• 제목/요약/키워드: Cholestrol

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Monascus pilosus M-15에 의한 콜레스테롤 합성저해제 Monacolin의 생산 (Production of Cholesterol Inhibitor, Monacolin Produced from Monasces pilosus M-15)

  • 류병호;안문규;박종옥
    • 한국식품영양과학회지
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    • 제24권1호
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    • pp.92-97
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    • 1995
  • The monacolin retard in vivo synthesis of cholestrol. This study was conducted to select the best strain of Monascus sp. for monacolin production among 21 strains. In addition, research on suitable condition for mass production was conducted. Monascus pilosus M-15 was selected as the best strain for production of monacolin. The appropriate substrate for the monacolin production seem to be as follow : glycerin 5%, glucose 2%, corn steep liquor 0.5%, sodium nitrate 0.5% and length of fermentation was at $25^{\circ}C$ for 10~12days, respectively. The monacolin obtained from this organism was compared with standard monacolin using UV, IR, and GC/MS system and it was very close to the standard monacolin.

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녹차의 음용이 지방과 콜레스테롤을 투여한 흰쥐의 혈청지질 및 간의 조직에 미치는 영향 (The Effects of Green Tea on the Serum Lipid and Liver Tissue of Cholesterol Fed Rats)

  • 신미경;한성희;한경조
    • 한국식품과학회지
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    • 제29권6호
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    • pp.1255-1263
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    • 1997
  • Sprague-Dawely계$(165{\pm}20\;g)$ 수컷 흰쥐를 난괴법에 따라 각 군당 6마리씩 C군(일반사료), 1G군(일반사료+1% 녹차물), L-1G군(돈지+1% 녹차물), L-3G군 (돈지+3% 녹차물), LC군(돈지+콜레스테롤), LC-1G군(돈지+콜레스테롤+l% 녹차물), LC-3G군(돈지+콜레스데롤+3% 녹차물) 등 7개군으로 나누어 고콜레스데롤을 초래하는 식이인 1% 콜레스테롤과 10 g의 라아드를 첨가한 식이와 함께 1%와 3% 농도의 녹차를 4주 동안 급여하여 혈청지질 및 콜레스테롤 수준과 간지방 침착정도을 조사하였다. 식이 평균 섭취량은 L-1G군, L-3G군, LC군, LC-1G군, LC-3G군은 C군과 1G군에 비해 전체적으로 낮았으며 녹차 평균 음용량은 모든군에서 $195.61{\sim}213.28\;mL$ 음용하여 증류수와 녹차의 농도에 따른 각 군간에는 차이가 없었다. 체중 증가량은 LC군 195 g으로 다른 모든군에 비하여 가장 높았고 특히 L-3G군 100 g에 비해서는 2배정도의 차이가 나타났다 식이효율은 LC군이 0.45로 모든군에 비해 높았으며 특히 1G군, LC-1G군에 비해 높았다. 혈청의 지질농도에서 TC수준은 LC군 68.67mg/dl, 1G군 48.33 mg/dl으로 LC군이 모든군에 비하여 높았으며 특히 1G군과는 차이를 나타냈다. 혈청의 HDL-C는 1G군이 61.00 mg/dl, L-lG군이 34.20 mg/dl로 1G 군이 TC수준과는 반대로 가장 높았으며(p<0.01) L-3G군, LC군, LC-1G군, LC-3G군이 비슷한 수준으로 낮았으나 C군과 L-1G군보다는 낮았다. HDL-C에 대한 TC의 비율은 1G군 0.79, LC군 1.68로 C군과 LC군에 비해 녹차를 음용한 1G군, LC-3G군, L-3G군, LC-1G군, L-1G군 순으로 낮았고 특히 HDL-C가 가장 높은 1G군이 낮았다. TG농도는 LC군 113.80 mg/dl로 모든 군에 비해 가장 높았으나 특히 3% 녹차 음용군인 L-3G군, LC-3G군은 낮았다. PL농도는 C군 152.00 mg/dl, LC군 148.67 mg/이, 1G군 119.00 mg/dl로 C군과 LC군은 모든 군에서 높았으나 특히 1G군과 LC-3G군은 낮았다. 간장의 총지질 함량은 LC군 8.16% 모든 군에서 높았으며 1G군이 3.68%로 가장 낮았다. 간조직의 지방침착 정도는 대조군은 oil red O 양성액포가 간소엽 전체에 매우 미약하고 작은 구상형태로 세포질에서 적색으로 관찰되어 거의 정상에 가까웠다. LC군은 모든 다른군의 oil red O 소견에 비해 양성 액포수도 많았고 액포의 크기도 가장 크게 나타나 지방침착이 심해졌음을 알 수 있었다. 이에 비해 즉차음용군은 oil red O 양성 액포수와 액포의 크기가 적어져 $55.6{\sim}75.7%$로 감소되어 지방침착의 감소경향을 보였다.

