• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.287-287
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• 1996

Long-circulating liposomes have prompted interests in using them as a drug delivery system. This improvements in delivery has been thought to be the results from sustained action of liposomes in plasma without RES uptake. Although methotrexate(MTX) has been one of the most widely used antineoplastc drug, its use was limited by prompt RES uptake. The purpose of this study was to prepare long-circulating liposomes for MTX using highly water-soluble polymer (PEG-PE). In vitro, release of MTX from liposomes in phosphate buffer (pH 7.4), rat liver homogenate, and rat plasma was investigated. The pharmacokinetics and organ distribution of fee drug, conventional and long-circulating liposomes were also compared with one another after intravenous administration to rats.

• Journal of Biosystems Engineering
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• v.34 no.5
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• pp.358-362
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• 2009

This study was conducted to evaluate the performance of a 12 tons capacity circulating concurrent flow rice dryer. An actual scale dryer with the capacity of 12 tons was developed to obtain a faster drying rate of 0.8~1.2%(w.b.)/h, while maintaining a lower drying energy consumption of 5,000 kJ/kg-water and achieving a drying quality that was comparable to a conventional cross-flow rice dryer. The Test-1 was conducted at $110^{\circ}C\;-\;20\;cmm/m^2$ and the Test-2 was conducted at $120-110-100-90^{\circ}C\;-\;20\;cmm/m^2$ under the same conditions as Test-1. In Test-1, the drying rate, drying energy consumption and crack ratio were 0.98 %(w.b.)/h, 4,573 kJ/kg-water and 3.2%, respectively. In Test-2, the drying rate, drying energy consumption and crack ratio were 0.74 %(w.b.)/h, 4,790 kJ/kg-water and 4.0%, respectively. The results of these tests demonstrated that this concurrent-flow dryer reached the desired drying rate, drying energy consumption and crack ratio.

• Journal of Navigation and Port Research
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• v.34 no.7
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• pp.525-532
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• 2010

Mobile Harbor (MH) is a new transportation platform that can load and unload containers onto and from very large container ships at sea. It could navigate near harbors where several vessels run, or it could navigate through very narrow channels. In the conceptual design phase when the candidate design changes frequently according to the various performance requirements, it is very expensive and time-consuming to carry out model tests using a large model in a large towing tank and a free-running model test in a large maneuvering basin. In this paper, a new Planar Motion Mechanism(PMM) test in a Circulating Water Channel (CWC) was conducted in order to determine the hydrodynamic coefficients of the MH. To do this, PMM devices including three-component load cells and inertia tare device were designed and manufactured, and various tests of the MH such as static drift test, pure sway test, pure yaw test, and drift-and-yaw combined test were carried out. Using those coefficients, course-keeping stability was analyzed. In addition, the PMM tests results carried out for the same KCS (KRISO container ship) were compared with our results in order to confirm the test validity.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.2
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• pp.114-126
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• 2009

The authors adopt the Unmanned Undersea Vehicle(UUV), which has taken the shape of manta(Sohn et al. 2006). They call here it Manta-type Unmanned Undersea Test Vehicle(MUUTV). MUUTV is based on the same design concept as UUV called Manta Test Vehicle, which was originally built and operated by the Naval Undersea Warfare Center(Lisiewicz and French 2000, Sirmalis et al. 2001). In order to evaluate manoeuvring motion characteristics of MUUTV, numerical simulation technique has been utilized. Previous mathematical model on manoeuvring motion of MUUTV(Sohn et al. 2006) is basically adopted. Result of static experiment carried out in circulating water channel and a part of NSRDC standard model(Feldman 1979) on rotational mode are supplemented. Some of the hydrodynamic derivatives are obtained from model experiment in circulating water channel and the rest of them are estimated.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.1-10
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• 2020

This paper investigates the influence of the Circulating Water Channel (CWC) side wall and support struts on the hydrodynamic coefficient prediction for Autonomous Underwater Vehicles (AUVs) experiments. Computational Fluid Dynamics (CFD) method has been used to model the CWC tests. The hydrodynamic coefficients estimated by CFD are compared with the prediction of experiments to verify the accuracy of simulations. In order to study the effect of side wall on the hydrodynamic characteristics of the AUV in full scale captive model tests, this paper uses the CWC non-dimensional width parameters to quantify the correlation between the CWC width and hydrodynamic coefficients of the chosen model. The result shows that the hydrodynamic coefficients tend to be constant with the CWC width parameters increasing. Moreover, the side wall has a greater effect than the struts.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.13 no.2
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• pp.9-14
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• 1977

