• Bulletin of the Korean Chemical Society
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• 제31권5호
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• pp.1355-1360
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• 2010

In order to search new inhibitors against farnesyl protein transferase (FPTase), a series of 2,3-bis-benzylidenesuccinaldehyde derivatives (1-29) were synthesized and their inhibition activities ($pI_{50}$) against FPTase were measured. From based on the reported results that the inhibitory activities of dimers 2,3-bis-benzylidenesuccinaldehydes were higher than those of monomers cinnamaldehydes, 3D-QSARs on FPTase inhibitory activities of the dimers (1-29) were studied quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. The statistical qualities of the optimized CoMFA model II ($r^2{_{cv.}}$= 0.693 and $r^2{_{ncv.}}$= 0.974) was higher than those of the CoMSIA model II ($r^2{_{cv.}}$ = 0.484 and $r^2{_{ncv.}}$ = 0.928). The dependence of CoMFA models on chance correlations was evaluated with progressive scrambling analyses. And the inhibitory activity exhibited a strong correlation with steric factors of the substrate molecules. Therefore, from the results of graphical analyses on the contour maps and of predicted higher inhibitory active compounds, it is suggested that the structural distinctions and descriptors that contribute to inhibitory activities ($pI_{50}$) against FPTase will be able to applied new inhibitor design.

• Asian-Australasian Journal of Animal Sciences
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• 제14권5호
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• pp.710-719
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• 2001

Several amino acid transport systems in mammary gland have been characterized during the last few years. These systems may be divided into two broad categories based on whether they are sodium-dependent or $Na^{+}$-independent, and each of these categories is subdivided into 3 groups depending on whether the systems prefer zwitterionic, cationic or anionic substrates. The zwitterion preferring transport processes in mammary gland are $Na^{+}$-dependent system A and $Na^{+}$-independent systems L and T. System $y^{+}$ is a $Na^{+}$-independent transporter of cationic amino acids and $X_{AG^{-}}$ is a $Na^{+}$-dependent system for anionic amino acids. A ($Na^{+}+Cl^{-}$)-dependent system, selective for $\beta$-amino acids has been reported in rat mammary tissue. In addition, there is yet another class of transporters that have still broader specificity. The $Na^{+}$-dependent systems $BCl^{-}$-dependent and $BCl^{-}$-independent and $Na^{+}$-independent system $y^{+}L$ have been reported to mediate the transport of zwitterionic as well as cationic amino acids. Each system has been characterized with respect to its substrate specificity, affinity, kinetics and ion-dependence. Transport of amino acids by mammary tissue is regulated by i) the intracellular substrate concentration, ii) lactogenic hormones and iii) milk stasis. Four of the above transport systems (i.e. A, L, $y^{+}$ and $BCl^{-}$-independent) are up-regulated by lactogenic hormones (insulin, cortisol and prolactin) in mammary gland.

• 패션비즈니스
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• 제13권5호
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• pp.66-80
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• 2009

The main purpose of this research is to investigate the present circumstances of internal marketing in domestic apparel-import company and study if the internal marketing activities in import apparel company have a significant effect on salespersons' job satisfaction. As a preliminary investigation, the interviews with 6 expert salespersons of imported apparel company were taken to develop a practical measuring tool. As a result, 21 categories which effect on internal marketing and 6 factors which influence on job satisfaction were extracted. Next, a survey with the salespersons who work in apparel-import company was taken, and 186 collected data were used in this study. To analyze the data, factor analysis, frequency analysis, and multiple regression analysis are executed by a statistics package, SPSS v12.0. The results are as follows. First, five factors which effect on internal marketing activities in have been identified as welfare, incentives, employment & training, communication, empowerment. Among them, four factors of welfare, incentives, employment & training, and communication have been come out as statistically significant factors which influenced on salesperson's job satisfaction. Second, the internal marketing activities of import apparel company according to salesperson's demographic factors - payment, working periods, and marriage have been demonstrated significant difference on salespersons' job satisfaction. When the marriage is examined, the job satisfaction of the single mostly depends on incentives while that of the married does on welfare. On the consideration of working periods, the less does the group have working experience, the more does it have a dependence on incentives. On the other hand, the group which has much payment and experience mostly relies on welfare. The middle class show to be dependent on communication and employment&training as well as welfare and incentives.

