• 제목/요약/키워드: Chronic dextromethorphan

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Effects of Chronic Dextromethorphan Administration on the Cellular Immune Responses in Mice

  • Kim, Hyoung-Chun;Jhoo, Wang-Kee;Kwan, Myung-Sang;Hong, Jau-Shyong
    • Archives of Pharmacal Research
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    • 제18권4호
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    • pp.267-270
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    • 1995
  • We examined the chronic effect of dextromethorphan(DM) on the cellular immune responses in mice. T cell simulator, phytohemagglutinin did not show singificant effect on lymphocyte proliferation. Costimulator of T and B cell, pokeweed mitogen, and B cell stimulator, lipopolysaccharide exhibited DM-induced decreased lymphocyte proliferation. Singificantly suppressed natural killer (NR) cell cytotoxicity was evidenced following 6 months DM exposure. These results suggest that chronic DM administration pertub B cell functioning and NK cell cytotoxicity. In addition, prenatal DM exposure did not potentiate the immunomodulation in postnatal effect induced by chronic DM.

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전반적인 신경병성 통증의 조절 및 치료 (The General Management and Treatment of Neuropathic Pain)

  • 전양현
    • 대한치과의사협회지
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    • 제49권6호
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    • pp.327-333
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    • 2011
  • Clinically, treatment goal of neuropathic pain focused on not elimination of etiology but management and control of symptoms because we don't know certain about clear etiology of neuropathic pain yet. The drugs used for the management of neuropathic pain were classified as drugs with strong evidence for benefit(antidepressants, anticonvulsants, opioid analgesics etc.), modest evidence for benefit(mexiletine, carbamazepine, clonidine etc.), preliminary evidence for benefit(NSAIDs, dextromethorphan, topiramate etc.). Finally, the treatment for trigeminal neuralgia was outlined separately since this disorder responds to a different group of drugs than other neuropathic pain conditions.