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Cholestrol Content and Formation of Oxidized Cholesterols in Processed Squids

  • Hong, Jeung-Hoon;Ryu, Hong-soo;Kim, Heung-Bae
    • Preventive Nutrition and Food Science
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    • 제1권2호
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    • pp.196-202
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    • 1996
  • The effect of cooking(boiling, steaming and baking0and drying on the cholesterol content and formation of oxidized cholesterols in quid(Japanese flying squid, Todarodes pacificus) was studied. Cholesterol content of live squid meat varied with the portion sampled, and results from spectrophotometric assay ranged from 263.2mg/1..g(mantle) to 315.8mg/100g(tentacle). The cholesterol levels analyzed by gas chromatography(GC) for squid samples were lower by 7% of total cholesterol for live squid meat and 24% for processed meat than those results by spectrophotometric assay. Cooking resulted in the decrease of the initial total cholesterol content of raw meat from 10%(boiling for 5min.) to 25%(steaming for 5min.) The amounts of cholesterol remaining after baking were 68% for microwave oven samples and 64% for convection oven samples. Drying of raw tissue caused the greater reduction in cholesterol content than cooking but showed no significant difference in samples stored for 6 weeks at 4$^{\circ}C$ and 2$0^{\circ}C$. Raw squid meats contained essentially no oxidized cholesterols, while the 22-hydroxychoesterol was detected in frozen meats. The additional oxidized cholesterols as cholestane-triol was indentified with 22-hydroxycholesterols in cooked samples. Sun dried meat stored at 4一 and 2$0^{\circ}C$ for 6 weeks had the three kinds of oxidized cholesterols such as 22-hydroxycholesterol, cholesta-3,5-dien-7-one and cholestane-triol.

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Mouse에 있어서 Ethanol의 간독성에 미치는 Capsaicin의 영향 (Effects of Capsaicin on the Liver Toxicity of Ethanol in Mice)

  • 안영근;김정훈;이선원;김성오
    • Environmental Analysis Health and Toxicology
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    • 제3권1_2호
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    • pp.21-31
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    • 1988
  • The effect of capsaicin on the toxicity of ethanol in mice were studied. Capsaicin was administered i.p. every other day for 4 weeks and 5% ethanol was provided ad libitum by tap water for 4 weeks. The administration of capsaicin 3.0 mg/kg showed the increase of body weight gain, ratio of liver wt./body wt., s-GPT. s-triglyceride and s-cholesterol, and showed the decrease of BUN as compared to control group. Capsaicin administered 3.0 mg/kg showed severe moth eaten appearance. eosinophilic necrosis and cholangitis in mouse liver The administration of 5% ethanol showed the decrease of body weight gain, ratios of liver, kidney and spleen wt./body wt., s-tryglyceride and s-cholestrol. Ethanol administered 5% solution showed little fatty change, moth eaten appearance, Kupffer cell proliferation, spotty necrosis and nuclear regeneration. The administration of capsaicin and ethanol together decreased the influence of ethanol on body weight gain, ratios of liver, kidney and spleen wt./body wt., s-triglyceride and s-cholesterol, and showed the less severe moth eaten appearance, eosinophilic necrosis and cholangitis. It might be concluded that the administration of capsaicin and ethanol together decreased the toxicity caused by capsaicin or ethanol respectively.

