• 생명과학회지
• /
• 제26권6호
• /
• pp.657-662
• /
• 2016

본 연구에서는 큰실말의 지질대사 효과를 연구하기 위하여 체중 158±10 g의 SD계 암컷 흰쥐 25마리를 대상으로 정상군, 고지방식이 대조군, 큰실말 섭취군, 큰실말 불용성 식이섬유 섭취군, 큰실말 수용성 식이섬유 섭취군으로 분류하여 52일간 사육하였다. 체중은 큰실말 섭취군이 고지방식이군에 비하여 유의적으로 감소하여 정상군에 가까운 수치를 나타냈다. 혈액에서의 HDL 수치는 대조군보다 큰실말 및 식이섬유를 섭취한 군의 수치가 더 높게 나타났고, TC, TG, LDL, GOT, GPT의 수치는 대조군보다 큰실말 및 식이섬유를 섭취한 군의 수치가 더 낮게 나타났다. 이와 같은 연구를 통해 큰실말 및 식이섬유가 혈중 콜레스테롤 농도를 개선시켜 지질 대사에 미치는 순기능적 효과를 보여주는 것으로 사료된다.

• 한국식품위생안전성학회지
• /
• 제29권4호
• /
• pp.370-375
• /
• 2014

Cladosiphon okamuranus is edible brown algae cultured commercially and massively at Okinawa coast. Dietary fiber occupying most of C. okamuranus isn't digested and absorbed by digestive enzymes of human. But it is known to prevent and treat constipation as metabolic disease. This study was to investigate the effects of dietary fiber extracted from C. okamuranus on the damage of liver and the blood cholesterol level in the high fat diet-fed rats. The effects were measured by the levels of aspartate aminotransferase (ALT), alanine aminotransferase (AST), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) in sera. The levels of ALT, AST, TC, TG and LDL were significantly reduced in the C. okamuranus-treated group compared with the high fat diet group. But HDL level was markedly increased. The results showed that the dietary fiber extracts from C. okamuranus have the inhibitive effects of cholesterol biosynthesis in the high fat diet-fed rats.

• ALGAE
• /
• 제24권2호
• /
• pp.79-83
• /
• 2009

Recently deschbed new species, Cladosiphon umezakii Ajisaka (Ectocarpales,Phaeophyceae) is reported in Korea based on morphology and plastid rbcL sequences. Cladosiphon umezakii occurred on low intertidal to subtidal zone along the south and southeast coasts in Korea. Thalli are gold to dark brown, ercct, cylindrical, irregularly branched,and very mucoid. Unitocular zoidangium is developed at the base uf assimilatory filaments. Assimilatory filaments are very long. Eight specimens of the pecies collected from Korea clustered with those of C. umezakii in Japan in rbcL tree. The pecies showed a sister relationship with C. okamuranus. The occurrence of this warm water species is thought an example of northward migration of marine algae caused by global warming. Because C. umezakii is of the economica! importance of the genus as foods and medidnes, the study on mass culture of the species is necessary in korea.

• Food Science and Biotechnology
• /
• 제16권2호
• /
• pp.212-217
• /
• 2007

Fucoidan (fucan sulfate) is a fucose-containing sulfated polysaccharide from brown algae such as Fucus vesiculosus, Ecklonia kurome, and Cladosiphon okamuranus. The aim of this study was to investigate the effect of fucoidan on the expression of diabetes-related genes in mouse cell line 3T3-L1. 3T3-L1 adipocytes were cultured for 48 hr with or without fucoidan (10, 100, and 500 ppm) on a 60 mm dish. Reverse transcription polymerase chain reaction (RT-PCR) was used for measurement of peroxisome proliferators activated receptor ${\gamma}\;(PPAR{\gamma})$, CCAAT/enhancer binding protein ${\alpha}\;(C/EBP{\gamma})$, and glucose transporter 4 (GLUT4) RT-PCR analysis revealed that expression level of GLUT4, $PPAR{\gamma}$, and $C/EBP{\alpha}$ mRNAs increased with fucoidan treatment from 10 to 500 ppm in a dose-dependent manner. Fucoidan appears to enhance insulin sensitivity by increasing the expression level of diabetes-related genes in 3T3-L1 adipocytes. Therefore, fucoidan is potentially useful as a natural therapeutic material for hyperglycemia in type II diabetes patients.