• 대한본초학회지
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• 제22권4호
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• pp.101-108
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• 2007

Objectives : To compare the anti-oxidant effects of Ligusticum chuanxiang and Cnidium officinale extracts and their mixture with Angelica gigas, we investigated the anti-oxidative activities using rat liver tissues. Methods : We investigated the anti-oxidative activities by analysis of lipid peroxidation, xanthine oxidase activity, aldehyde oxidase activity, hydroxyl radical scavenging activity, superoxide dismutase activity and catalase activity in rat liver tissues. Results : Both Ligusticum chuanxing and Cnidium offieinale inhibited the lipid peroxidation compared to the control, there is no significant differences between two groups. Cnidium officinale showed strong inhibitory effects on xanthine oxidase and aldehyde oxidase activities compared with that of Ligusticum chuanxing. Ligusticum chuanxing and Cnidium officinale were scavenged the hydroxy radicals, and increased SOD and catalase activities. These results suggested that Ligusticum chuanxing and Cnidium officinale were showed antioxidant activity, especially Cnidium officinale showed higher activity than Ligusticum chuanxing. Conclusions: These results suggest that Ligusticum chuanxing could be replaced by Cmdium afficinale in clinical trial.

• 분석과학
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• 제11권1호
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• pp.54-61
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• 1998

토천궁과 일천궁이 한방이나 가공시 기초 자료로 활용될 수 있도록 기본적인 화학 성분을 분석하였다. 일반성분은 토천궁이 조단백 함량이 높았으며, 무기질은 일천궁이 토천궁에 비해 칼륨과 나트륨이 높은 반면, 그외는 토천궁이 전체척으로 높았다. 유리당 조성은 sucrose만 검출되었고, fructose와 glucose는 검출되지 않았다. 지방산 조성은 linoleic acid, oleic acid, palmitic acid, linolenic acid 순으로 구성되었고, 토천궁과 일천궁의 주요 구성아미노산은 글루탐산, 아르기닌, 아스파르트산, 발린 순으로, 대부분 필수아미노산도 고루 분포되어 있었다.

• 한국약용작물학회지
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• 제27권1호
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• pp.17-23
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• 2019

Background: Cnidium officinale Makino and Ligusticum chuanxiong Hort. are important medicinal crops in Korea. However, there is insufficient information on the identification of thrips, which attack these plants. Until now, one species of thrips has been recorded as a main pest. Methods and Results: To identify the thrips emerging in C. officinale Makino and L. chuanxiong Hort., these plants were independently cultivated in two local areas. Thirty individuals of each plant species were selected randomly and surveyed for the presence of thrips. After confirming the existence of thrips, 100 thrips individuals were collected from each crop using the beating method. To identify thrips species, we performed PCR-restriction fragment length polymorphism (RFLP)-based analysis using ITS2 primer sets. Six thrips species were identified: western flower thrips (Frankliniella occidentalis), flower thrips (F. intonsa), onion thrips (Thrips tabaci), chrysanthemum thrips (T. nigropilosus), chilli thrips (Scirtothrips dorsalis), and grass thrips (Anaphothrips obscurus). The proportion of these species differed between the host plant species. Conclusions: Six thrips species were major pests of two medicinal crops. Integrated pest management is required to control these thrips species, and will enhance the yield and quality of C. officinale and L. chuanxiong.

• 대한본초학회지
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• 제20권4호
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• pp.95-101
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• 2005

Objectives : In order to distinguish Cnidii Rhizoma and Ligustici Chuanxiong Rhizoma (cultivated in Korea and China), their external and internal states were observed via microscopic examination. Methods : The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olymphus-BHT. Results : Cnidii Rhizoma, Ligustici Chuanxiong Rhizoma (from Korea), and Ligustici Chuanxiong Rhizoma (from China) all demonstrated similar patterns as following : 1. external form 1) showing irregular nodular form with $2{\sim}7cm$ diameter. 2) having several trochites in parallel, and nodulose root trace on surface. 3) in addition to yellow-white or yellow-gray intersections, yellow-brown oil sacs were distributed, with cambium resembling a form of annulus. 2. internal form 1) its root and rhizome is composed of 10 layers of cork, with narrow cortical layers. 2) its phloem is wide, and oval light yellow-brown oil sacs are distributed around. The closer to the cambium, the smaller it is. 3) cambium is a form of a wave-like ring or an irregular polygon. 4) xylem and vessel are rare, most of which are arranged in a 'V' format, and sometimes xylem fiber is found. 5) pith is composed of parenchymatous cell, and parenchyma is full of starch grains. Conclusions : In conclusion, C officinale, L. chuanxiong (from Korea), and L. chuanxiong (from China) have rhizomes in a similar form with no special difference. Therefore, it is concluded that C. officinale, L. chuanxiong (from Korea), and L. chuanxiong (from China) are categorized into the same species.

• Journal of Radiation Protection and Research
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• 제26권1호
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• pp.13-18
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• 2001

한의학에서 근경류(rhizomata)에 분류되어 있으며 각종 보익탕제에 주로 사용되는 대표적 생약인 백출(Baizhu, Atractylodes japonica), 천궁(Chuanxiong, Cnidium officinale), 산약(Shanyao, Discorea japonica) 및 승마(Shengma, Cimicifuga heracleifolia)의 방사선 방호효과를 확인하기 위해서 고선량 및 저선량의 방사선을 마우스에 조사하고 소장움 생존, 내재성 비장집락형성 및 apoptosis 유발 등을 관찰하였다. 방사선조사전 승마 투여 군에서 소장움세포의 생존율을 증가시켰으며 내재성 비장집락 형성 시험에서는 천궁 투여 군에서 평균치의 증가가 관찰되었고 천궁 및 승마는 저선량 방사선에 의한 apoptosis 형성을 억제시켰다. 이상의 결과에서 승마 및 천궁의 방사선 방호효과를 조혈세포의 생존과 회복, 소장움세포 생존을 통하여 확인하였으며 이는 독성이 적은 천연물이라는 관점에서 방사선 방호 식품으로서 적용이 가능할 것으로 사료된다.

