• Parasites, Hosts and Diseases
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• 제33권1호
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• pp.9-18
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• 1995

토고숲모기의 산란주기성을 관찰하기 위하여 모기를 흡혈시켜 1마리씩 용기에 사육하면서 매시간 관찰한 바 흡혈 후 한번에 산란을 끝낸 개체는 53.9% 2회에 걸쳐 산란을 끝낸 개체 는 26.9%. 3회에 걸쳐 산란을 끝낸 개체는 19.2%였다 흡혈 후 산란을 2회 이상에 걸쳐 끝낸 개체 중 50%가 산란 간격이 6시간 이내였다. 유충시기 영양상태에 따른 무흡혈 산란율을 관찰한 바 유충 개체 당 먹이량이 0.8 mg군, 1.6 mg군, 2.4 mg군에서 각각 6.9%, 22.5%, 44.4%의 산란율을 보여 영양상태에 따라 차이를 보였다. 염도 사이에서는 0%, 0.5%, 1.0%, 2.0%, 4.0% 군에서 각각 25.2%, 36.2%, 23.5%, 14.6%의 산란율을 나타내었다. 유충의 발육기간은 $25^{\circ}C$ 에서 숫모기가 10.73일로서 암모기의 11.85일 보다 단축되었다. 발육기간이 가장 빠른 염도는 1.0%로서 숫모기가 9.25일 암모기가 10.44일이었다. $20^{\circ}C$에서는 평균 9.3일 정도 길었다. 유충시기 영양상태에 따른 여포(follicle) 발육조사에서 여포수가 0.8 mg군은 180.7개, 1.6 mg군은 197.5개. 2.4 mg군은 202개였다. 10일째 관찰에서 0.8 mg, 1.6 mg, 2.4 mg의 3개 영양군은 각각 Christopher's stage IIa가 각각 71.0%, 61.9%, 39.9%로 대부분 Christopher's stage IIa였으며 무흡혈 산란개체도 관찰되었다.

• 한국컴퓨터게임학회논문지
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• 제31권4호
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• pp.175-184
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• 2018

게임의 상업적 성공에 힘입어 게임 원작의 애니메이션도 제작이 되었는데, 특히 1994년 <스트리트 파이터 II>로 시작해 현재까지 꾸준히 게임을 원작으로 한 실사판, 2D Animation, 3D Animaion의 영상이 다양하게 제작되고 있다. 그러나 대중적, 상업적으로 성공한 게임을 원작으로 애니메이션이 제작된다고 항상 흥행에 성공하진 않는다. 그 이유는 원작 게임이 애니메이션으로 다시 제작 되었을 때, 원작 게임 스토리의 서사 구조, 그리고 게임과 애니메이션의 설정에 대한 차이점이 두드러지기 때문이다. 그럼에도 불구하고 2016년 5월 19일에 개봉된, <앵그리버드> 게임을 원작으로 한 <앵그리버드 더 무비> 장편 애니메이션은 상업적으로도 큰 성공을 거두었는데, 본 논문에서는 크리스토퍼 보글러의 영웅의 여행 12단계가 <앵그리버드 더 무비>에 적용된 사례를 분석하고 다른 애니메이션과 비교하여 게임을 원작으로 한 애니메이션의 효과적인 서사 구조 발전방향에 관해 논의하고자 한다. 크리스토퍼 보글러는 헐리우드의 극작가로 신화 연구자인 조셉 캠밸의 <천의 얼굴을 가진 영웅>을 주 모티브로 신화의 공통된 서사 방식을 바탕으로 대중의 사랑을 받는 영화의 구조를 분석했다. 그가 정리한 서사방식은 영웅의 여행으로써 총 12단계의 서사구조를 통해 이야기 속 주인공이 자아를 찾고 원하는 바를 이루어내는 과정을 시나리오 작법에 응용했다. 해외의 영웅, 모험 영화들 뿐만 아니라 우리가 잘 알고 있는 디즈니, 픽사, 지브리 등 대형 제작사에서 나온 애니메이션들도 이 크리스토퍼 보글러의 이야기 전개 방식을 많이 응용하고 있다.

