• 제목/요약/키워드: Chon-cha

Search Result 59, Processing Time 0.025 seconds

A simple and novel equation to estimate the degree of bleeding in haemorrhagic shock: mathematical derivation and preliminary in vivo validation

  • Chon, Sung-Bin;Lee, Min Ji;Oh, Won Sup;Park, Ye Jin;Kwon, Joon-Myoung;Kim, Kyuseok
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.26 no.3
    • /
    • pp.195-205
    • /
    • 2022
  • Determining blood loss [100% - RBV (%)] is challenging in the management of haemorrhagic shock. We derived an equation estimating RBV (%) via serial haematocrits (Hct1, Hct2) by fixing infused crystalloid fluid volume (N) as [0.015 × body weight (g)]. Then, we validated it in vivo. Mathematically, the following estimation equation was derived: RBV (%) = 24k / [(Hct1 / Hct2) -1]. For validation, non-ongoing haemorrhagic shock was induced in Sprague-Dawley rats by withdrawing 20.0%-60.0% of their total blood volume (TBV) in 5.0% intervals (n = 9). Hct1 was checked after 10 min and normal saline N cc was infused over 10 min. Hct2 was checked five minutes later. We applied a linear equation to explain RBV (%) with 1 / [(Hct1 / Hct2) -1]. Seven rats losing 30.0%-60.0% of their TBV suffered shock persistently. For them, RBV (%) was updated as 5.67 / [(Hct1 / Hct2) -1] + 32.8 (95% confidence interval [CI] of the slope: 3.14-8.21, p = 0.002, R2 = 0.87). On a Bland-Altman plot, the difference between the estimated and actual RBV was 0.00 ± 4.03%; the 95% CIs of the limits of agreements were included within the pre-determined criterion of validation (< 20%). For rats suffering from persistent, non-ongoing haemorrhagic shock, we derived and validated a simple equation estimating RBV (%). This enables the calculation of blood loss via information on serial haematocrits under a fixed N. Clinical validation is required before utilisation for emergency care of haemorrhagic shock.

Expermental Studies of quantitative evaluation using HPLC (봉독침의 봉독함량분석)

  • Jang, Seong-Bong;Cha, Bae-Chon;Kwon, Ki-Rok
    • Journal of Pharmacopuncture
    • /
    • v.8 no.2
    • /
    • pp.53-58
    • /
    • 2005
  • Methods : This study was conducted to carry out quantitative evaluation using HPLC Content analysis was done using HPLC Results : According to HPLC analysis, each BVA-1 contained approximately $0.36{\mu}g$ melittin, and BVA-2 contained approximately $0.54{\mu}g$ melittin. But the volume of coating was so minute, slight difference exists between each needle. Conclusions : Above results indicate that the bee venom acupuncture can complement shortcomings of syringe usage as a part of Oriental medicine treatment, but extensive researches should be done for further verification.

Design of Diagnosis System for Color Therapy (Color therapy 진단 system 설계)

  • Chun, Soon-Yong;Ji, Un-Ho;Chun, Sae-Il;Lee, Keun-Taek
    • Proceedings of the KIEE Conference
    • /
    • 2008.10b
    • /
    • pp.157-158
    • /
    • 2008
  • 보완대제의학의 한분야인 Color Therapy에 대한 과학적 진단을 위해, 색(color)이 인체에 미치는 영향을 정량화 하기위한 선행 기초연구로서 자연광에 포함된 가시광선의 파장이 인체에 미치는 영향을 계측하고 분석하기 위한 시스템의 설계에 대하여 연구하였다. 인체를 구성하는 세포는 세포하나하나가 살아있는 생명체로서 주변환경에 대하여 반응을 하고, 그 반응으로부터 생체신호가 발생하며, 발생된 생계신호는 인체의 다양한 구성기관에 전달되고, 전달받은 기관은 그 신호에 반응한다[4][5]. 따라서 가시광선 영역의 색이 인체에 미치는 영 향분석은 보완대체의학 발전에 중요한 요소라 할 수 있다. 본 연구를 통해 설계한 "Color therapy 진단 System"은 가시광선 중에서 특정 파장대의 빛을 발생시켜 방사하며, 방사된 빛을 조사받은 사람의 신체가 반응하는 신체 상태를 한방적인 진단요소인 "맥", "기혈전류변화"[1][2], "체온변화"등을 계측하고 이를 정량화하는 연구를 수행하였다. 본 연구의 결과는 그 동안 시회저변에서 이루어지고 있던 보완대체의학 분야의 의료행위에 대한 과학화, 정량화를 위해 필요한 중요한 시발점으로 사료된다.

  • PDF

Electrical Properties of Organic Thin Films by Electric Field Stimulus (전계자격에 따른 유기박막의 전기 특성)

  • Chon, D.K.;Choi, Y.I.;Kim, J.M.;Cha, I.S.;Lee, K.S.
    • Proceedings of the KIEE Conference
    • /
    • 1998.11c
    • /
    • pp.807-809
    • /
    • 1998
  • We give pressure stimulation into organic thin films and detect the induced displacement current, In processing of a device manufacture, we can see the process is good from the change of a surface pressure for organic thin films and transfer ratio of area per molecule. The structure of manufactured device is Au/organic thin films(Kapton-Polyimide)/Au and I-V properties of the device is measured from 0(V) to +5(V). The maximum value of measured current is increased as the number of accumulated layers are decreased. The resistance for the number of accumulated layers, the energy density for an input voltage show desired results.

  • PDF