• 한국수학사학회지
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• 제24권4호
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• pp.97-118
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• 2011

수학사적으로 함수개념은 비례관계, 종속변수, 식, 대응 등으로 발달되어왔으며 수학교육과정에서는 3차, 7차, 7차 개정안에서 중학교 1학년에서 함수개념 도입을 위한 함수의 정의에서 강조점 바뀌었고 이러한 수정의 핵심은 "종속"과 "대응"이다. 본 연구는 종속과 대응에 초점을 둔 수업의 장단점을 비교하고자 각각을 대표할 수 있는 모델로서 물통 모델과 자판기 모델을 선정하여 중학교 1학년을 대상으로 함수의 개념과 함수의 표현에 대한 2차시 수업을 실시하고 형성평가 문항분석을 통하여 두 모델의 차이점과 효율성을 파악하였으며, 3개월 후 파지 효과를 조사하였다. 자판기모델은 중학교 1학년 학생의 함수의 정의 이해 뿐 아니라 특히 개념이미지를 만들고 회상하는데 도움을 주었다. 물통모델은 정의역의 모든 원소가 종속변수에 대응 된다는 "임의성"을 이해하는 데는 상대적으로 어려움을 나타냈지만, 함수식의 표현과 관련해서는 좋은 역할을 한 것으로 판단되었다.

• Applied Biological Chemistry
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• 제41권1호
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• pp.99-103
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• 1998

Triazolopyrimidine sulfonanilide (TP) 유도체는 널리 사용되고 있는 제초제 중의 하나이다. 우리는 TP 유도체 화합물의 골격을 이루고 있는 벤젠 고리를 pyrimidine 고리로 치환시킨 새로운 3 종류의 sulfonamide 유도체(TPP)를 합성하고, 보리에서 추출한 acetolactate synthase (ALS)의 저해 활성도를 측정한 결과 0.005 부터 2 mM 사이의$I_{50}$값을 얻었다. $I_{50}$ 값의 비교에서 pyrimidine 고리에 methyl기가 치환된 TPP 유도체는 methoxy기가 치환된 유도체 보다 높은 저해 활성도를 나타내었다. 또한 triazolopyrimidine 고리에 cyclopentano 고리로 치환된 TPP 유도체는 methyl- 및 phenyl가 치환된 유도체보다 우수한 저해 활성도를 보였다. 따라서 새로운 TPP 유도체의 제초 효력은 치환기에 의한 분자내 전자 분포 변화와 밀접한 관계가 있으나 치환기의 크기에 따른 입체적 장애 요인은 저해 활성도에 전혀 영향이 없음을 알 수 있었다.

• 대한기계학회논문집B
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• 제36권2호
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• pp.211-216
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• 2012

화석 에너지 고갈에 따라 에너지의 합리적 이용이 요구되면서 가용 에너지를 고려한 열에너지의 계단식 활용이 적극적으로 검토되고 있다. 이와 같은 배경에서 1 kW 급의 스털링 엔진을 기반으로 한 열병합발전 시스템이 분산 에너지 시스템을 구축하는 단위로서 제안되었다. 1 kW 의 용량은 가정용에 적합하며, 가정에서 활용하기 위해서는 공간을 작게 차지하도록 하면서도 소음과 유해가스의 배출을 철저하게 차단해야 한다. 이러한 조건들을 충족시키며 효율이 높은 시스템을 개발하기 위하여 슬롯 형태의 예혼합 버너를 제안하였고 버너의 연소 특성을 파악하기 위하여 일련의 실험을 수행하였다. 본 연구에서는 화염의 형상을 촬영하여 연소부하 및 공기비에 따른 연소 모드를 관찰하였고 배가스를 분석하여 연소 모드에 따른 배기 특성을 연구하였다.

• 한국재료학회지
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• 제22권8호
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• pp.409-415
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• 2012

$TiO_2$ thin films for high energy density capacitors were prepared by r.f. magnetron sputtering at room temperature. Flexible PET (Polyethylene terephtalate) substrate was used to maintain the structure of the commercial film capacitors. The effects of deposition pressure on the crystallization and electrical properties of $TiO_2$ films were investigated. The crystal structure of $TiO_2$ films deposited on PET substrate at room temperature was unrelated to deposition pressure and showed an amorphous structure unlike that of films on Si substrate. The grain size and surface roughness of films decreased with increasing deposition pressure due to the difference of mean free path. X-ray photoelectron spectroscopy (XPS) analysis revealed the formation of chemically stable $TiO_2$ films. The dielectric constant of $TiO_2$ films was significantly changed with deposition pressure. $TiO_2$ films deposited at low pressure showed high dissipation factor due to the surface microstructure. The dielectric constant and dissipation factor of films deposited at 70 mTorr were found to be 100~120 and 0.83 at 1 kHz, respectively. The temperature dependence of the capacitance of $TiO_2$ films showed the properties of class I ceramic capacitors. $TiO_2$ films deposited at 10~30 mTorr showed dielectric breakdown at applied voltage of 7 V. However, the films of 500~300 nm thickness deposited at 50 and 70 mTorr showed a leakage current of ${\sim}10^{-8}{\sim}10^{-9}$ A at 100 V.