The present paper concerns itself with characteristics of the circulating water tank, designed and constructed at the National Fisheries University of Busan. It is an elliptical ferro-concrete water tank 12 m long, 7 m wide and 1 m deep. The experimented part of water way is 5.67 In long, 1. 76 m wide and 1m deep. For the uniform straight flow are attached stainless plates in the curved parts and stainless pipes just befor the experimental part. The speed of flow can be easily controlled by changing the electric current in armarture of motor from 0 to 30 ampere according to the method of Toulon phase shift. The speed field is uniform and deviation is 0.04 when mean speed is 0.53m/sec at 225 R. P. M. except in the areas within 6cm from the walls.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.1
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• pp.76-87
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• 1996

Energy analysis for the hot water heating control system of apartment house complex is accomplished by computer simulation. Mathematical model of a boiler, pipe network and a unit-house is developed. The effects of heating control methods on the heating performance and energy consumption of the system are investigated. The heating control methods considered in this study are a continuous heating control, and on-off heating control and an intermittent heating control methods. For each control method, the effects of an outdoor temperature, indoor temperature sensing position and the capacities of the boilers and circulating pumps on the heating performance and energy consumption are obtained and "the best" control method is recommended.commended.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.19 no.2
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• pp.8-19
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• 2023

Hydronic heated road pavement (HHP) systems have well studied and documented by many researchers. However, most of the systems run on asphalt, only a few are tested with concrete, and there rarely is a comparison between those two common road materials in their heating and cooling performance. The aim of this study is to investigate the thermal performance of the HHP, such as heat dissipation performance in winter season while focusing on the surface temperature of the concrete and asphalt pavement. For preliminary study a small-scale experimental system was designed and installed to evaluate the heat transfer characteristics of the HHP in the test field. The system consists of concrete and asphalt slabs made of 1 m in width, 1 m in length, and 0.25 m in height. In two slabs, circulating water piping was embedded at a depth of 0.12 m at intervals of 0.16 m. Heating performance in winter season was tested with different inlet temperatures of 25℃, 30℃, 35℃ and 40℃ during the entire measurement period. The results indicated that concrete's heating performance is better than that of asphalt, showing higher surface temperatures for the whole experiment cases. However, the surface temperature of both concrete and asphalt pavement slabs remained above 0℃ for all experimental conditions. The heat dissipation performance of concrete and asphalt pavements was analyzed, and the heat dissipation of concrete pavement was greater than that of asphalt. In addition, the higher the set temperature of the circulating water, the higher the heat dissipation. On the other hand, the concrete pavement clearly showed a decrease in heat dissipation as the circulating water set temperature decreased, but the decrease was relatively small for the asphalt pavement. Based on this experiment, it is considered that a circulating water temperature of 20℃ or less is sufficient to prevent road ice. However, this needs to be verified by further experiments or computational fluid dynamic (CFD) analysis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.580-589
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• 2019

Indonesia has a very short supply of electricity. As a solution to this problem, plans for construction of thermal power plants are increasing. Thermal power plant require the cooling water system to cool the overheated engine and equipment that accompany power generation, and the circulation water pump chamber among the cooling water system are generally designed according to the ANSI (1998) standard. In this study, the design criterion $20^{\circ}$ for the spreading angle of the ANSI (1998) of the layout of the circulating water pump chamber can not be satisfied on the K-coal thermal power plant site condition in Indonesia. Therefore, 3-D numerical model experiment was carried out to obtain a hydraulically stable flow and stable structure. The Flow-3D model was used as numerical model. In order to examine the applicability of the Flow-3D model, the flow study results around the rectangular structure of Rodi (1997) and the numerical analysis results were compared around the rectangular structures. The longitudinal velocity distribution derived from numerical analysis show good agreement. In order to satisfy the design velocity in the circulating water pump chamber, a rectangular baffle favoring velocity reduction was applied. When the approach velocity into the circulating water pump chamber was occurred 1.5 m/s ~ 2.5 m/s, the angle of the separation flow on the baffle was occurred about $15^{\circ}{\sim}20^{\circ}$. By placing the baffle below the separation flow angle downstream, the design velocity of less than 0.5 m/s was satisfied at inlet bay.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.4
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• pp.550-560
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• 1996

Recently, fluidized bed heat exchangers with circulating liquid are widely used in a number of places-chemical, process, food concentration, waste water treatment facilities, etc. In a circulating heat exchanger, solid particles circulate with the liquid, thereby increase the heat transfer and reduce the fouling potential of the heat exchanger. In this study, glass beads were circulated through a vertical tube. The pressure loss and the heat transfer coefficient were measured. At low flow velocities, glass beads enhanced the heat transfer considerably. The enhancement increased as the volume fraction of the glass beads increased. The pressure loss showed a similar trend. From the observed particle behavior near tube wall, a possible explanation of the trend is provided.