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Interaction of Antihistaminics with Muscarinic Receptor (III) - Relationship between binding and functional in vitro data -

  • Lee, Shin-Woong;Park, Young-Joo
    • Archives of Pharmacal Research
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    • v.14 no.2
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    • pp.181-187
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    • 1991
  • The muscarinic antagonist 1-[benzilic 4, 4'-$[^3H]$ QUINUCLIDINYL BENZILATE $([^3H]$ QNB) bound to a single class of muscarinic receptors with high affinity in rabbit ileal membranes. The $K_D\;and\;B_{ max}$ values for $([^3H]$ QNB calculated from analysis of saturation isotherms were 52.5 pM AND 154 fmol/mg, respectively. Chlopheniramine (CHP), histamine $H_1$ blocker, increased $K_D$ vlue for $([^3H]$QNB without affecting the binding site concentrations and Hill coefficient. The $K_i$ value of CHP for inhibition of $([^3H]$QNB binding in ileal membranes was 1.44\mu{M}$ and the pseudo-Hill coefficient for CHP was close to unit. In the functional assay carbachol, muscarinic agonist, increased the contractile force of ileum with $ED_{50}$ value of $0.11\mu{M}$. CHP caused the rightward shift of the dose-response curve to carbachol. The $pA_2$ value of CHP determined from Schild analysis of carbacholinduced contraction was 5.77 and the slope was unity indicating competitive antagonism with carbachol. The dissociation constant $(K_i)$ of CHP obtained in competitive experiments with $([^3H]$ QNB was similar to the $K_A$ value (1.69 \mu{M)}$ of CHP as inhibitor of carbachol induced contraction in rabbit ileum. This result suggest that the binding of $H_i$ blocker. CHP, vs $([^3H]$QNB to muscarinic receptors in ileal membranes represents an interaction with a receptor of physiological relevance.

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Priority of Residential Choice and Housing Satisfaction among Studio-type Multi-family Housing Dwellers in the City of Gwangju (원룸형 다가구주택 거주자의 주거선택 중요도와 주거만족도 - 광주광역시를 중심으로 -)

  • Kang, Hi-Goo;Kim, Mi-Hee
    • Journal of the Korean housing association
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    • v.21 no.3
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    • pp.11-21
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    • 2010
  • The purpose of this study is to gather baseline data on perceived priority of residential choice and housing satisfaction rates among consumers with the aim of using this information for future planning. Self-administered questionnaires were provided to 196 studio-type multi-family housing dwellers in the City of Gwangju from 2009 Apri 5th to 29th. The collected data was used to conduct comparative and descriptive statistical analysis: factor analysis, t-test, one-way ANOVA, correlation analysis. The main findings obtained are as follows: Firstly, in relation to perceived priority of residential choice, dwellers identified seven factors as important. Secondly, in terms of housing satisfaction about a unit room, the respondents identified five factors as important. This study confirmed that there existed passive correlation between priority of residential choice and housing satisfaction among residents in studio-type multi-family housings in Gwangju. It is very necessary to project a studio-type multi-family housing close to transportation for easy access, avoiding commercial districts. Delicate interior and design will attract more female residents as well as fully-equipped parking lots for people who drive to their workplace. According to research on a degree of housing satisfaction, all respondents expressed dissatisfaction with "noise". Therefore, in dealing with construction plans of studio apartment units, from now on, sound proofing facilities are required to reduce the acoustic invasion of privacy, especially, for units with more than two people. In order to satisfy all the demand of residents in studio apartment units, we have to pursue systematic and succeeding research about a studio-type multi-family housing well-fitted for the actual circumstances of local area and suitable for longer stay. To sum up, more research and development will be required for high-class studio-type multiplex housing for sale in dealing with households with financial stability such as two-paycheck couples, so-called DINK, or a professional single person, in the future.