• 한국약용작물학회지
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• 제8권3호
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• pp.209-215
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• 2000

본 시험은 지하부 수량성 증대를 위한 천궁(川芎)의 체계적이고 종합적인 재배법을 확립하고, 지하부의 수량증대와 생산성 증대를 도모하고자 시험을 수행한 결과 다음과 같은 결과를 얻었다. 토천궁(土川芎)의 근수량은 짚, 백색비닐, 흑색비닐 피복구 순으로 생체중 및 건물중이 증가하는 경향을 나타냈다. 차광처리에 따른 토천궁의 지하부 생육특성에서는 백색차광에서 개체당 근경중, 세근중이 가장 높게 나타났다. 일천궁(日川芎) (Cnidium officinale)의 피복처리에 따른 지하부의 건물중은 무처리구에서 20.4 g 으로 가장 낮았고, 흑색비닐 피복구가 27.7 g으로 가장 높았다. 일천궁(日川芎)의 차광처리에 따른 지하부의 건물중은 백색차광 처리구에서 21.1 g으로 가장 높았고, 흑색비닐 처리구에는 16.3 g으로 가장 낮았다. 근경의 직경은 백색차광 처리구 (26. 1mm)가, 근장은 흑색차광 처리 구 (71. 9 mm)가 가장 높았다. 일천궁(日川芎)에 있어서 흑색비닐 피복은 무처리에 비해 36%의 건물중 증가를 가져 왔다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.405.2-405.2
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• 2002

A near infrared (NIR) method was developed to analyze specious diversity for morphologically similar umbelliferous herbal medicine. Cnidium officinale Makino. This herbal medicine has been widely used as 'chungung' without any discrimination of its quality and original plants. though it has the ambiguous origins of plants between various countries especially Korea. China and Japan. It is named by Cnidium officinale Makino in Korea and Japan. in comparison with Ligusticum chuanxiong Hort. in China. (omitted)

• 생약학회지
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• 제47권2호
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• pp.128-136
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• 2016

Tiny leaf fragments were found in the Annals of the Joseon Dynasty, which were compiled about 500 years ago. The records describing the detailed process of compiling the Annals indicate that silk bags packed with the powders of 'Cheongung' and 'Changpo', which have been used as traditional herbal medicines in the northeast Asian countries such as China and Japan as well as Korea, were put in the wooden storage boxes together with the volumes of the Annals. However, there is no record that parts of plants were used in the process of compiling the Annals. The botanical origin of leaf fragments was identified as Ligusticum sinense 'Chuanxiong' by the analysis of trnK of chloroplast DNA as well as the examination of leaf surface with SEM. The comparative analysis of trnK sequences showed that the chloroplast DNA haplotype of 'Tocheongung', a triploid species cultivated in Korea, was identical with Cnidium officinale, but different from L. sinense 'Chuanxiong'. The molecular results provide a new suggestion on the botanical origin of crude drugs used as 'Cheongung', which has been disputed in Korea.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.367.2-367.2
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• 2002

Cnidium Rhizome is a frequently prescribed herbal medicine in Korea, Japan as well as China, which has been successfully used in these countries for the treatment of diseases related to. gynecology, blood circulations and dental troublers in the name of 천궁. And it is circulated as the same chinese character, which is 천궁, although original plants are different as Cnidium officinale in pharmacopoeia of Korea or Japan and Ligusticum chuanxiong Hort. In that of China. (omitted)

• 한국약용작물학회지
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• 제8권3호
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• pp.201-208
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• 2000

천궁(川芎)의 재배조건별 생육특성을 파악하기 위하여 토천궁(土川芎)과 일천궁(日川芎) 각각에 대하여 재식거리별, 근중별 시험을 수행한 결과를 요약하면 다음과 같다. 재식밀도에 따른 토천궁(土川芎) (Ligusticum chuanxiong)의 지하부 생육특성으로서 건물중은 $50{\times}15cm$에서 32.9 g으로 가장 작았고, $50{\times}20cm$에서 34.4 g, $50{\times}25cm$에서 36.5 g으로 가장 높게 나타났다. 근경의 무게에 따른 지하부의 생육특성으로는 생체중이 10g 이하(以下)에서 35.7 g으로 가장 작게 나타났고 , 25 g 이하(以下)에서 45.9 g으로 가 장 높게 나타났다. 일천궁의 재식밀도에 따른 지하부의 생육 특성은 근수량에 있어서 $50{\times}15cm$의 처리구 에서 18.7 g(건물중) 으로 가장 낮은 수치를 보였으며, $50{\times}25cm$의 처리구에서 24 g(건물중) 으로 가장 높은 수치를 나타냈지만 처리 간 유의성은 인정되지 않았다. 일천궁(日川芎)의 근경중에 따른 지하부의 생육특성을 보면 개체당 근경의 생근중은 10 g이하 에서 27 g으로 가장 낮았고, 25 g에서 43.4 g으로 가장 높게 나타났으나 처리간 유의성은 인정되지 않았다. 전체 생근중에 있어서는 10 g이하가 43.9 g로 가장 낮고 , 25 g 이상이 94.6 g으로 가장 높게 나타났다.