• 한국막학회:학술대회논문집
• /
• 한국막학회 2005년도 춘계 총회 및 학술발표회
• /
• pp.67-70
• /
• 2005

• Journal of Acupuncture Research
• /
• 제22권2호
• /
• pp.191-201
• /
• 2005

Background & Objective: Articular cartilage is a potential target for drugs designed to inhibit the activity of matrix metalloproteinases (MMPs) to stop or slow the destruction of the proteoglycan and collagen in the cartilage extracellular matrix. The purpose of this study was to investigate the effects of Aralia cordata Thunb. in inhibiting the release of glycosaminoglycan (GAG), the degradation of collagen, and MMP activity in rabbit articular cartilage explants. Methods : The cartilage-protective effects of Aralia cordata Thunb. were evaluated by using glycosaminoglycan degradation assay, collagen degradation assay, colorimetric analysis of MMP activity, measurement of lactate dehydrogenase activity and histological analysis in rabbit cartilage explants culture. Results : Interleukin-la (IL-1a) rapidly induced GAG, but collagen was much less readily released from cartilage explants. Aralia cordata Thunb. significantly inhibited GAG and collagen release in a concentration-dependent manner. Aralia cordata Thunb. dose-dependently inhibited MMP-3 and MMP-13 expression and activities from IL-1a-treated cartilage explants cultures when tested at concentrations ranging from 0.02 to 0.2 mg/ml. Aralia cordata Thunb. had no harmful effect on chondrocytes viability or cartilage morphology in cartilage explants. Histological analysis indicated that Aralia cordata Thunb. reduced the degradation of the cartilage matrix compared with that of IL -1a-treated cartilage explants.

• Bulletin of the Korean Chemical Society
• /
• 제25권12호
• /
• pp.1932-1934
• /
• 2004

• 한국환경농학회지
• /
• 제42권4호
• /
• pp.396-407
• /
• 2023

The golden apple snail (Pomacea canaliculata) has been utilized as a natural and eco-friendly control of weeds in rice paddy fields. However, P. canaliculata can damage other crops. In this study, the effectiveness of plant extracts from various natural sources that are reportedly effective against pests in the control of P. canaliculata was investigated. The four plant extracts were effective against P. canaliculata and ranked in descending order as green tea seed (Camellia sinensis) > root of red spider lily (Lycoris radiata) > leaves of tobacco (Nicotiana tabacum) > root of sophora (Sophora flavescens). The mortality rate of P. canaliculata was increased using 200 to 2000 mg/kg of green tea seed powder. However, shrubby sophora root extract did not significantly increase the mortality rate. The LC₅₀ and LC₉₀ of green tea seed, tobacco leaves, shrubby sophora root, and red spider lily root were 900 and 2800 mg/L, 956 and 2320 mg/L, 2162 and 5325 mg/L, and 512 and 1054 mg/kg, respectively. The LC₅₀ and LC₉₀ of ground powder of C. sinensis, N. tabacum, S. flavescens and L. radiata were 248 and 646 mg/L, 403 and 733 mg/L, 409 and 905 mg/L, and 493 and 1141 mg/L, respectively. The findings indicate the remarkable control potency of green tea seeds against the golden apple snail. An organic material incorporating the four plant powders may help control green apple snail in an ecosystem-friendly manner.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2000년도 제13회 춘계학술대회 및 임시총회 학술발표 논문집
• /
• pp.774-779
• /
• 2000

B-to-B 통합은 뚜렷한 비용절감과 정시 공급망 관리와 자동화에 따른 업무처리를 통한 경영 효율을 가져온다. 전통적인 EDI 비용은 대부분의 기업에 부담이 되는 요소이므로 산업계는 인터넷 기반의 B-to-B 상거래로 전환을 하고 있다. 이의 핵심이 될 수 있는 기술이 XML/EDI이며 이는 문서작성과 교환처리를 위한 새로운 패러다임을 제시한다. XML/EDI는 전자상거래의 모든 기본구조를 제공하며, 기업들이 기업의 업무적 문제들을 해결하기 위해 현존하는 표준들을 어떻게 이용할 수 있는지를 정의한다. 본 논문에서는 전통적인 EDI의 현존하는 문제점들을 해결할 수 있는 B-to-B 전자상거래를 위한 XML/EDI 시스템 의 구축방안을 제시한다.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2000년도 제13회 춘계학술대회 및 임시총회 학술발표 논문집
• /
• pp.532-537
• /
• 2000