Atmospheric CO2 Uptake by Pinus densiflora and Quercus mongolica

  • Jo, Hyun-Kil;Ahn, Tae-Won
    • Journal of Environmental Science International
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    • v.12 no.8
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    • pp.853-860
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    • 2003
  • Plants sequester atmospheric CO$_2$, a major agent of climate change, during the growing periods and mitigate its rising accumulation in the atmosphere. Pinus densiflora and Quercus mongolica are the native tree species dominant in the temperate forests of Korea. This study quantified the annual CO$_2$ uptake by the two species at forest sites in Chuncheon in the middle of the country. The quantification was based on seasonal measurements of CO$_2$ exchange rates under natural conditions by an infrared gas analyzer over the growing season (1999). The monthly CO$_2$ uptake per unit leaf area ranged from 1.6-6.7 mg/d㎡/h for P. densiflora and from 3.7-8.9 mg/d㎡/h for Q. mongolica, with a maximum in mid-summer. An equation for each species was generated to estimate easily the annual CO$_2$ uptake by total leaf area per tree, which subtracted the CO$_2$ release (i.e. respiration) by leaves and woody organs from the gross CO$_2$ uptake (diurnal uptake and release by leaves). Annual CO$_2$ release by leaves and woody organs accounted for 58-73% of the gross CO$_2$ uptake across tree specimens. Annual CO$_2$ uptake per tree increased with increasing dbh (stem diameter at breast height) for the study diameter range, and was greater for Q. mongolica than for P. densiflora in the same dbh sizes. This was mainly associated with a greater total leaf area in the former. For example, the annual CO$_2$ uptake by one tree with dbh of 25 cm was 35.6 kg/yr for P. densiflora and 47.9 kg/yr for Q. mongolica. The results from this study can be applied to evaluate an atmospheric CO$_2$ reduction of woody plants by forest type and age class.

The Energy Analysis and Evaluation of the NEO-Hanok

  • Han, Sang Hee;Park, So Yeon;Park, Hyo Soon
    • KIEAE Journal
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    • v.14 no.2
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    • pp.77-86
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    • 2014
  • Plenty of efforts have been made in the traditional architecture of Korea, Hanok, to develop various elements such as restoration, the introduction of new design, and energy-saving while systemic setups on standard and evaluation of eco-friendly energy design of Hanok are lacking. If we evaluate energy performance based on current standards without reflecting unique features of Hanok on the system, Hanok will be included in the very low grade among the residential buildings being included in the approval system of eco-friendly architecture or the unique features will be modified and the burden of increased construction cost. Therefore, this study is to prepare the basic reference for the introductory evaluation system by evaluating the energy performance level of NEO-Hanok based on the current building energy rating system. The result for NEO-Hanok based on the building energy rating system, we propose the rating standard with scorecard elements of NEO-Hanok by considering the necessity of identity and standard for NEO-Hanok. As a result of infiltration test to check the tightness, it was measured as 10.81 times/h (50 ACH). As we switch from the main insulation for the wall from the glass wool 64k(0.035W/mk) to rigid polyurethane foam first class first unit (0.024W/mk), the result was slightly increased from the first demand quantity rating yield $249.8kWh/m^2{\cdot}yr$ to $235.0kWh/m^2{\cdot}yr$. Current certificate system is focused more on the heating load than the cooling load, it is disadvantageous for Hanok, which has less cooling energy consumption in summer. The rating result from the target building study is level 4.

Dentofacial transverse development in Koreans according to skeletal maturation: A cross-sectional study

  • Hwang, Soonshin;Noh, Yoonjeong;Choi, Yoon Jeong;Chung, Chooryung;Lee, Hye Sun;Kim, Kyung-Ho
    • The korean journal of orthodontics
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    • v.48 no.1
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    • pp.39-47
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    • 2018
  • Objective: The aim of this study was to establish the normative data of dentofacial transverse dimensions according to the skeletal maturation stage in Korean adolescents with good occlusion, assess gender differences and determine correlations between transverse variables. Methods: A total of 577 Korean subjects between ages 7 to 19 years and exhibiting skeletal Class I occlusion were categorized by skeletal maturation index (SMI) of Fishman using hand-wrist radiographs. Dentofacial transverse dimensions were assessed using posteroanterior cephalograms. Independent two-sample t-tests were used to analyze differences between genders. Pearson correlation coefficient was used to determine the correlation between transverse measurements. Results: Dentofacial transverse norms relevant to skeletal maturation stages were established. The average maxillomandibular width difference and ratio at growth completion was 22.16 mm and 77.01% for males; 23.70 mm and 74.06% for females, respectively. Males had greater facial, maxillary and mandibular widths compared to females at every SMI stage. The maxillary and mandibular intermolar widths showed the strongest correlation for both sexes (r = 0.826 for males, r = 0.725 for females). Conclusions: Dentofacial transverse norms of Korean adolescents were established according to developmental stage. All dentofacial widths were greater in males at growth completion. Maxillary and mandibular intermolar widths were strongly correlated. This study may serve as a guideline for the assessment of dentofacial transverse growth according to skeletal maturation stage in Korean adolescents with good occlusion.

