• 대한원격탐사학회지
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• 제11권1호
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• pp.31-45
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• 1995

The values of brightness temperature difference (BTD) between 11um and 12um infrared channels may reflect amounts of low-level water vapor and cloud types due to the different absorptivity for water vapor between two channels. A simple method of classifying cloud types at night was proposed. Two-dimensional histograms of brightness temperature of the 11um channel and the BTD between the split window data over subareas around characteristic clouds such as Cb(cumulonimbus), Ci(cirrus), and Sc(stratocumulus) was constructed. Cb, Ci and Sc can be classified by seleting appropriate thresholds in the two-dimensional histograms. And we can see amounts of low-level water vapor in clear area as well as cloud types in cloudy area in the BTD image. The map of cloud types and low-level water vapor generated by this method was compared with 850hPa and 1000hPa relative humidity(%) of numerical analysis data and nephanalysis chart. The comparisons showed reasonable agreement.

• 대한임상독성학회지
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• 제17권2호
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• pp.86-93
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• 2019

Purpose: The objective was to determine the association between PaCO₂ and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Methods: This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 hours later. The baseline characteristics and clinical course during hospitalization were collected and compared. The mean PaCO₂ during the first 6 hours after presentation was calculated. Results: The incidence rates of moderate (30 mmHg< PaCO₂ <35 mmHg) or severe (PaCO₂ ≤30 mmHg) hypocapnia at presentation after acute CO poisoning were 40.7% and 26.8%, respectively. The mean PaCO₂ during the first 6 hours was 33 (31-36.7) mmHg. The incidence of ACVEs during hospitalization was 50.5%. A significant linear trend in the incidence of ACVEs was observed across the total ranges of PaCO₂ variables. In multivariate regression analysis, mean PaCO₂ was independently associated with ACVEs (OR 0.798 (95% CI 0.641-0.997)). Conclusion: Mean PaCO₂ during the first 6 hours was associated with increased ACVEs. Given the high incidence of ACVEs and PaCO₂ derangement and the observed association between PaCO₂ and ACVEs, this study suggests that 1) PaCO₂ should be monitored at the acute stage to predict and/or prevent ACVEs; and 2) further study is needed to validate this result and investigate early manipulation of PaCO₂ as treatment.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2017년도 춘계공동학술대회
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• pp.80-80
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• 2017

국내에서 대부분 생산되는 사료(사일리지) 수확 작업은 베일 생산 및 비닐 래핑 작업이 독립적으로 수행되고 있어서 비효율적이다. 본 연구에서 개발한 조사료 수확기는 수집, 롤링, 베일 네트 생성, 래핑, 래핑 종료 및 베일 방출작업을 통합적으로 수행하도록 설계-제작하였다. 통합형 다목적 조사료수확기의 설계는 3D 디자인 툴 (CATIA V5R18)을 이용하여 실시하였으며, 기구부 23 파트 어셈블리, 전기제어 어셈블리, 유압요소기술을 통합하여 통합시작기를 제작하였다. 기초 프레임, 오거장치파트, 픽업장치파트, 하부롤러파트, 상부롤러파트, 하부 프레임 및 주행부 파트, 래핑회전파트, 롤러부 구동 동력부, 유압파트, 전기제어파트, 드로우바파트, 체결 및 컨트롤러 파트 등 25개 파트로 구성되어 있다. 본 연구에서 개발한 시작기의 견인력 및 소요동력 분석은 선행 연구에서 사용한 Brixius (1987) 제안 모델을 체택하여 분석하였다. 이 Brixius 제안 모델은 견인력 예측에서 토양변수 및 토양강도 특성을 나타내는 원추지수 (Cone Index, CI)를 이용하여 트랙터의 견인력 예측에 사용하였다. 또한 트랙터-조사료수확기 시스템의 소요 견인력을 예측하는데 있어, 트랙터-조사료수확기 시스템이 운용되는 토양조건과 트랙터의 마력에 따른 소요 견인력 특성을 분석하기 위해 대표적으로 3수준의 토양조건 (CI: 356 kPa, 543 kPa, 1,429 kPa)을 적용하였으며, 베일의 개당 최대무게는 최고 수준인 옥수수 기준으로 800 kgf를 적용하였다. 본 연구에서 적용된 3수준의 CI 조건은 연구팀에서 선행연구과정 (토양특성에 따른 최적 경운작업 시스템 개발, 2006)에서 분석한 전국 10개 지역의 33개 지점의 경반층 CI지수의 측정범위인 1,050-3,170 kPa에 대해 견인력이 많이 소요되는 열악한 조건 수준을 적용하였다. 각 작업에 사용된 소요동력은 베일 작업시 (ASABE D497.7, 2011) 그리고 래핑작업시 (Zhortuylov et al., 2013)를 사용하였으며 두 소요마력을 트랙터-조사료 수확기 시스템의 필요 소요마력의 합계로 계산하였다. 트랙터-조사료수확기 시스템의 최소 소요 동력, 차축 소요 동력과 PTO 소요 동력을 Zoz and Grisso (2003)을 이용하여 계산하였다. 연구에서는 기본적으로 ASAE의 작업속도 및 작업효율을 적용하였는데, 적용된 조사료수확기의 현장 작업효율은 60-86%의 범위이고 일반적으로 70%를 적용하고 이때 작업속도는 2.5-8.0 km/h이며 전형적으로 5.0 km/h를 기준하고 있다. 자주식 (SP; sief-propelled machine) 조사료수확기의 경우 작업속도가 2.5-10.0 km/h의 범위에서 작업효율은 60-85% 범위이다. 적용되는 조사료 수확기의 작업효율인 60-85% 범위에서 일반적으로 적용되는 작업효율인 70%를 적용하면 트랙터의 소요동력은 95hp를 적정 작업환경으로 하였다.