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사상체질별 혈중 호모시스테인에 관한 연구 (The Research on the Plasma Homocysteine in Sasang Constitution)

  • 서은희;하진호;서영호;박석준;구덕모;이정환
    • 사상체질의학회지
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    • 제18권1호
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    • pp.132-137
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    • 2006
  • 1. Objectives The purpose of this research is to find out the Constitutional difference between the amount of Plasma Homocysteine, Total cholesterol, and Triglyceride which are factor of Cerebrovascular disease. 2. Methods We enrolled 132 patients inexperienced Strokes who visited our hospital for a medical examination from April 26, 2004 to June 29, 2005 except patients whose body constitusions were undetermined according to QSCOII. This research investigated the Constitutional difference between the amount of Plasma Homocysteine, Total cholesterol and Triglyceride. 3. Results & Conclusions This research has shown that there is a statistical significance between the average amount of Plasma Homocystein level that is higher in Taeumin. But there is no significant difference between the average amount of Total Cholestrol and Triglyceride in Sasang Constitution.

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The relationship of serum chrominum with blood glucose and lipids in rural college women

  • Kim, Ae-Jung;Kim, Hea-Kyung;Chang, Ock-Ja;Kim, Soon-Kyung
    • 한국영양학회:학술대회논문집
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    • 한국영양학회 1998년도 춘계학술대회 초록
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    • pp.49-49
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    • 1998
  • Chrominum(cr) plays an important role in carbohydrate and lipid metabolism and Cr deficiency impairs glucose tolerance and increase serum cholestrol and triglyceride. The relationships of serum Cr with serum glucose and lipids was examined in 79 female college students in Choong-Nam ares. Subjects were devided into underweight. normal and overweight groups according to their BM11. The average age, weight, height and BMI were 21.9yr, 55.89kg, 158.54cm and $22.62kg/m^2$, respectively. Height were not di fferent between groups. Serum Cr and glucose concentrations were not signi ficantly different between groups. However, there were tendency of increasing serum Cr level with increasing body weight. Serum cholesterol and LDL-cholesterol concentrations were significantly lower in underweight group than other groups. BM! had positive corelations wi th LDL-cholesterol, Al and LPH, and negative corelations with HDL-cholesterolltotal cholesterol ratio. Serum Cr concentration had positive corelation with serum glucose concentration and negative corelation with LDL-chloestrol and LPH.nd LPH.

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일부(一部) 생명보험(生命保險) 가입자(加入者)의 혈청총(血淸總)콜레스테롤치(値)에 관(關)한 연구(硏究) (A Study of the Serum Total Cholesterol Levels of the Healthy Insured Group)

  • 조승호
    • 보험의학회지
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    • 제1권1호
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    • pp.110-118
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    • 1984
  • The serum total cholesterol levels were measured by Rosenthal modified method for the insured persons who had passed the medical examination in a life insurance company, Seoul. The sera were obtained from 1,878 adults, 626 males and 1,252 fermales, from sep 1980 to Dec. 1981. The results obtained in the measurement were as follows; 1. The mean and standard deviation of serum cholesterol level in the healthy insured persons were $163{\pm}$ in male, and $157{\pm}24mg%$ in female. The difference of the values between male and female showed statistical signifi- (p<0.01). With regard to sex and age differences, female were significantly higher than male in the 10's, and male were higher than female in the 20's and 50's between both sexes. 2. The cholesteol of male was gradully increased about 12mg% according to the increase of every 10-year interval, but no increase was observed from the 40's to the 50's. The cholesterol level of female was higher in the 10's than in the 20's, and was increased gradually from the 20's to the 50's. 3. No significant difference in serum total cholesterol levels between the insured persons and other normal Korean groups was observed; the frequency distribution of the cholestrol level for the population showed normal distribution.