• 디지털산업정보학회논문지
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• 제15권3호
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• pp.111-118
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• 2019

Chapter 1 and 2 of this study examined the methodology of modern storytelling using the hero narrative structure. This involved analyses of Joseph Campbell's monomyth structure, which is the prototype model of modern storytelling and Christopher Vogler's story structure in which the monomyth structure is classified into 3 Acts and 12 Stages. In addition, the movie 'Captain America' was analyzed based on Vogler's narrative structure theory. According to the analyses results, the hero of 'Captain America' fully follows Christopher Vogler's hero narrative structure but in some cases, he does not follow the existing hero narrative structure. It is interpreted that this is because heroes of modern tales have different birth backgrounds from mythical heroes. There is also a difference even in the stage where a hero completes all adventures and returns home between modern tales and myths due to different social backgrounds. Therefore, these findings provide a basis for modification and supplementation of a modern hero epic. Through this analysis, the modified modern hero narrative structure is evaluated to be appropriate as a basic model for modern storytelling. Further, it is expected that those who frame a film script can complete a new hero epic while following the structure of syntagmatic systems by selecting a level among Northrop Frye's paragmatic systems based on this structure and considering story themes and heroes' personality and characteristics.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.381-385
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• 2015

This research aims to investigate critical factors of the government's role in achieving success in Public Private Partnership (PPP) toll road projects in Indonesia according to government and private sectors' perceptions. A preliminary interview Subsequently a questionnaire survey was also conducted involving 143 respondents across the two sectors from eight operating toll were five critical factors of the government's roles in achieving success in PPP toll road projects, namely; "Active involvement in overall project stage activities", "Establishment of good bureaucracy", "Provision of conducive environment", "Appropriate project planning and competitive tendering" and "Provision of appropriate government support and supervision". This research finding is expected to assist the government in defining clear roles and underlying responsibilities in development of PPP toll roads in Indonesia.

• Molecules and Cells
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• 제46권3호
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• pp.176-186
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• 2023

The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the KEAP1/NRF2 pathway as pro-tumorigenic or anti-tumorigenic throughout stages of carcinogenesis (including initiation, promotion, progression, and metastasis) is complex. This mini review focuses on key studies describing how the KEAP1/NRF2 pathway affects cancer at different phases. The data compiled suggest that the roles of KEAP1/NRF2 in cancer are highly dependent on context; specifically, the model used (carcinogen-induced vs genetic), the tumor type, and the stage of cancer. Moreover, emerging data suggests that KEAP1/NRF2 is also important for regulating the tumor microenvironment and how its effects are amplified either by epigenetics or in response to co-occurring mutations. Further elucidation of the complexity of this pathway is needed in order to develop novel pharmacological tools and drugs to improve patient outcomes.

• 영어영문학
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• 제56권2호
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• pp.237-253
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• 2010

In Christopher Marlowe's Cambridge days in the 1580s, the British forward wits were engaged in the curious pursuit of magic and occult philosophy in order to discover the mystery of things. Magic, together with judiciary astronomy, astrology, mathematics, and logic, was one of the most practical disciplines. Marlowe, Shakespeare, and Jonson demonstrate their deep interest in magic and its language of spell and charms in the light of their analogical application to the alchemical theatre. As Shakespeare says that the poet, the lover, and the madman are of the same because they give forms to airy nothing, a magical illusion is, for the three playwrights, similar to the theatrical illusion in that both magic and theatre work in and by a language and both give us sportive pleasures through the deceptio visus. However, while Jonson is rather puritanically antagonistic to the illusive language of alchemy and magic, Marlowe and Shakespeare are attracted to the rapturous nature of the absolute language of magic. Doctor Faustus' indulgence in magic stands for the Marlovian aspiration for the absolute language which allows no discrepancy between thinking and willing, conceiving and actualizing. His uses of spells, charms, anagrams, and magic books are transformed and translated in the play into an alchemical theatre. Faustus is dependant on and bound by his books of magic, as is the actor on the stage. Faustus is the poet condemned from the beginning. Though he is mistakenly thinking that it is he himself that manipulates Mephostophilis the magical agent, it is otherwise. Faustus is a shadow or an actor in the Elizabethan language. He remains a farcical figure during the twenty-four years which are given to him for his sensual dalliance. Marlowe never forgets through his farcical clowning to satirize such Catholic rituals as exorcism and benediction for their illusive theatricalism. The sports of Faustus' playacting and play-directing rise at the last hour to the height of a tragedy. Ironically Marlowe the playwright succeeds as a tragedian at the point where Faustus fails as a magician.