• Journal of Preventive Medicine and Public Health
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• 제45권3호
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• pp.174-180
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• 2012

Objectives: An ambulance can be a potential source of contagious or droplet infection of a community. We estimated the prevalence of positive carriage of tuberculosis (TB), methicillin-resistant $Staphylococcus$ $aureus$ (MRSA), and vancomycin-resistant $Enterococci$ (VRE) in patients transported by ambulance. Methods: This was a retrospective observational study. We enrolled all patients who visited a tertiary teaching hospital emergency department (ED). Blood, sputum, urine, body fluid, and rectal swab samples were taken from patients when they were suspected of TB, MRSA, or VRE in the ED. The patients were categorized into three groups: pre-hospital ambulance (PA) group; inter-facility ambulance (IA) group; and non-ambulance (NA) group. Adjusted odds ratio (OR) and 95% confidence intervals (CI) were calculated using a multivariable logistic regression model for the prevalence of each infection. Results: The total number of patients was 89206. Of these, 9378 (10.5%) and 4799 (5.4%) were in the PA and IA group, respectively. The prevalence of TB, MRSA, and VRE infection were 0.3%, 1.1%, and 0.3%, respectively. In the PA group, the prevalence of TB, MRSA, and VRE were 0.3%, 1.8%, and 0.4%. In the IA group, the prevalence of TB, MRSA, and VRE were 0.7%, 4.6%, and 1.5%, respectively. The adjusted ORs (95% CI) of the PA and IA compared to the NA group were 1.02 (0.69 to 1.53) and 1.83 (1.24 to 2.71) for TB, 2.24 (1.87 to 2.69) and 5.47 (4.63 to 6.46) for MRSA, 2.59 (1.78 to 3.77) and 8.90 (6.52 to 12.14) for VRE, respectively. Conclusions: A high prevalence of positive carriage of TB, MRSA, and VRE in patients transported by metropolitan ambulances was found.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.257-260
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• 2002

Dissolved oxygen level of cell culture media has a critical effect on cellular metabolism, which governs specific productivity of recombinant proteins and mammalian cell growth However, in the cores of cell aggregates or cell-immobilized beads, oxygen level frequently goes below a critical level. Mammalian cells have a number of genes induced in the lower level of oxygen, and the genes contain a common cis-acting element (-RCGTG-), hypoxia response element (HRE). By binding of hypoxia inducible factor-l (HIF-I) to the HRE, promoters of hypoxia inducible genes are activated, which is a survival mechanism. In this work, to develop a CHO cell capable of producing recombinant proteins in immobilization and high density cell culture efficiently, mammalian expression vectors containing human tissue-type plasminogen activator (t-PA) gene controlled by HRE were constructed and stably transfected into the CHO cells. In $Ba^{2+}$ -alginate immobilization culture, CHO/pCl/dhfr/2HRE-t-PA cells produced 2 folds higher recombinant t-PA activity than CHO/pCl/dhfrlt-PA cells without $CoCl_2$ treatment. Furthermore, in repeated fed batch culture, productivity of t-PA in immobilized CHO/pCI/dhfr/2HRE-t-PA cells was 121 ng/ml/day, total production of 0.968 mg/day at 11 days culture while CHO/pCIIdhfrlt-PA cells was 22.8 ng/ml/day. All these results indicate that HRE is very useful for the enhancement of protein productivity in mammalian cell cultures.

• Radiation Oncology Journal
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• 제35권1호
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• pp.78-89
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• 2017

Purpose: To determine the optimal radiotherapy technique for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), we compared the dosimetric parameters and the risk of solid secondary cancer from scattered doses among anterior-posterior/ posterior-anterior parallel-opposed fields (AP/PA), anterior, posterior, right, and left lateral fields (4_field), 3-dimensional conformal radiotherapy (3D-CRT) using noncoplanar beams, and intensity-modulated radiotherapy composed of 7 coplanar beams (IMRT_co) and 7 coplanar and noncoplanar beams (IMRT_non). Materials and Methods: We retrospectively generated 5 planning techniques for 5 patients with gastric MALToma. Homogeneity index (HI), conformity index (CI), and mean doses of the kidney and liver were calculated from the dose-volume histograms. Applied the Biological Effects of Ionizing Radiation VII report to scattered doses, the lifetime attributable risk (LAR) was calculated to estimate the risk of solid secondary cancer. Results: The best value of CI was obtained with IMRT, although the HI varied among patients. The mean kidney dose was the highest with AP/PA, followed by 4_field, 3D-CRT, IMRT_co, and IMRT_non. On the other hand, the mean liver dose was the highest with 4_field and the lowest with AP/PA. Compared with 4_field, the LAR for 3D-CRT decreased except the lungs, and the LAR for IMRT_co and IMRT_non increased except the lungs. However, the absolute differences were much lower than <1%. Conclusion: Tailored RT techniques seem to be beneficial because it could achieve adjacent organ sparing with very small and clinically irrelevant increase of secondary solid cancer risk compared to the conventional techniques.