Rural Health subcenter Utilization Pattern and Its Related Factors (일부 농촌지역 주민의 보건지소 이용 양상과 관련요인)

  • Sohn, Seok-Joon
    • Journal of agricultural medicine and community health
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    • v.19 no.2
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    • pp.97-106
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    • 1994
  • In order to estimate the utilization pattern of a rural health subcenter, and to identify the recognition for it among the inhabitants in Kogsung district, a questionnaire survey was carried out for objects of 708 population. The results observed were as follows; 1. The annual utilization rate of a rural health subcenter for a basic health service unit was 27.5 per 100 persons, and annual mean visiting times was 1.43 times. 2. The most frequent disease by, annual health subcenter utilization illness was respiratory disease(26.5%), and the next was musculoskeletal disease(23.9%), gastrointestinal disease(15.9%) by order. 3. Favorite reasons for community health subcenter utilization were lower medical cost(23.4%), near distance from living place(20.7%) and lower disease severity(19.5%) by order. But disfavorite reasons for it were non effective treatment(26.2%), insufficient equipment(25.4%) and absence of specialist(17.4%) by order. 4. Insufficient items about community health subcenter utilization were restriction of treatment limit(47.1%), lower reliance(22.4%) and not punctral(21.8%) by order. 5. The results of logistic regression analysis suggested that statistically significant factors in health subcenter utilization were age, educational level and the nearest medical facility class. 6. There was no difference between recognition for a community health subcenter's work and actual utilizing service, and desirable works for it were disease preventing service, disease control of elderly and sanitation control by order. These results suggested that to increase the utilization of rural health subcenter and to promote the accessibility of rural residents to primary health care, there must be considered public relation about health subcenter, expansion of health equipment and recognition about access time.

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Performance of Ru-based Preferential Oxidation Catalyst and Natural Gas Fuel Processing System for 1 kW Class PEMFCs System (Ru계 촉매의 CO 선택적 산화 반응 및 1 kW급 천연가스 연료처리 시스템의 성능 연구)

  • Seo, Yu-Taek;Seo, Dong-Joo;Seo, Young-Seog;Roh, Hyun-Seog;Jeong, Jin-Hyeok;Yoon, Wang-Lai
    • Journal of Hydrogen and New Energy
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    • v.17 no.3
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    • pp.293-300
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    • 2006
  • KIER has been developing a Ru-based preferential oxidation catalysts and a novel fuel processing system to provide hydrogen rich gas to residential PEMFCs system. The catalytic activity of Ru-based catalysts was investigated at different Ru loading amount and different support structure. The obtained result indicated that 2 wt% loaded Ru-based catalyst supported on ${\alpha}-Al_2O_3$ showed high activity in low temperature range and suppressed the methanation reaction. The developed prototype fuel processor showed thermal efficiency of 78% as a HHV basis with methane conversion of 92%. CO concentration below 10 ppm in the produced gas is achieved with separate preferential oxidation unit under the condition of $[O_2]/[CO]=2.0$. The partial load operation have been carried out to test the performance of fuel processor from 40% to 80% load, showing stable methane conversion and CO concentration below 10 ppm. The durability test for the daily start-stop and 8 h operation procedure is under investigation and shows no deterioration of its performance after 50 start-stop cycles. In addition to the system design and development.