• The Plant Pathology Journal
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• 제24권2호
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• pp.101-111
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• 2008

The fungal genus Alternaria is comprised of many saprophytic and endophytic species, but is most well known as containing many notoriously destructive plant pathogens. There are over 4,000 Alternaria/host associations recorded in the USDA Fungal Host Index ranking the genus 10th among nearly 2,000 fungal genera based on the total number of host records. While few Alternaria species appear to have a sexual stage to their life cycles, the majority lack sexuality altogether. Many pathogenic species of Alternaria are prolific toxin producers, which facilitates their necrotrophic lifestyle. Necrotrophs must kill host cells prior to colonization, and thus these toxins are secreted to facilitate host cell death often by triggering genetically programmed apoptotic pathways or by directly causing cell damage resulting in necrosis. While many species of Alternaria produce toxins with rather broad host ranges, a closely-related group of agronomically important Alternaria species produce selective toxins with a very narrow range often to the cultivar level. Genes that code for and direct the biosynthesis of these host-specific toxins for the Alternaria alternata sensu lato lineages are often contained on small, mostly conditionally dispensable, chromosomes. Besides the role of toxins in Alternaria pathogenesis, relatively few genes and/or gene products have been identified that contribute to or are required for pathogenicity. Recently, the completion of the A. brassicicola genome sequencing project has facilitated the examination of a substantial subset of genes for their role in pathogenicity. In this review, we will highlight the role of toxins in Alternaria pathogenesis and the use of A. brassicicola as a model representative for basic virulence studies for the genus as a whole. The current status of these research efforts will be discussed.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3289-3292
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• 2013

Introduction: The purpose of this study was to identify clinical profiles of patients with low risk of having bone metastases, for which bone scanning could be safely eliminated. Materials and Methods: This retrospective cross sectional study looked at prostate cancer patients seen in the Urology Departments in 2 tertiary centres over the 11 year period starting from January 2000 to May 2011. Patient demographic data, levels of PSA at diagnosis, Gleason score for the biopsy core, T-staging as well as the lymph node status were recorded and analysed. Results: 258 men were included. The mean age of those 90 men (34.9%) with bone metastasis was $69.2{\pm}7.3$ years. Logistic regression found that PSA level (P=0.000) at diagnosis and patient's nodal-stage (P=0.02) were the only two independent variables able to predict the probability of bone metastasis among the newly diagnosed prostate cancer patients. Among thowse with a low PSA level less than 20ng/ml, and less than 10ng/ml, bone metastasis were detected in 10.3% (12 out of 117) and 9.7% (7 out of 72), respectively. However, by combining PSA level of 10ng/ml or lower, and nodal negative as the two criteria to predict negative bone scan, a relatively high negative predictive value of 93.8% was obtained. The probability of bone metastasis in prostate cancer can be calculated with this formula: -1.069+0.007(PSA value, ng/ml)+1.021(Nodal status, 0 or 1)=x Probability of bone metastasis=$2.718^x/1+2.718^x$. Conclusion: Newly diagnosed prostate cancer patients with a PSA level of 10ng/ml or lower and negative nodes have a very low risk of bone metastasis (negative predictive value 93.8%) and therefore bone scans may not be necessary.