• 대한의생명과학회지
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• 제26권4호
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• pp.310-318
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• 2020

The sciatic nerve is the largest nerve among the peripheral nerves, and the damage to the sciatic nerve is caused by mechanical and physical pressure. This is an important disease that consumes a lot of time and money in the treatment process. Among them, research on relieving nerve pain caused by damage to the peripheral sciatic nerve has been made efforts to prevent and treat this disease through various methods such as drugs, natural products, electrical stimulation, exercise therapy, and massage. Existing treatments are not very effective in neurological pain, and countermeasures are needed. Forsythia Fructus, used in this study, has been used as a therapeutic agent for infectious diseases and a pain reliever for cancer from the past, and in past studies, it has been known to properly control the inflammatory response. In this study, rengyolone, a physiologically active substance of Forsythiae Fructus, was administered to rats that caused chronic left nerve pain to verify the pain relief effect. As a result of the experiment, it was found that mechanical pain and cold stimulation pain were significantly reduced in the rengyolone-treated group compared to the non-administered group. In addition, it was found that nerve growth factor (NGF) mRNA expression was significantly reduced and Cyclin-dependent kinase 2 (Cdc2) expression was increased in the rengyolone administration group. This increase in NGF expression is thought to be related to rengyolone's anti-inflammatory regulatory mechanism. It is expected that the reduced NGF was directly involved in pain relief.

• 보건행정학회지
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• 제15권2호
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• pp.70-83
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• 2005

The purpose of this paper is to examine the relationship between socio-economic factors and self-rated health among older people living in the community. In addition, the study tries to determine whether risk differentials by these socio-economic factors can be explained by other demographic factors, chronic diseases, and functional status. We surveyed to investigate the self-rated health of 397 study samples which had been selected by stratified randomized sampling, $2.7\%$ by each Dong (district) of S-city in Gyeonggi-do. Our study found that the socioeconomic factors such as income, occupation, and insurance were significantly associated with self-rated health. The level of social economic status was positively associated with the level of self-rated health. Two-staged multivariate analysis demonstrated that this relationship was still significant even after adjustment for demographic factors, chronic diseases, and functional status. In conclusion, there are wide socio-economic disparities in self-rated health of older people in this community. It is important that government should know not only health status but also the health-associated factors in order to prepare for the aged society and improve the health status of the elderly. Further researches should uncover causality and mechanism by which SES affects changes in functional health among the elderly.

• 한국융합학회논문지
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• 제13권5호
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• pp.501-508
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• 2022

고혈압을 비롯한 기저질환자의 COVID-19 발생률과 사망률이 높다고 밝혀지고 있다. COVID-19 대유행 상황에서 건강관리를 위해서 손 씻기만큼 칫솔질은 매우 중요하다. 이에 본 연구의 목적은 고혈압 기저질환자의 칫솔질과 손 씻기 실천율과의 관련 요인을 파악하기 위하여 수행되었다. 지역사회건강조사 2020년 원시자료를 이용하여 만 40세 이상 고혈압 기저질환자 62,762명을 대상으로 분석하였다. 연구결과 여성, 연령이 낮을수록, 교육수준이 높을수록, 외출 시 마스크 착용자, 점심식사 후 칫솔질 실천자에서 손 씻기 실천율이 높게 나타났다. 칫솔질을 실천한 고혈압 기저질환자에서 손 씻기 실천율이 더 높은 것으로 나타나 구강위생과 개인방역 사이의 연관성을 확인하였다. COVID-19 감염에 취약한 기저질환자에게 감염병 예방 행태 실천율을 높이기 위한 지속가능한 방안 마련이 필요할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제49권2호
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• pp.207-216
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• 2000

