• 대한한의학회지
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• 제16권1호통권29호
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• pp.227-249
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• 1995

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

• 대한두경부종양학회지
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• 제26권1호
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• pp.30-32
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• 2010

Tracheo-gastric fistula is a very rare late complication of total laryngopharyngoesophagectomy with gastric pull-up procedure. It usually occurs after transhiatal esophagectomy, but it has only rarely been reported after total laryngopharyngoesophagectomy with gastric pull-up procedure. Chronic irritation and gastric ulcer may be the cause of tracheogastric fistula. To prevent fistula formation, active management of gastric ulcer and avoidance of mucosal irritation are necessary. We report a case of a tracheogastric fistula which occurred two years after total laryngopharyngoesophagectomy with gastric pull-up procedure that maybe occurred by chronic irritation and gastric ulcer.

• 대한두개안면성형외과학회지
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• 제17권4호
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• pp.222-224
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• 2016

Epidermal cysts are intradermal or subcutaneous cystic tumors that frequently occur in the face, scalp, neck, and body trunk. Acquired cases of epidermal cyst commonly occur as a result of various surgical operations, chronic irritation, or trauma, all of which may trigger the occurrence of the invagination of squamous epithelium. A 57-year-old man presented with a palpable mass $7cm{\times}2cm$ in size in the upper lip. The patient had a 3-year history of wearing a denture to restore missing bilateral maxillary central and lateral incisors, accompanied by inflammatory findings on the buccal mucosa due to chronic lip irritation. The resected oval-shaped cyst had a size of $5.5cm{\times}3.0cm{\times}2.5cm$, and it was an encapsulated mass with a well-defined margin. The histopathology was typical of epidermal cyst. This case of a rare giant upper lip epidermal cyst in a patient wearing a denture may be of interest to clinicians.

• Journal of Oral Medicine and Pain
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• 제26권2호
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• pp.115-120
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• 2001

Intraoral soft tissue can easily be injured by weak mechanical irritation. Each symptom by irritation is various, but most of patients show chronic inflammatory lesion. The fibroma is the most frequent disease found in intraoral area followed by pyogenic granuloma, epulis fissuratum, palatal papillomatosis, and epulis granulomatosum. The inflammatory hyperplasia by mechnical irritation is easily different from other disease, but this shows similar to several benign and malignant tumors required differential diagnosis. By microscopic feature, the lesions is divided by granulatory stage, mixed stage, and fibrotic tissue stage. The inflammatory hyperplasia is differently treated by each clinical features.: only removal of cause or, and excisional biopsy is/are required. This is the cases report of reactive hyperplasia of intraoral soft tissue by mechanical irritation that suggests various treatments of each cases.

• Journal of Korean Dental Science
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• 제13권1호
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• pp.35-41
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• 2020

Irritation fibroma is a reactive hyperplastic lesion caused by chronic stimuli with low intensity in the oral cavity. Irritation fibroma is common in middle-aged females but it may also occur at any age and sex. Clinical characteristics of irritation fibroma are similar to other reactive lesions or benign tumors, therefore, histological examination is essential to make an accurate diagnosis. This case report presents two cases of irritation fibroma occurred on the gingiva in young males. Two male patients in their 20s and 30s of age visited the clinic for the evaluation and treatment of painless gingival overgrowth in the anterior region. Clinically, the lesions were well-defined and firm, with similar color and texture to the adjacent normal gingiva. Excisional biopsy under local anesthesia was conducted with a scalpel, and the lesions were completely removed. Histopathologically, connective tissue consisting of dense collagen bundles, proliferation of fibroblasts and minor infiltrated inflammatory cells were observed. Based on the clinical and histopathological findings, the diagnosis of irritation fibroma was confirmed in both cases.

• 한방안이비인후피부과학회지
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• 제25권3호
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• pp.56-64
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• 2012

Objectives : This study was performed in order to investigate an immediate improvement effect of nasal obstruction after having patient with chronic rhinitis use nasal spray in nasal cavity after distilling Korean medicine, satisfaction for its fragrance and irritation and its effect continuance time. Methods : A questionnaire was performed for an immediate therapeutic effect of nasal spray 1, 2 and 3 weeks later after using spray by targeting 13 patients who used Korean medicine distillate spray for over 3 weeks among the patients who visited Sangji University Korean Medicine Hospital and whose symptoms were determined as chronic rhinitis and for whom Korean medicine distillate spray was prescribed. 3 weeks later after using spray, a questionnaire was performed for fragrance, irritation and continuance effect of Korean medicine. Immediate therapeutic effect being felt right after spraying was also surveyed and symptom scores was expressed from 10 to 0 and on the assumption that nasal obstruction symptom just before spraying was 10 points, symptom score after spraying was surveyed. In case of evaluation of satisfaction, satisfaction for fragrance and irritation of nasal spray was evaluated by scale based on full score of 5 point from 'very satisfied=5', 'satisfied=4', 'average=3', 'unsatisfactory=2' and 'very unsatisfactory=1', respectively. Effect continuance time after spraying was surveyed by dividing it into within 5 minutes, within 5-10 minutes, within 10-30 minutes and over 30 minutes. All the data was statistically analyzed by Friedman Test that is non-parametric test of Paired t-test and descriptive statistics. Results : Total surveyed patients were 13 persons including 6 males and 7 females and total average age was represented to be $27.1{\pm}17.7$ years old. Score of immediate nasal obstruction improvement effect at 1st week was $6.3{\pm}2.4$ points, at 2nd week $5.7{\pm}2.5$ points and at 3rd week $5.5{\pm}2.5$ points and when comparing 1st week, 2nd week and 3rd week statistically, p value was 0.047<0.05 and from this, it could be seen that the longer spray was used, the more was improvement effect represented with slight significance. In case of fragrance and irritation, both of its score was represented to be high as average $4.0{\pm}1.08 $points and average $4.4{\pm}0.8$ points, respectively. Effect continuance time below 10 minutes was represented in 8 persons who accounted for 61.5%. Conclusions: Immediate improvement effect of nasal obstruction being felt by the patients by using Korean medicine nasal spray could be confirmed and by having the patients use such spray for 3 weeks continuously, it could be realized that such effect was sustained and satisfaction for fragrance or irritation of Korean medicine nasal spray was significant. However, rather short sustained time was considered to be unsatisfactory and this shortcomings is required to be improved in the future.