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한약재 부산물 첨가가 육계의 성장과 생리적 변화에 미치는 영향 (Effects of Supplemention of Chinese Medicine Refuse on Performance and Physiology in Broiler Chicks)

  • 박성진;유성오
    • 한국가금학회지
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    • 제26권3호
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    • pp.195-201
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    • 1999
  • The present study was conducted to investigate the effects of dietary supplemental dry powder of chinese medicine refuse (CMR) on the growth performance and physiological status of broiler chicks. The treatments consisted of corn-soybean meal control diet, CMR 4 and 8% diets. A total of 120 Arbor Acre broiler chicks were randomly allotted to 12 pens ; four pens per treatment and 10 birds per pen. The body weight gain and feed intake did not show ant differences among the treatment groups, but feed conversion was significantly higher (P〈0.05) in CMR 8% group than that of the control group. Hunt L and b did not show ant differences among the treatment groups, but hunt a was darker (P〈0.05) in CMR 4 and 8% group than that of the control group. The blood concentrations of total protein, sugar, glutamic-oxaloacetic-transaminase (GOT), glutamic-pyruvic-transaminase (GPT) Hemogloben were not different among the treatment groups. The pH of thigh muscle were lower in CMR 4 and 8% groups than that of the control group, but crude fat, crude ash of thigh muscle and bone hardness in brolier chicks did not show ant differences among the treatment groups. The saturated fatty acid content of the thigh muscle tende to decrease dietary CMR increased.

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효소적 갈변 반응에 의하여 생성된 갈변 물질이 휜쥐 혈청콜레스테롤 농도에 미치는 영향 (Effects of proteins modified by enzymically oxidized caffic acid on yhe concentration of serum cholestrol of rats, part II)

  • 조영수;정순재
    • 생명과학회지
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    • 제5권2호
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    • pp.1-1
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    • 1995
  • Casein or soybean protein was subjected to there action with caffeic acidtyrosinase system at 30-35$\circ$C, pH 6.8 with aeration for 5hr. The resulting brown proteins were washed with acetone until the washings were on longer colored. However, modified protein still retained a light brown. The effects of the modified proteins and brown compounds on male Wistar strain rats were studied by pair-feeding of a cholesterol-free diet for 14days. Significant decrease in protein digestibility for the rats fed with the modified proteins were observed. Weight gain and protein digestibility were not influenced by feeding brown compounds, but the feeding of brown compound from casein caused an enlargement of caecum. The concentrations of serum cholesterol and triglyceride in the rats fed with modified proteins and brown compounds were mostly unchanged against the rats fed with untreated proteins. These results suggest that the decrease in protein digestibility induced by enzymic browning-reaction did not cause the decrease in concentration of serum cholesterol.

구약고구마(Glucomannan)의 섬유질이 간 및 혈청지질에 미치는 영향 (Studies on the Substrances Contained in Glucomannan Lowering Liver and Serum Cholesterol Levels)

  • 이숙경
    • 한국식품위생안전성학회지
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    • 제6권2호
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    • pp.73-78
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    • 1991
  • 한국 고유의 구황식품인 구약 고구마의 성분을 분석하고 식이성 섬유질로서 혈청지질 대사에 미치는 영향을 실험한 결과 다음과 같다. 1. 구약고구마는 팽윤성이나 점성이 높은 수용성 섬유성분이 다량 함유되어있다. 2. 체중 증가율에서 구약고구마 투여군은 대조군에 비해 유의성이 없었으나 cholesterol 투여군에서는 6.8%, 고 지방 투여군에서는 9.1% 증가되었다. 4. 간의 cholesterol 값은 구약고구마 투여군이 대조군에 배히 5.9% 낮았으며 cholesterol 투여군보다 30.5%가 낮았다. 5. 혈장 cholesterol 값은 대조군에 비해 13.4% 감소되었으나 고 지방 투여군은 10.7% 증가되었다. 6. 혈청 중 총 지질 함량에 있어서 GM 투여군은 대조군에 비해 7.5% 감소되고 반대로 고 지방 투여군은 11.3%가 증가되었다. 7 혈청효소의 활성 변화에서 구약고구마 투여군은 대조군에 비해 7.5% 감소되고 반대로 고 지방 투여군은 11.3%가 증가되었다. 7. 혈청효소의 활성 변화에서 구약고구마 투여군은 대조군에 비해 GOT가 9.0% 감소되었으나, cholesterol 투여군은 별다른 차이를 나타내지 않았다. GPT는 대조군에 비해 2.1% 감소, 고지방 투여군 보다는 18.5% 감소되었다.

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