연구배경 : 동종골수이식은 난치성 혈액질환의 효과적인 치료법이나 약 40%에서 치료와 관련된 합병증으로 사망하고, 그중 10-40%가 폐합병증이 주된 사인이므로 폐합병증의 발생유무는 동종골수이식 치료성적에 중요한 영향을 미친다. 국내에서는 이식편대숙주질환이 서구보다 적고 CMV감염률이 높아 폐합병중이 서구와는 다른 양상으로 나타나리라 사료되어 국내에서 동종 골수이식 후 발생한 폐합병증의 임상양상을 알아보고자 본 연구를 시행하였다. 방법 : 1993년 12월부터 1999년 5월까지 서울중앙병원에서 동종골수이식을 시행한 100명의 성인환자를 대상으로 후향적 코호트법으로 연구하였다. 패합병증은 발생시기에 따라 골수가 생착하는 시기인 30일 전후로 나누고 다시 병인에 따라 감염성 혹은 비감염성으로 분류하였다. 감염성 합병증은 혈액이나 BAL액, 흉막액, 객담검사등에서 병원체가 증명된 경우에서나 임상적으로 감염성 합병증이 의심되는 경우에서 항균제 혹은 항진균제를 사용하여 임상적, 방사선학적 호전이 있는 경우로 정의하였다. 결과 : 1) 폐합병증은 100명중 54명에서 83건이 발생하였다. 2) 30일 이전에는 비감염성 합병증이, 30일 이후에는 감염성 합병증이 더 많이 발생 하였고, 기저질환이 재발되거나 만성 이식편대숙주질환이 없으면 1년 이후에는 감염성 합병증은 발생하지 않았다. 3) 비감염성 합병증으로는 흉막액이 27건으로 가장 많았고, 그 외 비감염성 합병증으로는 폐부종 8건, 미만성 폐포출혈 1 건, BO 2건, BOOP 1건이 있었다. 4) 감염성 합병증은 세균성 폐렴 9 건, 바이러스성 폐렴 4건, 폐결핵 3건, PCP 1건, 진균성 폐렴 5건, 결핵성 흉막염 3건이 있었다. 5) CMV감염과 호중구 회복지연은 폐합병증과 관련된 위험인자로 확인되었다. 6) 폐합병증이 발생한 경우 동종골수이식 후 사망률이 유의하게 높았다. 결론 : 동종골수이식 후 폐합병증은 54%에서 발생하였고, 폐합병증이 발생한 경우에 이식 후 사망률이 증가하였다.

• Childhood Kidney Diseases
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• 제19권2호
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• pp.184-189
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• 2015

Poststreptococcal glomerulonephritis (PSGN) is one of the most well-known and important infectious renal diseases resulting from a prior infection with group A ${\beta}$-hemolytic streptococcus. The typical clinical characteristics of the disease reflect acute onset with gross hematuria, edema, hypertension and moderate proteinuria after the antecedent streptococcal infection. In children, usually PSGN is healed spontaneously but if it combines with fast progressing glomerulonephritis, it would be developed to chronic renal failure. Therefore, it is important to make a fast diagnosis and treatment by simple tools to predict the course and the prognosis of disease. Sonography is a simple tool for diagnosis but there is no typical renal sonographic finding in PSGN, so it is difficult to predict the course and the prognosis of disease by sonographic findings. In comparison between two cases of renal sonographic findings in PSGN, a patient who showed more increased echogenicity in more extended area of renal sonography had the severe results of renal pathology, prolonged treatment period and low serum C3 level. Here, we report the different findings of renal sonography and pathology depending on the degree of severity between two patients. Thus, it is necessary to gather more information from further studies to make a consensus about the relationship between the renal sonography and the prognosis of disease in PSGN.

• Pediatric Infection and Vaccine
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• 제21권3호
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• pp.225-230
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• 2014

최근 가와사키병에서 tumor necrosis factor-alpha(TNF-alpha) blocker인 infliximab 단일 정주 요법이 불응성 가와사키병 환자들에게 유용한 치료제로 여겨지고 있다. 장기적인 TNF-alpha blocker 사용이 기회감염의 위험을 증가시킬 수 있지만, 가와사키병 환자들에게 infliximab 사용이 심각한 부작용을 초래하지 않으며 안전하게 사용된 증례들이 보고된 바 있다. 불응성 가와사키병을 앓고 있는 5개월 된 영아에서 infliximab (5 mg/kg) 단일 정주 요법을 사용하였고 가와사키 증상이 호전되었으나 infliximab 치료 후 Acinetobacter lwoffii에 의한 패혈증이 발생하였다. 그래서 저자들은 불응성 가와사키병을 앓은 영아에서 infliximab 치료 후 발생한 패혈증의 첫 사례를 보고하며 infliximab 치료 선택에 있어 기회 감염의 위험성에 대해 고려할 것을 당부하는 바이다.