• 한국진공학회지
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• 제9권3호
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• pp.237-241
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• 2000

TFT-LCD(thin film transistor-liquid crystal display) 패널의 데이터 배선 재료로 사용하기 위하여 AlNd(2 wt%)의 Al합금 박막을 dc 마그네트론 스퍼터링 방법으로 유리 기판에 증착하여 열처리전과 열처리후의 구조적, 전기적, 식각 박막 특성을 조사하였다. 또한 증착한 박막을 식각하여 그 특성을 조사하였고, ITO를 증착하여 AlNd과의 접촉 저항을 Kelvin resistor를 사용하여 측정하였다. 증착된 박막을 $350^{\circ}C$에서 20분간 열처리 하였을때 AlW박막은 비저항이 감소하였고 약 $4\;{\mu\Omega}cm$의 아주 좋은 비저항 특성을 보였다. 주사전자 현미경(SEM)과 원자힘현미경(AFM)으로 표면을 분석한 결과 좋은 힐록방지 특성을 보임을 알 수 있었다. AlNd의 식각 특성은 아주 좋게 나타났고, ITO와 AlNd의 최저 접촉저항값은 약 $110\;{\mu\Omega}cm$이었다. 측정된 특성들을 바탕으로 AlNd(2 wt.%) 박막의 적용 가능성을 해상도와 화면 크기 측면에서 살펴보았을 때, 25인치 SXGA급 패널에 적용 가능함을 알 수 있었다.

• 대한건축학회논문집:계획계
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• 제35권9호
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• pp.131-142
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• 2019

The purpose of this study was to find out the characteristics of housing policies and apartment designs by comparison of supplying and remodeling apartments between France and Korea. The literature review was used in Korea cases and the literature review, site investigation, and expert interviews were used in France cases. At first, by reviewing the related literatures about the apartment developments and regenerations in France and Korea, twelve remodeling cases were represented respectively in Ile de France and Seoul. As a result, in housing policy, the Korean housing market had a shortage of low-priced houses related to biased apartment developments by private sector dependence. Consequently, the living in Korea generally required the high price in low quality houses. But in France, the housing policies were very successful in housing quantity, quality, and expense. It is involved in balances between the public housing supply and the activation of a private housing market based on the government support policy. Nevertheless, in the success of the apartment as a house type, apartments in France means the social elimination because of the supply method problems and the management failures of HLM institutions. However, in Korea, the apartment implies the successful life of the middle class population because of the competitive evolutions during 40 years as a market housing. Secondly, In the characteristics of remodeling, the remodeling in Korea was for property value improvements. It mainly executed to expand the size of a house by expansion of living space. However the remodeling in France was for social mixes and connections with the surrounding area. It mostly performed by various design methods such as vertical merging houses, partial removal, reconstruction, and construction of a local community centers and mixed-use residential buildings. This study shows the simultaneously remodeling features of those two countries. These findings can be used in developing effective strategies for the public housing regenerations in Korea and other countries.

• 디지털융복합연구
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• 제19권6호
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• pp.213-223
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• 2021

본 연구에서는 우리나라 95%이상의 청소년들이 소유하고 있는 스마트폰을 학교 수업에 활용하는 방안을 탐색하고자 스마트폰 활용 시스템을 설계하였다. 먼저 청소년 관련 요인과 스마트폰 수업 활용의 선행연구에 나타난 주의산만, 의존도, 동기부여, 협동심 고취 요인을 기반으로 필요 기능을 선정한 후에 학생, 교사, 부모의 교육적 역할에 따라 세 버전의 앱을 설계하였다. 이 앱을 이용함으로써 학생은 자율학습, 학습동기 부여, 활발한 상호작용이 가능하고 교사는 학생들과 더욱 밀착하여 세밀한 피드백을 하면서 수업의 질을 개선해 나갈 수 있으며 부모는 학생의 안전한 스마트폰 사용 학습을 확인할 수 있다. 이 방안으로 학교 수업에서 스마트폰 사용이 활성화되어 교육 효과를 높이는 데 도움이 될 수 있기를 기대한다.