XML/EDI는 데이터 전달에 초점을 둔 전통적인 EDI의 범위를 확대하여 전자상거래에 필요한 프레임워크(framework)를 제공한다는 면에서 전통적인 EDI와 정의가 다르다. 기존의 EDI 서비스를 인터넷 플랫폼으로 옮겨가고 다시 Web 플랫폼으로 옮겨감으로써 EDI 서비스 사용자들은 기존의 서로 다른 EDI 전용 소프트웨어의 사용에 따른 불편함이 없어지고 통합된 환경으로 EDI 서비스를 사용할 수 있다. 본 논문에서는 이러한 전자상거래 시스템의 핵심 요소인 웹 기반 XML/EDI시스템의 전체적인 설계 및 구현에 대해서 기술한다. 기술된 XML/EDI 시스템은 현재 80% 정도의 구현정도를 보이고 있으며, 웹을 통한 시연이 가능하다.

• 한국환경성돌연변이발암원학회지
• /
• 제16권1호
• /
• pp.19-23
• /
• 1996

This study was performed by the sister chromatid exchanges (SCEs) and micronuclei (MN) assays to investigate the adaptive response to ultraviolet light (UV) or ethyl methanesulfonate (EMS) in Chinese hamster ovary (CHO) and Sarcoma 180 (S180) cells. The pretreatment with 1 J/m$^2$ UV or 2 mM EMS decreased the frequency of SCEs induced by the treatment with 5 J/m$^2$ UV or 8 mM EMS in CHO cells. The pretreatment with UV (1 or 2 J/m$^2$) or EMS (1, 2 or 3 mM) did not affect the SCEs induced by the treatment with 7 J/m$^2$ UV or 10 mM EMS in S180 cells. On the other hand, the pretreatment with 1 J/m$^2$ UV or 2 mM EMS decreased the frequency of MN induced by the treatment with 5 J/m$^2$ UV or 8 mM EMS in CHO cells. The pretreatment with UV (1 or 2 J/m$^2$) or EMS (1, 2 or 3 mM) did not affect the frequency of MN induced by the treatment with 7 J/m$^2$ UV or 10 mM EMS in S180 cells. It is suggested that there are adaptive responses at the level of chromosome and micronuclei to UV and EMS in CHO cells.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1999년도 하계학술대회 논문집 A
• /
• pp.330-332
• /
• 1999

At the present, development of microelectronics technology caused an increase in using of induction motor for variable speed motor drive system instead of do motor. This paper is described the design of induction motor fed by inverter and analyzed 1.5kW motor performance using by finite element method (FEM).

• 대한한의학회지
• /
• 제27권1호
• /
• pp.220-228
• /
• 2006

Objectives : Interleukin-1 (IL-1)${\beta}$ in articular chondrocytes regulates differentiation, apoptosis, and inflammatory responses. It is still controversial, So, we investigated IL- $1{\beta}$ induces chondrocytes dedifferentiation and death. Also, we studied the role of the mitogen-activated protein kinase (MAPK) subtypes on IL-$1{\beta}$-induced dedifferentiation and apoptosis. Methods : To evaluation of dedifferentiation by chemokines of chondrocytes, we assessed such as proteoglycan, collagen, MMP-3 and MMP-13 by RT-PCR analysis. Also, to assess of apoptosis effect by chemokines, we measured annexin V/propidium iodode (PI) and sub G1 cells in chondrocytes by flowcytometric analysis Results : IL-$1{\beta}$ treatment did not affect activation of ERK-1/2, but stimulation of p38 kinase. Inhibition of phospho ERK-1/2 with PD98059 enhanced IL-1b-induced dedifferentiation, and apoptosis up to 13.5%, whereas inhibition of phospho p38 kinase with SB203580 inhibited dedifferentiation, and apoptosis. Conclusions : Our results indicate that SB203580, p38 kinase inhibitor, inhibits IL-$1{\beta}$-induced dedifferentiation, and apoptosis by the inhibition of type II collagen expression and proteoglycan synthesis of rabbit articular chondrocytes.

• 한방재활의학과학회지
• /
• 제29권2호
• /
• pp.101-113
• /
• 2019

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-$1{\beta}$ -treated primary rat chondrocytes. Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-$1{\beta}$ (10 ng/mL). Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and $PGE_2$, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-$1{\beta}$-treated primary rat chondrocytes. Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment.