• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.63-85
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• 2011

Objectives : This study was carried out to know the effects of Danggwisayeokgaohsuyusaenggang-tang(hereinafter referred to DST) on arthritis induced by collagen on DBA/1 OlaHsd mice. Methods : For this purpose, DST was orally administered to mouse with arthritis induced by collagen II. Cytotoxicity, high performance liquid chromatograph(HPLC) analysis, arthritis index, value of immunocyte in draining lymph node and paw joint, cytokine were measured in vivo. Results : 1. The cytotoxicity against human fibroblast cells(hFCs) was not measured in any concentration. 2. In HPLC analysis, There are high peak patterns at 8 minute(min), 12 min, 35 min, 45 min. 3. The arthritis index was decreased significantly. 4. The degree of arthritis induced damage of joint of DST group is slight compared with control group in histopathologic observation(Hematoxylin and eosin stain(H&E), Masson's trichrome(M-T) staining). 5. In total cell counts of draining lymph node(DLN) and paw joint, the cells in DLN decreased significantly on DST 200 mg/kg and the cells in paw joint decreased significantly on 200 mg/kg and 50 mg/kg. 6. In DLN, $CD4^+/CD25^+$, $CD3^+/CD69^+$, major histocompatibility complex(MHC), class-II/$CD11c^+$ cells decreased significantly on DST 200 mg/kg and 50 mg/kg $CD3^+/CD8^+$ cells decreased significantly on DST 200 200 mg/kg, $CD4^+$, $CD3^+/CD44^+$ cells decreased. 7. In paw joints, $CD4^+$, $CD11b^+/Gr-1^+$ cells decreased significantly on DST 200 mg/kg and 50 mg/kg. 8. In joints, levels of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, cyclo-oxygenase-2(COX-2), NOS-II were decreased on DST 200 mg/kg and DST 50 mg/kg. 9. In analysing of cytokine in CD3/CD28 activated spleen, IL-17 was decreased significantly, IL-4 was increased significantly $INF-{\gamma}$ was decreased on DST 200 mg/kg. 10. In analysing of cytokine in collagen activated spleen, IL-17 were decreased significantly, IL-4 was increased significantly. Conclusions : This results demonstrated that DST suppressed the inflammatory progression of collagen-induced arthritis(CIA) mice and supported further studies are required to survey continuously in looking for the effective substance and mechanism in the future.

• Journal of Life Science
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• v.25 no.7
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• pp.839-848
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• 2015

A molecular marker is a molecule contained within a sample taken from an organism or other matter. The development of molecular techniques for genetic analysis has led to a great contribution to our knowledge of plant genetics and our understanding of the structure and behavior of various genomes in plants. Recently, functional molecular markers have been developed to detect the presence of major genes from the analysis of pedigreed data in absence of molecular information. DNA markers have developed into many systems based on different polymorphism-detecting techniques or methods such as RFLP, AFLP, RAPD, SSR, SNP, etc. A new class of very useful DNA markers called genic molecular markers utilizing the ever-increasing archives of gene sequence information being accumulated under the EST sequencing projects on a large number of plant species. Functional markers are derived from polymorphic sequences, and are more likely to be involved in phenotypic trait variation. Based on this conceptual framework, the marker systems discussed below are all (gene)-targeted markers, which have the potential to become functional. These markers being part of the cDNA/EST-sequences, are expected to represent the functional component of the genome i.e., gene(s), in contrast to all other random DNA based markers that are developed/generated from the anonymous genomic DNA sequences/domains irrespective of their genic content/information. Especially I sited Poczai et al’ reviews, advances in plant gene-targeted and functional markers. Their reviews may be some useful information to study molecular markers in plants.

• Education of Primary School Mathematics
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• v.10 no.1 s.19
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• pp.57-70
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• 2007

This study is aimed at the improvement of the teaching mathematics via the use of the mathematical history based on the learning stages which are understanding the problem, seeking after and solving the problem, application and development, and understanding the homeworks. General questions of this study are as follows according to the purpose of this study: First, we develop materials to use the teaching and learning stages which are understanding the problem, seeking after and solving the problem, application and development, and understanding the homeworks. Second, we search the effective methods for using materials which are developed in this study. Third, we apply materials to the teaching and learning mathematics. To answer the problems, 1 class students of the 4th grade in Gwangju participated in this study. Teaching and learning which uses mathematical history based on the learning stages is performed. The following results were obtained in this research. First, the teaching and learning using materials which is related to mathematical history is effective in improvement of students' mathematical ability. Second, the teaching and learning using material which is related to mathematics history is effective in improvement of students' mathematical attitude. In special, mathematical attitude of students who are involved in learning using materials which is related to mathematical history is more positive than that of general students using traditional teaching methods. Lastly, generalization of newly developed materials should be done to get more development and upgrade.