A Case Study on the Operation and Management Simulation of Pension Insurance House in Later Life : In the Case of Muju Rural Village (노후연금보험주택의 운영과 관리 시뮬레이션 사례연구 : 무주군의 전원마을 모델을 중심으로)

  • Hong, Hyung-Ock;Kim, Jung-In
    • Journal of Families and Better Life
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    • v.27 no.1
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    • pp.61-71
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    • 2009
  • The purpose of this study was to resolve the issues of inferior housing environment and the population decrease in rural community by improving the environment and attracting urban inhabitants. A simulation on the costs and the local programs was operated from a point of view that Pension Insurance House with Long-term Lease and a plan for the program in connection with local resources should be accompanied to attract urban inhabitants. The study was carried out through mainly documents analysis and specialists' opinions. The simulation results are as follows. Firstly, the pre-existing rural housing development projects have only emphasized the hardware, while underestimated the post-management with operating programs. The software should be underlined when Pension Insurance House is developed. Secondly, as a result of the simulation on construction expenditure and the operating and maintenance cost for 30 years, about 82.3 million Wons are necessary residential expenses for 15 years per unit. Thirdly, in case of MUJU County, it has made the most of its pre-existing institutions. It's medical institutions provide medical care system with health education, facilities related leisure and culture offer recreational programs and the local community center and its program of each town helps new habitants adopt to the rural life. Additionally, the employment project of a local welfare center allow people living in a rural community to continue their careers with their talents and interests through local class programs for a life worth living. Lastly, guide for getting information of rural life, local community gathering and preliminary education should be carried out to reduce expectant tenants' incompatibility and assist them settle down early. The community program expansion is also required at the local government level.

Conceptual design of cooling anchor for current lead on HTS field coils

  • Hyeon, C.J.;Kim, J.H.;Quach, H.L.;Chae, S.H.;Yoon, Y.S.;Lee, J.;Han, S.H.;Jeon, H.;Choi, Y.H.;Lee, H.G.;Kim, H.M.
    • Progress in Superconductivity and Cryogenics
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    • v.19 no.2
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    • pp.38-43
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    • 2017
  • The role of current lead in high-temperature superconducting synchronous machine (HTSSM) is to function as a power supply by connecting the power supply unit at room temperature with the HTS field coils at cryogenic temperature. Such physical and electrical connection causes conduction and Joule-heating losses, which are major thermal losses of HTSSM rotors. To ensure definite stability and economic feasibility of HTS field coils, quickly and smoothly cooling down the current lead is a key design technology. Therefore, in this paper, we introduce a novel concept of a cooling anchor to enhance the cooling performance of a metal current lead. The technical concept of this technology is the simultaneously chilling and supporting the current lead. First, the structure of the current lead and cooling anchor were conceptually designed for field coils for a 1.5 MW-class HTSSM. Then, the effect of this installation on the thermal characteristics of HTS coils was investigated by 3D finite element analysis.

The Development and Application of Teaching Program to Utilize Emotional Intelligence Elements in Elementary School Science (초등학교 과학교과에서 정서지능 요소를 활용한 수업 프로그램의 개발과 적용)

  • Park, Jae-Keun;Moon, Bo-Ra
    • Journal of Korean Elementary Science Education
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    • v.33 no.1
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    • pp.82-94
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    • 2014
  • The purpose of this study is to develop teaching program which utilizes emotional intelligence elements as a measure to stimulate the motive and scientific attitude of learners and examine the effect of its application. The target unit for this study is 'world of plants' in the fourth grade of elementary school, and the teaching program is composed of 3 stages including I(encounter with myself), S(encounter with science), and U(encounter with friends). The teaching program is organized in the way to reflect 5 emotional intelligence elements including self-awareness, self-regulation, self-motivation, sympathy, and personal relations properly according to each stage of teaching program. The result of applying this program into actual classrooms is as follows. First, it is proven that the teaching program actually helps improving the motive of learners to study science. The emotional intelligence takes a role of positive motive for thinking, and the learners monitor their emotion and behavior patterns by using a mirror notebook to reduce their anxiety about science. Second, it is proven that the teaching program changes the science related attitude of learners positively. The emotional intelligence elements help the learners to create friendly feeling toward science subject and have a friendly attitude toward science and a sense of expectancy to science class. Third, it is proven that the teaching program contributes to the improvement of learners' science study achievement. The emotional intelligence takes an important role in improving the learners' science study achievement through the role of adjusting and controlling the recognition capability. However, emphasizing the emotional intelligence excessively also has a risk to break the balance between emotion and recognition, so it is considered that the balanced approach should be applied.