• 치위생과학회지
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• 제5권3호
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• pp.97-103
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• 2005

본 연구에서는 자극성 섬유종의 병인론을 이해하고자 1997년 1월부터 2004년 12월까지 연세대학교 치과대학 구강병리학교실에서 자극성 섬유종으로 진단된 88예와 구강 백반증으로 진단된 44예를 대상으로 연구하였다. 상처 치유 기전에서 작용하는 인자 중 TGF-${\beta}1$과 EGFR에 대한 일차 항체를 이용한 면역조직화학적 검색을 통하여 다음과 같은 결과를 얻었다. 1. TGF-${\beta}1$의 면역조직화학염색 결과, 자극성 섬유종과 구강 백반증의 상피에서 TGF-${\beta}1$ 발현이 감소하였고 자극성 섬유종 종괴내 섬유아세포의 TGF-${\beta}1$ 발현이 증가하였다. 2. EGFR의 면역조직화학염색 결과, 자극성 섬유종과 구강백반증 상피에서 EGFR의 발현이 증가하였다. 3. TGF-${\beta}1$과 EGFR간 피어슨 상관 계수를 구하였을 때 구강 백반증의 상피 조직에서 역상관관계의 발현 양상을나타내었다.

• 대한소아치과학회지
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• 제43권2호
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• pp.207-212
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• 2016

자극성 섬유종은 만성적인 자극 또는 외상에 의해 발생하는 구강 내의 흔한 섬유증식성 병소이다. 자극성 섬유종과 유사한 형태의 다른 양성 또는 악성 연조직종양의 감별진단을 위해서는 병리조직학적 검사가 필요하다. 본 증례는 엔젤만 증후군 환아에서 상악 좌측 중절치의 이소맹출로 인해 자극성 섬유종이 발생하여 미다졸람을 이용한 근육내 진정 하에 절제생검을 시행한 뒤, 병소의 재발 없이 양호한 치유 결과를 나타내고 있기에 보고하는 바이다.

• 농약과학회지
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• 제15권4호
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• pp.383-388
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• 2011

본 연구는 새롭게 개발된 제초제인 methiozolin의 인체 안전성을 평가하기 위해 급성독성시험을 수행하였다. 랫드를 이용한 급성 독성 시험에서 2,000 mg/kg의 용량을 고용량으로 하여 단계적으로 투여한 결과 methiozolin의 $LD_{50}$은 2,000 mg/kg bw 이상이었다. 급성 경피독성시험결과 시험물질을 고용량 4,000 mg/kg을 투여한 결과 별다른 사망동물이 발생하지 않아 시험물질의 $LD_{50}$이 4,000 mg/kg bw 이상으로 나타났다. 피부자극성 시험결과 시험물질의 약한 자극성이 나타났으며, 안점막 자극성 시험결과 약한 자극성이 있었다. 이상의 연구 결과 경구 독성의 경우 methozolin은 GHS 카테고리 IV에 해당하는 물질로 판단된다. 이러한 결과를 바탕으로 methiozolin은 안전한 제초제로서 추후 만성 독성 연구가 필요하다고 판단된다.

• 대한족부족관절학회지
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• 제11권1호
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• pp.62-66
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• 2007

Purpose: We try to retrospectively analyze the clinical results of the modified Chrisman-Snook procedure for chronic ankle instability. Materials and Methods: From November 1997 to April 2006, thirty-one patients who underwent modified Chrisman-Snook procedure for chronic ankle instability were analyzed. All patients were male and the mean age was 31 years. The follow-up period averaged 48 months. We evaluated the clinical results measured by Hasegawa method. Results: Among them, there were soldiers in 11, socker players in 6, patients who weigh more 80 kg in 5. And there were 9 patients who previously underwent modified Brostrom procedure for chronic ankle instability. The clinical results were rated as excellent in 29, fair in 2 who did not cooperate with postoperative rehabilitation program. There were complications of 2 cases of irritation of the sural nerve and recurrence respectively, 1 case of wound problem. Conclusion: Our results show that the modified Chrisman-Snook procedure is effective treatment method for patients with high-performance athlete/soldier or failed modified Brostrom procedure.