• Journal of Korean Society of Forest Science
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• v.76 no.1
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• pp.17-26
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• 1987

To develop the rehabilitation measures for rockily denuded forest lands which are widely distributed in Seoul metropolitan area, erosional characteristics of denudation should, first of all, be evaluated and analysed. As a fundamental study for developing such technical measures, the rockily denuded lands were classified into 6 types according to denudation features of the mountain land, and also movements of stone debris-and-sand on rock-exposed hillslopes were measured and analysed. The 6 basic types of denudation features include a) natural rock-outcrop-exposed land, b) stone debris-and-sand scattered land, c) stone debris-and-sand deposited land, d) coarse sand producing bare land susceptible to weathering and erosion, e) dwarfed pine growing land, and f) torrential valley susceptible to the debris slides. In the stone debris-and-sand scattered hillslopes (type b), average amount of moved-down debris reached to about 3.9 ton/ha/yr due to surface washing and slidings. In the particle size distribution of the moved-down debris, it amounts to about 25% of 10-25mm, about 15% of 5-10mm, about 24% of 2-5mm, and about 36% of less than 2mm in diameter class, respectively. The detailed experimental studies should be accomplished further more about the denudation processes including weathering, erosion and debris slides on rock-exposed hillslopes.

• Journal of Acupuncture Research
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• v.27 no.1
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• pp.75-86
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• 2010

Objectives : We developed and proposed a guideline for safety and performance assessment of electric moxibustion apparatus (class II medical device). Methods : We drafted the guideline for safety and performance assessment of electric moxibustion apparatus by referring the existing standards, guidelines and measurement data from commercially available products. Temperature characteristics such as maximum temperature and ramp time, and physical characteristics such as weight, noise and diameter were measured. User friendliness was also evaluated for commercial devices. Results : This guideline only can be applied to the electric moxibustion apparatus where moxa is being heated by electricity for medical proposes. Maximum temperature of higher than $50^{\circ}C$ can be achieved mostly. Ramp rate of temperature seems to be reliable. Control of temperature is needed to be improved. Moxa and its derivative products seem to be regulated for reliable temperature performance for clinical application. Requirements for design and development of electric moxibustion apparatus are suggested : temperature indicator, temperature control and its accuracy, safety measure, surge protection, user friendliness and instruction for use (IFU). Design recommendation of the reduction of noise level and energy loss are suggested for better products. Conclusions : We proposed a guideline for safety and performance assessment of electric moxibustion apparatus to improve the quality of relating products and aid their commercialization by aiming higher industrial competitiveness of the medical device sectors in Korea. Discussion with related institutes such as industry, academy and government is further required. Public hearings also need to be held prior to the establishment of a final guideline and standard.

• Korean Journal of Medicinal Crop Science
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• v.17 no.6
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• pp.421-426
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• 2009

The purpose of this study was to identify soil physical characteristics as guideline for high yield potential in ginseng cultivated field which produced 6 years root. Harvest yields of ginseng to be divided by parent rock was in order of phyllite and red shale 3.1 kg/$3.3\;m^2$ > granite and gneiss schist 3.0 kg > basalt 2.6 kg > porphyry 2.2 kg in upland and forest soil. Also, with classified by topography, it was in order of foot slope and alluvial fan 3.2 kg/$3.3\;m^2$ > valley 3.0 kg > low hill 2.9 kg > hill, lave flow and dilluvial terrace 2.8 kg in survey tilth. Class determination of soil texture, it was in order of sandy loam 3.1 kg/$3.3\;m^2$ > loam and silt loam 3.0 kg > clay loam 2.9 kg > silt clay loam 2.8 kg in survey tilth. Slope condition of farming land, in case of sloping (2~7%), it was 3.1 kg/$3.3\;m^2$ but deep sloping (15~30%) caused decreasing harvest yield. In drainage classes (excessively, well and moderately well), there was no significantly different in harvest yields. Relationship between harvest yield and soil series, Production sites as yielding 3.0 kg/$3.3\;m^2$ were seven sites, also it was contained 14 soil series. Production sites as yielding 2.5~3.0 kg/$3.3\;m^2$ were eleven sites, it was contained 16 soil series. Production sites as yielding 2.0~2.5 kg/$3.3\;m^2$ were 10 sites, it was contained 4 soil series.

• Tuberculosis and Respiratory Diseases
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• v.68 no.2
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• pp.67-73
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• 2010

Background: In previous study, most patients with bronchial anthracofibrosis (BAF) were non-miners, and non-occupational old aged females. However, the clinical significance of BAF in patients with coal workers' pneumoconiosis (CWP) is unknown. Methods: Among patients with CWP who transferred to our hospital for an evaluation of associated pulmonary diseases, 32 patients who had undergone a bronchofibroscopy (BFS) and chest computed tomography (CT) examination were evaluated for the association of the BAF using a retrospective chart review. Results: Nine of the 32 CWP patients (28%) were complicated with BAF. Four of the 16 simple CWP patients (25%) were complicated with BAF. According to the International Labor Organization (ILO) classification by profusion, 2 out of 3 patients in category 1, 1 out of 8 patients in category 2 and 1 out of 3 patients in category 3 were complicated with BAF. Five out of 16 complicated CWP patients were complicated with BAF. Three out of 7 patients in type A and 2 out of 5 patients in type C were complicated with BAF. CWP patients with BAF had significantly greater multiple bronchial thickening and multiple mediastinal or hilar lymph node enlargement than the CWP patients without BAF. There was no difference in the other clinical features between the CWP patients with BAF and those without BAF. Conclusion: Many CWP patients were complicated with BAF. The occurrence of BAF was not associated with the severity of CWP progression. Therefore, a careful evaluation of the airway with a bronchoscopy examination and chest CT is warranted for BAF complicated CWP patients who present with respiratory symptoms and signs, even ILO class category 1 simple CWP patients.

• Journal of the Korean earth science society
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• v.23 no.5
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• pp.397-405
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• 2002

This study investigated science gifted middle school students' philosophical views on scientific knowledge, and the effects of discussing and reading related to the knowledge. Ten eighth-graders in a science gifted class participated in this study. The results can be summarized as follows: 1, At the beginning, the students had one of six positions: (a) relativism (n = 2); (b) falsificationism (n = 2); (c) borderline between relativism and eclecticism (n = 1); (d) borderline between falsificationism and eclecticism (n = 3); (e) borderline among relativism, falsificationism, and eclecticism (n = 1); and (f) borderline inductivism and eclecticism (n = 1). This result indicated that most students had on almost modern philosophical view of scientific knowledge. 2, Some students, who had chosen the item of inductivism in some questions of the instrument at the beginning, maintained their selection despite discussions and readings related to scientific knowledge. The data were examples which indicated the difficulty of changing from a traditional view to a modern view of scientific knowledge.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.10C
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• pp.967-983
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• 2003

In wireless spread-spectrum communication systems utilizing PN (pseudo noise) sequences, a variety of noise sources from the channel affect the data reception performance. Among them, in this paper we are concerned with the narrowband interference that may arise from the use of the spectral bands overlapped by the existing narrowband users or the intentional jammers as in military communication. The effect of this interference can be reduced to some extent at the receiver with the PN demodulation by processing gain. It is known, however, that when the interferers are strong, the reduction cannot be sufficient and thereby requiring the extra use of narrowband interference cancellers (NIC's) at the receivers. A class of adaptive NIC's are studied here based on different two cost functions. One is the chip mean-squared error (MSE) computed prior to the PN demodulation and used in the conventional cancellers. Since thses conventional cancellers should be operated at the chip rate, the computational requirements are enormous. The other is the symbol MSE computed after the PN demodulation in which case the weights of the NIC's can be updated at a lot lower symbol rate. To compare the performance of these NIC's, we derive a common measure of performance, i.e., the symbol MSE after the PN demodulation. The analytical results are verified by computer simulation. As a result, it is shown that the cancellation capability of the symbol-rate NIC's are similar or better than the conventional one while the computational complexity can be reduced a lot.

• Earthquakes and Structures
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• v.13 no.1
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• pp.59-66
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• 2017

Modern seismic codes rely on performance-based seismic design methodology which requires that the structures withstand inelastic deformation. Many studies have focused on the inelastic deformation ratio evaluation (ratio between the inelastic and elastic maximum lateral displacement demands) for various inelastic spectra. This paper investigates the inelastic response spectra through the ductility demand ${\mu}$, the yield strength reduction factor $R_y$, and the inelastic deformation ratio. They depend on the vibration period T, the post-to-preyield stiffness ratio ${\alpha}$, the peak ground acceleration (PGA), and the normalized yield strength coefficient ${\eta}$ (ratio of yield strength coefficient divided by the PGA). A new inelastic deformation ratio $C_{\eta}$ is defined; it is related to the capacity curve (pushover curve) through the coefficient (${\eta}$) and the ratio (${\alpha}$) that are used as control parameters. A set of 140 real ground motions is selected. The structures are bilinear inelastic single degree of freedom systems (SDOF). The sensitivity of the resulting inelastic deformation ratio mean values is discussed for different levels of normalized yield strength coefficient. The influence of vibration period T, post-to-preyield stiffness ratio ${\alpha}$, normalized yield strength coefficient ${\eta}$, earthquake magnitude, ruptures distance (i.e., to fault rupture) and site conditions is also investigated. A regression analysis leads to simplified expressions of this inelastic deformation ratio. These simplified equations estimate the inelastic deformation ratio for structures, which is a key parameter for design or evaluation. The results show that, for a given level of normalized yield strength coefficient, these inelastic displacement ratios become non sensitive to none of the rupture distance, the earthquake magnitude or the site class. Furthermore, they show that the post-to-preyield stiffness has a negligible effect on the inelastic deformation ratio if the normalized yield strength coefficient is greater than unity.