• 대한임상독성학회지
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• 제20권2호
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• pp.75-81
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• 2022

Purpose: This study sought to compare the characteristics of patients with pathogen-positive and negative cultures, and to investigate factors predicting pathogen-positive culture results in patients of acute poisoning with suspected aspiration. Methods: Consecutive patients with acute poisoning admitted to an intensive care unit between January 2016 and December 2018 were retrospectively studied. Respiratory specimens were collected from the enrolled patients at the time of the suspected aspiration. We compared the characteristics of patients with pathogen-positive and negative culture results and analyzed the causative pathogens. Results: Among the 526 patients, 325 showed no clinical features that could be attributed to aspiration, and 201 patients had clinical features suggestive of aspiration. Of these, 113 patients had pathogen-positive culture, 61 were negative, and the specimens of 27 patients contained poor-quality sputum. In univariate analysis, patients with a positive culture showed a longer time to culture from ingestion (p=0.01), faster heart rate (p=0.01), and higher partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO₂/FiO₂) (p=0.02) than patients with negative culture. Multivariate analysis demonstrated that PaO₂/FiO₂ (adjusted odd ratio, 1.005; 95% confidence interval [CI], 1.002-1.008; p=0.005) was a significant risk factor for pathogen-positive culture. The area under the receiver operating characteristic curve of PaO₂/FiO₂ was 0.591 (95% CI, 0.510-0.669, p=0.05). Gram-negative pathogens (GNPs) were predominant and at least one GNP was observed in 84 (73.3%) patients among those with pathogen positive culture. Conclusion: We failed to find any clinical factors associated with positive culture results. Antibiotics that cover GNPs could be considered when deciding the initial antibiotic regimen at the time of suspected aspiration.

• Tuberculosis and Respiratory Diseases
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• 제78권3호
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• pp.190-195
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• 2015

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), $PaO_2/FiO_2$, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). Conclusion: This study shows that FVC, $PaO_2/FiO_2$ and serum protein level at presentation can significantly predict relapse in OP patients.

• Journal of Korean Biological Nursing Science
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• 제16권4호
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• pp.259-266
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• 2014

Purpose: The purpose of this study was to analyze risk factors in predicting medical patients transferred to Intensive Care Unit (ICU) on the general ward. Methods: We reviewed retrospectively clinical data of 120 medical patients on the general ward and a Modified Early Warning Score (MEWS) between ICU group and general ward group. Data were analyzed with multivariate logistic regression and the area under the receiver operating characteristic curves using SPSS/WIN 18.0 program. Results: Fifty-two ICU patients and 68 general ward patients were included. In multivariate logistic regression, the MEWSs (Odds Ratio [OR], 1.91; 95% confidence interval [CI], 1.32-2.76), sequential organ failure assessment score (OR, 1.28; 95% CI, 1.10-1.72), $PaO_2/FiO_2$ ratio (OR, 0.98; 95% CI, 0.98-0.99), and saturation (OR, 0.93; 95% CI, 0.88-0.99) were predictive of ICU transfer. The sensitivity and the specificity of the MEWSs used with a cut-off value of six were 80.8% and 70.6% respectively for ICU transfer. Conclusion: These findings suggest that early prediction and treatment of patients with high risk of ICU transfer may improve the prognosis of patients.

• 한국지반환경공학회 논문집
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• 제15권11호
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• pp.43-51
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• 2014

본 연구에서는 실트함유율과 상재하중에 따른 보강재(지오그리드)의 인발저항력의 변화를 알아보기 위하여 실트함유율이 각각 0 %, 17 %, 35 %, 수직하중이 각각 30 kPa, 60 kPa, 120 kPa인 형태로 그리드를 무보강과 마찰돌기 형태로 변화를 주어 인발시험을 시행하였다. 인발시험결과 일반 지오그리드의 경우 실트함유율이 증가하면 인발저항력이 감소되지만 마찰돌기를 부착한 그리드의 경우는 동일조건에서 약 20 %의 증가를 보이는 것으로 확인되었고, 상호작용계수는 실트함유량에 따라 0.7~1.6의 분포를 보였다. 이러한 결과를 바탕으로 낮은 수직하중상태에서 보강토옹벽의 설계 시 마찰돌기 부착형 보강재는 뒷채움재료 특성에 따라 사용 길이를 감소시킬 수 있을 것으로 평가되었다.