• 대한한의학방제학회지
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• 제19권2호
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• pp.119-133
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• 2011

Objectives : This study aimed to reveal the characteristics of formulas in "Key to Therapeutics of Children's Diseases" by analysis of crude drugs that constitute formulas. Methods : To analyze the formulas, We classified the formulas to presenting symptom classification. And within that categories, the crude drugs in formulas were diagrammatized. Results : After those analyses, we brought a conclusion as like these. 1. The formulas classified into some categories that include chronic consumption disease, parasitization, digestive system disease, febricity, infectious disease, respiratory disease, skin disease, infirmity and etc. 2. We analyzed the characteristic of formulas by categorization of crude drug combination. In this way, we recognized that Qian Yi(錢乙) frequently used cold crude drugs unlike the trend of S$\grave{o}$ng(宋) dynasty doctors. 3. The prescription that described in "Key to Therapeutics of Children's Diseases" can be found in "Treasured Mirror of Eastern Medicine(東醫寶鑑)" and the other books on posterity. Conclusions : Through these researches, we verified that Qian Yi affect cold herbal and mineral drugs. This tendency of Qian Yi have an effect on the Nourish yin school. And several decades of formulas of "Key to Therapeutics of Children's Diseases" contain in part of pediatrics on "Treasured Mirror of Eastern Medicine". We reconfirmed that Qian Yi affected profound influence on the development of pediatrics and Nourish yin school.

• Pediatric Infection and Vaccine
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• 제29권3호
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• pp.166-172
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• 2022

블라우증후군(Blau syndrome)은 nucleotide-binding oligomerization domain protein 2 (NOD2) 유전자의변이에 의해 발생하는 질환으로 육아종성 피부염 및 만성 포도막염, 관절염을 특징으로 한다. 증상이 비특이적이고 동시다발적으로 발생하지 않아 진단이 어려운 경우가 많다. 반복되는 피부 발진 및 발열에 대해 두 차례 가와사키병으로 오진되어 면역글로불린과 전신 스테로이드로 치료받은 바 있는 13개월 남자 환자에서 블라우 증후군을 진단한 증례를 보고하고자 한다.

• 대한소아치과학회지
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• 제50권2호
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• pp.131-141
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• 2023

치아우식증은 치아, 바이오필름(biofilm), 식이 요인의 상호작용을 기본으로 타액, 불소 등의 구강 환경요인과 생물학적, 행동적, 사회문화적, 유전적 요인이 관여하는 복잡한 다인성질환이다. 최근 치아우식증은 외부 병원체의 감염에 의한 것이 아닌 구강 미생물군의 생태적 변화에 따른 불균형(dysbiosis)의 결과로 이해되면서 전염성질병에서 비전염성 질병(non-communicable diseases, NCD)으로 전환되었다. 치아우식증은 심혈관질환이나 당뇨병과 같이 만성적으로 진행되는 비전염성 질환(NCD) 특성을 가지며, 식이섭취와 생활 습관과 환경적 요소들이 관여한다는 점에서 유사성이 있다. 높은 유병률과 함께 사람들의 건강과 삶의 질에 미치는 영향을 감안할 때 효과적인 구강 건강관리를 목표로 비전염성질환(NCD)로서 치아우식증에 대한 이해가 필요하며, 구강 미생물군의 생태적 균형을 이루기 위한 적절한 예방법과 효율적인 공중보건 정책들이 제공되어야 할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제82권4호
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• pp.348-356
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• 2019

Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients. Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed. Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01-7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of $3.3{\pm}2.8years$ post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%). Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.