate have linear relationship respectively. In short, dosage regimen of lithium carbonate is considered to be adjusted in the dose size and the dosing interval by degree of experimental renal failure.

• 대한약리학회지
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• 제31권2호
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• pp.251-259
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• 1995

Pharmacokinetics and pharmacodynamics of metoprolol, a selective beta-l blocker, were examined for 360 minutes after intravenous bolus administration of metoprolol to 6 dogs. Plasma concentration and excreted amount in the urine metoprolol were measured by liquid chromatography with fluorescence detection. PR interval and heart rate were measured by ECG monitoring. Blood pressure was monitored through intraarterial catheter in femoral artery and cardiac output by thermodilution method using Swan-Ganz catheter. To analyze the effect site concentration-response relationship, plasma concentration and pharmacological effects were simultaneously fitted to a two pharmacokinetic compartment linked to pharmacodynamic model with NONLIN program. Results are as follows. 1) The plasma concentration of metoprolol after intrvenous injection decreased biexponentially. The terminal half-life estimated was $1.33{\pm}0.40$ hours and the volume of distribution at steady state (Vdss) and the total body clearance were $1.04{\pm}0.4\;L/kg,\;6.55{\pm}2.21\;L/hr$, respectively. The central compartment volume of distribution and peripheral compartment volume of distribution were $0.35{\pm}0.14L/kg\;and\;0.69{\pm}0.34L/kg$. The renal clearance and intercompartment clearance were $0.53{\pm}0.25\;L/min\;and\;0.35{\pm}0.19\;L/min$. 2) Simulated biophase concentration-response curve shows hyperbolic relationship and the estimated concentration-effect relationship was best explained by Emax model when the prolongation of PR interval and the reduction of the heart rate were used as pharmacodynamic parameters. Emax and EC50 were estimated to be $26.3{\pm}4.7\;msec\;and\;88.8{\pm}82.3\;g/ml$ for PR interval, and $48.7{\pm}18.8\;beats/min\;and\;113.5{\pm}78.7\;ng/ml$ for heart rate, respectively. 3) The changes of cardiac output-effect site concentration relationship was best fitted by a linear model and the slope of the relationship was $0.005{\pm}0.003$. Diastolic blood pressure-effect site concentration relationship was also explained by the linear model and the slope of the relationship was $0.038{\pm}0.034$.

• 소음진동
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• 제3권1호
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• pp.29-37
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• 1993

This study is concerned about the impact type damper for effectively restraining the high vibration amplitude in the resonance regions. The theoretical analysis is based on the assumption that the impacts occur twice per cycle at an equal time interval. Simple but reasonable approximations have been derived for the optimum collision clearance and maximum amplitude ratio. Using the impact dampers which is rigidly attached to the primary vibration system, we have experimented for mass ratios and restitution coefficients. The experimental results are in good agreement with theoretical results.

• Communications for Statistical Applications and Methods
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• 제17권5호
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• pp.689-696
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• 2010

구간중도 절단자료는 감염 자료, 종양 발생 자료등 그 발생 시간을 정확하게 관측할 수 없는 경우에 흔히 발생되는 자료로 정확한 사건 발생 시간대신에 발생 전 마지막 관측시점과 발생 후 첫 번째 관측시점으로 구성된다. 이러한 종류의 자료는 Sun (2006)에 의해 자세하게 논의되었으며 관측 개체간의 독립성 가정 하에서 여러 가지 방법들에 의해 분석되어져 왔다. 본 논문에서는 관측 개체들이 군집으로부터 발생하여 더 이상독립성 가정이 적절하지 못한 경우를 고려한다. 특히 반응변수인 사건 발생 시간이 군집의 크기와 연관되어 있을 때, 이를 고려하기 위한 결합 모형을 제시한다. 제안된 모형은 림프계 필라리아병의 실제 자료에 적용한다.

• Biomolecules & Therapeutics
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• 제8권3호
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• pp.241-247
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• 2000

The present study was designed to assess the protective effect of a selective thromboxane $A_2$ receptor antagonist, KT2-962 (KT2) and possible mechanisms of adriamycin(AD)-induced nephrotoxicity in rats. The male Wistar rats were given either of AD (7.5 mg/kg, i.v.) alone in the AD-group (n=5) or in KT2+AD- group (n=5) which is a combination of AD and KT2 (30 mg/kg/day, i.p.) for 10 days from 3 days before and 7 days after AD injection. The body weight, 24-hours urine volume, urine protein and urinary N-acetyl-$\beta$-D-glu-cosaminidase (NAG) activity were measured with an interval of 2 days during 1 week. BUN, serum creatinine and creatinine clearance were measured on the 7th day. KT2 has significantly suppressed AD-induced change of body weight, 24-hours urine volume, urine protein and urinary NAG activity in the KT2+AD-group. The change of BUN, serum creatinine and creatinine clearance were significantly inhibited in the B7T2+AD-group. Based on these results, it is concluded that KT2 prevents AD-induced nephrotoxicity and suggests that endogenous thromboxane A2 may play an important role in AD-induced nephrotoxicity in rats.